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Arachidonate Metabolism And The Signaling Pathway Of Induction Of Apoptosis By Oxidized Ldl/Oxysterol, Sankhavaram R. Panini, Lin Yang, Antonio E. Rusinol, Michael S. Sinensky, Joseph V. Bonventre, Christina C. Leslie
Arachidonate Metabolism And The Signaling Pathway Of Induction Of Apoptosis By Oxidized Ldl/Oxysterol, Sankhavaram R. Panini, Lin Yang, Antonio E. Rusinol, Michael S. Sinensky, Joseph V. Bonventre, Christina C. Leslie
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Owing at least in part to oxysterol components that can induce apoptosis, oxidized LDL (oxLDL) is cytotoxic to mammalian cells with receptors that can internalize it. Vascular cells possess such receptors, and it appears that the apoptotic response of vascular cells to the oxysterols borne by oxLDL is an important part of the atherogenic effects of oxLDL. Thus, an analysis of the signaling pathway of apoptotic induction by oxysterols is of value in understanding the development of atherosclerotic plaque. In a prior study, we demonstrated an induction of calcium ion flux into cells treated with 25-hydroxycholesterol (25-OHC) and showed that …