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Marquette University

Theses/Dissertations

2020

Depression

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Generating Alternative Solutions When Depression Is The Problem, Benjamin Todd Johnson Oct 2020

Generating Alternative Solutions When Depression Is The Problem, Benjamin Todd Johnson

Dissertations (1934 -)

Generating alternative solutions for problem situations is a key component of effective problem solving. This process is used to generate a variety of potential options for managing a problem, from which the most effective approach or combination of approaches can be selected for implementation. Impaired alternatives generation provides fewer options from which to select a response, reducing the likelihood that a highly effective approach will be available for implementation, potentially leaving problems unresolved, generating additional problems, and fostering a sense of hopelessness and depression. Depression has been found to impair problem solving further by reducing engagement in the problem solving …


Chronic Variable Stress Induces Avolition And Disrupts Corticoaccumbens Encoding Of Approach Cues, Mitchell Spring Oct 2020

Chronic Variable Stress Induces Avolition And Disrupts Corticoaccumbens Encoding Of Approach Cues, Mitchell Spring

Dissertations (1934 -)

Disorders in the ability to process, evaluate, and interact with rewards are hallmarks of a range of mental illnesses. Such disorders are multi-faceted and arise from altered activity throughout diffuse brain regions. Chronic variable stress (CVS) is an oft-used tool for modeling reward-related disorders in preclinical research because it impairs the function of multiple brain regions and causes a range of severe hedonic and motivational deficits. While much research has focused on the former, the latter is poorly characterized. A panel of behavioral tests was used to characterize the effect of CVS exposure on different facets of reward related behaviors …