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Diffraction-Based Techniques For High Contrast X-Ray Imaging, Lubna Naseem Peerzada
Diffraction-Based Techniques For High Contrast X-Ray Imaging, Lubna Naseem Peerzada
Legacy Theses & Dissertations (2009 - 2024)
Two X-ray diffraction based techniques for high contrast were explored to improve contrast in radiology: diffraction enhanced imaging (DEI) and coherent scatter imaging.
Disparities Among Hispanic Ethnicity And Stage At Diagnosis For Invasive Breast And Colorectal Cancer, Raquel Velazquez
Disparities Among Hispanic Ethnicity And Stage At Diagnosis For Invasive Breast And Colorectal Cancer, Raquel Velazquez
Legacy Theses & Dissertations (2009 - 2024)
Objective: To assess the relationship between ethnicity and stage at diagnosis among invasive cases of breast and colorectal cancer.
Breast Cancer Susceptibility : An Education Intervention And Genetic Epidemiology Study, Nur Zeinomar
Breast Cancer Susceptibility : An Education Intervention And Genetic Epidemiology Study, Nur Zeinomar
Legacy Theses & Dissertations (2009 - 2024)
Background: Breast cancer is the most frequently diagnosed cancer (aside from non-melanoma skin cancers) and the second leading cause of cancer deaths among women in the United States. Our studies aimed to assess the effectiveness of a breast cancer educational intervention and to investigate genetic influences on the risk of post-menopausal breast cancer. The overarching theme and public health relevance of this dissertation was that our findings provided leads for breast cancer prevention.
The Lipogenic Phenotype Of Her2/Neu-Positive Breast Cancer Cells, Jan Martin Baumann
The Lipogenic Phenotype Of Her2/Neu-Positive Breast Cancer Cells, Jan Martin Baumann
Legacy Theses & Dissertations (2009 - 2024)
Recent work has shown that HER2/neu-positive breast cancer cells rely on a unique Warburg-like metabolism for survival and aggressive behavior. These cells are dependent on fatty acid (FA) synthesis, show markedly increased levels of stored fats and disruption of the synthetic process results in apoptosis. Supplementation of the growth media with physiological concentrations of saturated FAs induces cell death, whereas HER2-normal cells are not affected. This is particularly interesting in the context of new epidemiological data showing that a diet rich in saturated FAs is positively correlated with the development of HER2-negative disease, but not HER2/neu-positive disease.
Molecular Actions Of The Novel Histone Deacetylase Inhibitor Cg-1521 In Models Of Inflammatory Breast Cancer, Namita Chatterjee
Molecular Actions Of The Novel Histone Deacetylase Inhibitor Cg-1521 In Models Of Inflammatory Breast Cancer, Namita Chatterjee
Legacy Theses & Dissertations (2009 - 2024)
Inflammatory breast cancer (IBC) is a rare and particularly lethal form of breast cancer. Despite aggressive therapeutic approaches, the 5-year survival rate is only 34%. As this disease is severely understudied, we have investigated the therapeutic potential of the novel hydroxamic acid-derived histone deacetylase inhibitor (HDACi), CG-1521 in comparison to a structurally similar compound, Trichostatin A (TSA) in two IBC cell lines: SUM149PT and SUM190PT. In these cells, CG-1521 and TSA induce dose- and time-dependent induction of cell cycle arrest and apoptosis regardless of the presence of 17β-estradiol (E2). Interestingly, the cell lines have considerably different sensitivities to these treatments …
Coherent Scatter Imaging For Mammography, Katie Kern
Coherent Scatter Imaging For Mammography, Katie Kern
Legacy Theses & Dissertations (2009 - 2024)
Traditional x-ray images are good at distinguishing between materials with different absorption coefficients. The problem with mammography stems from the fact that there is very low contrast between cancerous and normal tissue types. Since cancerous and normal tissue have similar absorption coefficients, using conventional x-ray imaging to distinguish between the two is difficult. Coherent scatter is an alternative method to detect cancerous material within human breast tissue. Coherent scatter can distinguish between tissue types, if the intermolecular spacing of the tissues differ.
Molecular Actions Of The Vitamin D Receptor In Breast Cancer, Erika Laporta
Molecular Actions Of The Vitamin D Receptor In Breast Cancer, Erika Laporta
Legacy Theses & Dissertations (2009 - 2024)
1,25-Dihydroxyvitamin D (1,25D) exerts anti-cancer actions through the vitamin D receptor (VDR) but the specific targets that mediate these effects remain to be defined. In these studies, growth and genomic responses to 1,25D were evaluated in a cellular model system derived from mammary tumors generated in VDR knockout (KO) and wildtype (WT) mice. WT145 cells (derived from WT tumors) expressed VDR and were growth inhibited by 1,25D, whereas KO240 cells (derived from VDRKO tumors) lacked VDR and were not growth inhibited by 1,25D. KO240 cell clones stably expressing VDR (KOhVDR cells) were sensitized to 1,25D mediated growth arrest. Genomic profiling …