Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Alzheimer's Disease And Circadian Rhythms In A Drosophila Model, Lauren Alejo
Alzheimer's Disease And Circadian Rhythms In A Drosophila Model, Lauren Alejo
Honors Theses
Sleep disorders are commonly reported in Alzheimer's disease, a debilitating, age-related neurodegenerative disorder that affects neurons in the brain. Recently, several studies have suggested a role for sleep abnormalities and the internal "body clock" known as the circadian system, in the disease onset and progression. Since most of the data has been collected from mammals with complex neural circuitry, the molecular and cellular mechanisms that integrate the two neural networks are still limited. This study examined the relationship between circadian rhythmicity and Alzheimer's Disease presentation using a Drosophila model. Flies were crossed using the GAL4-UAS system to display Alzheimer's disease …