Digital Commons Network^™

Numerical Simulations Of Premixed Flames Of Multi Component Fuels/Air Mixtures And Their Applications, Essa Kh I J Salem

Theses and Dissertations--Mechanical Engineering

Combustion has been used for a long time as a means of energy extraction. However, in the recent years there has been further increase in air pollution, through pollutants such as nitrogen oxides, acid rain etc. To solve this problem, there is a need to reduce carbon and nitrogen oxides through lean burning, fuel dilution and usage of bi-product fuel gases. A numerical analysis has been carried out to investigate the effectiveness of several reduced mechanisms, in terms of computational time and accuracy. The cases were tested for the combustion of hydrocarbons diluted with hydrogen, syngas, and bi-product fuel in …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Patients' Perceptions And Patient-Reported Outcomes In Progressive-Fibrosing Interstitial Lung Diseases, Jeffrey J. Swigris, Kevin K. Brown, Rayid Abdulqawi, Ketan Buch, Daniel F. Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue

Internal Medicine Faculty Publications

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be …

Performance Of C2H4 Reductant In Activated-Carbon-Supported Mnox-Based Scr Catalyst At Low Temperatures, Guangli Liu, Dongtai Han, Jie Cheng, Yongshi Feng, Wenbin Quan, Li Yang, Kozo Saito

Mechanical Engineering Faculty Publications

Hydrocarbons as reductants show promising results for replacing NH₃ in SCR technology. Therefore, considerable interest exists for developing low-temperature (< 200 °C) and environmentally friendly HC-SCR catalysts. Hence, C₂H₄ was examined as a reductant using activated-carbon-supported MnOx-based catalyst in low-temperature SCR operation. Its sensitivity to Mn concentration and operating temperature was parametrically studied, the results of which showed that the catalyst activity followed the order of 130 °C > 150 °C > 180 °C with an optimized Mn concentration near 3.0 wt.%. However, rapid deactivation of catalytic activity also occurred when using C₂H₄ as the reductant. The mechanism of deactivation was explored and is …

Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur

Forestry and Natural Resources Faculty Publications

Background: Many forests within the southern Appalachian region, USA, have experienced decades of fire exclusion, contributing to regeneration challenges for species such as oaks (Quercus spp. L.) and pines (Pinus spp. L.), and threatening the maintenance of oak-dominated forests in the future. While the use of prescribed fire as a forest management tool is increasing within this region, there remains a lack of information on the potential role of wildfire. A wildfire within the Daniel Boone National Forest, Kentucky, USA, provided an opportunity to investigate how wildfire affected forest vegetation response.

Results: We examined the effects of fire …

The Relative Financial Cost And Benefit Of An Ophthalmology Resident Compared To An Advanced Practice Provider, Optometrist, Or Faculty Ophthalmologist, Daniel B. Moore, William Barr

Ophthalmology and Visual Science Faculty Publications

Objective The main objective of the article is to determine the relative direct financial cost and benefit of an advanced practice provider (APP), optometrist, and faculty ophthalmologist compared with an ophthalmology resident.

Design Single center cost–benefit financial analysis.

Methods The direct total expenses, including mean salary and benefits; the cost/week, based upon calculated hours worked; and net revenue, based upon technical collections subtracted from total expenses were collected for all APPs, optometrists, faculty ophthalmologists, and ophthalmology residents at the University of Kentucky for the 2016 to 2017 academic year. Optometry and ophthalmology faculty collections were adjusted for clinical full-time equivalents. …

Decays Of Pentaquarks In Hadrocharmonium And Molecular Scenarios, Michael I. Eides, Victor Yu. Petrov

Physics and Astronomy Faculty Publications

We consider decays of the hidden charm LHCb pentaquarks in the hadrocharmonium and molecular scenarios. In both pictures the LHCb pentaquarks are essentially nonrelativistic bound states. We develop a semirelativistic framework for calculation of the partial decay widths that allows the final particles to be relativistic. Using this approach we calculate the decay widths in the hadrocharmonium and molecular pictures. Molecular hidden charm pentaquarks are constructed as loosely bound states of charmed and anticharmed hadrons. Calculations show that molecular pentaquarks decay predominantly into states with open charm. Strong suppression of the molecular pentaquark decays into states with hidden charm is …

Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu

Computer Science Faculty Publications

Background: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible and widely available. RNA-seq provides unprecedented resolution to identify gene structures and resolve the diversity of splicing variants. However, currently available ab initio aligners are vulnerable to spurious alignments due to random sequence matches and sample-reference genome discordance. As a consequence, a significant set of false positive exon junction predictions would be introduced, which will further confuse downstream analyses of splice variant discovery and abundance estimation.

Results: …

Quantifying Bee Assemblages And Attractiveness Of Flowering Woody Landscape Plants For Urban Pollinator Conservation, Bernadette M. Mach, Daniel A. Potter

Entomology Faculty Publications

Urban and suburban landscapes can be refuges for biodiversity of bees and other pollinators. Public awareness of declining pollinator populations has increased interest in growing plants that provide floral resources for bees. Various publications and websites list “bee-friendly” plants, but such lists are rarely based on empirical data, nor do they emphasize flowering trees and shrubs, which are a major component of urban landscapes. We quantified bee visitation to 72 species of flowering woody landscape plants across 373 urban and suburban sites in Kentucky and southern Ohio, USA, sampling and identifying the bee assemblages associated with 45 of the most …

Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Bovine Mammary Gland Biopsy Techniques, Veridiana L. Daley, Charles Dye, Sophie H. Bogers, R. Michael Akers, Francisco C. Rodriguez, John P. Cant, John Doelman, Peter Yoder, Karan Kumar, Dane Webster, Mark D. Hanigan

Animal and Food Sciences Faculty Publications

Bovine mammary gland biopsies allow researchers to collect tissue samples to study cell biology including gene expression, histological analysis, signaling pathways, and protein translation. This article describes two techniques for biopsy of the bovine mammary gland (MG). Three healthy Holstein dairy cows were the subjects. Before biopsies, cows were milked and subsequently restrained in a cattle chute. An analgesic (flunixin meglumine, 1.1 to 2.2 mg/kg of body weight) was administered via jugular intravenous [IV] injection 15-20 min prior to biopsy. For standing sedation, xylazine hydrochloride (0.01-0.05 mg/kg of body weight) was injected via the coccygeal vessels 5-10 min before the …

Self-Compassion And Cultural Values: A Cross-Cultural Study Of Self-Compassion Using A Multitrait-Multimethod (Mtmm) Analytical Procedure, Jesus Montero-Marin, Willem Kuyken, Catherine Crane, Jenny Gu, Ruth A. Baer, Aida A. Al-Awamleh, Satoshi Akutsu, Claudio Araya-Véliz, Nima Ghorbani, Zhuo Job Chen, Min-Sun Kim, Michail Mantzios, Danilo N. Rolim Dos Santos, Luiz C. Serramo López, Ahmed A. Teleb, P. J. Watson, Ayano Yamaguchi, Eunjoo Yang, Javier García-Campayo

Psychology Faculty Publications

Self-compassion is natural, trainable and multi-faceted human capacity. To date there has been little research into the role of culture in influencing the conceptual structure of the underlying construct, the relative importance of different facets of self-compassion, nor its relationships to cultural values. This study employed a cross-cultural design, with 4,124 participants from 11 purposively sampled datasets drawn from different countries. We aimed to assess the relevance of positive and negative items when building the self-compassion construct, the convergence among the self-compassion components, and the possible influence of cultural values. Each dataset comprised undergraduate students who completed the “Self-Compassion Scale” …

Intimate Political Economies Of The Andes, Carmen Martínez Novo

Anthropology Faculty Publications

No abstract provided.

Improved Measurement Of The Longitudinal Spin Transfer To Λ And Λ¯ Hyperons In Polarized Proton-Proton Collisions At √S = 200 Gev, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. D. Brandenburg, Renee H. Fatemi, Suvarna Ramachandran

Physics and Astronomy Faculty Publications

The longitudinal spin transfer D_LL to Λ and Λ¯ hyperons produced in high-energy polarized proton-proton collisions is expected to be sensitive to the helicity distribution functions of strange quarks and antiquarks of the proton, and to longitudinally polarized fragmentation functions. We report an improved measurement of D_LL from data obtained at a center-of-mass energy of √s = 200  GeV with the STAR detector at RHIC. The data have an approximately twelve times larger figure of merit than prior results and cover |η| < 1.2 in pseudorapidity with transverse momenta p_T up to 6  GeV/c. In the forward scattering hemisphere …

Kinetics Of The Chromosome 14 Microrna Cluster Ortholog And Its Potential Role During Placental Development In The Pregnant Mare, Pouya Dini, Peter Daels, Shavahn C. Loux, Alejandro Esteller-Vico, Mariano Carossino, Kirsten E. Scoggin, Barry A. Ball

Maxwell H. Gluck Equine Research Center Faculty Publications

Background: The human chromosome 14 microRNA cluster (C14MC) is a conserved microRNA (miRNA) cluster across eutherian mammals, reported to play an important role in placental development. However, the expression kinetics and function of this cluster in the mammalian placenta are poorly understood. Here, we evaluated the expression kinetics of the equine C24MC, ortholog to the human C14MC, in the chorioallantoic membrane during the course of gestation.

Results: We demonstrated that C24MC-associated miRNAs presented a higher expression level during early stages of pregnancy, followed by a decline later in gestation. Evaluation of one member of C24MC (miR-409-3p) by in situ hybridization …

The Catalytic Mechanism Of Electron-Bifurcating Electron Transfer Flavoproteins (Etfs) Involves An Intermediary Complex With Nad+, Gerrit J. Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W. Mulder, Diep M. N. Nguyen, Gina L. Lipscomb, John Patrick Hoben, Angela Patterson, Carolyn E. Lubner, Paul W. King, John W. Peters, Brian Bothner, Anne-Frances Miller, Michael W. W. Adams

Chemistry Faculty Publications

Electron bifurcation plays a key role in anaerobic energy metabolism, but it is a relatively new discovery, and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on the bifurcating electron transfer flavoprotein (ETF) from the hyperthermophilic archaeon Pyrobaculum aerophilum. The EtfABCX enzyme complex couples NADH oxidation to the endergonic reduction of ferredoxin and exergonic reduction of menaquinone. We developed a model for the enzyme structure by using nondenaturing MS, cross-linking, and homology modeling in which EtfA, -B, and -C each contained FAD, whereas EtfX contained two [4Fe-4S] clusters. On the basis …

Is Individualism-Collectivism Associated With Self-Control? Evidence From Chinese And U.S. Samples, Jian-Bin Li, Alexander T. Vazsonyi, Kai Dou

Family Sciences Faculty Publications

Self-control plays an important role in human’s daily life. In the recent two decades, scholars have exerted tremendous effort to examine the etiologies of the individual differences in self-control. Among numerous predictors of self-control, the role of culture has been relatively overlooked. In this study, the influences of cultural orientation on self-control were examined based on the collectivism-individualism framework using both self-report and behavioral task to assess self-control. A convenience sample of 542 Chinese and 446 U.S. undergraduates participated in the research. They were invited to fill out self-report questionnaires reporting their levels of attitudinal self-control and individualistic-collectivistic orientation after …

Completion Of An Experiment, Michael J. Imperiale, Ira Blader, Patricia Bradford, Sarah E. F. D'Orazio, W. Paul Duprex, Craig D. Ellermeier, Ana Fernandez-Sesma, Katherine Mcmahon, Aaron Mitchell, Marcela F. Pasetti, Susannah Tringe

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

Dichotomous Scoring Of Tdp-43 Proteinopathy From Specific Brain Regions In 27 Academic Research Centers: Associations With Alzheimer's Disease And Cerebrovascular Disease Pathologies, Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson

Biostatistics Faculty Publications

TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific anatomic regions. To examine the comorbidities associated with TDP-43 pathology in aged individuals, we studied data from the National Alzheimer’s Coordinating Center (NACC) Neuropathology Data Set. Data were analyzed from 929 included subjects with available TDP-43 pathology information, sourced from 27 different American Alzheimer’s Disease Centers (ADCs). Cases with relatively unusual diseases including autopsy-proven frontotemporal lobar degeneration (FTLD-TDP or FTLD-tau) …

Large-Scale Genome-Wide Meta-Analysis Of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture For Different Diagnosis Criteria, Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser

Internal Medicine Faculty Publications

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related …

Determination Of Chemical Speciation Of Arsenic And Selenium In High-As Coal Combustion Ash By X-Ray Photoelectron Spectroscopy: Examples From A Kentucky Stoker Ash, Biao Fu, James C. Hower, Shifeng Dai, Sarah M. Mardon, Guijian Liu

Center for Applied Energy Research Faculty and Staff Publications

Knowledge of the chemical speciation of arsenic and selenium in coal fly ash is essential in the evaluation of the environmental behavior of fly ash disposed in a landfill in a natural environment. In this study, a series of high-As coal fly ash from stoker boilers were collected to determine the chemical forms of arsenic and selenium. The ash surface chemical characteristics and the speciation of arsenic and selenium were characterized by X-ray photoelectron spectroscopy and X-ray-induced Auger electron spectroscopy. The results indicate that the surface enrichment ratio for selenium (63.3–309.5) is higher than that of arsenic (1.2–21.2). The Wagner …

Stroke Outcomes With Vorapaxar Versus Placebo In Patients With Acute Coronary Syndromes: Insights From The Tracer Trial, Leo Ungar, Robert M. Clare, Fatima Rodriguez, Bradley J Kolls, Paul W. Armstrong, Philip Aylward, Claes Held, David J. Moliterno, John Strony, Frans Van De Werf, Lars Wallentin, Harvey D. White, Pierluigi Tricoci, Robert A. Harrington, Kenneth W. Mahaffey, Chiara Melloni

Gill Heart & Vascular Institute Faculty Publications

Background—Vorapaxar, a protease‐activated receptor‐1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage.

Methods and Results—TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) was a trial of vorapaxar versus placebo among patients with acute coronary syndrome. Strokes were adjudicated by a central events committee. Of 12 944 patients, 199 (1.5%) had ≥1 stroke during the study period (median follow‐up, 477 days). Four patients had a single stroke of unknown type; 195 patients had ≥1 stroke classified as hemorrhagic or nonhemorrhagic (165 nonhemorrhagic, 28 hemorrhagic, and 2 both). …

Lightweight Thermal Management Material For Enhancement Of Through-Thickness Thermal Conductivity, Matthew Collins Weisenberger

Center for Applied Energy Research Faculty Patents

A flexible sheet of aligned carbon nanotubes includes an array of aligned nanotubes held in a polymer matrix material. The carbon nanotubes have an average length of between about 50 microns and about 500 microns. The polymer matrix has an average thickness of between about 10 microns and about 500 microns. The flexible sheet has a density of about 0.2 to about 1.0 glee and includes between about 98 to about 60 weight percent aligned carbon nanotubes and between about 2 and about 40 weight percent polymer. A tape of aligned carbon nanotubes, a method for producing a tape of …

Detecting Radio Agn Signatures In Red Geysers, Namrata Roy, Kevin Bundy, Wiphu Rujopakarn, Michele Cappellari, Francesco Belfiore, Renbin Yan, Tim Heckman, Matthew Bershady, Jenny Greene, Kyle Westfall, Niv Drory, Kate Rubin, David Law, Kai Zhang, Joseph Gelfand, Dmitry Bizyaev, David Wake, Karen Masters, Daniel Thomas, Cheng Li, Rogemar A. Riffel

Physics and Astronomy Faculty Publications

A new class of quiescent galaxies harboring possible AGN-driven winds has been discovered using spatially resolved optical spectroscopy from the ongoing SDSS-IV MaNGA survey. These galaxies, termed "red geysers," constitute 5%–10% of the local quiescent population and are characterized by narrow bisymmetric patterns in ionized gas emission features. Cheung et al. argued that these galaxies host large-scale AGN-driven winds that may play a role in suppressing star formation at late times. In this work, we test the hypothesis that AGN activity is ultimately responsible for the red geyser phenomenon. We compare the nuclear radio activity of the red geysers to …

Spoil Type Influences Soil Genesis And Forest Development On An Appalachian Surface Coal Mine Ten Years After Placement, Kenton L. Sena, Carmen T. Agouridis, Jarrod Miller, Christopher D. Barton

Lewis Honors College Faculty Publications

Surface mining for coal (or other mineral resources) is a major driver of land-use change around the world and especially in the Appalachian region of the United States. Intentional and well-informed reclamation of surface-mined land is critical for the restoration of healthy ecosystems on these disturbed sites. In Appalachia, the pre-mining land cover is predominately mixed hardwood forest, with rich species diversity. In recent years, Appalachian mine reforestation has become an issue of concern, prompting the development of the Forestry Reclamation Approach, a series of mine reforestation recommendations. One of these recommendations is to use the best available soil substitute; …

Als Mutations Of Fus Suppress Protein Translation And Disrupt The Regulation Of Nonsense-Mediated Decay, Marisa Kamelgarn, Jing Chen, Lisha Kuang, Huan Jin, Edward J. Kasarskis, Haining Zhu

Toxicology and Cancer Biology Faculty Publications

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by preferential motor neuron death. Approximately 15% of ALS cases are familial, and mutations in the fused in sarcoma (FUS) gene contribute to a subset of familial ALS cases. FUS is a multifunctional protein participating in many RNA metabolism pathways. ALS-linked mutations cause a liquid–liquid phase separation of FUS protein in vitro, inducing the formation of cytoplasmic granules and inclusions. However, it remains elusive what other proteins are sequestered into the inclusions and how such a process leads to neuronal dysfunction and degeneration. In this study, we developed …

Mass-Analyzed Threshold Ionization Of Lanthanide Imide Lnnh (Ln = La And Ce) Radicals From N–H Bond Activation Of Ammonia, Yuchen Zhang, Silver Nyambo, Dong-Sheng Yang

Chemistry Faculty Publications

Ln (Ln = La and Ce) atom reactions with ammonia are carried out in a pulsed laser vaporization supersonic molecular beam source. Lanthanide-containing species are observed with time-of-flight mass spectrometry, and LnNH molecules are characterized by mass-analyzed threshold ionization (MATI) spectroscopy and quantum chemical calculations. The theoretical calculations include density functional theory for both Ln species and a scalar relativity correction, electron correlation, and spin-orbit coupling for the Ce species. The MATI spectrum of LaNH exhibits a single vibronic band system with a strong origin band and two weak vibronic progressions, whereas the spectrum of CeNH displays two band systems …

Coordinated Unmanned Aircraft System (Uas) And Ground-Based Weather Measurements To Predict Lagrangian Coherent Structures (Lcss), Peter J. Nolan, James Pinto, Javier González-Rocha, Anders Jensen, Christina N. Vezzi, Sean C. C. Bailey, Gijs De Boer, Constantin Diehl, Roger Laurence Iii, Craig W. Powers, Hosein Foroutan, Shane D. Ross, David G. Schmale Iii

Mechanical Engineering Faculty Publications

Concentrations of airborne chemical and biological agents from a hazardous release are not spread uniformly. Instead, there are regions of higher concentration, in part due to local atmospheric flow conditions which can attract agents. We equipped a ground station and two rotary-wing unmanned aircraft systems (UASs) with ultrasonic anemometers. Flights reported here were conducted 10 to 15 m above ground level (AGL) at the Leach Airfield in the San Luis Valley, Colorado as part of the Lower Atmospheric Process Studies at Elevation—a Remotely-Piloted Aircraft Team Experiment (LAPSE-RATE) campaign in 2018. The ultrasonic anemometers were used to collect simultaneous measurements of …

Serum Nutrient Levels And Aging Effects On Periodontitis, Jeffrey L Ebersole, Joshua Lambert, Heather Bush, Pinar Emecen Huja, Arpita Basu

Biostatistics Faculty Publications

Periodontal disease damages tissues as a result of dysregulated host responses against the chronic bacterial biofilm insult and approximately 50% of US adults > 30 years old exhibit periodontitis. The association of five blood nutrients and periodontitis were evaluated due to our previous findings regarding a potential protective effect for these nutrients in periodontal disease derived from the US population sampled as part of the National Health and Nutrition Examination Survey (1999–2004). Data from over 15,000 subjects was analyzed for blood levels of cis-β-carotene, β-cryptoxanthin, folate, vitamin D, and vitamin E, linked with analysis of the presence and severity of periodontitis. …

Epigenetic Modifications Acetylation And Deacetylation Play Important Roles In Juvenile Hormone Action, Amit Roy, Subba Reddy Palli

Entomology Faculty Publications

Background: Epigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.

Results: Exposure of Tribolium castaneum cells …