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Fetal Baboon Sex-Specific Outcomes In Adipocyte Differentiation At 0.9 Gestation In Response To Moderate Maternal Nutrient Reduction, Y. D. Tchoukalova, R. Krishnapuram, U. A. White, D. Burk, X. Fang, M. J. Nijland, P. W. Nathanielsz
Fetal Baboon Sex-Specific Outcomes In Adipocyte Differentiation At 0.9 Gestation In Response To Moderate Maternal Nutrient Reduction, Y. D. Tchoukalova, R. Krishnapuram, U. A. White, D. Burk, X. Fang, M. J. Nijland, P. W. Nathanielsz
Faculty Publications
Objective:To investigate in vitro adipocyte differentiation in baboon fetuses in response to reduced maternal nutrition.Design:Cross-sectional comparison of adipocyte differentiation in normally grown fetuses and fetuses of pregnant baboons fed 70% of the control global diet from 30 days of pregnancy to term.Subjects:The subjects comprised control (CTR) fetuses (five female and five male) of mothers fed ad libitum and fetuses of mothers fed 70% of the global diet consumed by CTR (maternal nutrient reduction (MNR), five female and five male fetuses). The expression of genes/proteins involved in adipogenesis (PPARγ, FABP4 and adiponectin) and brown adipose tissue development (UCP1, TBX15 and COXIV) …
Role Of Adipose Tissue In The Pathogenesis And Treatment Of Metabolic Syndrome, David Sanchez-Infantes, Jacqueline M. Stephens
Role Of Adipose Tissue In The Pathogenesis And Treatment Of Metabolic Syndrome, David Sanchez-Infantes, Jacqueline M. Stephens
Faculty Publications
© Springer International Publishing Switzerland 2014. Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrate organisms. Excess adipocyte size or number is a hallmark of obesity, which is currently a global epidemic. Obesity is not only the primary disease of fat cells, but also a major risk factor for the development of Type 2 diabetes, cardiovascular disease, hypertension, and metabolic syndrome (MetS). Today, adipocytes and adipose tissue are no longer considered passive participants in metabolic pathways. In addition to storing lipid, adipocytes are highly insulin sensitive cells that have important endocrine functions. Altering any …