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The Effects Of Perinatal Testosterone Exposure On The Dna Methylome Of The Mouse Brain Are Late-Emerging, Negar M. Ghahramani, Tuck Ngun, Pao-Yang Chen, Yuan Tian, Sangitha Krishnan, Stephanie Muir, Liudmilla Rubbi, Arthur P. Arnold, Geert De Vries, Nancy Forger, Matteo Pellegrini, Eric Vilain
The Effects Of Perinatal Testosterone Exposure On The Dna Methylome Of The Mouse Brain Are Late-Emerging, Negar M. Ghahramani, Tuck Ngun, Pao-Yang Chen, Yuan Tian, Sangitha Krishnan, Stephanie Muir, Liudmilla Rubbi, Arthur P. Arnold, Geert De Vries, Nancy Forger, Matteo Pellegrini, Eric Vilain
Neuroscience Institute Faculty Publications
Background
The biological basis for sex differences in brain function and disease susceptibility is poorly understood. Examining the role of gonadal hormones in brain sexual differentiation may provide important information about sex differences in neural health and development. Permanent masculinization of brain structure, function, and disease is induced by testosterone prenatally in males, but the possible mediation of these effects by long-term changes in the epigenome is poorly understood.
Methods
We investigated the organizational effects of testosterone on the DNA methylome and transcriptome in two sexually dimorphic forebrain regions—the bed nucleus of the stria terminalis/preoptic area and the striatum. To …