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Evaluation Of Aashto Seismic Design For Reinforced Concrete Bridge Columns, Andrew Leroy Grismer Jan 2024

Evaluation Of Aashto Seismic Design For Reinforced Concrete Bridge Columns, Andrew Leroy Grismer

Electronic Theses and Dissertations

Bridge failure can be catastrophic resulting in casualties and limiting the accessibility and emergency response efforts. Ensuring a high level of ductility for bridge columns through sufficient design methods and detailing is the most important aspect of the modern seismic codes. Reinforced concrete (RC) bridge columns are widely used in multi-span bridges located in seismic regions of the nation due to their controlled ductility and durability. The objective of this study was to systematically evaluate the AASHTO seismic design requirements for RC bridge columns and to comment on whether current bridge code is sufficient and safe. An extensive literature review …


Structural Construction And Surface Modification Of Copper Current Collectors For Lithium Metal Batteries, Yaohua Liang Jan 2024

Structural Construction And Surface Modification Of Copper Current Collectors For Lithium Metal Batteries, Yaohua Liang

Electronic Theses and Dissertations

Graphene, a prevalent anode material in commercial lithium-ion batteries, has reached its theoretical capacity limit. The imperative is to develop high-capacity anode materials to meet the growing demand for energy density. Lithium metal, renowned for its exceptionally high theoretical specific capacity density (3680 mAh g-1) and low reduction potential (-3.04 V, relative to the standard hydrogen electrode), is commonly dubbed the "Holy Grail" for negative electrode materials in high-energy-density batteries. However, practical advancements in lithium metal anodes face obstacles like low Coulombic efficiency, limited cycle life, and heightened reactivity to the electrolyte and internal short circuits resulting from lithium dendrite …


Development Of Innovative Flocculation Technologies For Agricultural Water Treatment, Noor Haleem Jan 2024

Development Of Innovative Flocculation Technologies For Agricultural Water Treatment, Noor Haleem

Electronic Theses and Dissertations

The development of innovative flocculation technologies is essential for addressing the challenges of agricultural water treatment. These technologies play a crucial role in removing contaminants such as suspended solids and nutrients, thereby ensuring safer water for irrigation and livestock consumption. By enhancing water quality and wastewater management, they contribute significantly to environmental sustainability and public health in agricultural communities. This comprehensive thesis extensively explores various dimensions of flocculation, with a focused effort on methodologies and resources aimed at strengthening sustainability and efficiency. A pivotal aspect of the research involves synthesizing cationic starch (CS), a flocculant derived from an underutilized resource, …


Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod Jan 2024

Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod

Electronic Theses and Dissertations

This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …


Advancing Biological Applications Through Microfluidic-Based Tool Development, K.M. Taufiqur Rahman Jan 2024

Advancing Biological Applications Through Microfluidic-Based Tool Development, K.M. Taufiqur Rahman

Electronic Theses and Dissertations

This research undertook an interdisciplinary approach, integrating bioengineering, microbiology, molecular biology, and systems biology to investigate bacterial dynamics behavior. Specifically, it delved into the development of microfluidic devices for biological applications such as bacterial cell counts, real-time observation of plant roots (here, specialized lectin-coated microbeads are used that mimic root characteristics), and soil microbe interactions. Furthermore, Next-Generation Sequencing and systems biology methodologies were employed to explore the intricate, multifaceted survival mechanisms of Escherichia coli persister population. Studying and quantifying persisters or testing for the existence of VBNC (viable but nonculturable) is challenging. These experiments require precise counts. It has been …


Effects Of Storage Regimes On Chemistry, Functional Properties, And Vitamin Profile Of Different Varieties Of Chickpea, Shirin Kazemzadeh Pournaki Jan 2024

Effects Of Storage Regimes On Chemistry, Functional Properties, And Vitamin Profile Of Different Varieties Of Chickpea, Shirin Kazemzadeh Pournaki

Electronic Theses and Dissertations

Chickpea (cicer arietinum) samples from five distinct varieties (crown, royal, orion, sierra, and frontier) were subjected to varying storage conditions to investigate the impact of temperature and relative humidity (rh) on their chemical, functional, physical properties, and vitamin b profile. over 360 days, samples were stored at two temperatures (21°c and 40°c) and three rh levels (40%, 55%, 65%), with collections made every 90 days. initial observations focused on key chemical properties including moisture, protein, fat, and total starch content. subsequently, protein and starch fractions were isolated for further analysis, employing techniques such as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) …


Portable X-Ray Fluorescence Spectrometry For Sensing Salinity And Sodicity In Glacial Northern Great Plains Soils With Machine Learning Models, Adam Devlin Jan 2024

Portable X-Ray Fluorescence Spectrometry For Sensing Salinity And Sodicity In Glacial Northern Great Plains Soils With Machine Learning Models, Adam Devlin

Electronic Theses and Dissertations

Saline and sodic soils are an increasing concern across the Northern Great Plains (NGP) due to factors of climate change and land management that are drawing geologically derived salts to the land surface. Traditional laboratory assessments, such as electrical conductivity (EC) and sodium adsorption ratio (SAR), are time and resource consumptive. Portable X-ray fluorescence (PXRF) may be a viable proximal sensing alternative, as it is able to provide elemental data in minutes, in situ or ex situ, and can directly quantify salinity-associated elements like Ca, Mg, and S. PXRF paired with predictive models has proven useful for a range of …


Contrastive Learning, With Application To Forensic Identification Of Source, Cole Ryan Patten Jan 2024

Contrastive Learning, With Application To Forensic Identification Of Source, Cole Ryan Patten

Electronic Theses and Dissertations

Forensic identification of source problems often fall under the category of verification problems, where recent advances in deep learning have been made by contrastive learning methods. Many forensic identification of source problems deal with a scarcity of data, an issue addressed by few-shot learning. In this work, we make specific what makes a neural network a contrastive network. We then consider the use of contrastive neural networks for few-shot learning classification problems and compare them to other statistical and deep learning methods. Our findings indicate similar performance between models trained by contrastive loss and models trained by cross-entropy loss. We …


Integrating Early Season Clover Cover Crops As A Living Mulch In Broccoli And Transitional Organic Winter Squash Production In Eastern South Dakota, Alexis Rose Barnes Jan 2024

Integrating Early Season Clover Cover Crops As A Living Mulch In Broccoli And Transitional Organic Winter Squash Production In Eastern South Dakota, Alexis Rose Barnes

Electronic Theses and Dissertations

Managing weeds, improving soil health, and reducing the use of plastic mulch continue to be priorities for South Dakota vegetable farmers. Farmers have expressed an interest in integrating cover crops into their farm systems. Clover cover crops used as a living mulch within and along cash crop rows may aid in weed suppression, nitrogen fixation, and prevent soil erosion. However, prior research has shown challenges of incorporating living mulch due to yield decreases. Research conducted in 2022 and 2023 in eastern South Dakota investigated the effects of four clover and four in-row soil management treatments on broccoli and organic winter …


The Hutton Project: Long-Term Agricultural Impacts On Soil Loss And Carbon Dynamics In Eastern South Dakota, Eli Halverson Jan 2024

The Hutton Project: Long-Term Agricultural Impacts On Soil Loss And Carbon Dynamics In Eastern South Dakota, Eli Halverson

Electronic Theses and Dissertations

Long-term and intensified agricultural land management has resulted in increased rates of soil erosion and has altered much of the carbon cycle at regional and global scales. Anthropogenic degradation of soil resources is a barrier to sustainable production, soil functioning, and ecosystem services. It is difficult to quantify the scope of pedogenic changes due to the lack of legacy data and short temporal scales. This study utilized decades to century-old soil information to quantify historical soil erosion losses and changes in soil carbon pools of eastern South Dakota soils. The results show that soils in the region have been significantly …


Utilizing Soil Sensors To Assess Soil Health And Investigating Cover Crops Impact On Methane Emission, Shailesh Pandit Jan 2024

Utilizing Soil Sensors To Assess Soil Health And Investigating Cover Crops Impact On Methane Emission, Shailesh Pandit

Electronic Theses and Dissertations

Soil health is influenced by climate change, cultural practices, topography, crop rotations, cover crops, soil parent materials, and soil biota. Interactions between these factors can improve or reduce soil health. This thesis investigates two topics, using soil sensors to provide a rapid assessment of soil health, and the impact of cover crops on soil biological activity and greenhouse gas emissions. Chapter 1 explores the use of two types of sensors to measure apparent electrical conductivity (ECa) and provides examples on the use of these sensors. Even though both sensors measure ECa using different processes, they provide useful information about temporal …


Rado Numbers For Two Systems Of Linear Equations, Anthony Glackin Jan 2024

Rado Numbers For Two Systems Of Linear Equations, Anthony Glackin

Electronic Theses and Dissertations

For any positive integer n and any equation E of either the form x1+x2+· · ·+xn = x0 or x1 + x2 + n = x0, the two-color Rado number R2(E) is the least integer such that any 2-coloring of the natural numbers 1 through R2(E) will contain a monochromatic solution to E. Let Ek be a system of k equations of the aforementioned form, where Ei represents the ith equation in Ek and the set I = {1, 2, . . . , k} is the set of indices of these equations. This thesis shows that the two-color Rado …


Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl Jan 2024

Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl

Electronic Theses and Dissertations

The Afrikaner breed of cattle is indigenous to South Africa and due to their hardiness was once the most popular breed amongst farmers. The objectives for this study were to: (1) estimate environmental effects (age at first calving, season) and (2) genetic variance affecting longevity in Afrikaner cattle using survival analysis and a Weibull model and (3) evaluate the effect of the Infusion Project on longevity utilizing a Cox model. For the first objective, age at first calving impacted longevity as younger age at first calving was associated with decreased longevity. Season of birth and year of birth also impacted …


Computational And Experimental Modeling Of Particle Transport Inside Respiratory Pathways And Indoor Environments, Abir Malakar Jan 2024

Computational And Experimental Modeling Of Particle Transport Inside Respiratory Pathways And Indoor Environments, Abir Malakar

Electronic Theses and Dissertations

This thesis aims to explore efficient drug delivery to clinical target sites along the human upper airway that strongly depends on variables associated with the delivery device and the drug formulation, e.g., the device plume angle, particle sizes of drug solution, drug delivery speed of the device, viscosity of the drug solution, delivery axis orientation, and the formulation density. In our investigation, we prioritize the nasopharynx, the primary site of initial viral infection, as the ideal target zone for drug delivery. We have used Large Eddy Simulation and Lagrangian techniques to replicate breathing at 15 L/min and quantify regional drug …


Breast Tissue As A Local Drug Reservoir For Anticancer Therapy In Breast Cancer, Sanila Shchinar Jan 2024

Breast Tissue As A Local Drug Reservoir For Anticancer Therapy In Breast Cancer, Sanila Shchinar

Electronic Theses and Dissertations

Breast cancer, particularly the estrogen receptor-positive (ER+) subtype, remains a formidable challenge in oncology. Traditional oral therapies for ER-positive breast cancer, such as selective estrogen receptor modulators (SERMs) like Tamoxifen (TAM) and Toremifene (TOR), often encounter issues related to limited bioavailability, metabolic complications, and significant systemic side effects. These side effects include the risk of blood clots, hot flashes, vaginal dryness, menstrual cycle disruptions, and uterus cancer, which can hinder long-term adherence to preventive therapy. The exploration of local drug delivery into breast tissue presents a promising alternative to tackle these challenges. In this study, we explored the feasibility of …


Evaluation Of Dietary Fiber Technologies In Sow Diets, Garrin Shipman Jan 2024

Evaluation Of Dietary Fiber Technologies In Sow Diets, Garrin Shipman

Electronic Theses and Dissertations

Various technologies and alternative ingredients are being developed to increase the nutrient value of fibrous feedstuffs, improve animal performance, and promote sustainable swine production. Fiber-degrading enzymes have been extensively studied in growing pigs, with few studies focused on gestating sows. When considering gestating sows have greater energy digestibility of fibrous feedstuffs than grower pigs, the efficacy of fiber-degrading enzymes needs to be determined for implementation in commercial sow diets. As fiber inclusion in gestation diets benefits sow performance, corn dried distiller grains with solubles (DDGS) are a candidate fiber source for gestation alternative energy ingredient. Functional fibers, such as yeast …


Physicochemical And Functional Properties Of Different Varieties Of Spring And Winter Peas Of South Dakota, Prakriti Dhakal Jan 2024

Physicochemical And Functional Properties Of Different Varieties Of Spring And Winter Peas Of South Dakota, Prakriti Dhakal

Electronic Theses and Dissertations

Peas are a good source of nutrients for both humans and animals, and they are the world's second most significant and sustainable legume. There have been studies on different kinds of pea grown in other parts of the world, but there is no information on the compositional and functional characteristics of pea varieties grown specifically in South Dakota. The objective of the study was to evaluate the proximate composition and functional properties of various pea varieties and determine if the pea variety impacted cookie properties. The proximate composition (moisture, protein, starch, and amylose), functional capacities (water holding, oil holding capacity, …


Nitrogen Application Timing And Cereal Rye (Secale Cereale L.) Cover Crop Influence Greenhouse Gas Emissions, Graig Reicks Jan 2024

Nitrogen Application Timing And Cereal Rye (Secale Cereale L.) Cover Crop Influence Greenhouse Gas Emissions, Graig Reicks

Electronic Theses and Dissertations

Dryland contributions to greenhouse gas (GHG) emissions are increased by N fertilizer applications and high soil water contents. Fertilizer timing and spring growth of cover crops prior to cash crop planting were investigated in separate studies to examine impacts on overall GHG emissions using a near continuous measurement system. There was a significant interaction between N fertilizer rate (0 vs. 224 kg N ha-1 surface-applied as urea) and application date (p= 0.01) for CO2 emissions. This interaction occurred because N fertilizer increased CO2 emissions by 35% for the 21 d interval following early spring application. When application was delayed until …


Estimating South Dakota’S Capacity To Meet K-12 School Meal Fruit And Vegetable Requirements With State-Grown Produce, Bridgette Bienias Jan 2024

Estimating South Dakota’S Capacity To Meet K-12 School Meal Fruit And Vegetable Requirements With State-Grown Produce, Bridgette Bienias

Electronic Theses and Dissertations

Objective: Quantify South Dakota (SD)’s capacity to procure locally-sourced fruit and vegetables (FVs) for K-12 school meals.
Methods: Secondary analysis of 2017 SD agricultural census and school meal data. Yields were converted to edible cups of FVs using school meal guidelines provided by the U.S. Department of Agriculture. Student enrollment and meal redemptions were used to estimate the number of FV cups needed.
Results: Estimated SD FV production met minimum total K-12 cup requirements, except for total fruit (66%) and dark green vegetables (80%). Legumes supplied 77% of the total cups of vegetables produced in 2017, whereas dark green vegetables …


I Can't Look Away: Parasocial Relationships With Dance Mom Characters Across Tv And Social Media, Kennedy Kay Pirlet Jan 2024

I Can't Look Away: Parasocial Relationships With Dance Mom Characters Across Tv And Social Media, Kennedy Kay Pirlet

Electronic Theses and Dissertations

In 2019, Dance Moms ended its airing on Lifetime at the completion of the eighth season. However, the show and its cast members remained popular on social media platforms like TikTok, but we still didn’t know the relationship between watching the show and following cast members on multiple social media platforms or who audiences were closest to. To answer this question, the celebrity-persona parasocial interaction scale and experience of parasocial interaction scale were utilized. These scales were used in this study and found reliable. Snowball recruitment focusing on social media platforms and emails yielded 180 eligible sample participants. Through a …


Removal Of Phosphorous, Copper And Zinc From Stormwater Using Powdered Activated Carbon (Pac) Based Water Treatment Residuals, Foysol Mahmud Jan 2024

Removal Of Phosphorous, Copper And Zinc From Stormwater Using Powdered Activated Carbon (Pac) Based Water Treatment Residuals, Foysol Mahmud

Electronic Theses and Dissertations

The main aim of this research was to evaluate the efficacy of Powdered Activated Carbon (PAC) based water treatment residual (WTR) in eliminating phosphorus (P), Copper (Cu), and Zinc (Zn) from stormwater. The characteristics of the PAC WTR were analyzed, and a series of batch and column tests were conducted to determine its capacity to remove P, Cu, and Zn from stormwater and synthetic solutions. The PAC WTR conformed to the Langmuir isotherm model, demonstrating P adsorption capacities of 3.51 mg/g at pH 5. Regarding Cu and Zn removal, the PAC WTR also adhered to the Langmuir isotherm model, showing …


Valuation Of Soybean Meal Versus Distillers Co-Products As A Protein Supplement For Finishing Beef Cattle: Effects On Growth Performance, Carcass Characteristics, And Efficiency Of Dietary Net Energy Utilization, Cassidy R. Ross Jan 2024

Valuation Of Soybean Meal Versus Distillers Co-Products As A Protein Supplement For Finishing Beef Cattle: Effects On Growth Performance, Carcass Characteristics, And Efficiency Of Dietary Net Energy Utilization, Cassidy R. Ross

Electronic Theses and Dissertations

Two randomized complete block design experiments were conducted to: 1) examine the effects of soybean meal with or without additional soybean hulls in replacement of modified corn distillers grains plus (MDGS) solubles on growth performance efficiency of dietary net energy utilization and carcass traits responses in finishing beef steers, 2) determine if partial or complete replacement of dried distillers grains plus solubles (DDGS) with solvent-extracted soybean meal (SBM) in diets based upon high-moisture ensiled corn influences growth performance, efficiency of dietary net energy utilization, sera urea-N (SUN) concentrations, or carcass traits in finishing beef steers. Experiment 1 was a 118-d …


Species Distribution Modeling Of Aquilegia Brevistyla (Ranunculaceae): A Critically Imperiled Black Hills Disjunct Species, Eric Daniel Puetz Jan 2024

Species Distribution Modeling Of Aquilegia Brevistyla (Ranunculaceae): A Critically Imperiled Black Hills Disjunct Species, Eric Daniel Puetz

Electronic Theses and Dissertations

Unchecked human activity is contributing to rising levels of greenhouse gas emissions, changes in land use, altered disturbance/fire regimes, spread of invasive species, and loss of biological diversity and related breakdown of ecosystem services. Additionally, climatic shifts may lead to phenological mismatches between species and their environments if these changes outpace a species’ ability to adapt or migrate to a more suitable habitat. Isolated mountain populations are particularly threatened by unpredictable climatic conditions, as they may have limited migration corridors and often lower levels of genetic diversity to move or adapt, respectively. As these negative feedbacks compound on the landscape, …


Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada Jan 2024

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …


Advancing Karl Jaspers: The Connection Between The Theory Of Existential Communication And Mentoring Satisfaction, Nolan Patrick Bowers Jan 2024

Advancing Karl Jaspers: The Connection Between The Theory Of Existential Communication And Mentoring Satisfaction, Nolan Patrick Bowers

Electronic Theses and Dissertations

Existential philosopher Karl Jaspers’s theory (1932/1970; 1935/1971b) of existential communication is understood to be his most important contribution to existentialism. Additionally, this theory has unique ties to the phenomena of communication, begging its use as a dialogic theory. However, Jaspers’s theory has been relatively untouched by academia. This thesis understands the theory of existential communication through an operationalization of its aspects and explicitly connecting them to communicative behaviors. These aspects of existential communication are (1) vulnerability, (2) open-mindedness, and (3) equality. This study set out to determine whether these aspects could be found within mentoring relationships and support the aspects …


Developing Machine Learning Models For Selection Of Management Zones, Sravanthi Bachina Jan 2024

Developing Machine Learning Models For Selection Of Management Zones, Sravanthi Bachina

Electronic Theses and Dissertations

Soil sampling and analyses play a crucial role in optimizing nutrient management and enhancing crop productivity. However, collecting representative samples across diverse landscapes is challenging due to knowledge gaps about spatial variability of soil properties, large fields, multiple samples, and analysis costs. Collecting soil samples based on the management zones can help farmers gather precise information about soil properties with fewer samples. Recent developments in precision agriculture and machine learning. This study aimed to develop machine learning models that can learn, analyze, and refine landscape and soil properties data for automated selection of soil sampling zones and generating prediction maps. …


The Spatial Ecology Of Plains Spotted Skunks In South Dakota: Insights From Species Distribution, Resource Selection, And Co-Occurrence Models, Kara M. White Jan 2024

The Spatial Ecology Of Plains Spotted Skunks In South Dakota: Insights From Species Distribution, Resource Selection, And Co-Occurrence Models, Kara M. White

Electronic Theses and Dissertations

The plains spotted skunk (Spilogale interrupta) is a data-deficient small carnivore native to the central plains of North America that has experienced significant population declines. My dissertation investigates the species’ distribution, habitat associations, and interspecific interactions in South Dakota, providing crucial information for conservation actions. In Chapter 1, I developed ensemble distribution models on a broad scale, incorporating species location data from 1985–2020, environmental factors, and six predictive modeling algorithms. I identified key predictors including mean temperature diurnal range and proportion of area as pasture, and estimated ~31,300 km2 of potential habitat, predominately in eastern South Dakota. In Chapter 2, …


Organizational Culture's Impact On Job Satisfaction: A Reconceptualization Of The Competing Values Framework, Isaac Thor Erickson Jan 2024

Organizational Culture's Impact On Job Satisfaction: A Reconceptualization Of The Competing Values Framework, Isaac Thor Erickson

Electronic Theses and Dissertations

Academic job satisfaction has been decreasing in the U.S. which has profound negative impacts such as burnout and decreased well-being of employees. One way that job satisfaction can be increased is through understanding and changing organizational cultures through better communication. The Competing Values Framework (CVF; Quinn & Rohrbaugh, 1983; Belasen & Frank, 2010; Lund, 2003) has been used to understand how organizational cultures and their communicative norms relate to job satisfaction. However, the CVF relies on categorical measures sitting on two axes that are not orthogonal. As such, the study posits breaking these two axes into four dimensions of organizational …


The Relationship Of Macronutrient Intake With Growth In Children With Type 1 Diabetes Mellitus, Jessica L. Freeling Jan 2024

The Relationship Of Macronutrient Intake With Growth In Children With Type 1 Diabetes Mellitus, Jessica L. Freeling

Electronic Theses and Dissertations

Child growth, a sensitive metric of overall health, results from the intricate interplay of nature and nurture. While the importance of nutrition in child growth is well established, growth trajectories exhibit substantial individual variability, influenced by sex and age, and often characterized by nonlinear patterns. Inadequate nutrition or disease can hinder growth, with potential for recovery upon proper nutrition or acute disease resolution. However, chronic disease or persistent malnutrition may lead to permanent growth perturbation. Notably, before the advent of insulin, chronic stunting and wasting were hallmarks of Type 1 diabetes mellitus (T1DM), though the specific impacts under modern standard …


Delivery Of Gemcitabine, Stearoyl Gemcitabine And Paclitaxel Through Plga Nanoparticles And Its Effect On The Desmoplasia Of Pancreatic Cancer Spheroids, Rishabh Bahl Jan 2024

Delivery Of Gemcitabine, Stearoyl Gemcitabine And Paclitaxel Through Plga Nanoparticles And Its Effect On The Desmoplasia Of Pancreatic Cancer Spheroids, Rishabh Bahl

Electronic Theses and Dissertations

Pancreatic cancer is one of the deadliest cancers to treat. The primary cause for the drug resistance is the dense extracellular matrix (ECM) that surrounds the tumor and restricts blood supply. Gemcitabine (GEM) and paclitaxel (PTX) are drugs that are clinically used in the treatment of pancreatic cancer. GEM, however, is rapidly metabolized by cytidine deaminase (CDA) and eliminated from the body, and paclitaxel is a substrate for P- glycoprotein (P-gp) efflux receptors. Drug delivery using nanoparticles has been reported to help improve drug half-lives and bypass efflux receptors. This thesis aims to encapsulate PTX in PLGA nanoparticles (PTX-NP) and …