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Articles 1 - 30 of 39
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Queer Monstrosity: Dis/Ability, Sexuality, And Gender, Savannah Olivia Aldridge
Queer Monstrosity: Dis/Ability, Sexuality, And Gender, Savannah Olivia Aldridge
Master's Theses
The queer monster feeds, yet what does it feed on? What does it look like? Is it considered homosexual in Nature? Does one think of it as a source of camp or pure fear? It consumes us, literally. as a bioweapon that shoots and eats and destroys. It has and always will be the feared/ spectated/ and degraded€¦ the dis/abled queer. I investigate 'queer monstrosity' as a schizophrenic, trans feminine academic who lives multiple lives. There are three parts to my inquiry that is focused on this creation of lived experience: gender, sexuality, and dis/ability. How does including dis/ability in …
The Characterization Of Inflammatory Extracellular Vesicles, Barak Balva
The Characterization Of Inflammatory Extracellular Vesicles, Barak Balva
Master's Theses
One of the driving factors behind innate immunity is the early response of inflammation. While beneficial in controlling infections, when uncontrolled it can lead to a plethora of disorders. Thus, it is essential to understand the driving factors behind inflammation. a cell's ability to recycle, discard, or transfer proteins is integral for survival and intercellular communication. It has been appreciated that inflammatory components, such as caspase-1, play a huge role in driving protein secretion. Thus, inflammation also plays a role in the distribution of proteins released from cells. These proteins are released via non-conventional secretory pathways, and our lab is …
Layperson's Norms Surrounding Politician Sexual Misconduct And Sexual Harassment, Yelyzaveta Distefano
Layperson's Norms Surrounding Politician Sexual Misconduct And Sexual Harassment, Yelyzaveta Distefano
Master's Theses
While there are legal definitions of what actions and circumstances constitute gender based prejudiced, sexual harassment, sexual assault, and rape, less is known about lay people's norms and perceptions of what behaviors and situations qualify as each of these categories, especially involving the role of context in which ambiguous social-sexual behaviors occur. Additionally, sexual harassment paradigms have not explored the unique power relationships of politicians and those working under them in political office, an especially topical locale of workplace SH in a post #MeToo America. 277 participants completed a survey with a 2 (setting: workplace, office party at the bar) …
Decreasing Women's Endorsement Of Benevolent Sexism, Kelsey Berryman
Decreasing Women's Endorsement Of Benevolent Sexism, Kelsey Berryman
Master's Theses
The aim of the current study was to reduce women's endorsement for benevolent sexist beliefs. the intervention aimed to educate women about the prevalence and seriousness of benevolent sexism. as this is a subtle and deceptively positive type of sexism, women are particularly susceptible in endorsing it (Glick & Fiske, 2001). in order to increase awareness for benevolent sexism in their everyday lives, some participants read an informational text about the pervasiveness and harmfulness of benevolent sexism in the U.S. This text was read after participants had already written about a time they engaged in benevolent sexism to elicit negative …
Transforming Growth Factor Beta Suppression Of Cd8+ T Cell Proliferation, Shena Geisinger
Transforming Growth Factor Beta Suppression Of Cd8+ T Cell Proliferation, Shena Geisinger
Master's Theses
Transforming Growth Factor Beta (TGF-beta) is highly suppressive to both CD4+ and CD8+ T cell proliferation and function. in tumor microenvironments, TGF-beta has been described as immune suppressive, particularly to CD8+ T cells, however, the molecular mechanism behind how TGF-beta signaling controls T cell growth is not fully understood. Here, we report that TGF-beta inhibits CD8+ T cell proliferation and reduces expression of the CARMA1/BCL10/MALT1 (CBM) signalosome complex in activated CD8+ T cells. the CBM signalosome is an essential scaffold that forms after T cell receptor (TCR) stimulation, leading to the activation of NF-kB and AP-1. This observed reduction in …
Tumor Immunology: Understanding The Immune System And Cancer To Enhance The Efficacy Of Cancer Immunotherapies, Natasha Malibu Lenart
Tumor Immunology: Understanding The Immune System And Cancer To Enhance The Efficacy Of Cancer Immunotherapies, Natasha Malibu Lenart
Master's Theses
Tumor cells are notorious for their ability to escape immune surveillance, but developments in the understanding of the tumor microenvironment and how the immune system can be re-activated in tumors have had significant clinical impact. Commercially available and experimental methods such as adoptive cellular therapy, cytokine stimulation, and immune checkpoint blockade are promising immunotherapies for a variety of cancers, including solid tumors and hematological malignancies. However, induction of persistent, long-term anti-tumor immunity after initial treatment is infamously difficult. as a result, scientists are searching for new approaches to improve established immunotherapies. by employing combination treatments or enhancing the functionality of …
Zika Virus Inactivates Polyamine Catabolism Via Alternative Splicing To Enhance Infection, Marion Lea Graham
Zika Virus Inactivates Polyamine Catabolism Via Alternative Splicing To Enhance Infection, Marion Lea Graham
Master's Theses
During viral infection, the virus and host must compete for resources inside the cell. One of these resources is polyamines. Polyamines are small, positively charged molecules that are found in all eukaryotic cells. They play a key role in several cellular functions including growth and proliferation, transcription and translation, and membrane stability. Viruses also rely polyamines for productive replication, utilizing them during DNA/RNa polymerization, nucleic acid packaging, and protein synthesis. in response to a virus infecting a host cell, the host cell will begin to regulate polyamine levels as a way to combat the infection. Polyamine levels are regulated by …
Investigating Dispersal Ability To Infer Diversification In The Birds Of Madagascar, Robert D. Lauer
Investigating Dispersal Ability To Infer Diversification In The Birds Of Madagascar, Robert D. Lauer
Master's Theses
The objective of this study was to investigate whether dispersal ability, as measured by a proxy of hand-wing index 2, influenced diversification of the birds of Madagascar at two scales. Madagascar is home to several avian lineages that have diversified greatly while other lineages are only represented by a single species. a key question in evolutionary biology is why some of these lineages diversified while others did not. One way to address this is to examine what features of these lineages promotes their diversification. Recent studies have focused on the relative importance of dispersal ability to diversification at the continental …
Latino Parents' Acculturative Stress And Their Preschoolers' Prosocial Development: Testing The Mediating Role Of Parenting Style, Zahra Fatima Naqi
Latino Parents' Acculturative Stress And Their Preschoolers' Prosocial Development: Testing The Mediating Role Of Parenting Style, Zahra Fatima Naqi
Master's Theses
Studies increasingly recognize the importance of cultural factors when studying the development of immigrant children from low-income backgrounds. There is reason to believe that parents' acculturative stress may be linked to children's prosocial development, via parenting. the present study included a sample of immigrant Latino parents of 3- to 5-year-old Head Start preschoolers (N = 28) to examine how parents' acculturative stress might be associated with children's prosocial behavior at home, as reported by parents, and at school, as reported by teachers. Furthermore, it studied whether this linkage is mediated by warm, supportive, and hostile parenting practices. Results indicated that …
The Creation And Evolution Of Introductory Courses In Women's Studies Programs, Tori Kay Olson
The Creation And Evolution Of Introductory Courses In Women's Studies Programs, Tori Kay Olson
Master's Theses
This study seeks to understand what affects knowledge production in introductory women's studies courses. Using critical discourse analysis, the study looks at the archives of two very different programs within the Chicago area. the two programs studied, Loyola University Chicago and University of Illinois€”Chicago, offer two different examples of how women's studies programs were created and evolved, and how this influenced the knowledge production in their introductory courses. in addition to the archival materials of these two universities, this study relies on various reports and accounts written by women's studies scholars during the same timeframe as the documented archival material …
Optimizing Gene Expression Prediction And Omics Integration In Populations Of African Ancestry, Paul Chukwuebuka Okoro
Optimizing Gene Expression Prediction And Omics Integration In Populations Of African Ancestry, Paul Chukwuebuka Okoro
Master's Theses
Popular transcriptome imputation methods such as PrediXcan and FUSIon use parametric linear assumptions, and thus are unable to flexibly model the complex genetic architecture of the transcriptome. Although non-linear modeling has been shown to improve imputation performance, replicability and potential cross-population differences have not been adequately studied. Therefore, to optimize imputation performance across global populations, we used the non-linear machine learning (ML) models random forest (RF), support vector regression (SVR), and K nearest neighbor (KNN) to build transcriptome imputation models, and evaluated their performance in comparison to elastic net (EN). We trained gene expression prediction models using genotype and blood …
Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes
Characterization Of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs, Nicholas Rohlfes
Master's Theses
Inflammation is the bodies first response to defend itself against foreign pathogens and damage. Cellular sensors are constantly monitoring the body and checking for homeostatic disruption. Microbial pathogens and tissue damage are sensed by pattern recognition receptors (PRRs), which sense pathogen associated molecular patterns and damage associated molecular patterns, termed PAMPs and DAMPs respectively. Within the family of PRRs are sensors that can induce the formation of the multi-protein complex termed the inflammasome following activation. the inflammasome complex is a molecular platform for which caspase 1, a cysteine protease, is incorporated and is responsible for the maturation of pro-inflammatory cytokines …
The Longitudinal Relationship Between Callous-Unemotional Traits And Exposure To Community Violence: Examining Primary And Secondary Psychopathy In Serious Adolescent Offenders, Elizabeth Sargent
Master's Theses
in youth, psychopathy is often represented by callous-unemotional traits, characterized by a lack of guilt and empathy. While justice-involved youth can exhibit such traits, less research has been done in adolescents than has been with adults in the justice system. Still, previous research supports that callous-unemotional traits in particular can predict higher risk for adverse outcomes and violent behavior in youth. Various vulnerabilities and experiences contribute to the development of callous-unemotional traits, and while some individuals with psychopathic traits are thought to have been born with an innate inability to feel empathy (primary psychopathy), others may experience psychological distress in …
Trajectories Of Adaptive Functioning Among Youth With Spina Bifida: The Influence Of Neurocognitive Functioning And Parental Scaffolding, Adrien Winning
Trajectories Of Adaptive Functioning Among Youth With Spina Bifida: The Influence Of Neurocognitive Functioning And Parental Scaffolding, Adrien Winning
Master's Theses
Youth with spina bifida (SB), a congenital birth defect affecting the central nervous system, are at risk of experiencing an array of psychosocial and functional deficits (Copp et al., 2015; Holmbeck et al., 2003). Indeed, previous research has documented difficulties across the three adaptive functioning domains outlined by the American Association on Intellectual and Developmental Disabilities (AAIDD): conceptual (e.g., communication, self-direction, functional academics), social (e.g., interpersonal skills), and practical (e.g., self-care, navigating health-care; Copp et al., 2015). Despite this evidence, whether or not children with SB typically acquire skills across development is largely unknown. Additionally, little is known about risk …
Condition Severity And Parent Psychosocial Functioning In Families Of Youth With Spina Bifida: The Role Of Parental Attitudes And Beliefs, Elicia Wartman
Condition Severity And Parent Psychosocial Functioning In Families Of Youth With Spina Bifida: The Role Of Parental Attitudes And Beliefs, Elicia Wartman
Master's Theses
Past research suggests that parents of youth with spina bifida (SB) have worse psychosocial outcomes than parents of typically developing youth. SB is a complex medical condition that is accompanied by varying degrees of physical disability and cognitive deficits. Research on stress and coping suggests that parents' attitudes and beliefs may contribute to their own psychosocial adjustment. This study unpacks condition severity and examines the role of severity of condition-related factors in predicting parental adjustment and parental attitudes and beliefs. Participants were recruited as part of a larger longitudinal study. Information on condition severity, including type of SB, lesion level, …
Wayfinder Application For Autistic Occupational Assistance, Nathaniel Edward Hishon
Wayfinder Application For Autistic Occupational Assistance, Nathaniel Edward Hishon
Master's Theses
Employment among autistic individuals is an area of noted difficulty, with an employment rate well below the general population [1]. Several barriers attributed to autistic unemployment, including difficulties communicating with employers and social interactions with coworkers, obsessive adherence to routine, and trouble organizing and completing workplace tasks, are also attributed to challenges in maintaining employment [2]. Several studies have concluded that long-term employment support is necessary to acquire and maintain autistic employment [3]. The noted benefit of intensive job training, such as access to job coaches, indicates the need for further support to help autistic individuals complete workplace tasks and …
Induction Of Zika And Dengue Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Natalie Jachym
Induction Of Zika And Dengue Virus-Specific Cd8+ T Cells By Means Of Dna Vaccine, Natalie Jachym
Master's Theses
Zika virus (ZIKV) and Dengue virus (DENV) are flaviviruses that circulate in the same endemic regions and can co-infect the same individual. While primary infection by DENV leads to life-long immunity to the infecting serotype, it does not provide immunity to other serotypes. Moreover, ZIKV and DENV antibodies can be cross-reactive and potentially enhance infection of the other virus through a process known as antibody-dependent enhancement (ADE). In this mechanism, antibodies weakly bind the infecting virus and direct virions to immunoglobulin Fc receptors on macrophages. This promotes viral uptake and infection rather than neutralize the virus. Due to this mechanism, …
Is It Because I'M Black Or A Woman? Constructing An Intersectional And Trauma-Informed Model Of Social Support, Moriah Lynn Johnson
Is It Because I'M Black Or A Woman? Constructing An Intersectional And Trauma-Informed Model Of Social Support, Moriah Lynn Johnson
Master's Theses
Inequality in the lives of Black women comes in many forms. As Kimberle Crenshaw observed, Black women experience inequality through the criminal (in)justice system, political and popular cultural representations that stereotype and exclude Black women and when accessing much needed social services (1991). As in the tradition of Black feminist scholars like Kimberle Crenshaw and Rose M. Brewer, this paper challenges stereotypical conceptions of Black womanhood within and outside of sociology, while proposing a relationship between the scholarship and social inequalities experienced by Black women. From this framework, I examine the inequalities Black women experience when accessing social services, consider …
Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz
Reducing Reperfusion Injury In An Adult Rat Stroke Model With St-115 Treatment, Morgan Rae Lenz
Master's Theses
The restoration of blood flow to ischemic cerebral tissue can result in reperfusion injury, and blocking reperfusion injury can significantly aid in recovery of ischemic tissue. Bradykinin has been shown to exhibit protective effects, but does not reach protective levels during reperfusion due to inactivation by aminopeptidase P2 (APP2). Therefore, inhibiting APP2 during reperfusion is a potential therapeutic strategy to aid in the reduction of reperfusion injury, leading to the development of ST-115, an APP2 inhibitor. It was hypothesized that administration of ST-115 during ischemic stroke, and just prior to reperfusion, will result in reduced neurological injury and increased functional …
Beyond Family: Patterns Of Kin And Fictive Kin Caregivers Among Children And Youth In The Child Welfare System, Jennifer Osborne
Beyond Family: Patterns Of Kin And Fictive Kin Caregivers Among Children And Youth In The Child Welfare System, Jennifer Osborne
Master's Theses
Children and youth in the child welfare system experience significant benefits from placement with custodial kin caregivers in psychological, social, relational, and educational domains (Winokur, Holtan, & Batchelder, 2018; Vasileva & Petermann, 2018). Additionally, the extant literature suggests that non-custodial kin and non-custodial fictive kin, or individuals unrelated by blood or marriage though afforded the same unofficial status as family (Taylor, Chatters, Woodward, & Brown, 2013), also contribute positive outcomes (Smetana, Campione-Barr, & Metzger, 2006). However, little research has examined the ways in which custodial kin, non-custodial kin, and non-custodial fictive kin work together to provide social support to children …
An Experimental Test Of Fiedler's Contingency Model Of Leadership Effectiveness: The Effect Of Gender, Samantha De Souza
An Experimental Test Of Fiedler's Contingency Model Of Leadership Effectiveness: The Effect Of Gender, Samantha De Souza
Master's Theses
The present study is an experimental test of Fiedler's (1967) Contingency Model of Leadership Effectiveness across genders, as Fiedler's Contingency Model has been tested largely with male participants. The model predicts group performance based on four key variables: leadership style, as indexed by the Least-Preferred Coworker (LPC) Scale, and three situational variables, leader-member relations, task structure, and position power. In situations characterized by high leader-member relations, and low position power, Fiedler predicts a negative correlation between the leader's LPC score and group performance when groups perform a structured task (Octant II), and a positive correlation when groups perform an unstructured …
Educational Debt: Educational Loans And The Family, Keyla Navarrete
Educational Debt: Educational Loans And The Family, Keyla Navarrete
Master's Theses
Student debt is a well-documented topic in sociological literature. It is well known that there is a student loan crisis in the United States. However, kinship or familial ties in educational debt is not as studied as individual student loans. The student debt crisis seems to reach a new catastrophic level as years pass. Yet, not much research exists that looks at external sources of financing for students such as parents, grandparents, or other familial ties. This study contributes to the literature of student debt by analyzing debt patterns across those that take out loans for themselves, their spouse, or …
Emotion Reactivity And Its Relation To Daily Affect And Sleep Experiences Among First Year College Students, Elizabeth Marie Rea
Emotion Reactivity And Its Relation To Daily Affect And Sleep Experiences Among First Year College Students, Elizabeth Marie Rea
Master's Theses
Individuals with high emotion reactivity may be at increased likelihood to experience emotions more intensely, frequently, and for longer periods of time than those with low emotion reactivity. This might lead to more extreme fluctuations in their daily experience of emotion. Additionally, those high in emotion reactivity may be at risk for poor sleep. The transition to college has been shown to be a difficult time for some students, and potentially contribute to these emotional fluctuations and shorter sleep duration. However, students high in emotion reactivity might be more likely to experience the negative effects of this transition than those …
A Chronic Route?: Examining The Path Between Community Violence Exposure, Posttraumatic Stress & Juvenile Delinquency In Low-Income, Urban, African-American Youth, Kaleigh Valencia Wilkins
A Chronic Route?: Examining The Path Between Community Violence Exposure, Posttraumatic Stress & Juvenile Delinquency In Low-Income, Urban, African-American Youth, Kaleigh Valencia Wilkins
Master's Theses
Background: Exposure to community violence (ECV; direct victimization and witnessing) can predict negative outcomes for youth such as posttraumatic stress (PTSS) and juvenile delinquent behavior (JDB). Psychosocial reactions to violence can be different based on gender. Predictors of ECV in youth is less understood. This study aims to explore potential chronic pathways between initial ECV and continued ECV for early adolescents. The relationship between ECV as a predictor and ECV as an outcome is hypothesized to be mediated by both PTSS and JDB and moderated by gender. Method: A total of 266 African-American, sixth grade students in high crime, high …
Dna Methylation Patterns Of Repetitive Elements On Hc21, Navy Neang
Dna Methylation Patterns Of Repetitive Elements On Hc21, Navy Neang
Master's Theses
Cancer is one of the most prominent diseases resulting in death, thus the need for early detection remains essential to its treatments. It is usually associated with DNA methylation changes during tumorigenesis. While many studies focus on euchromatin, some studies have looked at the methylation changes in heterochromatin, since the methylation changes of repetitive elements is common and they contribute to karyotypic instability leading to enhanced chances for more mutations in tumor progression. Using bisulfite PCR and HC21 as a model, this study examines the DNA methylation changes of three repetitive elements in prostate cancer, NBL2, satellite I subfamilies, and …
Understanding The Role Of Relationship Satisfaction In Social Support Provision For Youth In The Child Welfare System, Nathan Michael Lutz
Understanding The Role Of Relationship Satisfaction In Social Support Provision For Youth In The Child Welfare System, Nathan Michael Lutz
Master's Theses
The objective of this study was to examine kin social support and relationship satisfaction, as well as the interaction between these two variables, in terms of their association with placement stability, externalizing behaviors, and internalizing symptoms for youth in the child welfare system. Ordinary Least Squares Regression methods were used in conjunction with Poisson and Negative Binomial Regression methods. the study also examined two different methods for calculating the interaction term to determine relationship satisfaction's moderating effect on the relationship between social support and the outcomes. Results suggested that relationship satisfaction does act as a moderator when externalizing behaviors and …
Investigating The Role Of Hypusine In Viral Translation And Infection, Jeremy Joseph Esin
Investigating The Role Of Hypusine In Viral Translation And Infection, Jeremy Joseph Esin
Master's Theses
Polyamines are small, positively charged, molecules found in eukaryotic cells with roles in cellular function and viral infection. in previous work we have shown RNa viruses, including bunyaviruses, to be sensitive to polyamine depletion, but exact mechanisms are unknown. Bunyaviruses are emerging pathogens that cause encephalitis, hemorrhagic fevers, and meningitis. Rift Valley Fever Virus is a bunyavirus that infects both humans and livestock with severe mortality and morbidity. in previous work done with Rift Valley Fever Virus polyamine depleted results in noninfectious interfering particles without affecting the shape or size of the particles. Here, I investigate a specific metabolic pathway …
Predicting Drug Misuse Status Using Machine Learning On Electronic Health Records, Robert Arnold Kania
Predicting Drug Misuse Status Using Machine Learning On Electronic Health Records, Robert Arnold Kania
Master's Theses
Substance misuse is a major problem in the world. in 2014, as many as 52,404 deaths in the US were caused by drug overdoses. in 2001, the monetary cost of drug misuse has been estimated to be 414 billion dollars. in this work, we explore the use of different machine learning algorithms in the prediction of cocaine misuse using structured and unstructured data found in electronic health records. These records contain various attributes that can help with this prediction, including but not limited to chart text data, previous diagnoses of certain diseases and information about the area the patient lives …
The Effect Of Plastic On Leaf Litter Breakdown In Urban Streams, Lisa Haneul Kim
The Effect Of Plastic On Leaf Litter Breakdown In Urban Streams, Lisa Haneul Kim
Master's Theses
The plastic component of anthropogenic litter (AL) is an emerging ecological concern and has been a focus of research, as it is long-lived, mobile, interacts with physical and chemical components of aquatic ecosystems, and breaks down into smaller pieces (i.e., microplastic, <5mm particles). Rivers are considered a major source of plastic to oceans, but little is known about plastic's abundance, distribution, and effects on ecological processes in urban streams. Previous studies report plastic is abundant in freshwater systems, especially in naturally occurring debris dam structures and overhanging vegetation which accumulate high quantities of AL, especially plastic items (i.e. bags, wrappers, packaging material), along with leaf litter and other coarse particulate organic matter. in temperate, forested streams, leaf litter is a critical food source and plays an essential role in the stream food web. the rate at which leaves break down is affected by many variables such as hydrology, water chemistry, and macroinvertebrate and microbial communities. We predicted that plastic accumulation along with leaf litter can slow leaf breakdown by reducing diversity and abundance of microbial decomposers, as well as macroinvertebrate consumers. We measured leaf breakdown, and characterized macroinvertebrate and microbial (i.e., bacterial, fungal, algal) communities in 3 litter bag treatments: leaves alone, plastic alone, and leaves mixed with plastic. Although plastic did not reduce leaf breakdown rates or have a significant effect on macroinvertebrate consumer communities, it showed distinct microbial communities compared to leaf substrates. Results will provide a new understanding of how plastic and microbial communities interact, and set the framework for future studies to look at microbial succession and macroinvertebrate diversity on other synthetic substrates in freshwater systems.
Using Moral Foundations Framing To Influence Partisan Attitudes Toward Latino Immigrants, Salma Moaz
Using Moral Foundations Framing To Influence Partisan Attitudes Toward Latino Immigrants, Salma Moaz
Master's Theses
This study aims to use Moral Foundations Theory to reduce prejudiced attitudes towards Latino immigrants. Research has shown that liberals and conservatives tend to differ in their support of moral foundations. Liberals are more likely to endorse individualizing moral foundations (fairness and caring for others) while conservatives are more likely to endorse binding moral foundations (sanctity, loyalty, and authority). Participants read one of two brief messages in support of Latino immigrants framed in either the binding or individualizing morals. the hypothesis was that conservatives who read the binding message will have more pro-immigrant attitudes, be more supportive of pro-immigrant policies, …