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Novel Anti-Obesity Effects Of Beer Hops Compound Xanthohumol: Role Of Ampk Signaling Pathway, Janaiya S Samuels

PCOM Biomedical Studies Student Scholarship

Obesity, a chronic disease, is a global epidemic that affects millions of lives and increases the risk of several comorbidities such as Type 2 diabetes, musculoskeletal disorders, cardiovascular disease, and cancer. Obesity is the leading cause of death globally, and is associated with an excessive accumulation of white adipose tissue (WAT). Although obesity is a serious condition, safe, long-term drug therapies are limited. A second type of adipose tissue is known as brown adipose tissue (BAT), which functions as an energy dissipater in the form of heat, as opposed to energy storing WAT. Previous research has shown that the mitochondrial …

Reduction Of Opioid Medication Use In Chronic Pain Patients By Adding Memantine: A Pilot Study, Adam J. Bertino

PCOM Biomedical Studies Student Scholarship

An investigational clinical research pilot study is being conducted at a nursing facility and an academic primary care office to evaluate memantine as an adjunct to opioid therapy for treatment of chronic pain. Memantine can be beneficial in reducing pain because it is an N-methyl-D-aspartate receptor (NMDAr) antagonist with a pivotal action in the hippocampus: it initiates long-term potentiation in the anterior cingulate cortex and forebrain. These areas of action have a high probability for reducing the affective quality of pain.

This open-label, non-randomized pilot study is designed to observe any effects which may occur during addition of memantine to …

The Role Of Nadph Oxidase Isoform 1 (Nox1) In L-Name-Induced Leukocyte-Endothelial Interactions In Rat Mesenteric Postcapillary Venules, Alita Zabrecky

PCOM Biomedical Studies Student Scholarship

Vascular endothelial dysfunction is a component of many chronic illnesses such as cardiovascular disease, diabetes, and hypertension. This dysfunction is initiated by an inflammatory response triggering an increase in leukocyte endothelial interactions. It is characterized by increased oxidative stress often associated with reduced endothelial-derived nitric oxide (NO) bioavailability. Activation of NADPH oxidase is a major source of oxidative stress. NADPH oxidase has five NOX and two Doux isoforms. NOX1 is expressed on vascular endothelial and smooth muscle cells, but is not expressed on neutrophils. Therefore, the role of NOX1 in inflammation is not completely clear. A NOX1 selective inhibitor, 2-acetylphenothiazine …