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Understanding Huntington's Disease Using Machine Learning Approaches, Sonali Lokhande
Understanding Huntington's Disease Using Machine Learning Approaches, Sonali Lokhande
KGI Theses and Dissertations
Huntington’s disease (HD) is a debilitating neurodegenerative disorder with a complex pathophysiology. Despite extensive studies to study the disease, the sequence of events through which mutant Huntingtin (mHtt) protein executes its action still remains elusive. The phenotype of HD is an outcome of numerous processes initiated by the mHtt protein along with other proteins that act as either suppressors or enhancers of the effects of mHtt protein and PolyQ aggregates. Utilizing an integrative systems biology approach, I construct and analyze a Huntington’s disease integrome using human orthologs of protein interactors of wild type and mHtt protein. Analysis of this integrome …
Drug Repurposing Using The Anthrax Toxin Internalization Pathway, Leeor Zilbermintz
Drug Repurposing Using The Anthrax Toxin Internalization Pathway, Leeor Zilbermintz
KGI Theses and Dissertations
Pathogens and pathogenic agents such as lethal toxin, exploit host proteins for their success. Antibiotic discovery efforts have been focused on developing drugs that selectively target pathogens, despite the potential for drug resistance and providing no guarantee of fewer side effects for the patient. This dissertation describes the systematic efforts to identify drugs that alter those host proteins that are involved in the anthrax toxin internalization pathway. Anthrax is a rare and lethal disease caused by the toxin producing, gram-positive bacterium, Bacillus anthracis. The lethality of anthrax is largely attributed to the toxins that circulate within the host, destroying host …