Digital Commons Network^™

Exploring The Relation Between School Pushout And Future Outlook For Black Youth., Kish Cumi

Electronic Theses and Dissertations

This dissertation study is an examination of the relation between school pushout and future outlook for Black youth. Theoretically, this dissertation study is framed by Bronfenbrenner’s Ecological Model (Bronfenbrenner, 1977) and Racial Encounter Coping Appraisal and Socialization Theory (RECAST). In light of the systemic racial disparities entrenched in school pushout phenomena among Black youth, the researcher sought to explore parental warmth as a protective factor for youth subjected to school pushout. School pushout as praxis was discussed in conjunction with the school-toprison pipeline (STPP), as school pushout is identified as an entry point within the STPP. This dissertation study explored …

Effects Of A Text Message-Based Motivational Interviewing Intervention On Cigarette Smoking In College Students., Anna Jorayeva

Electronic Theses and Dissertations

Purpose: The purpose of this dissertation was to examine the effects of a novel text message-based motivational interviewing intervention on cigarette smoking behavior in college students. Three manuscripts comprised this dissertation and included: a state of the science review of motivational interviewing and text message-based smoking behavior interventions in adolescents and young adults; a critical review and analysis of instruments used to measure nicotine dependence in young adults; and a quasi-experimental study testing the effects of a novel text message-based motivational interviewing intervention on cigarette smoking behavior in college students. Background: Cigarette smoking is the number one preventable cause of …

Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham

Electronic Theses and Dissertations

Indian Knoll is an Archaic shell midden site located in the Green River region of west-central Kentucky, and was excavated twice in the first half of the 20^th century. While Indian Knoll has been the subject of frequent bioarchaeological studies, the present study presents an osteological analysis of the relationships between skeletal markers commonly associated with local inflammatory processes, and that have the potential to be used as proxies for systemic inflammation. The analysis revealed a significant positive association in the presence of periodontal disease (PD) and periosteal lesions (PL), suggesting a potential underlying hyper-inflammatory status or phenotype. These …

Spreading Speeds Along Shifting Resource Gradients In Reaction-Diffusion Models And Lattice Differential Equations., Jin Shang

Electronic Theses and Dissertations

A reaction-diffusion model and a lattice differential equation are introduced to describe the persistence and spread of a species along a shifting habitat gradient. The species is assumed to grow everywhere in space and its growth rate is assumed to be monotone and positive along the habitat region. We show that the persistence and spreading dynamics of a species are dependent on the speed of the shifting edge of the favorable habitat, c, as well as c^*(∞) and c^*(−∞), which are formulated in terms of the dispersal kernel and species growth rates in both directions. When …

Pro-Inflammatory Cytokines Promote Viral Replication And Cell Cycle Mediators In Arenavirus-Induced Hepatitis., Gretchen E. Holz

Electronic Theses and Dissertations

Lassa virus (LASV) is an arenavirus and causative agent of Lassa fever (LF), a viral hemorrhagic fever in West Africa for which there is no vaccine. Lymphocytic choriomeningitis virus (LCMV), is used as a surrogate to mimic LASV-induced liver pathology. LCMV-WE, not LCMV-ARM, causes disease in primates and mice characterized by hepatitis, high viral load, hepatocyte proliferation, and upregulated proliferative triggers (e.g. TNF-α, IL-6 ). We hypothesize LCMV-WE induces pathological hepatocyte proliferation via pro-inflammatory triggers (TNF-α, IL-6) from macrophages, leading to: increased viral replication, modulated cell cycle, and arrested cell cycle. RAW 264.7 macrophages and AML-12 hepatocytes, were used as …

Glutathione S-Transferase P In Glucose Homeostasis In Mice., Shubha Ghosh Dastidar

Electronic Theses and Dissertations

High calorie diets have fostered the current pandemic of obesity and comorbid conditions of non-alcoholic fatty liver disease (NAFLD), systemic insulin resistance (IR) and type 2 diabetes (T2D). Hepatic glutathione S-transferases (GSTs) are dysregulated in obesity, NAFLD and diabetes. The multifunctional GST pi isoform (GSTP) catalyzes acrolein metabolism and inhibits JNK (c-Jun NH₂-terminal kinase). The purpose of this study was to test specifically whether GSTP deficiency disturbs glucose homeostasis in mice. Hepatic GST proteins were downregulated by short-term high fat diet (HFD) in wild type (WT) mice concomitant with glucose intolerance, increased hepatic JNK activation and protein-acrolein …

Secular But Not Superficial : An Overlooked Nonreligious/Nonspiritual Identity., Daniel G. Delaney

Electronic Theses and Dissertations

Since Durkheim’s characterization of the sacred and profane as “antagonistic rivals,” the strict dichotomy has been framed in such a way that “being religious” evokes images of a life filled with profound meaning and value, while “being secular” evokes images of a meaningless, self-centered, superficial life, often characterized by materialistic consumerism and the cold, heartless environment of corporate greed. Consequently, to identify as “neither religious nor spiritual” runs the risk of being stigmatized as superficial, untrustworthy, and immoral. Conflicts and confusions encountered in the process of negotiating a nonreligious/nonspiritual identity, caused by the ambiguous nature of religious language, were explored …

Evaluating Cardiovascular Dysfunction During Increased Activity And Exercise Rehabilitation Following Incomplete Thoracic Spinal Cord Injury In The Adult Rat., Kathryn A. Harman

Electronic Theses and Dissertations

Spinal cord injury (SCI) results in whole-body dysfunction. While the majority of SCI research is focused on improving locomotor function after injury, cardiovascular (CV) disease continues to be the leading cause of morbidity in the chronic SCI patient population. The combination of injury-induced destruction of autonomic pathways, maladaptive plasticity within lumbosacral circuits, and the progressive decline in physical fitness contribute to the poor CV status of SCI individuals. Currently, there is little emphasis on implementing appropriately-timed acute rehabilitation techniques aimed to curtail maladaptive remodeling and improve CV outcomes. Furthermore, no pre-clinical or clinical studies have investigated the most appropriate time-course …

Experimental Observation Of The Relationship Between The Pressure Drop And Flow Rate Of Radial Flow Through Porous Media., Matthew William Okruch

Electronic Theses and Dissertations

This research experimentally observed the relationship between pressure drop and flow rate for high velocity, radial flow through porous media. The criterion for what represents high velocity is a function of the Reynold’s number of the flow. Pressure drop – flow rate curves were developed by flowing air and water through the porous carbon block samples. Each sample’s permeability was calculated from on the air test results. Each sample’s porosity was determined through digital microscope image analysis. Darcy’s Law, the Forchheimer equation, and the Ergun equation were converted to the radial flow domain and compared to the experimental data. The …

"We Weren't Created To Do It By Ourselves" : Good Mothering And Maternal Support Across Race, Class, And Family Structure., Cheryl Lynn Crane

Electronic Theses and Dissertations

Maternal support contributes to maternal and child well-being, yet not all mothers incorporate support into their maternal practices. Most research on mothering standards and practices in the U.S. focuses on white, middle-class, married mothers. This study expands upon this research by incorporating an intersectional lens to explore how mothers interpret standards of “good mothering” across race, class, and family structure. I conducted a mixed-method evaluation of a nonprofit program offering peer-based maternal support to mothers of color, lower-income mothers, and single mothers; 41 in-depth interviews with mothers to learn why maternal support resonated with some, but not all, mothers; and …

Practical Knowledge In Electrical Engineering : Applying Lessons From Industry To The Classroom., Tayce Lassiter

Electronic Theses and Dissertations

Objective: To identify and develop solutions for known gaps in existing electrical engineering curricula, by creating instruction modules applicable in a variety of settings. These instructional packages include: conductor sizing, conduit routing, how to read and create a P&ID, arc flash calculations, and area classification. With regards to conductor sizing, the importance of specifying the correct size of conductor, the standard sizes of conductors, the types of conductor insulation, and finally detail the calculations of conductor sizing and voltage drop will be discussed. The conduit routing module will introduce the student to basic guidelines of conduit routing as well as …

Knowledge Of Algebra For Teaching Quadratic Equations : The Impact Of Knowledge Dimensions On Planning And Pedagogical Strategies., Michael Raney

Electronic Theses and Dissertations

Planning and presenting meaningful instruction in the mathematics classroom is a demanding task requiring mental flexibility as well as a solid foundation in relevant content knowledge and pedagogical strategies. In the last three decades, there has been a growing interest in the way teachers utilize this specialized mathematical knowledge for teaching algebra in the practice of teaching, specifically in planning and presenting classroom instruction. Even more recently, a growing area of emphasis has been the application of these domains of knowledge in a specific focal context involving a singular topic or unit of instruction in the mathematics classroom. This study …

The Impact Of Paroxysmal Sympathetic Hyperactivity Following Traumatic Brain Injury On Intensive Care Unit Length Of Stay And Discharge Disposition., Kimberly S. Meyer

Electronic Theses and Dissertations

Paroxysmal Sympathetic Hyperactivity (PSH) is a complication affecting a subset of patients with severe traumatic brain injury (TBI). It is associated with increased morbidity, longer lengths of stay, and delayed recovery (Perkes, Baguley, Nott, & Menon, 2010). The most prevalent signs and symptoms of PSH include unprovoked tachycardia, tachypnea, hypertension, dystonia, and diaphoresis (Lemke, 2007). If untreated, PSH can lead to impaired cerebral blood flow, sub-endocardial damage, dehydration, malnourishment, and contractures (Lemke, 2007). Results from this retrospective study indicate that there is no difference in intensive unit (ICU) length of stay in TBI patients with PSH compared to those without …

Conductive Inks And Films Via Intense Pulsed Light., Gabriel L. Draper

Electronic Theses and Dissertations

This research focuses on the investigation of Earth abundant copper and carbon based nanomaterials that are subjected to Intense Pulsed Light Processing to create conductive films, as future flexible electronics and renewable energy solutions would benefit from the quick and scalable production of conductive films. Use of nanomaterials in their oxide/hydroxide forms leads to higher stability in aqueous inks for efficient large area solution deposition. IPL Processing utilized 2044 μs pulses ranging from 589 J - 2070 J over an area of 1.9 cm x 30.5 cm, with energy densities of 10.1, 12.8, 15.8, 19.2, 22.9, 26.8, 31.1 and 35.7 …

Examination Of The Relevance Of Pi3k And Pten Pathway In Ustilago Maydis., Nathaniel Edward Dalton

Electronic Theses and Dissertations

Ustilago maydis is a fungal pathogen that is an obligate parasite on Zea mays (Corn) in order to undergo and complete its sexual life cycle. The cells grow as a haploid form until they meet a compatible partner and undergo a dimorphic switch from a budding yeast-like cell type to a filamentous dikaryon. Infection of the host plant is characterized by leaf chlorosis, anthocyanin content, and formation of large galls that develop on the stem, leaves, cobs, and flowers. Many signaling cascades such as MAPK and PKA are involved in the regulation of the infection lifecycle. The Phosphatidylinosotiol 3 Kinase/ …

Scalable Production And Applications Of Metal Oxide Nanowires., Tu Quang Nguyen

Electronic Theses and Dissertations

Metal oxide nanowires are materials of interest in number of applications such as lithium ion batteries, solar cells, catalyst support, and gas sensing due to their unique charge transport properties and short diffusion length scales. To incorporate nanowires for any applications, one would need hundreds of grams to kilograms of these nanowires. However, state-of-the-art methods for producing metal oxide nanowires are limited to producing only milligrams to a gram in a batch. Hence, there is a need to develop scalable and cost effective processes and reactors to address this challenge. Direct gas phase oxidation of zinc metal powders using a …

Computational Methods For The Analysis Of Functional 4d-Ct Chest Images., Ahmed Soliman Naeem Soliman

Electronic Theses and Dissertations

Medical imaging is an important emerging technology that has been intensively used in the last few decades for disease diagnosis and monitoring as well as for the assessment of treatment effectiveness. Medical images provide a very large amount of valuable information that is too huge to be exploited by radiologists and physicians. Therefore, the design of computer-aided diagnostic (CAD) system, which can be used as an assistive tool for the medical community, is of a great importance. This dissertation deals with the development of a complete CAD system for lung cancer patients, which remains the leading cause of cancer-related death …

Workplace Spirituality And Employee Work Intentions : Examining The Relationship And The Mediating Role Of Ethical Leadership., Paula F. Soder

Electronic Theses and Dissertations

This dissertation examined the extent to which workplace spirituality was associated with work intentions, and whether ethical leadership served as a mediator of the relationship between workplace spirituality and work intentions. The study begins with an overview of the significant workplace spirituality literature, and a brief overview of work intentions and ethical leadership. A convenience sample of 405 U.S. based adults, employed full-time were surveyed. Using correlation and path analysis, results from the study showed a positive strong association between workplace spirituality and employee work intentions, and mediation via ethical leadership. The findings of the study provided support for both …

The Zodiac Army., Keith Charles Marks

Electronic Theses and Dissertations

This thesis is the beginning of a book title The Zodiac Army. The book is the first in a trilogy and follows three different characters. The first, Ash, is a teenage boy who discovers he is a powerful magician who, along with another magician, can control the elements of nature. The two form a Twin pairing and will fight for each other and for the safety of the kingdom. Alora, the second character, is a young and faithful priestess in the Temple. Her faith, in both the gods and those in charge of the Temple, could bring the entire system …

Psychophysiological Analysis Of A Pedagogical Agent And Robotic Peer For Individuals With Autism Spectrum Disorders., Mohammad Nasser Saadatzi

Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by ongoing problems in social interaction and communication, and engagement in repetitive behaviors. According to Centers for Disease Control and Prevention, an estimated 1 in 68 children in the United States has ASD. Mounting evidence shows that many of these individuals display an interest in social interaction with computers and robots and, in general, feel comfortable spending time in such environments. It is known that the subtlety and unpredictability of people’s social behavior are intimidating and confusing for many individuals with ASD. Computerized learning environments and robots, however, prepare a predictable, …

Identification And Characterization Of Genes Involved In Metabolism Of N5 Monoene Precursors To N5 Anacardic Acids In The Trichomes Of Pelargonium X Hortorum., Richa A. Singhal

Electronic Theses and Dissertations

Unusual monoenoic fatty acids (UMFA’s) and specialized metabolites called anacardic acids (AnAc) are produced in glandular trichomes of Pelargonium ´ hortorum (geranium). The UMFA’s, 16:1^∆11 and 18:1^∆13 are precursors for the synthesis of unsaturated AnAc 22:1n5and 24:1n5 that contribute to pest resistance in geraniums. UMFAs and their derived AnAc metabolites not only provide a useful biological marker that differentiates the biosynthetic pathway for unusual mononenes from the common fatty acids (i.e. stearic, palmitic, oleic, linoleic and linolenic) but also have industrial, medical and agricultural applications. Fatty acid biosynthesis enzymes like acyl carrier proteins (ACPs); thioesterases (TEs) and β-ketoacyl-ACP …

Transient Receptor Potential Cation Channel, Subfamilies V, Member 1 (Trpv1) And M, Member 1 (Trpm1) Contribute To Neural Signaling In Mouse Retina., Jennifer Noel

Electronic Theses and Dissertations

The retina processes light information through parallel pathways in order to extract and encode the visual scene. Light information is transmitted to the brain through approximately 30 ganglion cells (GCs), the retinal output neurons. Trp channels modulate the responses of retinal neurons within specific pathways. The study of the expression and function of the majority of Trp channels in the retina is largely in its infancy. My dissertation first investigated the expression and function of the transient receptor potential vanilloid-1 (TRPV1) receptor/channel in the retina. TRPV1, the first cloned and most highly studied Trp channel in the peripheral nervous system, …

Single Carrier Frequency Domain Equalization And Energy Efficiency Optimization For Mimo Cognitive Radio., Xiaohui Zhang

Electronic Theses and Dissertations

This dissertation studies two separate topics in wireless communication systems. One topic focuses on the Single Carrier Frequency Domain Equalization (SC-FDE), which is a promising technique to mitigate the multipath effect in the broadband wireless communication. Another topic targets on the energy efficiency optimization in a multiple input multiple output (MIMO) cognitive radio network. For SC-FDE, the conventional linear receivers suffer from the noise amplification in deep fading channel. To overcome this, a fractional spaced frequency domain (FSFD) receiver based on frequency domain oversampling (FDO) is proposed for SC-FDE to improve the performance of the linear receiver under deep fading …

Retinoic Acid Signaling Regulates Krt5 Independently Of Stem Cell Markers In Submandibular Salivary Gland Epithelium., Timur Maratovich Abashev

Electronic Theses and Dissertations

Vitamin A metabolism, which produces the signaling molecule Retinoic Acid (RA), has been demonstrated to be important for growth and branching morphogenesis of mammalian embryonic salivary gland epithelium. However, it is not known whether RA functions directly within epithelial cells or in associated tissues that influence morphogenesis of salivary epithelium. Moreover, downstream targets of RA transcriptional regulation have not been identified. Here we show that canonical RA signaling occurs in multiple tissues of embryonic mouse salivary glands, including epithelium, associated parasympathetic ganglion neurons, and non‑neuronal mesenchyme. By culturing epithelium explants in isolation from other tissues we demonstrate that RA influences …

The Role And Regulation Of Inhibitor Of Kappa B Kinase In The Impaired Monocyte Response., Norman James Galbraith

Electronic Theses and Dissertations

Trauma, major surgery and systemic infection can lead to a subsequent immunosuppressed state which can predispose patients to nosocomial infection and death. Approximately a sixth of patients will have impaired monocyte function, as determined by decreased HLA-DR expression or decreased TNF-α production in response to ex-vivo lipopolysaccharide (LPS) stimulation. This project aimed to develop an in-vitro model of impaired monocyte function using isolated monocytes from healthy volunteers, to study the effect of monocyte impairment on IκK signaling, and determine the role of IκK in the impaired monocyte response. These studies have provided the following results:

1. Monocytes treated with low dose …

The Role Of The Mir-200 Family On The Tumor Suppressor Rassf2 And The Effect On Mapk Pathway Activity In Colorectal Cancer., Jane V. Carter

Electronic Theses and Dissertations

This dissertation investigated the role of the miR-200 family in normal colon epithelial (CCD 841) and Dukes’ C (HT-29) colorectal cancer (CRC) cell lines. Our aim was to characterize expression of the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) in colorectal cell lines, study their effect on the tumor suppressor Ras Associated Domain-Containing Protein (RASSF) 2 and on subsequent activity within the mitogen-activated protein kinase (MAPK) signaling pathway. We wanted to determine whether regulation of miR-200 family members could change cell behavior towards more “cancer-like” in a normal colon epithelium (CCD 841) cell line, or less “cancer-like” in a …

Professional School Counselors : Integral Stakeholders In The Recruitment, Retention, And Support Of African American, Latino, And Low-Income Students In Advanced Placement Programs., Damien Sweeney

Electronic Theses and Dissertations

Numerous studies have been conducted that show the importance of diversifying Advanced Placement Courses. However, Griffin and Steen (2011) state that: Despite a vast body of literature that stresses the importance of school counselors in addressing inequities that exists in schools, few articles provide concrete strategies that school counselors can infuse in their practice. More research is warranted because many school counselors face barriers when trying to implement systemic change in the schools. (p. 76) This qualitative research study is based on a collective phenomenological case study of six participants (five Professional School Counselors and one Director of School Counselors) …

Mechanism Of Interaction Of Peptide Modified Nanoparticles With Porphyromonas Gingivalis., Ankita Jain

Electronic Theses and Dissertations

Studies suggest that P. gingivalis functions as a keystone pathogen and interacts with primary colonizers in the supragingival biofilm such as S. gordonii. This interaction contributes to the initial colonization of the oral cavity by P. gingivalis and thus represents a potential target for therapeutic intervention. We have identified a peptide (BAR) derived from the streptococcal SspB protein that functions to inhibit P. gingivalis adherence to S. gordonii. In addition, we showed that nanoparticles (NPs) functionalized with BAR inhibit this interaction more potently than free soluble peptide, possibly by promoting interaction with P. gingivalis at higher valency than …

Reflectivity Of Light Emitting Diodes (Led) And Incandescent Lights On Concrete And Asphalt Pavements., Jeremy Elliott Rice

Electronic Theses and Dissertations

The purpose of this study is to investigate the reflectivity of light on concrete and asphalt pavement systems. In 1983, the Illuminating Engineering Society (IES) published the first recommended practice (RP-8) for the design of roadway and parking lot lighting. This design method implemented empirically tested factors which were defined as the “reduced luminance coefficients” or the R-Tables. The R-Tables are essential for proper design of light pole installation dimensions, required power, and the distribution of light. The originally tested pavements are not necessarily representative of modern pavement materials used today. Moreover, recent Light Emitting Diodes (LED) are a relatively …

Dynamic Warehouse Optimization Using Predictive Analytics., Parvaneh Jahani

Electronic Theses and Dissertations

The forward area is a small area of a warehouse with a low picking cost. Two approaches that are investigated for selecting the SKUs of this area and the allocated space are the static and the dynamic approaches. In the case that decisions about the forward area are made periodically (e.g. yearly) and the products' demand patterns are completely ignored, the FRP is static. We developed two heuristics that solve the large discrete assignment, allocation, and sizing problem simultaneously. Replenishing the same product in the same place of the forward area brings about a ``Locked" layout of the fast picking …