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Articles 1 - 30 of 63
Full-Text Articles in Entire DC Network
The North American Carbon Program Multi-Scale Synthesis And Terrestrial Model Intercomparison Project – Part 1: Overview And Experimental Design, D. N. Huntzinger, C. Schwalm, A, M, Michalak, K. Schaefer, A. W. King, Y. Wei, A. Jacobson, S. Liu, R. B. Cook, W. M. Post, G. Berthier, D Hayes, M. Huang, A. Ito, H. Lei, Chaoqun (Crystal) Lu, J. Mao, C. H. Peng, S. Peng, B. Poulter, D. Ricciuto, X. Shi, Hanqin Tian, W. Wang, N. Zeng, F. Zhao, Q. Zhu
The North American Carbon Program Multi-Scale Synthesis And Terrestrial Model Intercomparison Project – Part 1: Overview And Experimental Design, D. N. Huntzinger, C. Schwalm, A, M, Michalak, K. Schaefer, A. W. King, Y. Wei, A. Jacobson, S. Liu, R. B. Cook, W. M. Post, G. Berthier, D Hayes, M. Huang, A. Ito, H. Lei, Chaoqun (Crystal) Lu, J. Mao, C. H. Peng, S. Peng, B. Poulter, D. Ricciuto, X. Shi, Hanqin Tian, W. Wang, N. Zeng, F. Zhao, Q. Zhu
Chaoqun (Crystal) Lu
Terrestrial biosphere models (TBMs) have become an integral tool for extrapolating local observations and understanding of land–atmosphere carbon exchange to larger regions. The North American Carbon Program (NACP) Multi-scale synthesis and Terrestrial Model Intercomparison Project (MsTMIP) is a formal model intercomparison and evaluation effort focused on improving the diagnosis and attribution of carbon exchange at regional and global scales. MsTMIP builds upon current and past synthesis activities, and has a unique framework designed to isolate, interpret, and inform understanding of how model structural differences impact estimates of carbon uptake and release. Here we provide an overview of the MsTMIP effort …
The Footprint And The Stepping Foot: Archival Records, Evidence, And Time, Kimberly D. Anderson
The Footprint And The Stepping Foot: Archival Records, Evidence, And Time, Kimberly D. Anderson
Kimberly D. Anderson
This paper provides an analysis of the archival concepts of “record” and “evidence” as socio-cultural constructs arising out of a particular view of time. Archival records are usually characterized as having certain relationships to evidence in its temporal aspects—specifically, the requirement for a temporal disconnect between creation and use. This disconnect also necessitates a break between knowledge and the knower in which the record must be externalized and set aside from its creator in order to have “recordness”. This paper explores how Western concepts of time impact concepts of records and archival evidences and proposes an alternative framing. Since records …
Interplay Of Hydrogen Bonds And N→Π* Interactions In Proteins, Gail J. Bartlett, Robert W. Newberry, Brett Vanveller, Ronald T. Raines, Derek N. Woolfson
Interplay Of Hydrogen Bonds And N→Π* Interactions In Proteins, Gail J. Bartlett, Robert W. Newberry, Brett Vanveller, Ronald T. Raines, Derek N. Woolfson
Brett VanVeller
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, hydrogen bonds, electrostatic effects, and van der Waals interactions. Among these interactions, the hydrogen bond is distinct in having its origins in electron delocalization. Recently, another type of electron delocalization, the n→π* interaction between carbonyl groups, has been shown to play a role in stabilizing protein structure. Here we examine the interplay between hydrogen bonding and n→π* interactions. To address this issue, we used data available from high-resolution protein crystal structures to interrogate asparagine side-chain oxygen atoms that are both acceptors of a hydrogen bond and donors of …
Ionic Liquids In Analytical Chemistry: Fundamentals, Advances, And Perspectives, Tien D. Ho, Cheng Zhang, Leandro W. Hantao, Jared L. Anderson
Ionic Liquids In Analytical Chemistry: Fundamentals, Advances, And Perspectives, Tien D. Ho, Cheng Zhang, Leandro W. Hantao, Jared L. Anderson
Jared L. Anderson
Since their initial discovery in 1914, ionic liquids (ILs) have been widely studied in multiple chemistry disciplines. Applications of ILs in analytical chemistry have enjoyed much success and contributed to the rapid evolution of the ionic liquid field. ILs are collectively known as organic salts which possess melting points at or below 100 °C. In most cases, ILs are composed of an organic cation and an organic or inorganic anion. It has been estimated there can be up to 1018 possible combinations of ILs, due to the ability to interchange their corresponding cationic/anionic moieties.
A Free-Ranging, Feral Mare Equus Caballus Affords Similar Maternal Care To Her Genetic And Adopted Offspring, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
A Free-Ranging, Feral Mare Equus Caballus Affords Similar Maternal Care To Her Genetic And Adopted Offspring, Cassandra M.V. Nuñez, James S. Adelman, Daniel I. Rubenstein
Cassandra M.V. Nuñez
Adoption of nongenetic offspring occurs in a variety of species but is rare in equids. We report a case of adoption by a free-ranging, feral mare Equus caballus and compare the maternal care received by her genetic offspring (born 1995) to that of her adopted offspring (born 1996) for the first 30 weeks of development. We compare five measures of care: (1) total time spent suckling, (2) mare aggression during suckling, (3) number of mare-terminated suckling bouts, (4) contact maintenance, and (5) mare-foal distance. For most behaviors, we detected no difference in the mare’s treatment of the two foals; however, …
Defining The Value Of Injection Current And Effective Electrical Contact Area For Egain-Based Molecular Tunneling Junctions, Felice C. Simeone, Hyo Jae Yoon, Martin M. Thuo, Jabulani R. Barber, Barbara Smith, George M. Whitesides
Defining The Value Of Injection Current And Effective Electrical Contact Area For Egain-Based Molecular Tunneling Junctions, Felice C. Simeone, Hyo Jae Yoon, Martin M. Thuo, Jabulani R. Barber, Barbara Smith, George M. Whitesides
Martin M. Thuo
Analysis of rates of tunneling across self-assembled monolayers (SAMs) of n-alkanethiolates SCn (with n = number of carbon atoms) incorporated in junctions having structure AgTS-SAM//Ga2O3/EGaIn leads to a value for the injection tunnel current density J0 (i.e., the current flowing through an ideal junction with n = 0) of 103.6±0.3 A·cm–2 (V = +0.5 V). This estimation of J0 does not involve an extrapolation in length, because it was possible to measure current densities across SAMs over the range of lengths n = 1–18. This value of J0 is estimated under the assumption that values of the geometrical contact area …
Transgenic Mosquitoes Expressing A Phospholipase A(2) Gene Have A Fitness Advantage When Fed Plasmodium Falciparum-Infected Blood, Ryan C. Smith, Christopher Kizito, Jason L. Rasgon, Marcelo Jacobs-Lorena
Transgenic Mosquitoes Expressing A Phospholipase A(2) Gene Have A Fitness Advantage When Fed Plasmodium Falciparum-Infected Blood, Ryan C. Smith, Christopher Kizito, Jason L. Rasgon, Marcelo Jacobs-Lorena
Ryan C. Smith
Genetically modified mosquitoes have been proposed as an alternative strategy to reduce the heavy burden of malaria. In recent years, several proof-of-principle experiments have been performed that validate the idea that mosquitoes can be genetically modified to become refractory to malaria parasite development. We have created two transgenic lines of Anophelesstephensi, a natural vector of Plasmodium falciparum, which constitutively secrete a catalytically inactive phospholipase A2 (mPLA2) into the midgut lumen to interfere with Plasmodium ookinete invasion. Our experiments show that both transgenic lines expressing mPLA2 significantly impair the development of rodent malaria parasites, but only one line impairs the development …
A Microfluidic Paper-Based Electrochemical Biosensor Array For Multiplexed Detection Of Metabolic Biomarkers, Chen Zhao, Martin M. Thuo, Xinyu Liu
A Microfluidic Paper-Based Electrochemical Biosensor Array For Multiplexed Detection Of Metabolic Biomarkers, Chen Zhao, Martin M. Thuo, Xinyu Liu
Martin M. Thuo
Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to …
Detection Of Boronic Acids Through Excited-State Intramolecular Proton-Transfer Fluorescence, Matthew R. Aronoff, Brett Vanveller, Ronald T. Raines
Detection Of Boronic Acids Through Excited-State Intramolecular Proton-Transfer Fluorescence, Matthew R. Aronoff, Brett Vanveller, Ronald T. Raines
Brett VanVeller
Boronic acids are versatile reagents for the chemical synthesis of organic molecules. They and other boron-containing compounds can be detected readily by the interruption of the excited-state intramolecular proton transfer (ESIPT) of 10-hydroxybenzo[h]quinolone. This method is highly sensitive and selective, and useful for monitoring synthetic reactions and detecting boron-containing compounds on a solid support.
Project Complexity Mapping In Five Dimensions For Complex Transportation Projects, Douglas D. Gransberg, Jennifer S. Shane, Carla Lopez Del Puerto
Project Complexity Mapping In Five Dimensions For Complex Transportation Projects, Douglas D. Gransberg, Jennifer S. Shane, Carla Lopez Del Puerto
Douglas D. Gransberg
Traditional three-dimensional project management theory is based on optimizing the cost-schedule-technical dimensions. Recent studies in the United Kingdom, Canada, and Australia have shown that the current project management body of knowledge may not be adequate to address interrelated and dependent variables encountered on complex projects. This paper reports the findings of an international research team’s detailed study of eighteen complex projects, which confirms the findings of the previous research and proposes a framework upon which a complex transportation project’s scope of work can be better conceptualized and a methodology to graphically display a project’s complexity in order to better understand …
Joint User Grouping And Linear Virtual Beamforming: Complexity, Algorithms And Approximation Bounds, Mingyi Hong, Zi Xu, Meisam Razaviyayn, Zhi-Quan Luo
Joint User Grouping And Linear Virtual Beamforming: Complexity, Algorithms And Approximation Bounds, Mingyi Hong, Zi Xu, Meisam Razaviyayn, Zhi-Quan Luo
Mingyi Hong
In a wireless system with a large number of distributed nodes, the quality of communication can be greatly improved by pooling the nodes to perform joint transmission/reception. In this paper, we consider the problem of optimally selecting a subset of nodes from potentially a large number of candidates to form a virtual multi-antenna system, while at the same time designing their joint linear transmission strategies. We focus on two specific application scenarios: 1) multiple single antenna transmitters cooperatively transmit to a receiver; 2) a single transmitter transmits to a receiver with the help of a number of cooperative relays. We …
More Thoughts On Microsoft, David R. King
More Thoughts On Microsoft, David R. King
David King
The analysis examining “The case of Microsoft’s Surface Tablet” was developed in the Spring of 2013, but the predictive ability of SWOT analysis is borne out by current events with Steve Ballmer announcing his retirement and Microsoft’s purchase of Nokia’s mobile division. The purchase of Nokia’s mobile division was enabled by the financial assets of Microsoft highlighted by the article, and it fills two strategic needs.
Aerodynamic Simulation Of Vertical-Axis Wind Turbines, A. Korobenko, Ming-Chen Hsu, I. Akkerman, Y. Bazilevs
Aerodynamic Simulation Of Vertical-Axis Wind Turbines, A. Korobenko, Ming-Chen Hsu, I. Akkerman, Y. Bazilevs
Ming-Chen Hsu
Full-scale, 3D, time-dependent aerodynamics modeling and simulation of a Darrieus-type vertical-axis wind turbine (VAWT) is presented. The simulations are performed using a moving-domain finite-element-based ALE-VMS technique augmented with a sliding-interface formulation to handle the rotor-stator interactions present. We simulate a single VAWT using a sequence of meshes with increased resolution to assess the computational requirements for this class of problems. The computational results are in good agreement with experimental data. We also perform a computation of two side-by-side counterrotating VAWTs to illustrate how the ALE-VMS technique may be used for the simulation of multiple turbines placed in arrays.
A Divalent Protecting Group For Benzoxaboroles, Brett Vanveller, Matthew R. Aronoff, Ronald T. Raines
A Divalent Protecting Group For Benzoxaboroles, Brett Vanveller, Matthew R. Aronoff, Ronald T. Raines
Brett VanVeller
1-Dimethylamino-8-methylaminonaphthalene is put forth as a protecting group for benzoxaboroles. The ensuing complex is fluorescent, charge-neutral, highly stable under basic conditions, stable to anhydrous acid, and readily cleavable in aqueous acid to return the free benzoxaborole.
The Genome And Developmental Transcriptome Of The Strongylid Nematode Haemonchus Contortus, Erich M. Schwarz, Pasi K. Korhonen, Bronwyn E. Campbell, Neil D. Young, Aaron R. Jex, Abdul Jabbar, Ross S. Hall, Alinda Mondal, Adina C. Howe, Jason Pell, Andreas Hofmann, Peter R. Boag, Xing-Quan Zhu, T. Ryan Gregory, Alex Loukas, Brian A. Williams, Igor Antoshechkin, C. Titus Brown, Paul W. Sternberg, Robin B. Gasser
The Genome And Developmental Transcriptome Of The Strongylid Nematode Haemonchus Contortus, Erich M. Schwarz, Pasi K. Korhonen, Bronwyn E. Campbell, Neil D. Young, Aaron R. Jex, Abdul Jabbar, Ross S. Hall, Alinda Mondal, Adina C. Howe, Jason Pell, Andreas Hofmann, Peter R. Boag, Xing-Quan Zhu, T. Ryan Gregory, Alex Loukas, Brian A. Williams, Igor Antoshechkin, C. Titus Brown, Paul W. Sternberg, Robin B. Gasser
Adina Howe
Background The barber's pole worm, Haemonchus contortus, is one of the most economically important parasites of small ruminants worldwide. Although this parasite can be controlled using anthelmintic drugs, resistance against most drugs in common use has become a widespread problem. We provide a draft of the genome and the transcriptomes of all key developmental stages of H. contortus to support biological and biotechnological research areas of this and related parasites. Results The draft genome of H. contortus is 320 Mb in size and encodes 23,610 protein-coding genes. On a fundamental level, we elucidate transcriptional alterations taking place throughout the life …
Paramagnetic Ionic Liquids For Measurements Of Density Using Magnetic Levitation, David K. Bwambok, Martin M. Thuo, Manza B.J. Atkinson, Katherine A. Mirica, Nathan D. Shapiro, George M. Whitesides
Paramagnetic Ionic Liquids For Measurements Of Density Using Magnetic Levitation, David K. Bwambok, Martin M. Thuo, Manza B.J. Atkinson, Katherine A. Mirica, Nathan D. Shapiro, George M. Whitesides
Martin M. Thuo
Paramagnetic ionic liquids (PILs) provide new capabilities to measurements of density using magnetic levitation (MagLev). In a typical measurement, a diamagnetic object of unknown density is placed in a container containing a PIL. The container is placed between two magnets (typically NdFeB, oriented with like poles facing). The density of the diamagnetic object can be determined by measuring its position in the magnetic field along the vertical axis (levitation height, h), either as an absolute value or relative to internal standards of known density. For density measurements by MagLev, PILs have three advantages over solutions of paramagnetic salts in aqueous …
Iron Oxidation Stimulates Organic Matter Decomposition In Humid Tropical Forest Soils, Steven J. Hall, Whendee L. Silver
Iron Oxidation Stimulates Organic Matter Decomposition In Humid Tropical Forest Soils, Steven J. Hall, Whendee L. Silver
Steven J. Hall
Humid tropical forests have the fastest rates of organic matter decomposition globally, which often coincide with fluctuating oxygen (O2) availability in surface soils. Microbial iron (Fe) reduction generates reduced iron [Fe(II)] under anaerobic conditions, which oxidizes to Fe(III) under subsequent aerobic conditions. We demonstrate that Fe (II) oxidation stimulates organic matter decomposition via two mechanisms: (i) organic matter oxidation, likely driven by reactive oxygen species; and (ii) increased dissolved organic carbon (DOC) availability, likely driven by acidification. Phenol oxidative activity increased linearly with Fe(II) concentrations (P < 0.0001, pseudo R2 = 0.79) in soils sampled within and among five tropical forest sites. A similar pattern occurred in the absence of soil, suggesting an abiotic driver of this reaction. No phenol oxidative activity occurred in soils under anaerobic conditions, implying the importance of oxidants such as O2 or hydrogen peroxide (H2O2) in addition to Fe(II). Reactions between Fe(II) and H2O2 generate hydroxyl radical, a strong nonselective oxidant of organic compounds. We found increasing consumption of H2O2 as soil Fe(II) concentrations increased, suggesting that reactive oxygen species produced by Fe(II) oxidation explained variation in phenol oxidative activity among samples. Amending soils with Fe(II) at field concentrations stimulated short-term C mineralization by up to 270%, likely via a second mechanism. Oxidation of Fe(II) drove a decrease in pH and a monotonic increase in DOC; a decline of two pH units doubled DOC, likely stimulating microbial respiration. We obtained similar results by manipulating soil acidity independently of Fe(II), implying that Fe(II) oxidation affected C substrate availability via pH fluctuations, in addition to producing reactive oxygen species. Iron oxidation coupled to organic matter decomposition contributes to rapid rates of C cycling across humid tropical forests in spite of periodic O2 limitation, and may help explain the rapid turnover of complex C molecules in these soils.
Joint Access Point Selection And Power Allocation For Uplink Wireless Networks, Mingyi Hong, Alfredo Garcia, Jorge Barrera, Stephen G. Wilson
Joint Access Point Selection And Power Allocation For Uplink Wireless Networks, Mingyi Hong, Alfredo Garcia, Jorge Barrera, Stephen G. Wilson
Mingyi Hong
We consider the distributed uplink resource allocation problem in a multi-carrier wireless network with multiple access points (APs). Each mobile user can optimize its own transmission rate by selecting a suitable AP and by controlling its transmit power. Our objective is to devise suitable algorithms by which mobile users can jointly perform these tasks in a distributed manner. Our approach relies on a game theoretic formulation of the joint power control and AP selection problem. In the proposed game, each user is a player with an associated strategy containing a discrete variable (the AP selection decision) and a continuous vector …
Covalent Immobilization Of Lysozyme On Ethylene Vinyl Alcohol Films For Nonmigrating Antimicrobial Packaging Applications, V. Muriel-Galet, Joey N. Talbert, P. Hernandez-Munoz, R. Gavara, J. M. Goddard
Covalent Immobilization Of Lysozyme On Ethylene Vinyl Alcohol Films For Nonmigrating Antimicrobial Packaging Applications, V. Muriel-Galet, Joey N. Talbert, P. Hernandez-Munoz, R. Gavara, J. M. Goddard
Joey Talbert
The objective of this study was to develop a new antimicrobial film, in which lysozyme was covalently attached onto two different ethylene vinyl alcohol copolymers (EVOH 29 and EVOH 44). The EVOH surface was modified with UV irradiation treatment to generate carboxylic acid groups, and lysozyme was covalently attached to the functionalized polymer surface. Surface characterization of control and modified films was performed using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and dye assay. The value of protein loading after attachment on the surface was 8.49 μg protein/cm2 and 5.74 μg protein/cm2 for EVOH 29 and EVOH 44, respectively, …
Adults With Greater Weight Satisfaction Report More Positive Health Behaviors And Have Better Health Status Regardless Of Bmi, Christine E. Blake, James R. Hebert, Duck-Chul Lee, Swann A. Adams, Susan E. Steck, Xuemei Sui, Jennifer L. Kuk, Meghan Baruth, Steven N. Blair
Adults With Greater Weight Satisfaction Report More Positive Health Behaviors And Have Better Health Status Regardless Of Bmi, Christine E. Blake, James R. Hebert, Duck-Chul Lee, Swann A. Adams, Susan E. Steck, Xuemei Sui, Jennifer L. Kuk, Meghan Baruth, Steven N. Blair
Duck-Chul Lee
Background. Prior studies suggest that weight satisfaction may preclude changes in behavior that lead to healthier weight among individuals who are overweight or obese. Objective. To gain a better understanding of complex relationships between weight satisfaction, weight-related health behaviors, and health outcomes. Design. Cross-sectional analysis of data from the Aerobics Center Longitudinal Study (ACLS). Participants. Large mixed-gender cohort of primarily white, middle-to-upper socioeconomic status (SES) adults with baseline examination between 1987 and 2002 (𝑛 19,003). Main Outcome Variables. Weight satisfaction, weight-related health behaviors, chronic health conditions, and clinical health indicators. Statistical Analyses Performed. Chi-square test, t-tests, and linear and multivariate …
Effect Of Continued Nitrogen Enrichment On Greenhouse Gas Emissions From A Wetland Ecosystem In The Sanjiang Plain, Northeast China: A 5 Year Nitrogen Addition Experiment, Changchun Song, Lili Wang, Hanqin Tian, Deyan Liu, Chaoqun (Crystal) Lu, Xiaofeng Xu, Lihua Zhang, Guisheng Yang, Zhongmei Wan
Effect Of Continued Nitrogen Enrichment On Greenhouse Gas Emissions From A Wetland Ecosystem In The Sanjiang Plain, Northeast China: A 5 Year Nitrogen Addition Experiment, Changchun Song, Lili Wang, Hanqin Tian, Deyan Liu, Chaoqun (Crystal) Lu, Xiaofeng Xu, Lihua Zhang, Guisheng Yang, Zhongmei Wan
Chaoqun (Crystal) Lu
Mounting evidence supports that wetland ecosystems, one of the largest carbon pools on the earth, are exposed to ample nitrogen (N) additions due to atmospheric deposition or N loading from upstream agricultural fertilizer application. However, our understanding of how N enrichment affects the fluxes of greenhouse gases (GHGs) in wetlands is weak. A 5 year N addition experiment was conducted to examine the responses of CH4 and N2O fluxes as well as ecosystem respiration from wetlands in the Sanjiang Plain, Northeast China, through 2005 to 2009. Four levels of N addition (control, 0 kg N ha−1 yr−1; low-level, 60 kg …
Distributed Linear Precoder Optimization And Base Station Selection For An Uplink Heterogeneous Network, Mingyi Hong, Zhi-Quan Luo
Distributed Linear Precoder Optimization And Base Station Selection For An Uplink Heterogeneous Network, Mingyi Hong, Zhi-Quan Luo
Mingyi Hong
In a heterogeneous wireless cellular network, each user may be covered by multiple access points such as macro/pico/relay/femto base stations (BS). An effective approach to maximize the sum utility (e.g., system throughput) in such a network is to jointly optimize users' linear procoders as well as their BS associations. In this paper, we first show that this joint optimization problem is NP-hard and thus is difficult to solve to global optimality. To find a locally optimal solution, we formulate the problem as a noncooperative game in which the users and the BSs both act as players. We introduce a set …
N→Π* Interactions Of Amides And Thioamides: Implications For Protein Stability, Robert W. Newberry, Brett Vanveller, Ilia A. Guzei, Ronald T. Raines
N→Π* Interactions Of Amides And Thioamides: Implications For Protein Stability, Robert W. Newberry, Brett Vanveller, Ilia A. Guzei, Ronald T. Raines
Brett VanVeller
Carbonyl–carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins. By combining experimental and computational approaches, we show that relevant amidic carbonyl groups associate through an n→π* donor–acceptor interaction with an energy of at least 0.27 kcal/mol. The n→π* interaction between two thioamides is 3-fold stronger than between two oxoamides due to increased overlap and reduced energy difference between the donor and acceptor orbitals. This result suggests that backbone thioamide incorporation could stabilize protein structures. Finally, we demonstrate that intimate carbonyl interactions are described more completely as donor–acceptor orbital interactions rather than dipole–dipole interactions.
House Finch Populations Differ In Early Inflammatory Signaling And Pathogen Tolerance At The Peak Of Mycoplasma Gallisepticum Infection, James S. Adelman, Laila Kirkpatrick, Jessica L. Grodio, Dana M. Hawley
House Finch Populations Differ In Early Inflammatory Signaling And Pathogen Tolerance At The Peak Of Mycoplasma Gallisepticum Infection, James S. Adelman, Laila Kirkpatrick, Jessica L. Grodio, Dana M. Hawley
James S. Adelman
Host individuals and populations often vary in their responses to infection, with direct consequences for pathogen spread and evolution. While considerable work has focused on the mechanisms underlying differences in resistance—the ability to kill pathogens— we know little about the mechanisms underlying tolerance— the ability to minimize fitness losses per unit pathogen. Here, we examine patterns and mechanisms of tolerance between two populations of house finches (Haemorhous [formerly Carpodacus] mexicanus) with different histories with the bacterial pathogen Mycoplasma gallisepticum (MG). After infection in a common environment, we assessed two metrics of pathology, mass loss and eye lesion severity, as proxies …
Extremes Of Nonlinear Vibration: Comparing Models Based On Moments, L-Moments, And Maximum Entropy, Steven R. Winterstein, Cameron A. Mackenzie
Extremes Of Nonlinear Vibration: Comparing Models Based On Moments, L-Moments, And Maximum Entropy, Steven R. Winterstein, Cameron A. Mackenzie
Cameron A. MacKenzie
Wind and wave loads on offshore structures show nonlinear effects, which require nonGaussian statistical models. Here we critically review the behavior of various nonGaussian models. We first survey moment-based models; in particular, the four-moment “Hermite” model, a cubic transformation often used in wind and wave applications. We then derive an “L-Hermite” model, an alternative cubic transformation calibrated by the response “L-moments” rather than its ordinary statistical moments. These L-moments have recently found increasing use, in part because they show less sensitivity to distribution tails than ordinary moments. We find here, however, that these L-moments may not convey sufficient information to …
Safety Impacts Of Signal-Warning Flashers And Speed Control At High-Speed Signalized Intersections, Zifeng Wu, Anuj Sharma, Fred L. Mannering, Shefang Wang
Safety Impacts Of Signal-Warning Flashers And Speed Control At High-Speed Signalized Intersections, Zifeng Wu, Anuj Sharma, Fred L. Mannering, Shefang Wang
Anuj Sharma
For many years, to reduce the crash frequency and severity at high-speed signalized intersections, warning flashers have been used to alert drivers of potential traffic-signal changes. Recently, more aggressive countermeasures at such intersections include a speed-limit reduction in addition to warning flashers. While such speed-control strategies have the potential to further improve the crash-mitigation effectiveness of warning flashers, a rigorous statistical analysis of crash data from such intersections has not been undertaken to date. This paper uses 10-year crash data from 28 intersections in Nebraska (all with intersection approaches having signal-warning flashers; some with no speed-limit reduction, and the others …
Enterobacter-Activated Mosquito Immune Responses To Plasmodium Involve Activation Of Srpn6 In Anopheles Stephensi, Ryan C. Smith, Abraham G. Eappen, Marcelo Jacobs-Lorena
Enterobacter-Activated Mosquito Immune Responses To Plasmodium Involve Activation Of Srpn6 In Anopheles Stephensi, Ryan C. Smith, Abraham G. Eappen, Marcelo Jacobs-Lorena
Ryan C. Smith
Successful development of Plasmodium in the mosquito is essential for the transmission of malaria. A major bottleneck in parasite numbers occurs during midgut invasion, partly as a consequence of the complex interactions between the endogenous microbiota and the mosquito immune response. We previously identified SRPN6 as an immune component which restricts Plasmodium berghei development in the mosquito. Here we demonstrate that SRPN6 is differentially activated by bacteria in Anopheles stephensi, but only when bacteria exposure occurs on the lumenal surface of the midgut epithelium. Our data indicate that AsSRPN6 is strongly induced following exposure to Enterobacter cloacae, a common component …
55 Years Old With A 33 Year Library Career: What Now?, Kathy A. Parsons
55 Years Old With A 33 Year Library Career: What Now?, Kathy A. Parsons
Kathy A. Parsons
After reading the July 2012 Will’s World column “Your Mileage May Vary” in American Libraries, I found myself pondering about library fatigue, retirement, and the value of what I do for a living. In 2013, I will be 55 with 33 years of experience in libraries. Was I that librarian that needed to retire? I sincerely hope not but I saw a large part of myself in those statements. But part of me was still that person who could embrace technology changes and find fun in the everyday tasks. Was library fatigue taking over? Could I reverse “the odometer” and …
Finite Element Simulation Of Wind Turbine Aerodynamics: Validation Study Using Nrel Phase Vi Experiment, Ming-Chen Hsu, Ido Akkerman, Yuri Bazilevs
Finite Element Simulation Of Wind Turbine Aerodynamics: Validation Study Using Nrel Phase Vi Experiment, Ming-Chen Hsu, Ido Akkerman, Yuri Bazilevs
Ming-Chen Hsu
A validation study using the National Renewable Energy Laboratory (NREL) Phase VI wind turbine is presented. The aerodynamics simulations are performed using the finite element arbitrary Lagrangian–Eulerian–variational multiscale formulation augmented with weakly enforced essential boundary conditions. In all cases, the rotor is assumed to be rigid and its rotation is prescribed. The rotor-only simulations are performed for a wide range of wind conditions, and the computational results compare favorably with the experimental findings in all cases. The sliding-interface method is adopted for the simulation of the full wind turbine configuration. The full-wind-turbine simulations capture the blade–tower interaction effect, and the …
Medial Knee Joint Loading During Stair Ambulation And Walking While Carrying Loads, M. Hall, Jason C. Gillette, G. A. Mirka
Medial Knee Joint Loading During Stair Ambulation And Walking While Carrying Loads, M. Hall, Jason C. Gillette, G. A. Mirka
Jason C Gillette
Carrying loads while walking or using stairs is a common activity of daily living. Knee osteoarthritis is associated with increased external knee adduction moment (KAM) during walking, so understanding how the additional challenges of stairs and carrying loads impact these moments is of value. Sixteen healthy individuals performed three types of MOTION (walking, stair ascent, stair descent) under three LOAD conditions (no load, carrying a 13.6kg front load, carrying 13.6kg load in a backpack). Three-dimensional gait analysis was used to measure KAM. Results of ANOVA showed a significant main effect of both MOTION and LOAD on peak KAM (p<0.001), but no significant MOTION×LOAD interaction (p=0.250). Peak KAM during stair ascent was about two-times those seen in stair descent (p<0.001) and was significantly higher than those seen in walking (p<0.001). Conditions with LOAD generated significantly greater KAM as compared to the no-LOAD conditions (p<0.001). These findings suggest that carrying a load of moderate magnitude while climbing stairs significantly increases the peak KAM - a risk factor associated with knee osteoarthritis.