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Cognitive Impairments And Reversibility Among Opioid Users, Jingxiu Zhao

Scripps Senior Theses

Extensive studies have shown that acute and chronic use of opioids is related to cognitive impairments in different aspects. This study aims to explore impairments in executive functions among opioid users, focusing on cognitive impulsivity, cognitive flexibility, spatial working memory, and verbal working memory, as well as investigating the potential reversibility of these impairments under conditions of methadone maintenance treatment. In a sample including active opioid users, methadone maintenance patients, and healthy controls from downtown Los Angeles who do not meet exclusion criteria, the research will employ four tasks and scales to evaluate and compare executive functioning among these groups. …