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In Silico Study Of Polyphenol Compounds From Green Tea (Camellia Sinensis L.) As Inhibitors Of 3clpro Of Sars-Cov2, Junaidin Junaidin, Selvira Anandia Intan Maulidya, Krisyanti Budipramana, Faisal Ismail, Tegar Achsendo Yuniarta, Diana Sylvia
In Silico Study Of Polyphenol Compounds From Green Tea (Camellia Sinensis L.) As Inhibitors Of 3clpro Of Sars-Cov2, Junaidin Junaidin, Selvira Anandia Intan Maulidya, Krisyanti Budipramana, Faisal Ismail, Tegar Achsendo Yuniarta, Diana Sylvia
The Thai Journal of Pharmaceutical Sciences
Background: Coronavirus disease (COVID-19) outbreak prompts the world to develop novel drugs to treat the disease. Targeting the virus protein has attracted a great interest in COVID-19 drug discovery. The 3-chymotrypsin-like cysteine protease (3CLpro) of SARS-CoV-2 protein is one of the promising targets for its important role in viral replication. Various efforts have been made to find a specific therapeutic for COVID-19, including those derived from plants as anti-COVID-19. Green tea (Camellia sinensis L.) contains polyphenols which have been known for their health benefits. Objectives: This study aims to discover the activity of green tea polyphenols as 3CLpro …
Covid-19 Infection Following Third-Dose Booster Covid-19 Vaccination In A Spondyloarthritis Patient Treated With Methotrexate: A Case Report, Suwimon Yeephu, Supharat Wattanasombat
Covid-19 Infection Following Third-Dose Booster Covid-19 Vaccination In A Spondyloarthritis Patient Treated With Methotrexate: A Case Report, Suwimon Yeephu, Supharat Wattanasombat
The Thai Journal of Pharmaceutical Sciences
It has been clearly established that getting the coronavirus disease 2019 (COVID-19) vaccination reduces the risk of serious illness, hospitalization, and even death. Although, since vaccines are not 100% effective at preventing infection, some people who are fully vaccinated will still get COVID-19. This report presents the event of COVID-19 infection following third-dose booster of mRNA COVID-19 vaccination in a Thai female patient with spondyloarthritis, whose disease was well controlled by methotrexate, sulfasalazine and indomethacin. She got a full course of inactivated COVID-19 vaccine (Sinovac-CoronaVac vaccine) and one booster shot of messenger RNA (mRNA) COVID-19 vaccine (Pfizer-BioNTech). Around three months …