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Error Allocation In Complex Systems Design, Robert A. Mcdonald
Error Allocation In Complex Systems Design, Robert A. Mcdonald
Robert A. McDonald
A fidelity trade environment was conceived, formulated, developed, and demonstrated. This development relied on the advancement of enabling techniques including error propagation, metamodeling, and information management. These techniques were integrated with an existing commercial systems design framework and an intuitive graphical interface to create a fidelity trade environment. A sensitivity approach to the propagation of error through complex systems was developed. This approach relied on the system sensitivity matrix to model the behavior of a complex system as a whole. In verification tests, the sensitivity approach provided approximate results substantially similar to a Monte Carlo approach that was many orders …
Re-Examining The Politics Of U.S. Intervention In Early 20th Century Nicaragua: José Madriz And The Conservative Restoration, Yann P. Kerevel
Re-Examining The Politics Of U.S. Intervention In Early 20th Century Nicaragua: José Madriz And The Conservative Restoration, Yann P. Kerevel
Yann P. Kerevel
This research re-examines the U.S. intervention in Nicaragua in 1909-10. Most literature of this period argues that the United States forced the dictator Zelaya out of office in 1909; however, I contend that the argument that U.S. intervention caused the fall of Zelaya does not clearly match up to the historical record. Instead, I argue it is much more compelling to examine U.S. policy toward José Madriz to understand the impact of the intervention. It is clear that U.S. policy was the decisive factor in the fall of Madriz, while it is less convincing in the case of Zelaya.
On The Debt Capacity Of Growth Options*, Michael Barclay, Clifford W. Smith, Erwan Morellec
On The Debt Capacity Of Growth Options*, Michael Barclay, Clifford W. Smith, Erwan Morellec
Clifford W Smith
No abstract provided.
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Michael Sinensky
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility …
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Michael Sinensky
The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation of farnesylated prelamin A leads to these accelerated aging phenotypes is not understood. Here we present evidence that in HGPS and RD fibroblasts, DNA damage checkpoints are persistently activated because of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their …