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Discovery Of New Biomarkers Of Mild Cognitive Impairment And Alzheimer's Disease Risk In Buccal Cells Using Laser Scanning Cytometry, Maxime Francois

Theses: Doctorates and Masters

Previous studies have shown that mild cognitive impairment (MCI) may reflect the early stages of more pronounced neurodegenerative disorders such as Alzheimer’s disease (AD). In clinical practice, patients with AD are not usually identified until the disease has progressed to a stage when primary prevention is no longer possible. Therefore there is a need for a minimally invasive and inexpensive diagnostic to identify those who exhibit cellular pathology indicative of MCI and AD risk so that they can be prioritised for primary prevention. Human buccal cells are accessible in a minimally invasive manner, and exhibit cytological and nuclear morphologies that …

High Performance Magneto-Optic Garnet Materials For Integrated Optics And Photonics, Mohammad Alam

Theses: Doctorates and Masters

This work explores the preparation, characteristics and properties of highly bismuth (Bi) substituted, metal doped, iron garnet compounds and investigates their potential for various emerging applications in the visible and near infrared spectral regions.

Bi-substituted iron garnet and garnet-oxide nanocomposite films of generic composition type (Bi, Dy/Lu)3(Fe, Ga/Al)5O12 are prepared by using a radio frequency (RF) magnetron sputtering technique. The physical properties (crystallinity, film morphology, optical absorption spectra across the visible spectral range and the elemental composition of layers), and magneto-optic behaviour (Faraday rotation, hysteresis loops of Faraday rotation, and magnetic switching behaviour) of these sputtered garnet films are investigated …