Digital Commons Network^™

Dynamics Of Suspended Sediment Flux On The Rivers Bandon And Owenabue, Ireland, S. T. Harrington, Joseph R. Harrington

Publications

Monitoring, analysis and modelling of suspended sediment transport in riverine systems has received much attention in recent decades. Quantitive analysis techniques have been applied to allow river basin managers to assess suspended sediment transport and its importance in transporting a range of pollutants including excess metals and nutrients, which negatively impact on aquatic systems. In this paper, an analysis of the suspended sediment fl ux (SSF) dynamics is presented for the small and medium sized catchments of the River Owenabue and the River Bandon, respectively. The results contribute to the fi lling of a research gap in an Irish context …

Investigating Broadband Variability Of The Tev Blazar 1es 1959+650, P. T. Reynolds, Veritas

Physical Sciences Publications

We summarize broadband observations of the TeV-emitting blazar 1ES 1959+650, including optical R-band observations by the robotic telescopes Super-LOTIS and iTelescope, UV observations by Swift Ultraviolet and Optical Telescope, X-ray observations by the Swift X-ray Telescope, high-energy gamma-ray observations with the Fermi Large Area Telescope, and very-high-energy (VHE) gamma-ray observations by VERITAS above 315 GeV, all taken between 2012 April 17 and 2012 June 1 (MJD 56034 and 56079). The contemporaneous variability of the broadband spectral energy distribution is explored in the context of a simple synchrotron self Compton (SSC) model. In the SSC emission scenario, we find that the …

Analysis Of Heart Rate Variability Amongst Cyclists Under Perceived Variations Of Risk Exposure, Ronan Doorley, Vikram Pakrashi, Eoin Byrne, Samuel Comerford, Bidisha Ghosh, John A. Groeger

NIMBUS Articles

Cycling as a mode of travel provides an opportunity for many people to increase their levels of regular physical activity and contribute to their mental and physical health. Heart rate is often used as a means of measuring the intensity and energy expenditure of physical activity. However, heart rate is also linked to emotional factors such as anxiety and fear. Perceptions of risk due to external factors such as other road users and infrastructure may arouse such emotions in urban cyclists. The present study set out to investigate whether or not perceptions of risk among urban cyclists may lead to …

Facilitating External Engagement And Developing Industry-Focused Programmes In Cork Institute Of Technology, Irene Sheridan, Deirdre Goggin, Daithí Fallon

Conference Papers

As organisations focus on economic indicators and return on investment their approaches to learning and development opportunities are transformed. In a challenging, competitive climate there is a need to ensure that long and short term benefits are maximised. While engagement is often presented as a third mission of universities, encompassing the full range of external interactions with enterprises, individuals and communities, separate and distinct from the first two missions of teaching and research, is only effective if it is closely interlinked with them.

Vorley and Nelles (2008) describe the third mission as a ‘thread that has the capacity to weave …

The Implications Of Regional And National Demographic Projections For Future Gms Costs In Ireland Through To 2026, Aisling Conway Lenihan, Martin Keneally, Noel Woods, Andreas Thummel, Marie Ryan

Dept. of Management & Enterprise Publications

As the health services in Ireland have become more resource-constrained, pressure has increased to reduce public spending on community drug schemes such as General Medical Services (GMS) drug prescribing and to understand current and future trends in prescribing. The GMS scheme covers approximately 37% of the Irish population in 2011 and entitles them, inter alia, to free prescription drugs and appliances. This paper projects the effects of future changes in population, coverage, claims rates and average claims cost on GMS costs in Ireland.

Constraints On Very High Energy Emission From Grb 130427a, P. T. Reynolds, Et Al

Physical Sciences Publications

Prompt emission from the very fluent and nearby (z = 0.34) gamma-ray burst GRB 130427A was detected by several orbiting telescopes and by ground-based, wide-field-of-view optical transient monitors. Apart from the intensity and proximity of this GRB, it is exceptional due to the extremely long-lived high-energy (100 MeV to 100 GeV) gamma-ray emission, which was detected by the Large Area Telescope on the Fermi Gamma-Ray Space Telescope for ~70 ks after the initial burst. The persistent, hard-spectrum, high-energy emission suggests that the highest-energy gamma rays may have been produced via synchrotron self-Compton processes though there is also evidence that …

Heat Transfer Characteristics Of Ggbs Concrete In Fire, Ted Mckenna, Mark G. Richardson, Brian O’Rourke

Publications

Partial replacement of high clinker content cements by Ground Granulated Blastfurnace Slag (GGBS) can reduce the carbon footprint of concrete, with consequent benefits in respect of sustainable construction. Furthermore a state-of-the-art report indicated that use of GGBS as a binder replacement may increase the fire resistance of concrete. If so this could lead to thinner sections in fire compartment elements, especially non-loadbearing walls, leading to further gains in respect of sustainable development. Concrete is considered an effective material in protecting against the detrimental effects of fire in structures. However, exposure to high temperatures can degrade concrete performance. Fire resistance performance …

Enhanced Expression Of Codon Optimized Mycobacterium Avium Subsp. Paratuberculosis Antigens In Lactobacillus Salivarius, Christopher D. Johnston, John P. Bannatine, Rodney Govender, Lorraine Endersen, Daniel Pletzer, Helge Weingart, Aidan Coffey, Jim O'Mahony, Roy D. Sleator

Department of Biological Sciences Publications

It is well documented that open reading frames containing high GC content show poor expression in A+T rich hosts. Specifically, G+C-rich codon usage is a limiting factor in heterologous expression of Mycobacterium avium subsp. paratuberculosis (MAP) proteins using Lactobacillus salivarius. However, re-engineering opening reading frames through synonymous substitutions can offset codon bias and greatly enhance MAP protein production in this host. In this report, we demonstrate that codon-usage manipulation of MAP2121c can enhance the heterologous expression of the major membrane protein (MMP), analogous to the form in which it is produced natively by MAP bacilli. When heterologously over-expressed, antigenic determinants …

Vascular Endothelial Cell Markers And Serum Ferritin In Platelet And Blood Donors, Frances Duggan, W. Murphy, M. Thomas, Michael Healy, K. O'Sullivan, K. Patrick, J. Power

Department of Biological Sciences Publications

The aim of this protocol was to perform a prospective analysis of prothrombotic and iron status markers to assess the coagulation and haematinic effects of regular, anticoagulated extracorporeal circulation – using a Trima Accel blood cell separator. First time male whole blood donors, who never donated platelets or whole blood, were used as the control group.

Very-High Energy Observations Of The Galactic Center Region By Veritas In 2010-2012, P. T. Reynolds, Et. Al.

Physical Sciences Publications

The Galactic center is an interesting region for high-energy (0.1-100 GeV) and very-high-energy (E > 100 GeV) γ-ray observations. Potential sources of GeV/TeV γ-ray emission have been suggested, e.g., the accretion of matter onto the supermassive black hole, cosmic rays from a nearby supernova remnant (e.g., Sgr A East), particle acceleration in a plerion, or the annihilation of dark matter particles. The Galactic center has been detected by EGRET and by Fermi/LAT in the MeV/GeV energy band. At TeV energies, the Galactic center was detected with moderate significance by the CANGAROO and Whipple 10 m telescopes and with high significance by …

Metagenomic Identification Of A Novel Salt Tolerance Gene From The Human Gut Microbiome Which Encodes A Membrane Protein With Homology To A Brp/Blh-Family Beta-Carotene 15,15'-Monooxygenase, Eamonn P. Culligan, Roy D. Sleator, Julian R. Marchesi, Colin Hill

Department of Biological Sciences Publications

The human gut microbiome consists of at least 3 million non-redundant genes, 150 times that of the core human genome. Herein, we report the identification and characterisation of a novel stress tolerance gene from the human gut metagenome. The locus, assigned brpA, encodes a membrane protein with homology to a brp/blh-family β-carotene monooxygenase. Cloning and heterologous expression of brpA in Escherichia coli confers a significant salt tolerance phenotype. Furthermore, when cultured in the presence of exogenous β-carotene, cell pellets adopt a red/orange pigmentation indicating the incorporation of carotenoids in the cell membrane.

Metagenomic Identification Of A Novel Salt Tolerance Gene From The Human Gut Microbiome Which Encodes A Membrane Protein With Homology To A Brp/Blh-Family Beta-Carotene 15,15'-Monooxygenase, Roy D. Sleator, Et. Al.

Department of Biological Sciences Publications

The human gut microbiome consists of at least 3 million non-redundant genes, 150 times that of the core human genome. Herein, we report the identification and characterisation of a novel stress tolerance gene from the human gut metagenome. The locus, assigned brpA, encodes a membrane protein with homology to a brp/blh-family β-carotene monooxygenase. Cloning and heterologous expression of brpA in Escherichia coli confers a significant salt tolerance phenotype. Furthermore, when cultured in the presence of exogenous β-carotene, cell pellets adopt a red/orange pigmentation indicating the incorporation of carotenoids in the cell membrane.

Preparation And Biological Properties Of Ring-Substituted Naphthalene-1-Carboxanilides, Eoghan Nevin, Rodeney Govender, Jim O'Mahony, Aidan Coffey, Et. Al.

Department of Biological Sciences Publications

In this study, a series of twenty-two ring-substituted naphthalene-1-carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl)naphthalene-1-carboxamide, N-(3-methoxy-phenyl)naphthalene-1-carboxamide, N-(3-methylphenyl)naphthalene-1-carboxamide, N-(4-methylphenyl)naphthalene-1-carboxamide and N-(3-fluorophenyl)naphthalene-1-carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value …

Dissolved And Particulate Nutrient Transport Dynamics Of A Small Irish Catchment: The River Owenabue, S. T. Harrington, Joseph R. Harrington

Publications

The objective of this research was to investigate the relationship between water and sediment discharge on the transport of nutrients: nitrogen and phosphorus. Water discharge, suspended sediment concentration and dissolved and particulate forms of nitrogen and phosphorus were monitored on the 105 km2 River Owenabue catchment in Ireland. Water discharge was found to have an influence on both particulate and dissolved nutrient transport, but more so for particulate nutrients. The particulate portion of N and P in collected samples was found to be 24 and 39 %, respectively. Increased particulate nitrogen concentrations were found at the onset of high discharge …

Spatially Resolving The Very High Energy Emission From Mgro J2019+37 With Veritas, P. T. Reynolds, Et. Al.

Physical Sciences Publications

We present very high energy (VHE) imaging of MGRO J2019+37 obtained with the VERITAS observatory. The bright extended (~2°) unidentified Milagro source is located toward the rich star formation region Cygnus-X. MGRO J2019+37 is resolved into two VERITAS sources. The faint, point-like source VER J2016+371 overlaps CTB 87, a filled-center remnant (SNR) with no evidence of a supernova remnant shell at the present time. Its spectrum is well fit in the 0.65-10 TeV energy range by a power-law model with photon index 2.3 ± 0.4. VER J2019+378 is a bright extended (~1°) source that likely accounts for the bulk of …

Test Of Models Of The Cosmic Infrared Background With Multiwavelength Observations Of The Blazar 1es 1218+30.4 In 2009, P. T. Reynolds

Physical Sciences Publications

We present the results of a multi-wavelength campaign targeting the blazar 1ES 1218+30.4 with observations with the 1.3 m McGraw-Hill optical telescope, the Rossi X-ray Timing Explorer (RXTE), the Fermi Gamma-Ray Space Telescope, and the Very Energetic Radiation Imaging Telescope Array System (VERITAS). The RXTE and VERITAS observations were spread over a 13 day period and revealed clear evidence for flux variability, and a strong X-ray and γ-ray flare on 2009 February 26 (MJD 54888). The campaign delivered a well-sampled broadband energy spectrum with simultaneous RXTE and VERITAS very high energy (VHE, >100 GeV) observations, as well as …

Combined Metagenomic And Phenomic Approaches Identify A Novel Salt Tolerance Gene From The Human Gut Microbiome, Eamon Culligan, Julian R. Marchesi, Colin Hill, Roy D. Sleator

Department of Biological Sciences Publications

In the current study, a number of salt-tolerant clones previously isolated from a human gut metagenomic library were screened using Phenotype MicroArray (PM) technology to assess their functional capacity. PM's can be used to study gene function, pathogenicity, metabolic capacity and identify drug targets using a series of specialized microtitre plate assays, where each well of the microtitre plate contains a different set of conditions and tests a different phenotype. Cellular respiration is monitored colorimetrically by the reduction of a tetrazolium dye. One clone, SMG 9, was found to be positive for utilization/transport of L-carnitine (a well-characterized osmoprotectant) in the …

The Case Of Vpl And Industry Focused Programmes In Cork Institute Of Technology, Deirdre Goggin, Irene Sheridan, Daithí Fallon, Tim Horgan

Conference Papers

As organisations focus on economic indicators and return on investment their approaches to learning and development opportunities are transformed. In a challenging, competitive climate there is a need to ensure that the long and short term benefits are maximised. This masterclass describes the experience and issues raised for Cork Institute of Technology, a Higher Education Institution (HEI) in Ireland in implementing programmes developed in partnership with industry which are mutually beneficial and maintain academic standards. It also addresses the enablers, challenges and barriers in customised course development.

Deep Broadband Observations Of The Distant Gamma-Ray Blazar Pks 1424+240, P. T. Reynolds, Et Al

Physical Sciences Publications

We present deep VERITAS observations of the blazar PKS 1424+240, along with contemporaneous Fermi Large Area Telescope, Swift X-ray Telescope, and Swift UV Optical Telescope data between 2009 February 19 and 2013 June 8. This blazar resides at a redshift of z ≥ 0.6035, displaying a significantly attenuated gamma-ray flux above 100 GeV due to photon absorption via pair-production with the extragalactic background light. We present more than 100 hr of VERITAS observations over three years, a multiwavelength light curve, and the contemporaneous spectral energy distributions. The source shows a higher flux of (2.1 ± 0.3) × 10–7 photons m–2 …

Observations Of The Unidentified Gamma-Ray Source Tev J2032+4130 By Veritas, P. T. Reynolds, Et. Al.

Physical Sciences Publications

TeV J2032+4130 was the first unidentified source discovered at very high energies (VHEs; E > 100 GeV), with no obvious counterpart in any other wavelength. It is also the first extended source to be observed in VHE gamma rays. Following its discovery, intensive observational campaigns have been carried out in all wavelengths in order to understand the nature of the object, which have met with limited success. We report here on a deep observation of TeV J2032+4130 based on 48.2 hr of data taken from 2009 to 2012 by the Very Energetic Radiation Imaging Telescope Array System experiment. The source is …

Still Sparkling The Phenomenon Of Bottled Water—An Irish Context, Hayley Collins, Angela Wright

Dept. of Organisation & Professional Development Publications

Why choose to buy one brand of bottled water over another, when, as consumers, we are effectively just buying water — H2O — a colourless, odourless product? This study investigates the power of branding in the bottle water market—a billion euro industry that has been created to sell a product with little or no distinguishable features. Sales of bottled water continue to increase year on year globally, and in Ireland. Ballygowan and Volvic have the largest market share of the water market in Ireland, and, interestingly, they also invest the most in their marketing. One of the aims of this …

The Domestic Death Of A Global Icon? A Situational Analysis Of The Irish Public House, Gail Cotter Buckley, Angela Wright

Dept. of Organisation & Professional Development Publications

The public house has formed an intrinsic part of the Irish way of life for centuries, but it may soon be gone due to changes in demographics, alcohol consumption, and other variables including psychographic and geographic factors. Changes in Irish society during the rise in affluence characteristic of the Celtic Tiger era, and applicable Government policies have all played a role in altering the Irish pub culture. This research examines the current situation of the public house market in Ireland today with an aim of recommending some viable solutions to this declining industry. Government intervention in the future will be …

Transcriptome Analysis Of Listeria Monocytogenes Exposed To Biocide Stress Reveals A Multi-System Response Involving Cell Wall Synthesis, Sugar Uptake, And Motility, Aidan Casey, Edward M. Fox, Stephan Schmitz-Esser, Aidan Coffey, Olivia Mcauliffe, Kieran Jordan

Department of Biological Sciences Publications

Listeria monocytogenes is a virulent food-borne pathogen most often associated with the consumption of “ready-to-eat” foods. The organism is a common contaminant of food processing plants where it may persist for extended periods of time. A commonly used approach for the control of Listeria monocytogenes in the processing environment is the application of biocides such as quaternary ammonium compounds. In this study, the transcriptomic response of a persistent strain of L. monocytogenes (strain 6179) on exposure to a sub-lethal concentration of the quaternary ammonium compound benzethonium chloride (BZT) was assessed. Using RNA-Seq, gene expression levels were quantified by sequencing …

A Three-Year Multi-Wavelength Study Of The Very-High-Energy Gamma-Ray Blazar 1es 0229+200, P. T. Reynolds, Et. Al.

Physical Sciences Publications

The high-frequency-peaked BL Lacertae object 1ES 0229+200 is a relatively distant (z = 0.1396), hard-spectrum (Γ ~ 2.5), very-high-energy (VHE; E > 100 GeV) emitting γ-ray blazar. VHE measurements of this active galactic nucleus have been used to place constraints on the intensity of the extragalactic background light and the intergalactic magnetic field (IGMF). A multi-wavelength study of this object centered around VHE observations by Very Energetic Radiation Imaging Telescope Array System (VERITAS) is presented. This study obtained, over a period of three years, an 11.7 standard deviation detection and an average integral flux F(E > 300 GeV) = (23.3 ± 2.8stat …

Phages Of Non-Diary Lactococci: Isolation And Characterization Of Phi L47, A Phage Infecting The Grass Isolate Lactococcus Lactis Ssp Cremoris Dpc6860, Daniel Cavanagh, Caitríona M. Guinane, Horst Neve, Aidan Coffey, R. Paul Ross, Gerald F. Fitzgerald, Olivia Mcauliffe

Department of Biological Sciences Publications

Lactococci isolated from non-dairy sources have been found to possess enhanced metabolic activity when compared to dairy strains. These capabilities may be harnessed through the use of these strains as starter or adjunct cultures to produce more diverse flavor profiles in cheese and other dairy products. To understand the interactions between these organisms and the phages that infect them, a number of phages were isolated against lactococcal strains of non-dairy origin. One such phage, ΦL47, was isolated from a sewage sample using the grass isolate L. lactis ssp. cremoris DPC6860 as a host. Visualization of phage virions by transmission electron …

Long-Term Tev And X-Ray Observations Of The Gamma- Ray Binary Hess J0632+057, P. T. Reynolds, Veritas, Hess

Physical Sciences Publications

HESS J0632+057 is the only gamma-ray binary known so far whose position in the sky allows observations with ground-based observatories in both the northern and southern hemispheres. Here we report on long-term observations of HESS J0632+057 conducted with the Very Energetic Radiation Imaging Telescope Array System and High Energy Stereoscopic System Cherenkov telescopes and the X-ray satellite Swift, spanning a time range from 2004 to 2012 and covering most of the system's orbit. The very-high-energy (VHE) emission is found to be variable and is correlated with that at X-ray energies. An orbital period of days is derived from the …

N-Substituted 5-Amino-6-Methylpyrazine-2,3-Dicarbonitriles: Microwave-Assisted Synthesis And Biological Properties, Aidan Coffey, Jiahui Guo, Et. Al.

Department of Biological Sciences Publications

In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using microwave assisted synthesis with experimentally set and proven conditions. This approach for the aminodehalogenation reaction was chosen due to its higher yields and shorter reaction times. The products of this reaction were characterized by IR, NMR and other analytical data. The compounds were evaluated for their antibacterial, antifungal and herbicidal activity. Compounds 3 (R = 3,4-Cl), 9 (R = 2-Cl) and 11 (R = 4-CF3) showed good antimycobacterial activity against Mycobacterium tuberculosis (MIC = 6.25 µg/mL). It was found that the lipophilicity is …

Results From Ireland's 2014 Report Card On Physical Activity In Children And Youth, Deirdre M. Harrington, Sarahjane Belton, Tara Coppinger, Muireann Cullen, Alan Donnelly, Kieran Dowd, Teresa Keating, Richard Layte, Marie Murphy, Niamh Murphy, Elaine Murtagh, Catherine Woods

Publications

Background: Physical activity (PA) levels are a key performance indicator for policy documents in Ireland. The first Ireland Report Card on Physical Activity in Children and Youth aims to set a robust baseline for future surveillance of indicators related to PA in children and youth. Methods: Data collected between 2003-2010 on more than 35,000 7- to 18-year-old children and youth were used and graded using a standardized grading system for 10 indicators. Results: Grades assigned for the indicators were as follows: overall physical activity levels, D-; sedentary behavior (TV viewing), C-; organized sport participation, C-: physical education, D-; active play, …

Stock Aggregation Model And Virtual Archetype For Large Scale Retrofit Modelling Of Local Authority Housing In Ireland, James Pittam, Paul D. O’Sullivan, Garrett O’Sullivan

Conference Papers

Developing representative archetypes using a bottom up approach for stock modelling is an excellent tool for evaluating the overall performance of the building stock; however it requires detailed analysis of the various building types. Currently there is no detailed housing data base for Local Authority housing in Cork City, Ireland that catalogues the housing stocks geometric properties and thermal characteristics for each typology. This study details a methodology to catalogue the LAH stock and build a detailed housing data base. The GIS web based mapping application Google Street View is used to identify 20 house typologies across 36 LAH developments; …

Simplified Method To Derive The Kalman Filter Covariance Matrices To Predict Wind Speeds From A Nwp Model, Conor Lynch, Michael J. O'Mahony, Ted Scully

NIMBUS Articles

This paper espouses a simplified approach to predict wind speed 1 hour ahead for a wind turbine located on the Cork Institute of Technology (CIT) college campus by utilising a Kalman Filter to predict the bias between a campus based turbine and the output from a Numerical Weather Prediction (NWP) model for Cork Airport.

Furthermore, this paper investigates the optimum number of samples required (n) in a fixed sampling interval process to derive the covariance matrix of the system equation Qt and the covariance matrix of the observation equation Rt . The main contents of this paper include …