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Epigenetic Alterations In Rassf1a In Human Aberrant Crypt Foci, Emily J. Greenspan, Melissa A. Jablonski, Thiruchandurai V. Rajan, Joel Levine, Glenn S. Belinsky, Daniel W. Rosenberg
Epigenetic Alterations In Rassf1a In Human Aberrant Crypt Foci, Emily J. Greenspan, Melissa A. Jablonski, Thiruchandurai V. Rajan, Joel Levine, Glenn S. Belinsky, Daniel W. Rosenberg
UCHC Articles - Research
CpG island methylation (CIM) is an epigenetic mechanism for transcriptional silencing that occurs at various stages of colon tumorigenesis. CIM has been found in serrated adenomas and hyperplastic polyps. There is also evidence for hypermethylation in aberrant crypt foci (ACF) that are found in resected colons from cancer patients. Our study addresses promoter methylation of a tumor suppressor gene, RASSF1A, within the colonic epithelium of subjects undergoing screening colonoscopies in the absence of synchronous tumors. Patients included in this study were at elevated risk for colorectal cancer (CRC) based on family history, but without a previously occurring or synchronous …
Orthogonal Activation Of The Reengineered A3 Adenosine Receptor (Neoceptor) Using Tailored Nucleoside Agonists, Tatiana Sonin, Bruce T. Liang
Orthogonal Activation Of The Reengineered A3 Adenosine Receptor (Neoceptor) Using Tailored Nucleoside Agonists, Tatiana Sonin, Bruce T. Liang
UCHC Articles - Research
An alternative approach to overcome the inherent lack of specificity of conventional agonist therapy can be the reengineering of the GPCRs and their agonists. A reengineered receptor (neoceptor) could be selectively activated by a modified agonist, but not by the endogenous agonist. Assisted by rhodopsin-based molecular modeling, we pinpointed mutations of the A3 adenosine receptor (AR) for selective affinity enhancement following complementary modifications of adenosine. Ribose modifications examined included, at 3′: amino, aminomethyl, azido, guanidino, ureido; and at 5′: uronamido, azidodeoxy. N6-variations included: 3-iodobenzyl, 5-chloro-2-methyloxybenzyl, and methyl. An N6-3-iodobenzyl-3′-ureido adenosine derivative 10 activated phospholipase C …
Association Between Two Μ-Opioid Receptor Gene (Oprm1) Haplotype Blocks And Drug Or Alcohol Dependence, Henry R. Kranzler
Association Between Two Μ-Opioid Receptor Gene (Oprm1) Haplotype Blocks And Drug Or Alcohol Dependence, Henry R. Kranzler
UCHC Articles - Research
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the μ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol dependence (AD) and/or drug dependence (DD)] and 338 EA healthy controls. These SNPs delineated two haplotype blocks. Genotype distributions for all SNPs were in Hardy–Weinberg equilibrium (HWE) in controls, but in cases, four SNPs in Block I and three SNPs in Block II showed deviation from HWE. Significant differences were found between cases and controls in allele and/or genotype frequencies for six SNPs in Block I and two SNPs in Block …