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Synthetic Development Of Cyanine Dyes And Investigation Of Their Interaction With Duplex Dna, Cory Holder
Synthetic Development Of Cyanine Dyes And Investigation Of Their Interaction With Duplex Dna, Cory Holder
Chemistry Theses
This thesis outlines two projects that examine interactions between DNA and cyanine dyes: 1) Investigation of monomethine cyanine dye through the synthesis and optical characteristics with a goal to synthetically manipulate these systems to develop a fluorescent biological probe. Several asymmetric and one symmetrical monomethine cyanine dyes were synthetically prepared and their optical properties versus structural changes were explored. Representative dyes were selected for spectroscopically investigating DNA binding to enhance existing probe designs. 2) Early stage development of a non-metalated photosensitizer for photodynamic therapy (PDT) by screening experimentally derived cleavage activities of a number of polymethine cyanine dyes with various …
Modifications To The Benzophenoxazine Architecture: Synthesis And Characterization, Vincent Martinez
Modifications To The Benzophenoxazine Architecture: Synthesis And Characterization, Vincent Martinez
Chemistry Theses
Nile red and Nile blue are intensely colored fluorescent dyes from the benzophenoxazine family. Modification of the donor amine with varying alkyl substituents was achieved with the principle aim being to investigate differences, both optical and physical, between dye scaffolds outfitted with secondary amines versus tertiary amines. These changes to the dyes’ architectural framework gave holistic effects to the bulk molecule by modulating hydrophobicity, optical properties, and protein binding constants to human serum albumin.