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Veterinary Microbiology and Preventive Medicine Publications

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Strong Concordance Between Transcriptomic Patterns Of Spleen And Peripheral Blood Leukocytes In Response To Avian Pathogenic Escherichia Coli Infection, Erin E. Sandford, Megan Orr, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont Dec 2012

Strong Concordance Between Transcriptomic Patterns Of Spleen And Peripheral Blood Leukocytes In Response To Avian Pathogenic Escherichia Coli Infection, Erin E. Sandford, Megan Orr, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont

Veterinary Microbiology and Preventive Medicine Publications

Avian pathogenic Escherichia coli (APEC) causes morbidity in chickens and exhibits zoonotic potential. Understanding host transcriptional responses to infection aids the understanding of protective mechanisms and serves to inform future colibacillosis control strategies. Transcriptomes of spleen and peripheral blood leukocytes (PBLs) of the same individual birds in response to APEC infection were compared to identify common response patterns and connecting pathways. More than 100 genes in three contrasts examining pathology and infection status were significantly differentially expressed in both tissues and similarly regulated. Tissue-specific differences in catalytic activity, however, appear between birds with mild and severe pathology responses. Early expression ...


Leukocyte Transcriptome From Chickens Infected With Avian Pathogenic Escherichia Coli Identifies Pathways Associated With Resistance, Erin E. Sandford, Megan Orr, Mandy Shelby, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont Jan 2012

Leukocyte Transcriptome From Chickens Infected With Avian Pathogenic Escherichia Coli Identifies Pathways Associated With Resistance, Erin E. Sandford, Megan Orr, Mandy Shelby, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont

Veterinary Microbiology and Preventive Medicine Publications

Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which is responsible for morbidity and mortality in chickens. Gene expression patterns have previously been demonstrated to differ between chicken populations that are resistant vs. susceptible to bacterial infection, but little is currently known about gene expression response to APEC. Increased understanding of gene expression patterns associated with resistance will facilitate genetic selection to increase resistance to APEC. Male broiler chicks were vaccinated at 2 weeks of age and challenged with APEC at 4 weeks of age. Peripheral blood leukocytes were collected at 1 and 5 day post-infection. Lesions on the liver, pericardium ...