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Complement In Reproductive White Adipose Tissue Characterizes The Obese Preeclamptic-Like Bph/5 Mouse Prior To And During Pregnancy, Kelsey N. Olson, Dorien Reijnders, Viviane C.L. Gomes, R. Caitlin Hebert, Chin Chi Liu, Jacqueline M. Stephens, Leanne M. Redman, Nataki C. Douglas, Jennifer L. Sones

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Preeclampsia (PE) is a serious hypertensive disorder of pregnancy characterized by abnormal placental development with an unknown etiology. To better understand which women will develop PE, a number of maternal risk factors have been identified, including obesity. Visceral white adipose tissue (WAT) contains inflammatory mediators that may contribute to PE. To explore this, we utilized the blood pressure high (BPH)/5 mouse model of superimposed PE that spontaneously recapitulates the maternal PE syndrome. We hypothesized that BPH/5 visceralWAT adjacent to the female reproductive tract (reproductiveWAT) is a source of complement factors that …

The Effects Of Skeletal Muscle Specific Cpt1b Knock Out On Genetically Obese Ay Mice, Allison Stone

LSU Master's Theses

Fatty acid oxidation inhibition is one approach to reducing blood glucose levels in type II diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1b^m-/-) cannot transport long-chain fatty acids into the mitochondria to be oxidized in order to produce energy. Cpt1b^m-/- mice have debilitated fat oxidation, less fat mass and improved glucose utilization compared to control C57BL/6 mice fed a 25% fat diet.

We hypothesized that CPT1b inhibition could reduce fat mass and lower blood glucose levels in a genetic mouse model of obesity and diabetes. To test this, we bred Cpt1b^m-/- mice to A …

A Role For Oncostatin M In The Impairment Of Glucose Homeostasis In Obesity, Irene Piquer-Garcia, Laura Campderros, Siri D. Taxerås, Aleix Gavaldà-Navarro, Rosario Pardo, María Vila, Silvia Pellitero, Eva Martínez, Jordi Tarascó, Pau Moreno, Joan Villarroya, Rubén Cereijo, Lorena González, Marjorie Reyes, Silvia Rodriguez-Fernández, Marta Vives-Pi, Carles Lerin, Carrie M. Elks, Jacqueline M. Stephens, Manel Puig-Domingo, Francesc Villarroya, Josep A. Villena, David Sánchez-Infantes

Faculty Publications

© 2019 Endocrine Society 2019. Context: Oncostatin M (OSM) plays a key role in inflammation, but its regulation and function during obesity is not fully understood. Objective: The aim of this study was to evaluate the relationship of OSM with the inflammatory state that leads to impaired glucose homeostasis in obesity. We also assessed whether OSM immunoneutralization could revert metabolic disturbances caused by a high-fat diet (HFD) in mice. Design: 28 patients with severe obesity were included and stratified into two groups: (1) glucose levels /dL and (2) glucose levels >100 mg/dL. White adipose tissue was obtained to examine OSM …

Hepatic Ikkε Expression Is Dispensable For High-Fat Feeding-Induced Increases In Liver Lipid Content And Alterations In Glucose Tolerance, J. Jason Collier, Heidi M. Batdorf, Tamra M. Mendoza, David H. Burk, Thomas M. Martin, Jingying Zhang, Randall L. Mynatt, Susan J. Burke

Faculty Publications

© 2020 the American Physiological Society. There are endocrine and immunological changes that occur during onset and progression of the overweight and obese states. The inhibitor of nuclear factor-κB kinase-ε (IKKε) was originally described as an inducible protein kinase; whole body gene deletion or systemic pharmaceutical targeting of this kinase improved insulin sensitivity and glucose tolerance in mice. To investigate the primary sites of action associated with IKKε during weight gain, we describe the first mouse line with conditional elimination of IKKε in the liver (IKKεAlb-/-). IKKεAlb-/- mice and littermate controls gain weight, show similar changes in body composition, and …