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Antiinflammatory Photodynamic Therapy Potential Of Polyoxyethylene-Substituted Perylene Diimide, Nitrocatechol, And Azo Dye, Özgül Hakli, Kasim Ocakoğlu, Furkan Ayaz
Antiinflammatory Photodynamic Therapy Potential Of Polyoxyethylene-Substituted Perylene Diimide, Nitrocatechol, And Azo Dye, Özgül Hakli, Kasim Ocakoğlu, Furkan Ayaz
Turkish Journal of Chemistry
Photodynamic therapy (PDT) applications enable light-controlled activation of drug candidates instead of their constitutive activities to prevent undesired side effects associated with their constant activities. A specific wavelength of light is utilized to enable electron mobility in the chemical structure, which results in differential activities that may alter cell viability and cellular functions. Canonical photodynamic therapy applications mostly focus on cytotoxicity-based antimicrobial and anticancer properties of the PDT agents. In this study, we focused on subtoxic concentrations of three different molecules containing polyoxyethylene group and examined their antiinflammatory activities on stimulated mammalian macrophages. Stimulated macrophages produce proinflammatory cytokines TNF and …
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS). Materials and methods: Nineteen adult male individuals (18-65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-α, IL-6, and IL-10 of patients were evaluated …
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Immune Dysfunction In Covid-19 And Judicious Use Of Antirheumatic Drugs For Thetreatment Of Hyperinflammation, Abdurrahman Tufan, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
: In the Wuhan province of China, almost two years ago, in December 2019, the novel Coronavirus 2019 has caused a severe involvement of the lower respiratory tract leading to an acute life-threatening respiratory syndrome, coronavirus disease-19 (COVID-19). Subsequently, coronavirus 2 (SARS-CoV-2) rapidly spread to the entire world causing a pandemic and affected every single person on earth either directly or indirectly with destroying all facets of social life and economy. Since the announcement of COVID-19 as a global pandemic, we have witnessed tremendous scientific work on all aspects of COVID-19 across the globe, which has never been witnessed before. …
Evaluation Of Serum Cxc Chemokine Ligand 16 (Cxcl16) As A Novel Inflammatory Biomarker Or Familial Mediterranean Fever Disease, Taner Akyol, Tolga Düzenli̇, Alpaslan Tanoğlu
Evaluation Of Serum Cxc Chemokine Ligand 16 (Cxcl16) As A Novel Inflammatory Biomarker Or Familial Mediterranean Fever Disease, Taner Akyol, Tolga Düzenli̇, Alpaslan Tanoğlu
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF) is a disease that is mainly diagnosed with clinical features. Several wellknown inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in the acute phase response. In this study, we aimed to investigate the relationship between CXCL16 levels and FMF disease and to evaluate CXCL16 levels as a novel biomarker for FMF. Materials and methods: Fifty-three male patients diagnosed with FMF and sixty healthy individuals were included in this crosssectional study. Blood …
Synthesis, Characterization, Cox1/2 Inhibition And Molecular Modeling Studies On Novel 2-Thio-Diarylimidazoles, Zafer Şahi̇n, Meli̇ke Kalkan, Barkin Berk, Leyla Yurttaş, Ceysu Bender, Sevde Nur Bi̇lteki̇n Kaleli̇, Şeref Demi̇rayak
Synthesis, Characterization, Cox1/2 Inhibition And Molecular Modeling Studies On Novel 2-Thio-Diarylimidazoles, Zafer Şahi̇n, Meli̇ke Kalkan, Barkin Berk, Leyla Yurttaş, Ceysu Bender, Sevde Nur Bi̇lteki̇n Kaleli̇, Şeref Demi̇rayak
Turkish Journal of Chemistry
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological activities. In this study, nine novel 2-[(1,5-diphenyl-1H-imidazole-2-yl)thio]-N-(thiazole-2-yl)acetamide derivatives (Compound 1-9) were synthesized via the reaction of 1,5-disubstitued phenyl-imidazole-2-thiole and N-thiazole acetamide. The inhibitory effects of COX-1 and COX-2 enzymes were tested for the synthesized compounds. Enzyme-ligand interactions of the most active compound on COX subtypes were elucidated by molecular modeling studies. The percent inhibitory effect for compound 1, which is the naked derivative among all the compounds, was …
High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş
High Mobility Group Box-1 Levels May Be Associated With Disease Activity Of Behcet's Disease, Di̇lara Dönmez Güler, Ayşe Bahar Keleşoğlu Di̇nçer, Zeynep Ceren Karahan, Hasan Seli̇m Güler, Müçteba Enes Yayla, Serdar Sezer, Emi̇ne Gözde Aydemi̇r Gülöksüz, İlyas Ercan Okatan, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Mehmet Levent Yüksel, Tahsi̇n Murat Turğay, Gülay Kinikli, Aşkin Ateş
Turkish Journal of Medical Sciences
Background/aim: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet's disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated. Materials and methods: Ninety BD patients and 50 age-sex matched HC were included in the study. Disease activity scores were assessed by Behcet Disease Current Activity Form (BDCAF) and Behcet Syndrome Activity Score (BSAS). Serum HMGB- 1 levels were measured …
Il-1r1 Deficiency Impairs Liver Regeneration After 2/3 Partial Hepatectomy In Aged Mice, Deming Li, Ze Wang, Chunyan Zhang, Cunshuan Xu
Il-1r1 Deficiency Impairs Liver Regeneration After 2/3 Partial Hepatectomy In Aged Mice, Deming Li, Ze Wang, Chunyan Zhang, Cunshuan Xu
Turkish Journal of Biology
Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment was to determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) and the IL-1R1 knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation. Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative realtime polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient …
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Turkish Journal of Biology
Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate that gut-lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which, in turn, can affect distal organs such as the brain. Moreover, gut microbiota …
A Sensitive Indicator For The Severity Of Covid-19: Thiol, Özcan Erel, Sali̇m Neşeli̇oğlu, Merve Ergi̇n Tunçay, Esra Firat Oğuz, Funda Eren, Meryem Sena Akkuş, Hati̇ce Rahmet Güner, İhsan Ateş
A Sensitive Indicator For The Severity Of Covid-19: Thiol, Özcan Erel, Sali̇m Neşeli̇oğlu, Merve Ergi̇n Tunçay, Esra Firat Oğuz, Funda Eren, Meryem Sena Akkuş, Hati̇ce Rahmet Güner, İhsan Ateş
Turkish Journal of Medical Sciences
Background/aim: Thiol status is a good reflector of the cellular redox and have vital roles in various cellular signaling pathways. The purpose of the study was to investigate thiol status in patients with SARS-CoV-2 infection. Materials and methods: A total of 587 subjects (517 patients/70 healthy controls) were enrolled in the study.The patients were categorized into the groups regarding to the severity of disease (mild, moderate, severe, and critical).Thiol status of all groups were compared. Results: The patients had significantly diminished thiol levels compared to controls. Thiol levels were gradually decreased as the severity of the disease increased. Logistic regression …
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in …
Serum Chitotriosidase And Ykl-40 In Acute Pancreatitis: Reliability As Prognostic Markerfor Disease Severity And Correlation With Inflammatory Markers, Ece Ünal Çeti̇n, Fati̇h Kamiş, Adi̇l Uğur Çeti̇n, Yavuz Beyazi̇t, Murat Keki̇lli̇
Serum Chitotriosidase And Ykl-40 In Acute Pancreatitis: Reliability As Prognostic Markerfor Disease Severity And Correlation With Inflammatory Markers, Ece Ünal Çeti̇n, Fati̇h Kamiş, Adi̇l Uğur Çeti̇n, Yavuz Beyazi̇t, Murat Keki̇lli̇
Turkish Journal of Medical Sciences
Background/aim: Chitotriosidase and YKL-40, also called chitinase 3-like protein 1, are homologs of family 18 glycosyl hydrolases, secreted by human macrophages and granulocytes under inflammatory conditions. Although increased levels of chitotriosidase and YKL-40 are linked with several inflammatory diseases, the physiological utility of these two enzymes is still not fully characterized. This study aims to analyse the serum YKL-40 and chitotriosidase levels of acute pancreatitis patients to assess whether their activity correlates with acute pancreatitis and its severity. Materials and methods: Chitotriosidase and YKL-40 levels, along with routine laboratory parameters, were determined from the serum samples of 41 acute pancreatitis …