Digital Commons Network^™

Assessment Of Achieved Systolic Blood Pressure In Newly Treated Hypertensive Patients Aged 60-79 Years Before And After Eighth Joint National Committee Recommendations, Michael S. Kelly, Joseph J. Saseen, Joel C. Marrs

Pharmacy Faculty Articles and Research

Objective:

To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update.

Methods:

A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60–79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included. The mean first-achieved and last-stable SBPs of patients newly prescribed antihypertensive medications from 1 January 2012 to 31 December 31 2013 (before cohort) were compared …

Social Media At Work: The Roles Of Job Satisfaction, Employment Status, And Facebook Use With Co-Workers, Brett W. Robertson, Kerk Kee

Communication Faculty Articles and Research

Limited research has studied workplace satisfaction in a computer-mediated context, particularly with the use of social media. Based on an analysis of an online survey of working adults (N=512) in various companies and organizations in a metropolitan area in Southern California, we tested the relationships among time spent on Facebook interacting with coworkers, employment status, and job satisfaction. Results show that an employee’s satisfaction at work is positively associated with the amount of time they spend on Facebook interacting with co-workers. Contrary to our initial predictions, results to the second and third hypotheses revealed that part time employees reported having …

Language Assessment In A Snap: Monitoring Progress Up To 36 Months, Jill Gilkerson, Jeffrey A. Richards, Charles R. Greenwood, Judy K. Montgomery

Communication Sciences and Disorders Faculty Articles and Research

This article describes the development and validation of the Developmental Snapshot, a 52-item parent questionnaire on child language and vocal communication development that can be administered monthly and scored automatically. The Snapshot was created to provide an easily administered monthly progress monitoring tool that enables parents to better recognize language milestones and offers professionals prompt information to fine-tune intervention strategies. Initial items were piloted by 15 families; refinement and further development of the instrument was conducted with parents of 308 typically developing children. Reliability and criterion validity metrics were examined on subsets of approximately 60 children who completed the Snapshot …

All-Pay Auctions With Ties, Alan Gelder, Dan Kovenock, Brian Roberson

ESI Working Papers

We study the two-player, complete information all-pay auction in which a tie ensues if neither player outbids the other by more than a given amount. In the event of a tie, each player receives an identical fraction of the winning prize. Thus players engage in two margins of competition: losing versus tying, and tying versus winning. Two pertinent parameters are the margin required for victory and the value of tying relative to winning. We fully characterize the set of Nash equilibria for the entire parameter space. For much of the parameter space, there is a unique Nash equilibrium which is …

Probing Quantumness With Joint Continuous Measurements Of Non-Commuting Observables, Luis Pedro García-Pintos, Justin Dressel

Mathematics, Physics, and Computer Science Faculty Articles and Research

We analyze the continuous measurement of two noncommuting observables for a qubit, and investigate whether the simultaneously observed noisy signals are consistent with the evolution of an equivalent classical system. Following the approach outlined by Leggett and Garg, we show that the readouts violate macrorealistic inequalities for arbitrarily short temporal correlations. Moreover, the derived inequalities are manifestly violated even in the absence of Hamiltonian evolution, unlike for Leggett-Garg inequalities that use a single continuous measurement. Such a violation should indicate the failure of at least one postulate of macrorealism: either physical quantities do not have well-defined values at all times …

Can Functional Traits Predict Plant Community Response To Global Change?, Sarah Kimball, Jennifer L. Funk, Marko J. Spasojevic, Katharine N. Suding, Scot Parker, Michael K. Goulden

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One primary goal at the intersection of community ecology and global change biology is to identify functional traits that are useful for predicting plant community response to global change. We used observations of community composition from a long-term field experiment in two adjacent plant communities (grassland and coastal sage shrub) to investigate how nine key plant functional traits were related to altered water and nitrogen availability following fire. We asked whether the functional responses of species found in more than one community type were context dependent and whether community-weighted mean and functional diversity were significantly altered by water and nitrogen …

Can Functional Traits Predict Plant Community Response To Global Change?, Sarah Kimball, Jennifer L. Funk, Marko J. Spasojevic, Katharine N. Suding, Scot Parker, Michael K. Goulden

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One primary goal at the intersection of community ecology and global change biology is to identify functional traits that are useful for predicting plant community response to global change. We used observations of community composition from a long-term field experiment in two adjacent plant communities (grassland and coastal sage shrub) to investigate how nine key plant functional traits were related to altered water and nitrogen availability following fire. We asked whether the functional responses of species found in more than one community type were context dependent and whether community-weighted mean and functional diversity were significantly altered by water and nitrogen …

A Bounded Affinity Theory Of Religion And The Paranormal, Joseph O. Baker, Christoper Bader, F. Carson Mencken

Sociology Faculty Articles and Research

We outline a theory of bounded affinity between religious experiences and beliefs and paranormalism, which emphasizes that religious and paranormal experiences and beliefs share inherent physiological, psychological, and ontological similarities. Despite these parallels, organized religious groups typically delineate a narrow subset of experiences and explanatory frames as acceptable and True, banishing others as either false or demonic. Accordingly, the theory provides a revised definition of the “paranormal” as beliefs and experiences explicitly rejected by science and organized religions. To demonstrate the utility of the theory, we show that, after controlling for levels of conventional religious practice, there is a strong, …

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 …

Advances And Perspectives In Genetics Of Congenital Thyroid Disorders Associated With Thyroglobulin Gene Mutations, Héctor M. Targovnik, Cintia E. Citterio, Sofi Siffo, Carina M. Rivolta

Pharmacy Faculty Articles and Research

Dyshormonogenesis due to thyroglobulin (TG) gene mutations is a rare cause of congenital hypothyroidism with an estimated incidence of approximately 1 in 100,000 newborns. The TG gene is organized in 48 exons, spanning over 270 kb on human chromosome 8q24. The human TG mRNA is 8.5 Kb long and the preprotein monomer is composed of a 19 amino acids signal peptide followed by a 2749 residues polypeptide. Until now, one hundred seventeen deleterious mutations in the human TG gene have been identified and characterized, originating structural changes in the protein that alter the normal protein folding, assembly and …

Comparison Of Outcomes Following A Switch From A Brand To An Authorized Vs. Independent Generic Drug, Richard Hansen, Jingjing Qian, Richard L. Berg, James G. Linneman, Enrique Seoane-Vazquez, Sarah Dutcher, Saeid Raofi, C. David Page, Peggy L. Peissig

Pharmacy Faculty Articles and Research

Authorized generics are identical in formulation to brand drugs, manufactured by the brand company but marketed as a generic. Generics, marketed by generic manufacturers, are required to demonstrate pharmaceutical and bioequivalence to the brand drug, but repetition of clinical trials is not required. This retrospective cohort study compared outcomes for generics and authorized generics, which serves as a generic vs. brand proxy that minimizes bias against generics. For the seven drugs studied between 1999-2014, 5,234 unique patients were on brand drug prior to generic entry and 4,900 (93.6%) switched to a generic. During the 12-months following the brand-to-generic switch, patients …

A Perspective On Electronic Alternatives To Traditional Currencies, Gabriele Camera

ESI Working Papers

The institution of money is rapidly evolving thanks to developments in computer-based cryptography. Technological advances have made possible the creation of cost-effective electronic alternatives to banknotes and coins, which are the traditional physical currencies. This document aims to describe — based on scientific literature — the use and characteristics of money, some of the problems associated with issuing a new currency or a new payment instrument, and the possible comparative advantages of a central bank in leading the way relative to private issuers.

39th Annual Chapman University Economic Forecast, Anderson Center For Economic Research

Anderson Center Press Releases

No abstract provided.

Stability Of Peatland Carbon To Rising Temperatures, R. M. Wilson, A. M. Hopple, M. M. Tfaily, S. D. Sebestyen, C. W. Schadt, L. Pfeifer-Meister, Cassandra Medvedeff, K. J. Mcfarlane, J. E. Kostka, M. Kolton, R. K. Kolka, L. A. Kluber, Jason K. Keller, T. P. Guilderson, N. A. Griffiths, J. P. Chanton, S. D. Brigham, P. J. Hanson

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Peatlands contain one-third of soil carbon (C), mostly buried in deep, saturated anoxic zones (catotelm). The response of catotelm C to climate forcing is uncertain, because prior experiments have focused on surface warming. We show that deep peat heating of a 2 m-thick peat column results in an exponential increase in CH4 emissions. However, this response is due solely to surface processes and not degradation of catotelm peat. Incubations show that only the top 20–30 cm of peat from experimental plots have higher CH4 production rates at elevated temperatures. Radiocarbon analyses demonstrate that CH4 and CO2 are produced primarily from …

“All Museums Will Become Department Stores”: The Development And Implications Of Retailing At Museums And Heritage Sites, Jamie Larkin

Art Faculty Articles and Research

Museums and heritage sites have provided merchandise for visitors to purchase since their earliest incarnations as public attractions in the 18th century. Despite this longevity scant academic research has been directed towards such activities. However, retailing – formalised in the emergence of the museum shop – offers insights into a range of issues, from cultural representation and education, to eco- nomic sustainability. This paper outlines the historical development of retailing at museums and heritage sites in the UK, before offering a summary of current issues, illustrated by a case study of contemporary retailing at Whitby Abbey. The paper demonstrates how …

Synthesis Of Rhamnosylated Arginine Glycopeptides And Determination Of The Glycosidic Linkage In Bacterial Elongation Factor P, Siyao Wang, Leo Corcilius, Phillip B. Sharp, Andrei Rajkovic, Michael Ibba, Benjamin L. Parker, Richard J. Payne

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A new class of N-linked protein glycosylation – arginine rhamnosylation – has recently been discovered as a critical modification for the function of bacterial elongation factor P (EF-P). Herein, we describe the synthesis of suitably protected α- and β-rhamnosylated arginine amino acid “cassettes” that can be directly installed into rhamnosylated peptides. Preparation of a proteolytic fragment of Pseudomonas aeruginosa EF-P bearing both α- and β-rhamnosylated arginine enabled the unequivocal determination of the native glycosidic linkage to be α through 2D NMR and nano-UHPLC-tandem mass spectrometry studies.

53rd Annual Holiday Wassail, Chapman Orchestra, Chapman University Choir, Chapman University Singers, Chapman University Women's Choir, Chapman Percussion Ensemble, William Wells

Printed Performance Programs (PDF Format)

No abstract provided.

Henri Temianka (Miscellaneous Items), Chapman Univeristy

Henri Temianka Ephemera

This collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.

Asymmetric Social Norms, Gabriele Camera, Alessandro Gioffré

ESI Working Papers

Studies of cooperation in infinitely repeated matching games focus on homogeneous economies, where full cooperation is efficient and any defection is collectively sanctioned. Here we study heterogeneous economies where occasional defections are part of efficient play, and show how to support those outcomes through contagious punishments.

Sea Surface Temperature Rises Shift Migration Patterns Due To Ecosystem Changes, Alexia Skrbic, Hesham El-Askary

Student Scholar Symposium Abstracts and Posters

The continuing climate change is negatively impacting ecosystems, specifically oceans which are declining and food webs are being altered by the increase of greenhouse gases. The increase of the carbon dioxide and other greenhouse gases is increasing sea surface temperature of the world’s oceans. Certain organisms lower on the food chain like phytoplankton and zooplankton are directly affected by the warming which alters how they process nutrients and their productivity. The limited amount of these primary producers in the oceans and specifically the location they inhabit directly affects all the organisms above them on the food chain. Several marine animals …

Theatre And Leadership, The Perfect Marriage, Samantha Schlernitzauer, Jocelyn Buckner

Student Scholar Symposium Abstracts and Posters

As my four years at university are ending, I begin to critically think about my choice of study and ask, “did I make the right decision?” I am choosing to not go into my field which I spent the last four years studying, devoting my time to, and learning about and instead pursue my new-found passion for leadership. Many times when I explain my decision I am met with the follow up question of “why study theatre,” especially if one is not going into acting or directing.

This question of “why study theatre” often leads me to question and analytically …

Play This Paper: Forms Of Time In The Open World, Branching Narrative, Roleplaying Game, Jimmy Evans

Student Scholar Symposium Abstracts and Posters

This paper is an analysis of chronotopes in The Witcher 3: Wild Hunt that reveals how the procedurality of video games might suggest a refined heteroglossic form. Synthesizing contemporary american philosopher Ian Bogost’s concept of procedural rhetoric with the materialist linguistic theory of Mikhail Bakhtin, this ultimately hypertextual and interactive article reflects on language as Bakhtin once did: as "agent and agency” (MPL 146). After detailing how the three major processes of the game coordinate spacetime, it is necessary to conclude that its kaleidoscopic nature provides new opportunities for the rendering of the geometry of thought in what is a …

Manual And Automated Solid Phase Synthesis Of Peptides For Breast Cancer Cell Targeting, Savannah Carlson

Student Scholar Symposium Abstracts and Posters

Four peptides were synthesized using solid phase peptide synthesis. The two target peptides synthesized were based off peptide 18-4 and its negative analog. Each were synthesized once manually, and once using an automatic peptide synthesizer. Peptide 18-4 has a high affinity for breast cancer cells, allowing it to be used to detect circulating tumor cells (CTCs) in blood (Kaur et. al, 2015). Manual solid phase peptide synthesis is performed by anchoring the first amino acid to Wang resin and coupling each Fmoc protected amino acid individually until the target sequence is achieved. To synthesize the peptides automatically, the automated Tribute …

California Consumers Optimism Is Slightly Deflated, Anderson Center For Economic Research

Anderson Center Press Releases

No abstract provided.

The Authentic Workplace: Theatrical Practices In The Corporate World, Katherine Dumas

Student Scholar Symposium Abstracts and Posters

"We are beginning to bring our whole selves to work… That type of separation probably never existed… Instead of putting on some kind of fake “all-work persona,” I think we benefit from expressing our truth, talking about personal situations, and acknowledging that professional decisions are emotionally driven."(1) In her award-winning 2013 book Lean In: Women, Work, and the Will to Lead, Sheryl Sandberg explains the movement in the corporate world to look for emotional intelligence in potential employees before they are hired. Qualities such as this are nurtured and practiced regularly in the world of theatre, as evidenced by the …

Beyond The Stage: The Influence Of Theatre In Walt Disney Imagineering, Cassaundra Soumas

Student Scholar Symposium Abstracts and Posters

Walt Disney Imagineering is the head design team behind Walt Disney Parks and Resorts. Their experts and creators spearhead all projects, from shows and attractions to architecture and locations. Their groundbreaking work has put them at the forefront of the Themed Entertainment Industry. While they have become trendsetters in the world of entertainment, much of their foundation is still based in the world of theatre. Through this thesis, I will examine just how much of an influence theatre has had in the foundation of Walt Disney Imagineering. From simple verbiage to designs, theatre is present in many levels. I will …

Student Pianists In Recital, Aaron Grisez, Rachel Gossen, Ariel Chien, Niki Black, Rebekah Dennis, Madeline Barrett, Lewis Gehami, Yusuke Sumoyama, Avery Roberts, Mai Phuong Duong, Dylan Kanner, Ashley Shahbazi, Michael Seaman

Printed Performance Programs (PDF Format)

No abstract provided.

“A Flower Which Blossoms And Fades”: Depictions Of Tuberculosis In 19th-Century Opera, Daniel Goldberg

Student Scholar Symposium Abstracts and Posters

The romantic period in art and music is a time that focused on the regular person and had a fascination with nature, emotion, and death. One of the most common themes used was disease. One of the more common diseases of the time in both opera and real life was tuberculosis. In opera tuberculosis is always brought upon the same type of person time and time again and is always shown both by the character, and also though a series of metaphors. This character is always a woman and these “tubercular heroines” always are young, beautiful, frail people who need …

Contributing Factors To Perspectives On Gun Regulations, Syd Kotar

Student Scholar Symposium Abstracts and Posters

With a rising amount of gun violence, issues of stricter gun regulations have been brought to the government’s attention. Location, gender, and ideology all contribute to how one perceives the individual use of firearms, and believes how much the government should intervene. This paper will explore the different variables such as the three listed above that affect one’s opinions on government intervention concerning stricter gun regulations. The results of data analysis from the ANES 2012 studies conclude that the more conservative one self identifies as, one would want either the same or less government intervention concerning stricter gun regulations. Data …

Images Of Sexually Deviant Women In French Film, Lara Fox

Student Scholar Symposium Abstracts and Posters

This research explores representations of sexually deviant women in French film beginning with the New Wave film movement of the1960s and continuing to present day. This work examines the extent to which the gender of a film’s director affects the presentation of female nudity, infidelity, homosexuality, BDSM, and pornography onscreen. Through the lens of scholarly articles of film theorists and feminists such as Laura Mulvey, Simone de Beauvoir, and Hélène Cixous; and of both feministic and anti-feministic works of famous French directors such as Jean-Luc Godard, Catherine Breillat, and Emmanuelle Bercot, this capstone work identifies filmic triumphs and failures of …