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Investigating Pirna Expression And Function In Regenerating Tissue Of Segmented Annelid Capitella Teleta, Beatriz Schueng Zancanela
Investigating Pirna Expression And Function In Regenerating Tissue Of Segmented Annelid Capitella Teleta, Beatriz Schueng Zancanela
Honors Theses
Regeneration can be observed virtually in all animals and previous studies have identified numerous genes involved in this process. In some invertebrates, the P-element induced wimpy testis (PIWI) genes appear to have an essential role. One such organism is Capitella teleta, a widely accepted model for annelid development. PIWI proteins are associated with small non-coding RNA called PIWI-interacting RNAs or piRNAs, which are involved in transposon silencing in the germline cells of many animals. It was previously believed that these proteins were only expressed in germline cells, however, recent studies have shown expression in somatic tissues as well. The function …
Investigating Subcellular Localization Of Somatic Piwi Proteins In The Annelid Capitella Teleta, Tierra D. Cooper
Investigating Subcellular Localization Of Somatic Piwi Proteins In The Annelid Capitella Teleta, Tierra D. Cooper
Honors Theses
PIWI proteins are well known for their various roles and localization in germline development of diverse organisms, yet their specific role and function in somatic tissue remains elusive. PIWI proteins are essential for the biogenesis of PIWI-interacting RNA (piRNA), silencing mechanisms, sexual reproduction, and regeneration. piRNAs are PIWI bound RNAs that play an essential role in transposon silencing. PIWI and piRNAs expression and localization have been discovered in the model organism Drosophila melanogaster and mice; however, its localization in the C. teleta annelid is currently unknown and the subject remains an active area of research. In the present study, the …