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Self-Assembly Of 3d Nanostructures In Electrospun Polycaprolactone-Polyaniline Fibers And Their Application As Scaffolds For Tissue Engineering, Samerender Nagam Hanumantharao, Carolynn Que, Smitha Rao
Self-Assembly Of 3d Nanostructures In Electrospun Polycaprolactone-Polyaniline Fibers And Their Application As Scaffolds For Tissue Engineering, Samerender Nagam Hanumantharao, Carolynn Que, Smitha Rao
Department of Biomedical Engineering Publications
The fabrication of synthetic scaffolds that mimic the microenvironment of cells is a crucial challenge in materials science. The honeycomb morphology is one such bio-mimicking structure that possesses unique physical properties and high packing efficiency in a 3-dimensional space. Here, we present a novel method for electrospinning polycaprolactone-polyaniline with continuous, self-assembled, uniform, interwoven nanofibers forming patterns without the use of templates or porogens. By using the approach presented here, unique architectures mimicking the natural mechanical anisotropy of extracellular matrix were created by varying the electric field. Adult human dermal fibroblasts (HDFa) cells were successfully cultured on the nanofiber scaffolds without …
Polydopamine And Collagen Coated Micro-Grated Polydimethylsiloxane For Human Mesenchymal Stem Cell Culture, Dhavan Sharma, Wenkai Jia, Fei Long, Shweta Pati, Qing-Hui Chen, Yibing Qyang, Bruce P. Lee, Chang Kyoung Choi, Feng Zhao
Polydopamine And Collagen Coated Micro-Grated Polydimethylsiloxane For Human Mesenchymal Stem Cell Culture, Dhavan Sharma, Wenkai Jia, Fei Long, Shweta Pati, Qing-Hui Chen, Yibing Qyang, Bruce P. Lee, Chang Kyoung Choi, Feng Zhao
Department of Biomedical Engineering Publications
Natural tissues contain highly organized cellular architecture. One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality. To address this issue, micro-patterned polydimethylsiloxane (PDMS) substrates have been widely used in cell sheet engineering due to their low microfabrication cost, higher stability, excellent biocompatibility, and most importantly, ability to guide cellular growth and patterning. However, the current methods for PDMS surface modification either require a complicated procedure or generate a non-uniform surface coating, leading to the production of poor-quality cell layers. A simple and efficient surface coating method is critically …
A Comparison Of Hyperelastic Constitutive Models Applicable To Shear Wave Elastography (Swe) Data In Tissue-Mimicking Materials, David P. Rosen, Jingfeng Jiang
A Comparison Of Hyperelastic Constitutive Models Applicable To Shear Wave Elastography (Swe) Data In Tissue-Mimicking Materials, David P. Rosen, Jingfeng Jiang
Department of Biomedical Engineering Publications
Shear wave elastography (SWE) techniques have received substantial attention in recent years. Strong experimental data in SWE suggest that shear wave speed changes significantly due to the known acoustoelastic effect (AE). This presents both challenges and opportunities toward in vivo characterization of biological soft tissues. In this work, under the framework of continuum mechanics, we model a tissue-mimicking material as a homogeneous, isotropic, incompressible, hyperelastic material. Our primary objective is to quantitatively and qualitatively compare experimentally measured acoustoelastic data with model-predicted outcomes using multiple strain energy functions. Our analysis indicated that the classic neo-Hookean and Mooney-Rivlin models are inadequate for …