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Iowa State University

2018

Plant Sciences

Graduate Theses and Dissertations

Abiotic stress

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A Tale Of Regulation: Analysis Of The Role Of Snrk1 And Glutathione In Autophagy In Arabidopsis Thaliana, Junmarie Soto-Burgos Jan 2018

A Tale Of Regulation: Analysis Of The Role Of Snrk1 And Glutathione In Autophagy In Arabidopsis Thaliana, Junmarie Soto-Burgos

Graduate Theses and Dissertations

Autophagy is a degradation process in which cells break down and recycle their cytoplasmic contents when subjected to environmental stress or during development. Upon activation of autophagy, a double membrane vesicle called the autophagosome forms around the cargo and delivers it to the vacuole/lysosome for degradation. In mammals, regulation of autophagy has been extensively studied. In plants, key regulators of autophagy have been identified, but their upstream components are poorly understood. This dissertation summarizes my efforts in studying the regulation of autophagy in Arabidopsis thaliana.

AMPK in animals, and its yeast homolog Snf1, are positive regulators of autophagy. The ...