Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Publication Year
Articles 1 - 30 of 146
Full-Text Articles in Entire DC Network
Chlorogenic Acid Ameliorates Memory Dysfunction Via Attenuating Frontal Lobe Oxidative Stress And Apoptosis In Diabetic Rat Model, Ramedhea Laila Afifa An Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cayhani Ratna Sari
Chlorogenic Acid Ameliorates Memory Dysfunction Via Attenuating Frontal Lobe Oxidative Stress And Apoptosis In Diabetic Rat Model, Ramedhea Laila Afifa An Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cayhani Ratna Sari
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus, characterized by hyperglycemia, causes various complications, one of which is memory dysfunction. The frontal lobe is known to be responsible for impaired memory function due to hyperglycemia and is associated with oxidative stressmediated neuronal cell apoptosis. Chlorogenic acid (CGA) is reported to have neuroprotective effects. However, its effect on the frontal lobe in diabetes mellitus (DM) rats is not widely known. This research aimed to elucidate the effect of CGA on the mRNA expressions of SOD1, SOD2, p53, and Bcl-2 in the frontal lobe of DM rats. Materials and methods: Thirty male Wistar rats (2-month-old, 150–200 gBW) …
Elucidating Melatonin-Mediated Distinct Mechanistic Of Specific Gene Expression Of Coriander (Coriandrum Sativum L.) Under Chromium Stress, Arwa Abdulkreem Al-Huqail, Suliman Mohammed Suliman Alghanem, Haifa Abdulaziz Sakit Alhaithloul, Nayab Naeem, Wajiha Sarfraz, Noreen Khalid, Baber Ali
Elucidating Melatonin-Mediated Distinct Mechanistic Of Specific Gene Expression Of Coriander (Coriandrum Sativum L.) Under Chromium Stress, Arwa Abdulkreem Al-Huqail, Suliman Mohammed Suliman Alghanem, Haifa Abdulaziz Sakit Alhaithloul, Nayab Naeem, Wajiha Sarfraz, Noreen Khalid, Baber Ali
Turkish Journal of Agriculture and Forestry
The current investigation demonstrates that the application of MEL (0, 1 and 2 µmol L−1) mitigates the effects of Cr stress 0 (no Cr), 50 and 100 mg kg−1 on coriander (Coriandrum sativum L.) plants. Results from the present study showed that the increasing levels of Cr concentration in the soil induced a significant decrease in shoot length, root length, shoot fresh weight, root fresh weight, shoot dry weight, root dry weight, chlorophyll-a, chlorophyll-b, total chlorophyll, carotenoid contents, net photosynthesis, transpiration rate and stomatal conductance by 36%, 24%, 17%, 64%, 27%, 23%, 19%, 29%, 36%, 18%, 73%, 83% and 43% …
Physiological And Biochemical Responses Of Maize (Zea Mays L.) Cultivars Under Salinity Stress, Nosheen Iftikhar, Shagufta Perveen, Baber Ali, Muhammad Hamzah Saleem, Mohammad Khalid Al-Sadoon
Physiological And Biochemical Responses Of Maize (Zea Mays L.) Cultivars Under Salinity Stress, Nosheen Iftikhar, Shagufta Perveen, Baber Ali, Muhammad Hamzah Saleem, Mohammad Khalid Al-Sadoon
Turkish Journal of Agriculture and Forestry
Salt stress is a serious threatening factor for cereal crops such as maize (Zea mays L.) by affecting their growth and development. In the current era, the requirement for staple crops is increasing, so it is important to screen out salt-tolerant genotypes. For this purpose, a pot experiment was designed within three replications on ten different genotypes of the maize. The plants were planted in plastic pots and salt stress (0, 40, 70, 100 mM) was maintained. The salt stress induced a noticeable reduction in plant growth traits (shoot length, root length, shoot, root fresh and dry weight, and leaf …
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Turkish Journal of Veterinary & Animal Sciences
Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …
The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen
The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen
Turkish Journal of Medical Sciences
In this prospective observational study, our goal was to investigate the relationship between serum levels of oxidative stress (OS) parameters and regional cerebral oxygen saturation (rSO2) in addition to evaluating postoperative clinical outcomes among patients undergoing coronary artery bypass graft surgery (CABG).Materials and methods: This study comprised 64 adult patients undergoing elective CABG (on-pump [n = 48] and off-pump [n = 16]) procedures. Serum OS levels and rSO2 values were measured intraoperatively at three specific time points: T1 (after induction), T2 (15 min before aortic cross-clamp removal or the final distal anastomosis), and T3 (15 min after aortic cross-clamp removal …
Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan
Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan
Turkish Journal of Medical Sciences
Traumatic spinal cord injury (TSCI) is an important health problem, especially in developing countries withadditional socioeconomic loss. Humic acid (HA) usually has antioxidant, antiinflammatory, blood circulating, and antiviral effects.Hence, it was aimed herein to show the effect of HA on neuroprotection in a TSCI model.Materials and method: A TSCI model was used, in which 24 Wistar albino rats were divided into 4 groups: control group: subjectedto only laminectomy; sham group: subjected to laminectomy + TSCI; HA 5 mg/kg group: subjected to laminectomy + TSCI +intraperitoneal (IP) injection of 5 mg/kg of HA; and HA 10 mg/kg group: subjected to laminectomy …
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls. Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel …
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX) is a folic acid antagonist that is widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune and inflammatory diseases. The most important concerns with MTX are its poor solubility and high toxicity, particularly in liver cells. To enhance its solubility and to minimize its toxicity, we encapsulated MTX in niosomes and investigated its hepatotoxicity mechanisms using genetic biomarkers. Materials and methods: Niosomes were successfully prepared using a modified thin film method, and the prepared monodisperse smallsized formulation was subsequently characterized. In vitro cytotoxicity studies were performed both in hepatocarcinoma (HEP3G) and healthy liver (AML12) cell lines. …
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Turkish Journal of Biology
Background/aim: The novel field of nanomaterials allows infinite possibilities in order to create antioxidant therapies. The present review is aimed to describe the state of art concerning on nanomaterials and their effects on reactive oxygen species (ROS) production. A wide range of nanoparticles has been designed for this purpose, and each one possesses some particular characteristics which allow these significant antioxidant results. Several in vivo and in vitro works state the ability of these nanoparticles to mimic the redox systems of the cells, and thus, the potential role of nanoparticles as antioxidant treatment for several diseases. Materials and methods: This …
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar
Turkish Journal of Medical Sciences
Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Turkish Journal of Medical Sciences
Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. …
The Effects Of Tarantula Cubensis Extract On Renal Ischemia Reperfusion Injury In Rats, Sai̇me Özbek Şebi̇n, Tuncer Nacar, Ayhan Tanyeli̇, Ersen Eraslan, Mustafa Can Güler, Erdem Toktay, Eli̇f Polat, Hati̇ce Tuğçe Gedi̇k
The Effects Of Tarantula Cubensis Extract On Renal Ischemia Reperfusion Injury In Rats, Sai̇me Özbek Şebi̇n, Tuncer Nacar, Ayhan Tanyeli̇, Ersen Eraslan, Mustafa Can Güler, Erdem Toktay, Eli̇f Polat, Hati̇ce Tuğçe Gedi̇k
Turkish Journal of Medical Sciences
Background/aim: Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) is a homeopathic drug that has antiinflammatory and antioxidant effects. This study aimed to investigate the effects of TCE on renal ischemia-reperfusion injury in rats. Materials and methods: This study was carried out on 48 Spraque-Dawley male rats, which were divided into six groups. The first, second, and third groups were control, sham, and IR groups, respectively. Group four received IR and 0.2 mL of 96% ethanol. Group five and six received ischemia and reperfusion …
Alleviating Effects Of Salicylic Acid Spray On Stage-Based Growth And Antioxidative Defense System In Two Drought-Stressed Rice (Oryza Sativa L.) Cultivars, Asma ., Iqbal Hussain, Muhammad Yasin Ashraf, Muhammad Hamzah Saleem, Muhammad Arslan Ashraf, Baber Ali, Aisha Shereen, Ghulam Farid, Muhammad Ali, Muhammad Ubaidullah Shirazi, Ammara Saleem, Yasser S. Mostafa, Mohamed Hashem, Ghulam Yasin
Alleviating Effects Of Salicylic Acid Spray On Stage-Based Growth And Antioxidative Defense System In Two Drought-Stressed Rice (Oryza Sativa L.) Cultivars, Asma ., Iqbal Hussain, Muhammad Yasin Ashraf, Muhammad Hamzah Saleem, Muhammad Arslan Ashraf, Baber Ali, Aisha Shereen, Ghulam Farid, Muhammad Ali, Muhammad Ubaidullah Shirazi, Ammara Saleem, Yasser S. Mostafa, Mohamed Hashem, Ghulam Yasin
Turkish Journal of Agriculture and Forestry
Approximately 33% of the arable land around the world is vulnerable to drought, which is a very serious issue affecting the yield and productivity of cereal crops. Two contrasting rice (Oryza sativa L.) genotypes, HTT-138 (drought tolerant) and (HTT-39 droughtsensitive), under various levels of water treatments, i.e. control flooded (CF) as recommended for rice (control), control saturated (CS) 100% field capacity (FC), 80% FC, and 60% FC without or with foliar spray (100 mg L-1) of salicylic acid (SA) evaluated to enhance the yield for food security. The results showed that leaf gas exchange parameters, water use …
Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao
Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao
Turkish Journal of Medical Sciences
Background/aim: Curcumin may have potential as a therapy for wound healing, but the underlying mechanism remains unclear. It is not known whether curcumin can promote wound healing by activating Nrf2 signaling pathway and inducing apoptosis. This study determined the role of Nrf2 signaling pathway and apoptosis in curcumin-promoting skin wound healing. Materials and methods: The full-thickness skin defect model of mice was made and randomly divided into a control group and a curcumin group. The mice in the curcumin group and in the control group received respectively a daily topical treatment of Vaseline cream with or without 5 mg curcumin. …
Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz
Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz
Turkish Journal of Zoology
Increased use of fertilizers to increase plant production causes important environmental pollution not only in soil but also in water resources. Soil structure, water quality, water systems, and biodiversity are adversely affected by the unconscious use of fertilizers. In this study, Capoeta capoeta (Guldenstaedt 1773) were used to investigate the degenerative effects of nitrogen fertilizer. Twentyfour fish were equally allocated into three groups; group 1 (control), group 2 (15 mg/L nitrogen fertilizer in water) and group 3 (15 mg/L nitrogen fertilizer in water). Fish were exposed to the fertilizer for 15 days and then the tissues of gill, liver and …
The Effect Of Dystocia On Oxidative Stress, Colostral Antibody/Passive Immune Status, Andblood Gases In Damascus Goats And Their Kids, Tuğra Akkuş, Ömer Korkmaz, Bi̇rten Emre, Abuzer Kafar Zonturlu, Peli̇n Fatoş Polat Di̇nçer, Ömer Yaprakci
The Effect Of Dystocia On Oxidative Stress, Colostral Antibody/Passive Immune Status, Andblood Gases In Damascus Goats And Their Kids, Tuğra Akkuş, Ömer Korkmaz, Bi̇rten Emre, Abuzer Kafar Zonturlu, Peli̇n Fatoş Polat Di̇nçer, Ömer Yaprakci
Turkish Journal of Veterinary & Animal Sciences
The present study was conducted to investigate the effect of dystocia on oxidative stress, venous blood gases, and colostrum and serum immunoglobulins G (IgG) in Damascus goats and their kids, respectively. The study sample comprised a total of 40 Damascus goats with of their own 40 kids separated into 2 groups according to the type of birth. Group 1 consisted of goats with eutocia (n = 20) and their kids (n = 20), and Group 2 consisted of goats with dystocia (n = 20) and their kids (n = 20). Blood samples were taken from the goats and their kids …
Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu
Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu
Turkish Journal of Medical Sciences
Background/aim: Alpha-lipoic acid (ALA) is a natural compound, one of the natural antioxidants with high activity. In the NADPH oxidase family, NADPH oxidase 4 (NOX4) is an important subunit participating in the production of ROS. NADPH oxidase 2 (NOX2) can form active NADPH oxidase complexes when binding to several other subunits in the cytoplasm, and NOX2 is its major functional subunit. Rapid atrial pacing (RAP) model was constructed to study the effects of ALA on electrical and structural remodeling in rabbits. Materials and methods: Thirty rabbits were divided into SHAM group, RAP group and ALA+RAP group. Their right atriums were …
Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir
Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Background/aim: Ultrasonography and fine-needle aspiration biopsy are frequently used to diagnose thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. This study investigated whether there is a relationship between thiol/ disulphide homeostasis and cytological and histopathological diagnosis of thyroid nodules. Materials and methods: The patient group consisted of 81 individuals with euthyroid nodular (single/multiple) goiter scheduled for thyroidectomy, and the control group consisted of 28 age- and sex-matched healthy volunteers who had no thyroid nodule on ultrasonographic evaluation. All participants were selected among the admissions to the study clinic between June 2017 and June 2018, and …
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca
Turkish Journal of Medical Sciences
Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …
Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin
Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin
Turkish Journal of Medical Sciences
Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investi- gate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status. Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was ob- served between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF dur- ing an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.
Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman
Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman
Turkish Journal of Agriculture and Forestry
Chromium (Cr) is a heavy metal of commercial importance; thus, significant amounts are released in wastewaters. The mobility and distribution of metals in the environment is related not only to their concentration but also to their availability in the environment. Most chromium (Cr) exists in oxidation states ranging from 0 to VI in soils but the most stable and common forms are Cr(0), Cr(III), and Cr(VI) species. Cr can have positive and negative effects on health, according to the dose, exposure time, and its oxidation state. Its behavior in soil, its soil-plant transfer and accumulation in different plant parts vary …
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Acute cerebral infarction (ACI) occurs as a result of instant disruption of vascular flow that causes disbalance between oxidative/antioxidative activity. We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke. Materials and methods: One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The patient group was evaluated with demographic data (including arrival serum biochemical assessment), clinical disability scores, infarct volume, serum …
Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir
Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir
Turkish Journal of Chemistry
In this study, a water-soluble metal-free phthalocyanine (SPC) containing sodium 2-mercaptoethanesulfonate substituents at the peripheral positions was used to investigate the algaecidal properties and oxidative effects on the growth of two microalgal species, Arthrospira platensis and Chlorella vulgaris. Although OD at 560 nm and chlorophyll-a content were decreased in Arthrospira platensis during 7 days depending on dose and time, increases in both OD at 750 and chlorophyll-a content at 8 ppb (parts per billion) concentration on the 7th day were observed in Chlorella vulgaris. However, total SOD (superoxide dismutase) and GR (glutathione reductase) enzyme activity of A. platensis cultures did …
Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer
Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate whether vaccenic acid (VA) added to TRIS semen extender has an effect on freezing bull semen. The semen was collected at intervals of three days through an artificial vagina then pooled. The pooled ejaculates were divided into five components as the control (C; no supplement) and VA (25, 50, 100, and 200 μg / mL) groups then extended with the TRIS-based medium. The samples were left in a cold air cabinet for cooling process (4 °C), then they were equilibrated for 4 h. Afterward, the samples in the groups were frozen by …
What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz
What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel
Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: The aim of present study was to investigate the dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis (DKA). Materials and methods: A total of 77 participants consisting of 32 patients with DKA and 45 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] were measured in both groups (patient group and control group) using a brand new method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. Results: Total thiol, native thiol, and disulfide levels in blood were found …
Manipulation Of Lipophilic Antioxidants To Enhance Oxidative Stress Tolerance Andnutritional Quality In Transgenic Sweetpotato, Hosoo Kim, Rengi̇n Özgür Uzi̇lday, Bariş Uzi̇lday, Soeun Kim, Chanju Lee, Sulu Park, Xiaofeng Bian, Yizhi Xie, Sang-Soo Kwak
Manipulation Of Lipophilic Antioxidants To Enhance Oxidative Stress Tolerance Andnutritional Quality In Transgenic Sweetpotato, Hosoo Kim, Rengi̇n Özgür Uzi̇lday, Bariş Uzi̇lday, Soeun Kim, Chanju Lee, Sulu Park, Xiaofeng Bian, Yizhi Xie, Sang-Soo Kwak
Turkish Journal of Botany
Overproduction of reactive oxygen species (ROS) in plant cells under environmental stress cause oxidative stress, which is one of major factors limiting the plant productivity. To prevent this limitation by stress conditions, a possible strategy is to strengthen the antioxidant defense of plants by gene manipulation of antioxidant enzymes and low molecular-weight (LMW) antioxidants. LMW antioxidants are important for the plant protection to environmental stress and also have nutritional merits for humans as antiaging and antidisease molecules. Sweetpotato [Ipomoea batatas (L.) Lam] as a nutritional food crop has many advantages in terms of the cultivation on the global marginal lands. …