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Platelet-Cancer Cell Interactions: Insights From The Canine Model, Shauna Ashtin Fuhrmann
Platelet-Cancer Cell Interactions: Insights From The Canine Model, Shauna Ashtin Fuhrmann
Theses and Dissertations
Animal models have been recognized for the valuable roles they serve in both animal and human medicine. Dogs share many of the same naturally occurring tumors as humans including osteosarcoma, lymphoma, and mammary tumors. In addition, dogs share the same environment as humans, have a shorter lifespan, and often have a quicker progression of disease, making them an attractive model of human disease. Platelets are small anucleate cell fragments that have essential roles in hemostasis, angiogenesis, and wound healing, and, more recently recognized, roles in development, survival, growth, and metastasis of various cancers. Their roles in angiogenesis has proven to …
The Relationship Between Canine Platelets And Cancer Cells, Sandra Curotto Bulla
The Relationship Between Canine Platelets And Cancer Cells, Sandra Curotto Bulla
Theses and Dissertations
Platelets are small and anucleate blood cells that are well known for their role in hemostasis. Other less recognized platelet functions include contributions to cancer vascularization, growth, and metastasis. Although the participation of platelets in cancer biology has been broadly studied in mouse models, there is no information in the literature regarding the crosstalk of platelets and cancer cells in dogs. The objective of this dissertation was to explore the interaction of canine platelets and tumor cells in vitro. The main hypothesis was that canine platelets were similar to human and murine platelets, and would interact with tumor cells, resulting …
Use Of Biophotonic Models To Monitor Biological Compounds Via The Angiogenic System, Ramey C. Youngblood
Use Of Biophotonic Models To Monitor Biological Compounds Via The Angiogenic System, Ramey C. Youngblood
Theses and Dissertations
Angiogenesis is a central process to both physiological and pathological aspects of living organisms. Understanding the angiogenic system via the key mediator, vascular endothelial growth factor (VEGF), has led to the development of biophotonic models capable of monitoring how this process is programmed. The whole animal model tested here is based on the involvement of angiogenesis in a wound healing environment. This model proved to be functional as a system monitor but lacked the precision to yield significant results between the biological compounds tested (estrogen, methoxychlor, and relaxin). The in vitro model is based on angiogenesis in a cancer environment. …
Roles Of Vitamin D And Calcium In Cancer And Diet History Of Vitamin D And Calcium In Cancer Patients And Participants Without Cancer, Gwendolyn Mcneely Howard
Roles Of Vitamin D And Calcium In Cancer And Diet History Of Vitamin D And Calcium In Cancer Patients And Participants Without Cancer, Gwendolyn Mcneely Howard
Theses and Dissertations
Vitamin D and calcium play major roles in our bone health in addition to roles in tissues and cells. These roles in tissues and cells are associated with some cancers. The purpose of this study was to determine attitudes of cancer patients towards their dietary intakes of vitamin D and calcium. A questionnaire was completed by 128 volunteers (mean age=53.5 years±16.6, 94 women, 34 men) from the Montgomery Cancer Clinic in Montgomery, Alabama. Cancer-reporting participants (n=59) were likely to agree more (p=0.048) to the statement, “I try to eat healthy every day” compared to non-cancer reporting participants (n=69) on a …
Investigations Of The Roles Of G Protein-Coupled Receptors And Receptor Tyrosine Kinases In Metabolic Syndrome And Cancer, Lakshmi Rajan Pillai
Investigations Of The Roles Of G Protein-Coupled Receptors And Receptor Tyrosine Kinases In Metabolic Syndrome And Cancer, Lakshmi Rajan Pillai
Theses and Dissertations
The study utilizes the yeast two-hybrid system to try and unravel the molecular link between the G protein-coupled receptors (GPCR) and the receptor tyrosine kinases (RTK). The fourth melanocortin receptor (MC4R) and the angiotensin receptor AT1 are both GPCRs while the insulin receptor (IR) and the epidermal growth factor receptor subtype-2 (ErbB2) belong to the RTK family. Alteration in the functioning of MC4R receptor can cause obesity. Development of insulin resistance and diabetes is a risk factor associated with obesity. Overexpression of the ErbB2 receptor is seen in a number of breast cancers. The interaction between the AT1 and ErbB2 …
Three Stage Level Set Segmentation Of Mass Core, Periphery, And Spiculations For Automated Image Analysis Of Digital Mammograms, John E. Ball
Theses and Dissertations
In this dissertation, level set methods are employed to segment masses in digital mammographic images and to classify land cover classes in hyperspectral data. For the mammography computer aided diagnosis (CAD) application, level set-based segmentation methods are designed and validated for mass periphery segmentation, spiculation segmentation, and core segmentation. The proposed periphery segmentation uses the narrowband level set method in conjunction with an adaptive speed function based on a measure of the boundary complexity in the polar domain. The boundary complexity term is shown to be beneficial for delineating challenging masses with ill-defined and irregularly shaped borders. The proposed method …