Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Functional Morphology Of The Lingual Apparatus Of Sandgrouse (Aves: Pteroclidae)., Werner Muller
Functional Morphology Of The Lingual Apparatus Of Sandgrouse (Aves: Pteroclidae)., Werner Muller
LSU Historical Dissertations and Theses
The morphology of the lingual apparatus of three species of sandgrouse (Aves; Pteroclidae) has been described. All biomechanically important parts were included in the description, i.e., all muscles potentially involved in the functioning of the lingual apparatus, all skeletal parts, the salivary glands associated with the lingual apparatus, and the surface morphology of the oropharyngeal cavity. For each muscle its potential functions have been described. In a comparison with data from the literature of three other groups of birds it was found that the functional organization of the lingual apparatus of the sandgrouse is strikingly similar to the one found …
Resolution Of Genotypic And Phenotypic Properties Of Herpes Simplex Virus Type 1 Temperature-Sensitive Mutanttsz47: Evidence For Allelic Complementation In The Unique Long Gene Ul28., James Daniel Cavalcoli
Resolution Of Genotypic And Phenotypic Properties Of Herpes Simplex Virus Type 1 Temperature-Sensitive Mutanttsz47: Evidence For Allelic Complementation In The Unique Long Gene Ul28., James Daniel Cavalcoli
LSU Historical Dissertations and Theses
This research focuses on the phenotypic and genotypic characteristics of a temperature sensitive mutant of herpes simplex virus type 1, HSV-1 (tsZ47). This virus was previously reported to carry two different mutations, which caused it to be temperature sensitive for viral replication and transport of glycoproteins to the infected cell surface. However, altered glycoprotein transport to the cell surface was not observed in this study. In addition, cells transformed with unique long gene 28 (UL28), but not glycoprotein B (gB), complemented tsZ47 at the nonpermissive temperature indicating that a single mutation could restore the wild type phenotype to the mutant …
A New Therapeutic Concept Based On Hyperstabilization Of Sense-Antisense Duplexes., Dae-Yong Kim
A New Therapeutic Concept Based On Hyperstabilization Of Sense-Antisense Duplexes., Dae-Yong Kim
LSU Historical Dissertations and Theses
We proposed that known helix-stabilizing, minor-groove binding agents such as CC-1065 and its analog, U-71,184, might be feasibly targeted to specific mRNA by tethering them to antisense oligonucleotides. The CC-1065-tethered antisense oligonucleotide might be hyperstabilized to the target mRNA and arrest the translation of mRNA. Our hypothesis is that these agents can bind and increase the stability of RNA-DNA duplexes which may occur between mRNA and antisense oligonucleotides. To verify our hypothesis, we evaluated the ability of CC-1065, U-71,184, and distamycin A to bind and hyperstabilize the 20-mer sense sequence (5$\sp\prime$-TTACTTCAGTTATGAGACCA-3$\sp\prime)$ duplexed with complementary (antisense) oligonucleotide sequence made with phosphodiester …
Strongylus Vulgaris: Protection, Pathology And Humoral Immune Responses In The Immunized Pony., Clifton Michael Monahan
Strongylus Vulgaris: Protection, Pathology And Humoral Immune Responses In The Immunized Pony., Clifton Michael Monahan
LSU Historical Dissertations and Theses
Protective resistance to Strongylus vulgaris infection was examined by immunization of ponies with radiation-attenuated larvae or soluble parasite homogenates. Twelve yearling ponies raised and maintained under parasite-free conditions were divided into four groups which received either radiation-attenuated L$\sb3$; aqueous-soluble adult somatic antigens plus adjuvant; aqueous-soluble larval somatic antigens with excretory/secretory products and adjuvant; or media with adjuvant. Ponies were immunized twice; radiation-attenuated L$\sb3$ were administered orally and soluble antigens or control injections were given intramuscularly. Six weeks following the second immunization, ponies were challenged per os with virulent S. vulgaris L$\sb3.$ Ponies were monitored twice daily for rectal temperatures and …