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Medicinal Plants And Herbs For Cancer Prevention, Madeline Mctigue, Julianna Goelzer, William Ranahan
Medicinal Plants And Herbs For Cancer Prevention, Madeline Mctigue, Julianna Goelzer, William Ranahan
Research Symposium
Modern medicine has yet to produce selective treatments for the vast majority of cancer types. Most chemotherapies, though complex, remain non-specific, and thus destroy healthy cells. Over 25% of cancer patients die from the effects of chemotherapy before the actual tumor would have progressed to the point of organismal death (Megget 2008). Early detection remains the most accurate indicator of successful treatment outcome. But why wait until the disease presents to deal with it? Here the authors argue that a well supported immune system coupled with a dietary regimen of key food-based medicines is a far superior strategy. Given that …
Total Synthesis And Biological Evaluation Of Siderophores: Key To Develop Iron Chelators And Tackle Antibiotic Delivery To Gram-Negative Bacteria, .Pratibha Desman
Total Synthesis And Biological Evaluation Of Siderophores: Key To Develop Iron Chelators And Tackle Antibiotic Delivery To Gram-Negative Bacteria, .Pratibha Desman
Research Symposium
Siderophores are molecules that act as iron carriers in bacteria. As they sequester iron from the environment and penetrate bacterial cells through active transporters, they can bypass the porin-mediated transportation in Gram-negative bacteria. Therefore, conjugating antibiotics that lacks the ability to pass through porins to siderophores and forming “sideromycins” has been proven as a way to battle antibiotic resistance in Gram-negative bacteria. My research will focus on synthesizing two siderophores, catenulobactin B and talarazine A as well as their analogs and exploring their potential to synthesize sideromycins. These molecules will be synthesized in a modular way and their cytotoxicity, ability …