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Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher
Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher
College of Science & Mathematics Departmental Research
Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the formation of mucocutaneous lesions (cold sores), but asymptomatic reactivation accompanied by viral shedding is more frequent and allows virus spread to new hosts. HSV-1 DNA has been detected in many oral tissues. In particular, HSV-1 can be found in periodontal lesions and several studies associated its presence with more severe periodontitis pathologies. Since gingival fibroblasts may become exposed to salivary …
Preparing Students For A Bright Outlook: Survey Of The Preparation Of High School Counselors For Advising On Technician Careers, Sarah Ferguson, Benita Kluttz-Drye, Katrina A. Hovey
Preparing Students For A Bright Outlook: Survey Of The Preparation Of High School Counselors For Advising On Technician Careers, Sarah Ferguson, Benita Kluttz-Drye, Katrina A. Hovey
College of Science & Mathematics Departmental Research
This paper details a survey study of high school counselors’ awareness of and comfort with advising students in technician/technologist careers. The survey focused on careers designated as Bright Outlook by the US Department of Labor to explore familiarity with these careers, the effectiveness of the current career advising process, and recommendations on additional support or resources. Results indicate participants were more familiar with technician/technologist careers in health and medicine than those in engineering or other areas of science. Counselors acknowledged the importance of familiarity with a career in the career advising process, but communicate a number of challenges they face …
Prefrontal Corticotropin-Releasing Factor (Crf) Neurons Act Locally To Modulate Frontostriatal Cognition And Circuit Function., Sofiya Hupalo, Andrea J Martin, Rebecca K Green, David M Devilbiss, Craig W Berridge
Prefrontal Corticotropin-Releasing Factor (Crf) Neurons Act Locally To Modulate Frontostriatal Cognition And Circuit Function., Sofiya Hupalo, Andrea J Martin, Rebecca K Green, David M Devilbiss, Craig W Berridge
Rowan-Virtua School of Osteopathic Medicine Departmental Research
The PFC and extended frontostriatal circuitry support higher cognitive processes that guide goal-directed behavior. PFC-dependent cognitive dysfunction is a core feature of multiple psychiatric disorders. Unfortunately, a major limiting factor in the development of treatments for PFC cognitive dysfunction is our limited understanding of the neural mechanisms underlying PFC-dependent cognition. We recently demonstrated that activation of corticotropin-releasing factor (CRF) receptors in the caudal dorsomedial PFC (dmPFC) impairs higher cognitive function, as measured in a working memory task. Currently, there remains much unknown about CRF-dependent regulation of cognition, including the source of CRF for cognition-modulating receptors and the output pathways modulated …
Interaction Between Nectin-1 And The Human Natural Killer Cell Receptor Cd96., Veronica M Holmes, Carlos Maluquer De Motes, Paige T Richards, Jessenia Roldan, Arjun K Bhargava, Jordan S Orange, Claude Krummenacher
Interaction Between Nectin-1 And The Human Natural Killer Cell Receptor Cd96., Veronica M Holmes, Carlos Maluquer De Motes, Paige T Richards, Jessenia Roldan, Arjun K Bhargava, Jordan S Orange, Claude Krummenacher
College of Science & Mathematics Departmental Research
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating and inhibitory signals acquired at the immunological synapse with potential target cells. NK cells express paired receptors from the immunoglobulin family which share common ligands from the nectin family of adhesion molecules. The activating receptor CD226 (DNAM-1) binds to nectin-2 and CD155, which are also recognized by the inhibitory receptor TIGIT. The third receptor in this family is CD96, which is less well characterized and may have different functions in human and mouse models. Human CD96 interacts with CD155 and ligation of this receptor activates …