Digital Commons Network^™

Conditional Discrimination And Reversal In Amnesia Subsequent To Hypoxic Brain Injury Or Anterior Communicating Artery Aneurysm Rupture, C. E. Myers, J. Deluca, Ramona O. Hopkins, M. A. Gluck

Faculty Publications

Human anterograde amnesia can develop following bilateral damage to the hippocampus and medial temporal lobes, as in hypoxic brain injury, or following damage to the basal forebrain, as following anterior communicating artery (ACoA) aneurysm rupture. In both cases, the mnestic deficit may be similar when assessed by standard neuropsychological measures. However, animal and computational models suggest that there are qualitative differences in the pattern of impaired and spared memory abilities following damage to hippocampus versus basal forebrain. Here, we show such a dissociation in human amnesia using a single two-stage task, involving conditional discrimination and reversal. Consistent with a prior …