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Next-Generation Protein Sequencing (Ngps) For Determining Complete Sequences For Unknown Proteins And Antibodies, Alexis S. Howard
Next-Generation Protein Sequencing (Ngps) For Determining Complete Sequences For Unknown Proteins And Antibodies, Alexis S. Howard
Honors Undergraduate Theses
Next-Generation protein sequencing (NGPS) creates newfound ways of fully identifying every protein species in a single biological organism. It is an effort to use technology to determine proteomic data. The purpose of this research project is to use the current technology to sequence proteins and potentially find treatments for some diseases that are common today. Through NGPS, scientists can identify low abundant proteins including those that go through post-translational modifications (PTM) [1]. NGPS will allow us to fully determine protein sequences from protein samples using mass spectrometry with the ultimate goal of being able to determine the primary sequence of …
Exploring Interleukin 21 And Its Role In Humoral Immunity In The Mouse Model Of Influenza Infection, Samantha E. Gallahan
Exploring Interleukin 21 And Its Role In Humoral Immunity In The Mouse Model Of Influenza Infection, Samantha E. Gallahan
Honors Undergraduate Theses
In summary, this study will be focused on Il-21 and its implications in the antibody response in influenza. The isotype classes primarily involved in this process will also be examined. This will be accomplished by looking at the serum of mice and analyzing the present influenza specific antibodies using ELISA. Another goal was to optimize the ELISA in order to make it sensitive enough to catch small differences in the results. This topic is important due to its implications for improving influenza vaccinations and preventions as current vaccines are not 100% effective. Influenza contributes to significant disease and death around …