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Evolutionary Analysis Of Host Proteins Cd4, Cxcr4 And Ccr5, And Hiv/Siv Gp12, Lana Bunning
Evolutionary Analysis Of Host Proteins Cd4, Cxcr4 And Ccr5, And Hiv/Siv Gp12, Lana Bunning
Biological Sciences
The acquired immune deficiency syndrome, AIDS, is a growing epidemic in the United States and the world. Since its discovery in 1981, the virus that causes AIDS, human immunodeficiency virus (HIV), has escalated. .Certain African ape (i.e., chimpanzees and gorillas) and monkey species are known to harbor forms of the virus termed SIV (simian immunodeficiency virus). Chimpanzees are the natural hosts of the SIV strains from which HIV-I evolved, but do not rapidly progress to AIDS, unlike their human relatives. In the wild, gorillas have been observed to harbor SIV, but this species' disease progression is currently unknown. As the …
The Role Of Trna Modification Systems In The Cellular Stress Response, Margaret Daly
The Role Of Trna Modification Systems In The Cellular Stress Response, Margaret Daly
Biological Sciences
Transfer RNA(tRNA) is a small chain of nucleotides that participates in protein synthesis by pairing its anticodon with an mRNA codon and transferring an amino acid to a growing polypeptide chain. tRNA methyltransferases are a group of enzymes that can modify nucleosides in or around the anticodon, as well as at other parts of the tRNA. Recently, some of these modifications have been reported to enhance the translation of proteins that help the cell respond to and/or repair DNA damage. We hypothesize that the modifications catalyzed by some of the tRNA methyltransferases (Trms) stabilize the interaction between the mRNA codon …
Effects Of Carbachol And Vitamin C On Submandibular Salivary Gland Branching Morphogenesis, Nasiratu Larry
Effects Of Carbachol And Vitamin C On Submandibular Salivary Gland Branching Morphogenesis, Nasiratu Larry
Biological Sciences
The Submandibular Salivary Gland (SMG) is formed by iterative branching of epithelial cells into secretory acinar endbuds and branched ducts that are extensively innervated by parasympathetic nerves which can influence gland development. Carbarrylcholine or carbachol, (an acetylcholine neurotransmitter analog), is a drug that binds to and activates the acetylcholine receptor. Previous research has suggested that carbachol on SMGs might delay ductal differentiation and affect actin localization in cells lining the lumen of ducts. Vitamin C has been shown to enhance matrix protein synthesis, which may accelerate cell differentiation. My goal was to test whether and how carbachol or modulation of …
Investigating The Persistence Of Hedge Fund Returns Over The Period Of 1998 To 2005, John Conway
Investigating The Persistence Of Hedge Fund Returns Over The Period Of 1998 To 2005, John Conway
Financial Analyst
No abstract provided.
The Effect Of Teachers' Unions On Issues In School Reform, Katie Reed
The Effect Of Teachers' Unions On Issues In School Reform, Katie Reed
Public Administration & Policy
The thesis is divided into a number of sections. Part II examines some of the relevant literature on teachers’ unions and reform in education (specifically, merit pay, charter school, and school voucher reforms). The literature review presented in Part II is split up into two sections itself; Section A which examines the actual effectiveness of the aforementioned school reform programs on student achievement, and Section B, which examines literature showing the ways in which teachers’ unions impact school reform. In Part III, primary sources, including direct statements and information from teacher union websites and newspaper articles, are analyzed to determine …
Mortgage Lending Reform Finding Innovative State Responses To The Foreclosure Crisis, Leann Lu
Mortgage Lending Reform Finding Innovative State Responses To The Foreclosure Crisis, Leann Lu
Public Administration & Policy
In today’s American housing market, foreclosure can be seen as an epidemic resulting from the legal mass marketing of risky loan products and systematic overcharging of consumers in susceptible positions. Subprime mortgages are high-cost home loans intended for people with weak or blemished credit histories, and though they are intended to encourage and facilitate homeownership, not only did politicians create a flawed mortgage industry to push for this “American Dream” but it is arguably a manipulative industry that can easily be taken advantage of.1 Thus, current snapshots of the subprime market show that one in every five subprime mortgages made …
Assessing "Founder's Chic": An Examination Of Recent Studies Of Benjamin Franklin For Insights Into The Resurgence Of The Founders In American Historiography, David Zahn
History
No abstract provided.
The Synagogue Of Dura Europos: An Inclusive Narrative, Joanna Smith
The Synagogue Of Dura Europos: An Inclusive Narrative, Joanna Smith
Art & Art History
In 1932, the discovery of the Synagogue of Dura Europos in Syria presented a turning point in the study of art, architecture, and Art History in general. The reason behind the turning point was the fact that this discovery yielded the first ever examples of Jewish art and architecture. Within the Synagogue were fresco panels telling stories from the Hebrew bible. The report of this discovery was felt throughout the entire Art History world not only at this point in time, but in the modern day as well. In addition to the continued discussion surrounding the frescoes, their legitimacy as …
“A Woman’S Story At A Winter’S Fire”: Gender Performativity And The Intrinsic Power Of The Feminine In Shakespeare’S Macbeth, Whitney Sperrazza
“A Woman’S Story At A Winter’S Fire”: Gender Performativity And The Intrinsic Power Of The Feminine In Shakespeare’S Macbeth, Whitney Sperrazza
English
No abstract provided.
Our Greatest Want: An Examination Of The Rhetorical Tendencies Employed By African American Female Abolitionist Frances Ellen Watkins Harper (1825-1911), Lauren Deborah Nye
Our Greatest Want: An Examination Of The Rhetorical Tendencies Employed By African American Female Abolitionist Frances Ellen Watkins Harper (1825-1911), Lauren Deborah Nye
English
You are standing at the doorway of a church in Philadelphia. Looking in, you see a mass of heads, all turned toward the podium, waiting for someone to get behind that podium. Then you see her. She is an attractive African American with “a fair figure, long, lustrous hair, and facial features pleasant to behold” (Logan 49). You overhear one person comment that she looks like “a bronze muse” (Logan 31). A reporter will later write that she has “a strong face, with a shadowed glow upon it, indicative of thoughtful fervor, and of a nature most femininely sensitive, but …
The Effect Of Vegetated Roofs On Acid Precipitation Runoff, Jennifer Gillen
The Effect Of Vegetated Roofs On Acid Precipitation Runoff, Jennifer Gillen
Geology Theses and Dissertations
Vegetated, or “green” roofs are used in urban architecture and sustainable building to capture stormwater and enhance urban wildlife. Most research to date has focused on their water retention capabilities, but green roofs also have the potential to treat anthropogenic acid precipitation in urban environments. More specifically, green roofs could reduce sulfate, nitrate and hydrogen ion concentrations in runoff. One previous study has demonstrated that nitrate was reduced in water draining from a green roof (Berndtsson, et al. 2006), but this unpublished thesis appears to be the first comprehensive study of the effects of vegetated roof materials on major ions …
Metal Concentrations In Native Yupik Foodstuffs From St. Lawrence Island, Alaska, Judith Kricheff
Metal Concentrations In Native Yupik Foodstuffs From St. Lawrence Island, Alaska, Judith Kricheff
Geology Theses and Dissertations
The Yupik people of St. Lawrence Island, Alaska have a traditional subsistence lifestyle with the majority of their diet consisting of local birds, fish, seal, walrus, and whale. Diets based on fish and marine mammals, such as the Yupik diet, are potential pathways for exposure to mercury and other toxic metals. At St. Lawrence Island, metal contaminants may come from local sources such as weathered rock or two abandoned U.S. military bases or remote sources through atmospheric deposition or seasonal migration of animals to the island.
The main goals of this study are to determine the total concentrations of copper …
Mercury Uptake By Aquatic Macrophytes In Urban And Rural Watersheds, Albany County, Ny, Bernd G. Neumann
Mercury Uptake By Aquatic Macrophytes In Urban And Rural Watersheds, Albany County, Ny, Bernd G. Neumann
Geology Theses and Dissertations
Plants growing in metalliferous soils may restrict metal uptake and transport depending on metal concentration, sediment characteristics, and plant species. As native plants are replaced by invasives, different patterns of metal cycling can occur, making continued study of this process important. Sediments and tissues of four aquatic plant species/genera: Phragmites australis (common reed); Iris versicolor (blueflag iris); Typha latifolia (broadleaf cattail); and genera Cyperus sp. (sedge) from three urban and two rural sites in Albany County, NY were analyzed for total mercury (HgT) by cold vapor atomic absorption spectroscopy. Sediments were also measured for organic carbon (OC) by …
Geochemical Fingerprinting Of Volcanic Airfall Deposits: A Tool In Stratigraphic Correlation, Soumava Adhya
Geochemical Fingerprinting Of Volcanic Airfall Deposits: A Tool In Stratigraphic Correlation, Soumava Adhya
Geology Theses and Dissertations
Chemical fingerprints of volcanic airfall deposits obtained from high-precision electron microprobe analysis of glass and phenocrysts phases provide geochemical correlations with temporal precision unattainable by other methods. In this research electron microprobe analysis (EMA) techniques, to fingerprint chemically and correlate fresh and altered volcanic airfall deposits, have been utilized to test the value of this tool for future research on stratigraphic correlation. The following samples were chosen from within a variety of sedimentary rocks widely separated spatially and temporally: (1) ∼450 Ma old upper Middle Ordovician K-bentonites (altered volcanic airfall deposits) collected from eastern United States. (2) Relatively fresh Pleistocene …
Biomonitoring Of Perfluorochemicals In Human Blood, Breast Milk, Saliva, And Urine, Lin Tao
Biomonitoring Of Perfluorochemicals In Human Blood, Breast Milk, Saliva, And Urine, Lin Tao
Legacy Theses & Dissertations (2009 - 2024)
Perfluorochemicals (PFCs) have been used as surfactants and surface protectors in a large number of consumer products. PFCs have been reported to elicit adverse health effects in laboratory animals and humans, and have been detected in foodstuffs and in human bodies. In this dissertation, analytical methods were developed for the determination of trace levels of PFCs in human blood, dried blood spot, breast milk, saliva, and urine. An assessment of human exposure to PFCs was performed by analyzing human specimens collected from the United States and several Asian countries. Blood, breast milk, and dried blood spots were found to be …
Progress Towards Critical Dimension Low Vacuum Scanning Electron Microscopy, Vasiliki Tileli
Progress Towards Critical Dimension Low Vacuum Scanning Electron Microscopy, Vasiliki Tileli
Legacy Theses & Dissertations (2009 - 2024)
Low vacuum scanning electron microscopy (LVSEM) is proposed and evaluated for next generation Critical Dimension (CD) metrology. Its ability to control charging artifacts and hydrocarbon contamination in order to obtain high signal-to-noise ratio, high resolution image data from insulating materials make the technology an excellent match for the increased use of high-k dielectrics and shrinking feature size in the semiconductor industry. The presence of a gas in the LVSEM chamber means that the probe characteristics and secondary electron amplification, detection, and signal-to-noise ratio differ significantly from conventional high vacuum tools. In order for low vacuum CD approaches to be viable, …
Genetically Engineered Repetitive Polypeptides : Design, Synthesis, Characterization, And Applications, Natalya I. Topilina
Genetically Engineered Repetitive Polypeptides : Design, Synthesis, Characterization, And Applications, Natalya I. Topilina
Legacy Theses & Dissertations (2009 - 2024)
This work is dedicated to the investigation of protein folding with the emphasis on the aggregation and amyloid fibrils formation. The focus of the research is to elucidate the relationship between polypeptide chain sequence and folding/aggregation properties. For this purpose, i) libraries of the de novo macromolecular repetitive β-sheet forming polypeptides were designed, and ii) the strategy for their rapid creation was developed. The strategy enables retention of a basic polypeptide core, yet allowing variations in the repetitive sequence, degree of polymerization and distribution of specific amino acids. The polypeptides were expressed in E. coli, purified, and characterized by various …
Almost Everywhere Convergence Of Weighted Ergodic Averages, Christopher Michael Wedrychowicz
Almost Everywhere Convergence Of Weighted Ergodic Averages, Christopher Michael Wedrychowicz
Legacy Theses & Dissertations (2009 - 2024)
Let $(X,\mathcal{B},\lambda,T)$ be a dynamical system and $\mbox{Log}_{(n)}x$
Raman Spectroscopy Of Body Fluids : A Nondestructive Identification Technique For Forensic Applications, Kelly Virkler
Raman Spectroscopy Of Body Fluids : A Nondestructive Identification Technique For Forensic Applications, Kelly Virkler
Legacy Theses & Dissertations (2009 - 2024)
The analysis of body fluid evidence during forensic investigations is a complicated process, yet it is a critical step in determining the key facts of a crime. There is no doubt that DNA analysis is an extremely useful tool that can identify a suspect or victim, but crime scene investigators must first locate and identify potential body fluid stains that can be collected for DNA analysis. Current screening tests are destructive to the sample and can give false positive results, so a nondestructive technique such as Raman spectroscopy, that can possibly confirm the presence of a particular fluid, could lend …
The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf
The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf
Legacy Theses & Dissertations (2009 - 2024)
Although estradiol (E2) has numerous effects in the central nervous system, this review will focus on addressing the effects of E2 on behaviors related to mood in women and animal models and include recent findings from our laboratory related to this topic. E2's anti-anxiety and anti-depressant-like effects may depend upon many factors (e.g. age, reproductive history/status, time in E2 deficient state before initiation of E2 therapy, regimen and dosing of E2, neuropsychiatric/stress history). First, evidence of how factors may alter responses to E2 in people and in animal models will be discussed. Second, interactions of E2 with the hypothalamic-pituitary-adrenal axis/stress …
Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu
Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu
Legacy Theses & Dissertations (2009 - 2024)
The overall goal of this dissertation is to investigate the mechanisms underlying the large interindividual variations in susceptibility to lung carcinogenesis. We focused on CYP2A13, a respiratory tract-specifically expressed enzyme, which is the most efficient P450 towards bioactivation of a tobacco-related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The expression level of CYP2A13 varies substantially among human lung samples. Our central hypothesis is that CYP2A13 expression level is affected by both genetic regulators and non-genetic factors. The specific aims are 1) to identify the mechanisms underlying the decreased allelic expression of a CYP2A13 allele (7520C>G); 2) to identify frequent single-nucleotide polymorphisms (SNPs), associated …
A Multidimensional Analysis Of The Relationship Between Leader-Member Exchange And Organizational Citizenship Behavior With An Alternative Measure Of Leader-Member Exchange, Yann-Jang Wu
Legacy Theses & Dissertations (2009 - 2024)
Leader-Member Exchange (LMX) theory proposed that a leader will develop a unique exchange pattern with each subordinate (Liden, Wayne, & Stilwell, 1993). Empirically, LMX has shown significant associations with many work outcomes (Gerstner & Day, 1997). One of these valued outcomes is organizational citizenship behavior (OCB), which is defined as action enacted beyond one's assigned duties on the job (Farh, Podsakoff, & Organ, 1990). Positive correlations between LMX and OCB have been demonstrated in previous research (Podsakoff, MacKenzie, Paine, & Bachrach, 2000). Both LMX and OCB were proposed to comprise several sub-factors; nevertheless, correlations between LMX and OCB have always …
The Effects Of Intercollegiate Athletic Participation On Student Academic Achievement And Leadership Performance In A Selective Institution, Craig A. Yunker
The Effects Of Intercollegiate Athletic Participation On Student Academic Achievement And Leadership Performance In A Selective Institution, Craig A. Yunker
Legacy Theses & Dissertations (2009 - 2024)
The purpose of this study was to examine the influence of various intensity levels of athletic participation on academic and leadership performance in a selective institution. For the purpose of this study a retrospective analysis of existing admissions and student performance data was conducted. The continuous dependent variables were academic and leadership performance scores. The categorical independent variables were the three intensity levels of athletic participation (high commitment athletes, moderate commitment athletes, general population students), gender and race. The subjects for this study included 4977 of the 4998 students that graduated from a selective institution from 1992 through 1996. Results …
Role Of Cyp2a5 In Drug Metabolism, Chemical Toxicity, And Maintenance Of Steroid Hormone Homeostasis : Insights From Studies On A Novel Cyp2a5-Null Mouse Model, Xin Zhou
Legacy Theses & Dissertations (2009 - 2024)
The central hypothesis is that CYP2A5 plays an important role in the metabolism of xenobiotic substrates, and in the toxicity induced by over-exposure to drugs, as well as in the metabolism of endogenous compounds and regulation of steroid hormone homeostasis. The specific aims are: 1) to generate and characterize a Cyp2a5-null mouse; 2) to determine the role of CYP2A5 in the systemic clearance of nicotine and cotinine; and 3) to explore the mechanisms underlying the resistance of the lateral nasal gland (LNG) of male Cyp2g1-null/Cyp2a5-low mouse and Cyp2a5-null mouse to acetaminophen (AP) toxicity.
Biotechnology For Immune Cell Detection And Evaluation : Devices Specifically Designed To Capture, Detect Or To Evaluate Alterations In Leukocyte Structure And Function, Thomas Joseph Zieziulewicz
Biotechnology For Immune Cell Detection And Evaluation : Devices Specifically Designed To Capture, Detect Or To Evaluate Alterations In Leukocyte Structure And Function, Thomas Joseph Zieziulewicz
Legacy Theses & Dissertations (2009 - 2024)
The advent of Nano-biotechnology has opened a whole new area of biological study that has allowed us to pattern, manipulate, separate, evaluate and detect biological structures and functions that were previously not possible. This dissertation will describe different types of micro-fabricated devices that were designed to quantify and/or evaluate the functional activities of cells of the immune system. The micro-fabricated devices were developed in collaboration with our colleagues at Princeton University as part of our Cellular Micro-dynamics Program of the Nanobiotechnology Center (NBTC) at Cornell University.
Leadership Behaviors In Cross-Boundary Information Sharing And Integration : Comparing The Us And China, Lei Zheng
Legacy Theses & Dissertations (2009 - 2024)
This study comprises a comparative analysis between the US and China regarding public sector leadership behaviors in the context of cross-boundary information sharing and integration. Based on the literature on leadership, public sector information sharing, and cross-cultural analysis, the research begins with an original case study in China set in the product safety and food safety policy domain. The case explores leadership behaviors of middle-level information leaders in the technological, organizational, and legal context of cross-boundary information sharing in this domain. Qualitative data were collected from in-depth interviews and government documents. The data were analyzed with an inductive approach to …
Impulsivity, Offending, And The Neighborhood : Investigating The Person-Context Nexus, Gregory M. Zimmerman
Impulsivity, Offending, And The Neighborhood : Investigating The Person-Context Nexus, Gregory M. Zimmerman
Legacy Theses & Dissertations (2009 - 2024)
A key assumption of the traditional trait-based approach to the study of crime is that personality traits cause people to act similarly across a wide array of contexts. This approach has been challenged for its failure to acknowledge differences in the social environments to which individuals are exposed. Similarly, community-level explanations of crime have been criticized for failing to acknowledge that there are important individual differences between criminals and non-criminals. Ultimately, a full understanding of crime requires the consideration of both individual and environmental differences, perhaps most importantly because they may interact to produce offending behavior. In particular, the influence …
Molecular Evolution Of Genes Underlying Phenotypic Differences Between Humans And Chimpanzees, Santhoshi Bandla
Molecular Evolution Of Genes Underlying Phenotypic Differences Between Humans And Chimpanzees, Santhoshi Bandla
Legacy Theses & Dissertations (2009 - 2024)
Chimpanzees (Pan troglodytes) and bonobos (P. paniscus) are often used as models to study the genetic and morphological changes on the lineage leading to the modern humans (Homo sapiens). Results of this dissertation suggest that, in comparison to other hominoids, chimpanzees and bonobos are more derived in their relative testes sizes and promiscuous mating systems. Phylogenetic analysis of genes that might underlie increased testes size revealed that, in addition to being a sex-determining gene, SRY displays Pan-specific amino acid replacements that make it a compelling candidate as a testes-size determining gene. Strikingly, SRY and another candidate gene, DMRT3, display patterns …
Competitiveness And Addictive Behaviors : Exploring The Role Of Competitiveness And Gender In Exercise Dependence, Disordered Eating, And Alcohol Use, Holly Felicia Serrao
Competitiveness And Addictive Behaviors : Exploring The Role Of Competitiveness And Gender In Exercise Dependence, Disordered Eating, And Alcohol Use, Holly Felicia Serrao
Legacy Theses & Dissertations (2009 - 2024)
The current study explored whether or not trait competitiveness existed as an underlying factor contributing to the higher rates of exercise dependence, disordered eating, and alcohol use among athletes. Additionally, the study examined whether certain gender differences occurred, such that the relationship between competitiveness and disordered eating would be stronger for female athletes, the relationship between competitiveness and alcohol use would be stronger for male athletes, and the relationship between competitiveness and exercise dependence would be gender neutral.
Multiple Antibiotic Resistant Staphylococcus Spp. In Environmental Settings, Stephen Shost
Multiple Antibiotic Resistant Staphylococcus Spp. In Environmental Settings, Stephen Shost
Legacy Theses & Dissertations (2009 - 2024)
Ninety staphylococci carrying the mecA gene, including 17 strains of methicillin-resistant Staphylococcus aureus (MRSA), were isolated from environmental settings within New York State. Waterborne staphylococci harboring mecA were isolated from multiple sources: the Hudson River near a combined sewage overflow; urban streams; freshwater and marine beaches; a swimming pool; swimming pool decks; combined sewage; as well as wastewater treatment plant (WWTP) primary sewage influent, mixed liquor, aeration water, and final (unchlorinated) effluent. Environmental MRSA strains were isolated from beach water (n=3); swimming pool deck water (n=1); Hudson River water (n=2); combined sewage (n=3); as well as wastewater treatment plant mixed …