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Pancreatic Β-Cell Production Of Cxcr3 Ligands Precedes Diabetes Onset, Susan J. Burke, Michael D. Karlstad, Adrianna E. Eder, Kellie M. Regal, Danhong Lu, David H. Burk, J. Jason Collier
Pancreatic Β-Cell Production Of Cxcr3 Ligands Precedes Diabetes Onset, Susan J. Burke, Michael D. Karlstad, Adrianna E. Eder, Kellie M. Regal, Danhong Lu, David H. Burk, J. Jason Collier
Faculty Publications
© 2016 International Union of Biochemistry and Molecular Biology Type 1 diabetes mellitus (T1DM) results from immune cell-mediated reductions in function and mass of the insulin-producing β-cells within the pancreatic islets. While the initial trigger(s) that initiates the autoimmune process is unknown, there is a leukocytic infiltration that precedes islet β-cell death and dysfunction. Herein, we demonstrate that genes encoding the chemokines CXCL9, 10, and 11 are primary response genes in pancreatic β-cells and are also elevated as part of the inflammatory response in mouse, rat, and human islets. We further established that STAT1 participates in the transcriptional control of …
5-Lipoxygenase-Activating Protein Rescues Activity Of 5-Lipoxygenase Mutations That Delay Nuclear Membrane Association And Disrupt Product Formation, Jana Gerstmeier, Marcia E. Newcomer, Sophie Dennhardt, Erik Romp, Jana Fischer, Oliver Werz, Ulrike Garscha
5-Lipoxygenase-Activating Protein Rescues Activity Of 5-Lipoxygenase Mutations That Delay Nuclear Membrane Association And Disrupt Product Formation, Jana Gerstmeier, Marcia E. Newcomer, Sophie Dennhardt, Erik Romp, Jana Fischer, Oliver Werz, Ulrike Garscha
Faculty Publications
© FASEB. Leukotrienes (LTs) are proinflammatory lipid mediators formed from arachidonic acid in a 2-step reaction catalyzed by 5-lipoxygenase (5-LOX) requiring the formation of 5-HPETE [5(S)-hydroperoxy-6-trans-8,11,14-ciseicosatetraenoic acid] and its subsequent transformation to LTA4 . 5-LOX is thought to receive arachidonic acid from the nuclear membrane-embedded 5-LOX-activating protein (FLAP). The crystal structure of 5-LOX revealed an active site concealed by F177 and Y181 (FY cork). We examined the influence of the FY cork on 5-LOX activity and membrane binding in HEK293 cells in the absence and presence of FLAP. Uncapping the 5-LOX active site by mutation of F177 and/or Y181 to …
Regulation Of Inflammatory Biomarkers By Intravenous Methylprednisolone In Pediatric Ards Patients: Results From A Double-Blind, Placebo-Controlled Randomized Pilot Trial, Andreas Schwingshackl, Dai Kimura, Cynthia R. Rovnaghi, Jordy S. Saravia, Stephania A. Cormier, Bin Teng, Alina N. West, Umberto G. Meduri, Kanwaljeet J.S. Anand
Regulation Of Inflammatory Biomarkers By Intravenous Methylprednisolone In Pediatric Ards Patients: Results From A Double-Blind, Placebo-Controlled Randomized Pilot Trial, Andreas Schwingshackl, Dai Kimura, Cynthia R. Rovnaghi, Jordy S. Saravia, Stephania A. Cormier, Bin Teng, Alina N. West, Umberto G. Meduri, Kanwaljeet J.S. Anand
Faculty Publications
© 2015 Elsevier Ltd. Objective: A double-blind, randomized controlled trial showed that low-dose glucocorticoid therapy in pediatric ARDS patients is feasible and may improve both ventilation and oxygenation indices in these patients. However, the molecular mechanisms underlying potential changes in outcomes remain unclear. Based on these clinical findings, this study was designed to examine the effects of intravenous methylprednisolone on circulating inflammatory biomarkers in pediatric ARDS patients. Design: Double-blind, placebo-controlled randomized trial with blood collection on study entry and day 7. Setting: Tertiary care children's hospital. Patients: Children (0-18. years) with ARDS undergoing mechanical ventilation. Interventions: 35 children were randomized …
Extraction And Biochemical Characterization Of Alligator Mississippiensis Glycosaminoglycans And An Ex-Vivo Murine Pilot Study To Test Their Potential Effect On A Selected Panel Of Genes Associated With Cystic Fibrosis, Jose Daniel Estrada Andino
Extraction And Biochemical Characterization Of Alligator Mississippiensis Glycosaminoglycans And An Ex-Vivo Murine Pilot Study To Test Their Potential Effect On A Selected Panel Of Genes Associated With Cystic Fibrosis, Jose Daniel Estrada Andino
LSU Doctoral Dissertations
Cystic fibrosis (CF) is a genetic disorder with a median survival age of 40.7 years. Chronic airway inflammation and dehydration are critical features of CF. The size and structure-dependent hydration and anti-inflammatory properties of glycosaminoglycans (GAGs) such as hyaluronic acid (HA) may help ameliorate these symptoms. The GAGs contained in farmed Alligator mississippiensis by-products offer a potential to improve waste management practices and increase revenue in the alligator industry, through their development for use in biomedical applications. This study aimed to efficiently extract and characterize GAGs from alligator carcasses (ACS), backstraps (ABS), feet (AFT) and eyeballs (AEB), to evaluate their …
Nucleobindin-2: A Novel Regulator Of Immune-Metabolic Interactions, Anthony Ravussin
Nucleobindin-2: A Novel Regulator Of Immune-Metabolic Interactions, Anthony Ravussin
LSU Doctoral Dissertations
Over the past half century, obesity has become a widespread concern to human health. Obesity is defined as having a body mass index above 30 and is accompanied by altered metabolic physiology. Obesity is one of the leading causes of mortality in the United States and in the world. The prevalence of obesity has increased over the past few decades. High body fat in adipose, excess calorie intake, low aerobic fitness are all associated with the comorbidities of obesity. Recently, an emphasis has been given to increased leukocytes in adipose tissue and the resulting low-grade systemic inflammation on the development …