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Development Of Plga-Coated Β-Tcp Scaffolds Containing Vegf For Bone Tissue Engineering, Arash Khojasteh, Farahnaz Fahimipour, Mohamadreza Baghaban Eslaminejad, Mohammad Jafarian, Shahrbanoo Jahangir, Farshid Bastami, Mohammadreza Tahriri, Akbar Karkhaneh, Lobat Tayebi
Development Of Plga-Coated Β-Tcp Scaffolds Containing Vegf For Bone Tissue Engineering, Arash Khojasteh, Farahnaz Fahimipour, Mohamadreza Baghaban Eslaminejad, Mohammad Jafarian, Shahrbanoo Jahangir, Farshid Bastami, Mohammadreza Tahriri, Akbar Karkhaneh, Lobat Tayebi
School of Dentistry Faculty Research and Publications
Bone tissue engineering is sought to apply strategies for bone defects healing without limitations and short-comings of using either bone autografts or allografts and xenografts. The aim of this study was to fabricate a thin layer poly(lactic-co-glycolic) acid (PLGA) coated beta-tricalcium phosphate (β-TCP) scaffold with sustained release of vascular endothelial growth factor (VEGF). PLGA coating increased compressive strength of the β-TCP scaffolds significantly. For in vitro evaluations, canine mesenchymal stem cells (cMSCs) and canine endothelial progenitor cells (cEPCs) were isolated and characterized. Cell proliferation and attachment were demonstrated and the rate of cells proliferation on the VEGF released scaffold was …