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Tfap2e/Ap-2e Is A Transcriptional Regulator Controlling Neuronal Identity And Circuitry Formation In The Mouse Accessory Olfactory System, Jennifer M. Lin
Tfap2e/Ap-2e Is A Transcriptional Regulator Controlling Neuronal Identity And Circuitry Formation In The Mouse Accessory Olfactory System, Jennifer M. Lin
Legacy Theses & Dissertations (2009 - 2024)
Developmental progression is driven by specific spatiotemporal gene expression, which give rise to consistently patterned organisms despite environmental and genetic variation. The specific activation of robust gene regulatory networks that define tissue structure and individual cellular identity are necessary for tissue and cell specific programs to be activated. Cellular specification is guided by the interplay of intrinsic and extrinsic signals at specific developmental timepoints. The molecular mechanisms underlying the acquisition and maintenance of individual cellular identity remains a fundamental question across biological systems. Understanding the regulatory networks controlling the acquisition of neuronal identity, diversity, and connectivity in the formation of …
The Role Of Gaba Signaling In Gnrh Neuron Migration And Function, Tyler Mitchell
The Role Of Gaba Signaling In Gnrh Neuron Migration And Function, Tyler Mitchell
Legacy Theses & Dissertations (2009 - 2024)
Gonadotropin-releasing hormone (GnRH) neurons are key regulators of sexual development and reproduction of animals from ascidians to vertebrates. Gamma-amino butyric acid (GABA) has been implicated, in literature, as one of the major players in the regulating GnRH neuronal development and neuronal activity. GABA usually acts as an inhibitory neurotransmitter, however, in GnRH neurons it has been described as an excitatory stimulus in different animal models. In my master thesis I will present and discuss a series of scientific articles on this topic to summarize the current understanding of how GABA signaling affects GnRH neuronal development and physiological activity in reproduction.
Role Of Smad4 Dependent Signaling In Controlling The Functioning And Connectivity Of Basal Vomeronasal Sensory Neurons, Ankana S. Naik
Role Of Smad4 Dependent Signaling In Controlling The Functioning And Connectivity Of Basal Vomeronasal Sensory Neurons, Ankana S. Naik
Legacy Theses & Dissertations (2009 - 2024)
ABSTRACT