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Scanning Probe Investigations Of Magnetic Nanoparticles, Protein Binding And The Synthesis Of Rare Earth Oxide Nanoparticles Using Nanoscale Lithography, Lauren Elizabeth Englade-Franklin
Scanning Probe Investigations Of Magnetic Nanoparticles, Protein Binding And The Synthesis Of Rare Earth Oxide Nanoparticles Using Nanoscale Lithography, Lauren Elizabeth Englade-Franklin
LSU Doctoral Dissertations
Approaches to prepare spatially selective surfaces were developed in this dissertation for constructing assemblies of biomolecules and inorganic materials. Nanoscale surface patterns of organic thin films were prepared using particle lithography combined with organosilane chemistry. Biological and inorganic nanomaterials can be patterned with tailorable periodicities, which can be controlled by selecting the diameter of mesospheres used as surface masks. The surface platforms of well-defined nanopatterns are ideal for high resolution investigations using scanning probe microscopy (SPM). Local measurements of surface properties combined with visualization of the steps of chemical reactions at the molecular level were accomplished. Fundamental studies of the …
Chronic Toxicity Of Nano Metallics On Red Swamp Crayfish (Procambarus Clarkii) In Laboratory And Mesocosm Studies, Jake Andrew Farlow
Chronic Toxicity Of Nano Metallics On Red Swamp Crayfish (Procambarus Clarkii) In Laboratory And Mesocosm Studies, Jake Andrew Farlow
LSU Master's Theses
Nanotechnology has become integrated in commercial, industrial and medical products, and its use has grown exponentially in the past several years. Although potential applications of nanoparticles (NPs) are numerous, concerns about their water quality, environmental, and human health impacts remain unclear. Crayfish are ubiquitous to streams and wetland habitats, are used as a food source, and inhabit areas that could be impacted by water quality issues. Numerous studies have been conducted on the toxicity of various classes of agricultural pesticides and oils to crayfish (Procambarus clarkii) as a non-target organism. However, there is little evidence published on chronic toxicity of …
Bioavailability Of Alpha-Tocopherol Entrapped In Poly (Lactide-Co-Glycolide) (Plga) And Plga-Chitosan Nanoparticles, Lacey Caroline Simon
Bioavailability Of Alpha-Tocopherol Entrapped In Poly (Lactide-Co-Glycolide) (Plga) And Plga-Chitosan Nanoparticles, Lacey Caroline Simon
LSU Master's Theses
Alpha-tocopherol (áT) is a hydrophobic, antioxidant molecule shown to prevent or retard the effects of free radicals associated with diseases. It is hypothesized that the bioavailability of áT can be improved when entrapped in PLGA (Poly lactide-co-glycolide) and PLGA-Chi (PLGA-Chitosan) nanoparticles and that the mucoadhesive properties of chitosan may enhance absorption more than PLGA alone. PLGA and PLGA-Chi NPs synthesized with PVA as surfactant were characterized by measuring entrapment efficiency, size, PDI, and zeta potential when suspended in DI water. Nanoparticle physical stability was evaluated via NP exposure to environmental pH ranging from 2.5-9. Chemical stability of entrapped áT was …
Physical Stability Of Poly (Lactic-Co-Glycolic Acid) And Plga/Chitosan Nanoparticles And Chemical Stability Of Entrapped Alpha-Tocopherol And Lutein, Meocha Whaley
LSU Master's Theses
The published benefits of polymeric nanoparticles as a system for antioxidant delivery have encompassed topics of improved oral delivery, bioavailability, and modified release to name a few. Generally accepted as safe polymers Poly(lactic-coglycolic acid) and the mucoadhesive chitosan were selected to entrap alpha-tocopherol and lutein. This study proposed to assess the physical stability of PLGA and Chi/PLGA nanoparticles with entrapped bioactives in varying biological suspension medias ( water, pbs, hbss and cell media). Also, to assess the chemical stability of the entrapped antioxidants lutein and alpha-tocopherol within the same media as deemed relevant for in-vitro and and in-vivo studies. Of …
Synthetic Routes To Therapeutic Agents Via Masked Functionalities: From Orthogonal Peptide Crosslink To Photothermal Cancer Prodrug, Chyree Shantel Batton
Synthetic Routes To Therapeutic Agents Via Masked Functionalities: From Orthogonal Peptide Crosslink To Photothermal Cancer Prodrug, Chyree Shantel Batton
LSU Doctoral Dissertations
The theonellamides are a family of compounds distinguished by their crosslinking ô-histidinoalanine (ô-HAL) residue. Part one of this dissertation details the synthesis of an orthogonally protected ô-HAL building block that will be incorporated into a total synthesis of theonellamide C. Selective deprotection of each amine and acid of this orthogonally protected building block is also demonstrated. Various reaction partners for the assembly of ô-histidinoalanine were explored. One approach involved the coupling of N-Fmoc-â-iodoalanine benzyl ester and (Nðim)-blocked histidine nucleophiles including a fused bicyclic urea and a Boc-His(Nð-Pac)-OMe. While the imidazolium salts were identified by mass spectrometry, elimination of the iodide …