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The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to emphasize the importance of routine bedside biliary ultrasonography (USG) for the differential diagnosis of biliary tract disorders in patients admitted with acute isolated epigastric pain. Materials and methods: Adult patients who were admitted to the emergency department with acute isolated epigastric pain were included in the study. Emergency residents (ERs) were asked whether they planned to perform biliary USG during the initial evaluation and following diagnosis/treatment (secondary evaluation) of these patients. Bedside biliary USG examinations were performed by a sonologist and a radiologist evaluated the video recordings. Results: A total of 103 …
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. Materials and methods: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G). Results: For diabetic patients without foot ulcers, 17 of 30 (56.6%) patients were found to have nonprotective TIG levels whereas for diabetic …
Intracranial Intraventricular Tumors: Long-Term Surgical Outcome Of 25 Patients, Si̇ma Sayyahmelli̇, Oğuz Baran, Doğa Uğurlar, Rahşan Kemerdere, Veysel Antar, Taner Tanriverdi̇
Intracranial Intraventricular Tumors: Long-Term Surgical Outcome Of 25 Patients, Si̇ma Sayyahmelli̇, Oğuz Baran, Doğa Uğurlar, Rahşan Kemerdere, Veysel Antar, Taner Tanriverdi̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this paper is to provide the long-term surgical outcome of patients with intracranial intraventricular tumors. Materials and methods: Twenty-five patients operated on for intraventricular tumors between June 1999 and June 2014 are reviewed. Data from before, during, and after surgery were obtained from the patients' files and patients were followed regularly after surgery. Results: The group of patients comprised 15 females and 10 males with a mean age of 31.6 ± 16 years. The majority were adults and only 3 children were included. Three, 4, and 18 patients had tumors in the 4th, 3rd, and frontal …
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Endometriosis-Associated Changes In Serum Levels Of Interferons And Chemokines, Andrei Mihai Malutan, Tudor Drugan, Razvan Ciortea, Carmen Bucuri, Maria Patricia Rada, Dan Mihu
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. Materials and methods: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly …
Hpv Types And E6/E7 Mrna Expression In Cervical Samples From Turkish Women With Abnormal Cytology In Ankara, Turkey, İpek Tüney, Ayli̇n Altay, Koray Ergünay, Sevgen Çeli̇k Önder, Alp Usubütün, Mehmet Coşkun Salman, Gülendam Bozdayi, Erdem Karabulut, Osman Seli̇m Badur, Kunter Yüce, Ahmet Pinar
Hpv Types And E6/E7 Mrna Expression In Cervical Samples From Turkish Women With Abnormal Cytology In Ankara, Turkey, İpek Tüney, Ayli̇n Altay, Koray Ergünay, Sevgen Çeli̇k Önder, Alp Usubütün, Mehmet Coşkun Salman, Gülendam Bozdayi, Erdem Karabulut, Osman Seli̇m Badur, Kunter Yüce, Ahmet Pinar
Turkish Journal of Medical Sciences
Background/aim: Human papillomaviruses have been established as a risk factor for invasive carcinoma of the uterine cervix. HPV E6/E7 oncogene expression has recently emerged as a promising biomarker to determine the risk for progression to high-grade cervical lesions. The aim of this study was to evaluate HPV mRNA and DNA detection in samples with abnormal cytology. Materials and methods: Cervical specimens were obtained at the Department of Obstetrics and Gynecology via cervical brushes during January-October 2011. Liquid-based cytology slides were evaluated according to the 2001 Bethesda System. Cytology specimens from a total of 81 women with abnormal cytology were included. …
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …
Neutrophil-To-Lymphocyte Ratio Is Elevated In Recurringnonmuscle Invasive Bladder Cancer, Emrah Yürük, Theodore Robert Saitz, Serkan Gönültaş, Ege Can Şerefoğlu, Ahmet Yaser Müslümanoğlu
Neutrophil-To-Lymphocyte Ratio Is Elevated In Recurringnonmuscle Invasive Bladder Cancer, Emrah Yürük, Theodore Robert Saitz, Serkan Gönültaş, Ege Can Şerefoğlu, Ahmet Yaser Müslümanoğlu
Turkish Journal of Medical Sciences
Background/aim: Although it has been shown that the neutrophil-to-lymphocyte ratio (NLR) may predict the progression of nonmuscle invasive bladder cancer (NMIBC), its association with the recurrence of NMIBC has been poorly studied. The aim of this study is to evaluate the association between NLR and disease recurrence in patients with NMIBC. Materials and methods: The medical records of 428 consecutive initially diagnosed NMIBC patients who underwent transurethral resection between January 2010 and July 2014 were retrospectively reviewed. Patients without a preoperative NLR (n = 6), without a minimum of 6 months of follow-up (n = 56), who were lost to …
The Genicular Nerve: Radiofrequency Lesion Application For Chronic Knee Pain, Paki̇ze Kirdemi̇r, Serdar Çatav, Fi̇li̇z Alkaya Solmaz
The Genicular Nerve: Radiofrequency Lesion Application For Chronic Knee Pain, Paki̇ze Kirdemi̇r, Serdar Çatav, Fi̇li̇z Alkaya Solmaz
Turkish Journal of Medical Sciences
Background/aim: We investigated the short- and medium-term effectiveness of genicular nerve radiofrequency (RF) applied in patients with chronic knee pain due to osteoarthritis. Materials and methods: Radiofrequency was performed in 49 patients with a diagnosis of knee osteoarthritis. VAS and WOMAC were measured at baseline and at 1, 4, and 12 weeks postprocedure. Under fluoroscopic guidance, the cannula was advanced percutaneously towards the area connecting the shaft to the epicondyle. The RF electrode was inserted through the cannula and the electrode tip temperature was raised to 80 °C for 90 s. One RF lesion was made for each genicular nerve. …
Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi
Analysis Of Meiotic Spindle And Zona Pellucida Birefringenceof Ivm Oocytes In Pcos Patients, Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi
Turkish Journal of Medical Sciences
Background/aim: Polycystic ovarian syndrome (PCOS) is one of the most common causes of infertility. One of the best therapeutic options for PCOS patients is intracytoplasmic sperm injection (ICSI). In vitro maturation (IVM) can also be a useful technique for these women. The goal of this study was to evaluate both the zona pellucida (ZP) birefringence and meiotic spindle (MS) of in vivo- and in vitro-matured oocytes from PCOS patients using the PolScope system. Materials and methods: Immature oocytes undergoing IVM and MII oocytes were obtained from PCOS patients in an ICSI program. Using PolScope, the presence of MS and ZP …
The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt
The Effect Of Transcatheter Aortic Valve Implantation On Mean Platelet Volume, Mehmet Burak Özen, Hüseyi̇n Ayhan, Haci Ahmet Kasapkara, Telat Keleş, Tahi̇r Durmaz, Kemal Eşref Erdoğan, Bi̇lge Duran Karaduman, Serdal Baştuğ, Cenk Sari, Abdullah Nabi̇ Aslan, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Transcatheter aortic valve implantation (TAVI) is an innovative approach to the treatment of aortic stenosis (AS) as an alternative to surgery in high-risk patients. Mean platelet volume (MPV) is considered an indicator of endothelial dysfunction, platelet function, and activation. In this study, we aimed to investigate MPV changes in patients undergoing TAVI. Materials and methods: This study included 100 patients diagnosed with symptomatic severe AS and treated with TAVI between July 2011 and August 2013. Hematological parameters of the patients were examined prior to the procedure and 24 h, 1 month, and 6 months after TAVI. Results: A statistically …
The Assessment Of Work Productivity And Activity Impairment In Behçet's Disease, Gonca Mumcu, Fadi̇me Lehi̇mci̇, Özlem Fi̇dan, Hülya Gük, Uğur Alpar, Ali̇ Uğur Ünal, Zeynep Ertürk, Fatma Ali̇baz Öner, Güzi̇de Nevsun İnanç, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇
The Assessment Of Work Productivity And Activity Impairment In Behçet's Disease, Gonca Mumcu, Fadi̇me Lehi̇mci̇, Özlem Fi̇dan, Hülya Gük, Uğur Alpar, Ali̇ Uğur Ünal, Zeynep Ertürk, Fatma Ali̇baz Öner, Güzi̇de Nevsun İnanç, Safi̇ye Atlas Tüli̇n Ergun, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the relationships between the course of Behçet's disease (BD), disease-specific fears, and work productivity and activity impairment. Materials and methods: In this cross-sectional study, 110 consecutive BD patients were included. The Work Productivity and Activity Impairment questionnaire was used. Results: In the group of employed patients, 30.41% had missed work during the previous week. The mean percentages of daily activity impairment were higher in patients with musculoskeletal involvement (39.81 ± 33.61%) compared to those without (23.48 ± 32.45%) (P = 0.008). A greater decrease in working hours was observed in patients …
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Effects Of Ankaferd Bloodstopper On Dermal Healing In Diabetic Rats, Sertaç Aktop, Burcu Çevreli̇, Deni̇z Genç, Emel Serdaroğlu Kaşikçi, Ni̇l Çomunoğlu Üstündağ, Noushi̇n Zi̇bandeh, Eli̇f Merve Özcan, Gökhan Göçmen, Mehmet Kami̇l Göker, İsmai̇l Tayfun Uzbay, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus inhibits wound-induced angiogenesis, impairs the wound healing process, and leads to the development of chronic wounds. Ankaferd BloodStopper (ABS) is a new and promising local haemostatic agent. Although the mechanism of ABS-mediated haemostasis is well established, little is known about the associated histological and biochemical tissue reactions. The aim of this study was to evaluate the effects of this new-generation local haemostatic agent on short-term soft-tissue healing in streptozotocin (STZ)-treated rats. Materials and methods: The 24 Wistar albino rats used in this study were divided into STZ-treated (STZ, n = 12) and nontreated groups (control, n = …
The Influence Of Intraabdominal Pressure On The Mortalityrate Of Patients With Acute Pancreatitis, Petar Svorcan, Maja Stojanovic, Predrag Stevanovic, Aleksandar Karamarkovic, Radmilo Jankovic, Nebojsa Ladjevic
The Influence Of Intraabdominal Pressure On The Mortalityrate Of Patients With Acute Pancreatitis, Petar Svorcan, Maja Stojanovic, Predrag Stevanovic, Aleksandar Karamarkovic, Radmilo Jankovic, Nebojsa Ladjevic
Turkish Journal of Medical Sciences
Background/aim: Intraabdominal hypertension (IAH) is a common clinical finding in patients with acute pancreatitis and is associated with poor prognosis. This study aimed to determine the impact of intraabdominal pressure (IAP) on the mortality rate in patients with acute pancreatitis in an intensive care unit. Materials and methods: A total of 50 patients with acute pancreatitis were included in this prospective cohort study. Based on the obtained values of IAP, the patients were divided into two groups: those with normal IAP (n = 14) and increased IAP (n = 36). Mean values of IAP were compared with examined variables. Results: …
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Epidemiology Of Under-Five Mortality In İstanbul: Changes From 1988 To 2011, Fahri̇ye Aysun Buzcu, Ayli̇n Yeti̇m Şahi̇n, Esra Karapinar, Özge Erol, Emi̇ne Gülbi̇n Gökçay
Turkish Journal of Medical Sciences
Background/aim: Understanding the causes of under-five deaths is key to realizing sustainable developmental goals. The aim of this descriptive study was to investigate the causes of under-five mortality in İstanbul during 2011 and compare the findings to those of 1988 and 2000. Materials and methods: All burial records of İstanbul were evaluated, and cemetery records of 1494 children, who died at under five years of age and were buried in İstanbul Metropolitan Municipality Cemeteries between 1 January and 31 December 2011, were analyzed. Several sociodemographic characteristics and causes of death were compared with the results of studies carried out in …
Groin And Thigh Reconstructions With Pedicled Rectus Abdominis Myocutaneous Flaps, Hakan Uzun, Ozan Bi̇ti̇k, Yahya Baltu, Mehmet Dadaci, Aycan Uğur Kayikçioğlu
Groin And Thigh Reconstructions With Pedicled Rectus Abdominis Myocutaneous Flaps, Hakan Uzun, Ozan Bi̇ti̇k, Yahya Baltu, Mehmet Dadaci, Aycan Uğur Kayikçioğlu
Turkish Journal of Medical Sciences
Background/aim: Resection of tumors from the groin and thigh regions with safe margins often results in significant soft tissue defects, which preclude primary closure. This study presents a series of rectus abdominis myocutaneous flaps for irradiated thigh and groin wounds with the purpose of evaluating the efficacy and outcomes of these flaps in this population. Materials and methods: From 2008 to 2015, all patients who underwent resection of thigh or groin region tumors and reconstruction with an inferiorly based rectus abdominis myocutaneous flap were retrospectively identified. Medical records of the patients were reviewed. Results: A total of 27 patients, aged …
Serum Ischemic Modified Albumin (Ima) Concentration And Ima/Albumin Ratio In Patients With Hepatitis B-Related Chronic Liver Diseases, Fatma Yavuz, Murat Biyik, Mehmet Asil, Ramazan Dertli̇, Ali̇ Demi̇r, Hakki Polat, Sali̇ha Uysal, Hüseyi̇n Ataseven
Serum Ischemic Modified Albumin (Ima) Concentration And Ima/Albumin Ratio In Patients With Hepatitis B-Related Chronic Liver Diseases, Fatma Yavuz, Murat Biyik, Mehmet Asil, Ramazan Dertli̇, Ali̇ Demi̇r, Hakki Polat, Sali̇ha Uysal, Hüseyi̇n Ataseven
Turkish Journal of Medical Sciences
Background/aim: Albumin is the most important protein synthesized by the liver. Posttranscriptional changes occur in the molecular structure of albumin due to various factors and isoforms arise. Ischemic modified albumin (IMA) is one such isoform. This study was conducted to evaluate serum IMA concentrations in patients with hepatitis B virus (HBV)-related chronic liver diseases. Materials and methods: This study included 74 treatment-naive chronic hepatitis B patients, 25 patients with HBV-related cirrhosis, and 49 healthy controls. Serum IMA concentration was measured spectrophotometrically using the albumin cobalt binding test. Results: The mean IMA concentrations in the chronic hepatitis B group and healthy …
Frequency Of Human Parvovirus 4 (Parv4) Viremia Among Hbv-Infected Patients And Healthy Donors In Shiraz, Iran, Fereshte Amirahmadi, Jamal Sarvari, Seyed Younes Hosseini, Neda Pirbonyeh, Ali Akbar Gorzin
Frequency Of Human Parvovirus 4 (Parv4) Viremia Among Hbv-Infected Patients And Healthy Donors In Shiraz, Iran, Fereshte Amirahmadi, Jamal Sarvari, Seyed Younes Hosseini, Neda Pirbonyeh, Ali Akbar Gorzin
Turkish Journal of Medical Sciences
Background/aim: PARV4, a small DNA virus belonging to the family Parvoviridae, was first isolated in an HBV injecting drug user. Several studies have investigated PARV4 co-infection with HBV and HCV and its effect on the progression of liver disease. The aim of this study was to determine the frequency of PARV4 among HBV-infected patients and healthy individuals. Materials and methods: A group of 90 HBV patients and a group of 90 healthy subjects were included in this study. Samples were selected after screening tests such as HBsAg ELISA, anti-HCV ELISA, and anti-HIV ELISA. Nested-PCRs were conducted to detect the PARV4 …
A Comparison Of Culture And Pcr Methods For Identifying Propionibacterium Acnes In Lesions Isolated From Patients With Acne, Negin Naghdi, Masood Ghane
A Comparison Of Culture And Pcr Methods For Identifying Propionibacterium Acnes In Lesions Isolated From Patients With Acne, Negin Naghdi, Masood Ghane
Turkish Journal of Medical Sciences
Background/aim: One of the factors that affect the occurrence of acne is the presence of Propionibacterium acnes. The present study was conducted to compare the culture and polymerase chain reaction (PCR) methods for identifying P. acnes in lesions isolated from patients with acne. Materials and methods: To examine the presence of P. acnes, 70 samples of acne lesions were collected. Microbial culture and the PCR molecular technique were used to identify P. acnes. Results: Of the total of 70 samples, 14 cases (20%) were identified as P. acnes positive using microbial culture and 58 cases (82.85%) using PCR. The results …
Effect Of Inhaled Steroids On Clinical And Inflammatoryparameters In Children With Cystic Fibrosis, Zeynep Seda Uyan, Gökseni̇n Ünlügüzel Üstün, Goncagül Haklar, Erkan Çakir, Sedat Oktem, Refi̇ka Ersu, Bülent Taner Karadağ, Fazi̇let Karakoç, Eli̇f Dağli
Effect Of Inhaled Steroids On Clinical And Inflammatoryparameters In Children With Cystic Fibrosis, Zeynep Seda Uyan, Gökseni̇n Ünlügüzel Üstün, Goncagül Haklar, Erkan Çakir, Sedat Oktem, Refi̇ka Ersu, Bülent Taner Karadağ, Fazi̇let Karakoç, Eli̇f Dağli
Turkish Journal of Medical Sciences
Background/aim: The effectiveness of inhaled corticosteroids (ICSs) in cystic fibrosis (CF) is controversial. The aim of this study was to investigate the effect of an ICS on bronchial hyperreactivity (BHR), oxidative status, and clinical and inflammatory parameters in CF patients. Materials and methods: CF patients were randomized to receive either 2 mg/day nebulized budesonide or 0.9% normal saline as placebo for 8 weeks. Results: Twenty-nine CF patients (mean age: 10.5 $\pm$ 2.9 years) were enrolled in the study. There was no statistically significant difference between the two groups at the end of 8 weeks in terms of symptoms, pulmonary function, …
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Turkish Journal of Medical Sciences
Background/aim: Irrational drug use is a common problem. This study aimed to evaluate patients' knowledge and habits concerning drug use, and compare them in terms of some sociodemographic characteristics. Materials and methods: A face-to-face questionnaire was given to outpatients from family healthcare centres (FHCs) and state hospitals (SHs) in 12 provinces in Turkey during May 2010. A total of 4470 patients (FHCs: 2209; SHs: 2261) responded to the questionnaire (response rate: 93.1%). Results: Getting prescriptions without a physical examination was common (second place in FHCs; third place in SHs); 51.0% stated that they wanted physicians to prescribe drugs that they …
Investigation Of Glucocorticoid Receptor And Calpain-10 Gene Polymorphisms In Turkish Patients With Type 2 Diabetes Mellitus, Naci̇ye Selcen Bayramci, Leyla Açik, Çağdaş Kalkan, İlhan Yetki̇n
Investigation Of Glucocorticoid Receptor And Calpain-10 Gene Polymorphisms In Turkish Patients With Type 2 Diabetes Mellitus, Naci̇ye Selcen Bayramci, Leyla Açik, Çağdaş Kalkan, İlhan Yetki̇n
Turkish Journal of Medical Sciences
Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes mellitus (T2DM).Materials and methods: Peripheral blood samples were obtained from 125 patients with T2DM and 112 healthy volunteers. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There were no statistically significant differences found between the allele and genotype frequencies of CAPN10 SNP-19, CAPN10 SNP-44, and NR3C1 N363S polymorphisms and T2DM development (P > 0.05). The CAPN10 SNP-19 del-allele, CAPN10 SNP-44 C-allele, and NR3C1 …
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively. The incidence of proven/probable IFI was 6.7%. The incidence of IFI among patients who received prophylaxis was significantly higher than among those who did not receive it (11.3% vs. 4.6%, P = 0.005). There …
Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang
Evaluation Of Pulmonary Vein Anatomy Using 256-Slice Computed Tomography, Yinghong Shi, Shaohua Mi, Yunxia Shi, Hongbo Wang, Jian Li, Benxia Yu, Fengli Liu, Heng Ma, Bin Wang
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate pulmonary vein (PV) anatomy using 256-slice computed tomography (CT), which may be necessary for electrophysiologists to know before radiofrequency catheter ablation (RFCA) therapy.Materials and methods: A total of 102 patients with paroxysmal and persistent atrial fibrillation underwent 256-slice cardiac CT angiography prior to catheter ablation. PV morphology, ostial diameter, ostial orientation, and distance from ostium to first bifurcation were evaluated using three-dimensional volume-rendering and multiplanar-reformatting technology. Results: We found that 72.5% of patients had four conventional PVs. On the right, 22.5% of patients had one accessory PV, 4.9% had 2 accessory PVs, 1% had …
Comparing The Effectiveness Of Ultrasound-Guided Versus Blind Steroid Injection In The Treatment Of Severe Carpal Tunnel Syndrome, Özgür Zeli̇ha Karaahmet, Eda Gürçay, Murat Kara, Azi̇ze Serçe, Zeynep Kiraç Ünal, Fatma Aytül Çakci
Comparing The Effectiveness Of Ultrasound-Guided Versus Blind Steroid Injection In The Treatment Of Severe Carpal Tunnel Syndrome, Özgür Zeli̇ha Karaahmet, Eda Gürçay, Murat Kara, Azi̇ze Serçe, Zeynep Kiraç Ünal, Fatma Aytül Çakci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the effectiveness of ultrasound (US)-guided injection versus blind injection of corticosteroids in the treatment of carpal tunnel syndrome (CTS). Materials and methods: This prospective, randomized clinical trial included patients with severe CTS based on clinical and electrophysiological criteria. The patients were evaluated for clinical and electrophysiological parameters at baseline and 4 weeks after treatment. Symptom severity and hand function were assessed by the Boston questionnaire. The patients underwent blind injection or US-guided injection. Results: When compared with baseline, both groups showed significant improvement in Boston questionnaire scores and all electrophysiological parameters. Significant differences were …
Tnf-Α And Tgf-Ss Level After Intraoperative Allogeneic Red Blood Cell Transfusion In Orthopedic Operation Patients, Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohammad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh
Tnf-Α And Tgf-Ss Level After Intraoperative Allogeneic Red Blood Cell Transfusion In Orthopedic Operation Patients, Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohammad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh
Turkish Journal of Medical Sciences
Background/aim: Blood transfusion is associated with immunosuppression, referred to as transfusion-related immunomodulation (TRIM). In this study, for the first time, changes in the concentration of TGF-ß and TNF-α were measured postoperatively in orthopedic patients with intraoperational allogeneic red blood cell transfusion. Considering the use of packed cell units with different ages, it is possible to suggest the more appropriate product for clinical applications.Materials and methods: Two groups of 35 orthopedic surgery patients (with or without transfusion as case and control groups, respectively) were involved. Serum levels of TNF-α and TGF-ß were measured by ELISA.Results: The data suggested significant differences in …
Tnf-Alpha 863c > A Promoter And Tnfrii 196t > G Exonic Variationsmay Be Risk Factors For Juvenile Idiopathic Arthritis, Bahadir Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven
Tnf-Alpha 863c > A Promoter And Tnfrii 196t > G Exonic Variationsmay Be Risk Factors For Juvenile Idiopathic Arthritis, Bahadir Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven
Turkish Journal of Medical Sciences
Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients. Materials and methods: We analyzed eight polymorphisms, TNF-alpha-863 C > A, TNFRII 196 T > G, IL2-631 G > A, IL13-1112 C > T, CCR2 190 G > A, CCR5delta32, CTLA4-1661 A > G, and PTPN22 1858 C > T, in 76 patients with JIA and in …
Turkish Version Of The Motor Function Measure Scale (Mfm-32) Forneuromuscular Diseases: A Cross-Cultural Adaptation, Reliability, And Validity Study, Habi̇be Serap İnal, Ela Tarakçi, Devri̇m Tarakçi, Gülcan Aksoy, Sezan Mergen Kiliç, Hakan Beşer, Çi̇ğdem Beşer, Arzu Razak Özdi̇nçler, Hacer Durmuş Tekçe, Fatma Yeşi̇m Parman, Feza Deymeer, Zehra Pi̇raye Oflazer
Turkish Version Of The Motor Function Measure Scale (Mfm-32) Forneuromuscular Diseases: A Cross-Cultural Adaptation, Reliability, And Validity Study, Habi̇be Serap İnal, Ela Tarakçi, Devri̇m Tarakçi, Gülcan Aksoy, Sezan Mergen Kiliç, Hakan Beşer, Çi̇ğdem Beşer, Arzu Razak Özdi̇nçler, Hacer Durmuş Tekçe, Fatma Yeşi̇m Parman, Feza Deymeer, Zehra Pi̇raye Oflazer
Turkish Journal of Medical Sciences
Background/aim: The Motor Function Measure (MFM-32) is a classification system for ambulant and nonambulant patients with neuromuscular diseases (NMDs). We aimed to translate it into Turkish, culturally adapt it, and test its reliability and validity for Turkish patients with NMDs.Materials and methods: The translation of the 32 items assessing three functional areas: standing position and transfers (D1: 13), axial/proximal (D2: 12), and distal (D3: 7) motor functions was performed according to the established guidelines for cross-cultural adaptation. Totally 51 patients (12.56 ± 8.84 years; F/M 12/39) were tested. Vignos and Brooke scores for the lower and upper extremities, respectively, were …
Evaluation Of Quality Of Life And Cost-Effectiveness Of Definitive Surgery And The Levonorgestrel Intrauterine System As Treatment Options For Heavy Menstrual Bleeding, Cevdet Adigüzel, Sevtap Seyfetti̇noğlu, Deni̇z Aka Satar, Sefa Arlier, Eda Eski̇mez, Fatma Kaya, Hakan Nazi̇k
Evaluation Of Quality Of Life And Cost-Effectiveness Of Definitive Surgery And The Levonorgestrel Intrauterine System As Treatment Options For Heavy Menstrual Bleeding, Cevdet Adigüzel, Sevtap Seyfetti̇noğlu, Deni̇z Aka Satar, Sefa Arlier, Eda Eski̇mez, Fatma Kaya, Hakan Nazi̇k
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the levonorgestrel intrauterine system (LNG-IUS) with abdominal hysterectomy (TAH) and total laparoscopic hysterectomy (TLH) as first-line treatments for heavy menstrual bleeding (HMB). Materials and methods: Ninety-eight patients aged 20-55 years who complained of regular heavy menstrual bleeding were enrolled in the study. The TAH group included 29 patients, the LNG-IUS group included 34, and the TLH group included 35. These groups were compared in terms of quality of life and the cost-effectiveness of the selected methods. Quality of life was assessed using the 36-Item Short Form (SF-36), and cost-effectiveness was assessed according to the …
The Turkish Version Of The Physical Activity Scale For Theelderly (Pase): Its Cultural Adaptation, Validation, And Reliability, Ender Ayvat, Muhammed Kilinç, Nuray Kirdi
The Turkish Version Of The Physical Activity Scale For Theelderly (Pase): Its Cultural Adaptation, Validation, And Reliability, Ender Ayvat, Muhammed Kilinç, Nuray Kirdi
Turkish Journal of Medical Sciences
Background/aim: This study aimed to describe the cultural adaptation of the Turkish Physical Activity Scale for the Elderly (PASE) and to examine the reliability and validity of the scale in older Turkish adults. Materials and methods: Eighty elderly people were recruited for the study. The assessments included the PASE, the International Physical Activity Questionnaire (IPAQ), the Short Physical Performance Battery and Short Form-36 Quality of Life Questionnaire (SF-36), and the Mini Mental State Test. Outcome measures were conducted twice within a week (test-retest) for reliability. Results: Cronbach's α coefficient was 0.714 for the initial evaluation. The intraclass correlation coefficient for …
Rational Design Of Rabies Vaccine Formulation For Enhanced Stability, Veysel Kayser, Alain Francon, Herve Pinton, Jean-Francois Saluzzo, Bernhardt L. Trout
Rational Design Of Rabies Vaccine Formulation For Enhanced Stability, Veysel Kayser, Alain Francon, Herve Pinton, Jean-Francois Saluzzo, Bernhardt L. Trout
Turkish Journal of Medical Sciences
Background/aim: Vaccines are often lyophilized in order to retain their stability and efficacy for a longer period of time. However, the same lyophilization process may also cause a major degradation of the vaccine, especially during early phases of manufacturing, leading to a loss of potency of the product. Many viral diseases, such as rabies, are acute and fatal unless the vaccine is administered prior to exposure or the onset of symptoms in the case of postexposure treatment. Materials and methods: We investigated the effect of lyophilization on the stability of the virus structure during rabies vaccine manufacturing using dynamic light …