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9s1r Nullomer Peptide Induces Mitochondrial Pathology, Metabolic Suppression, And Enhanced Immune Cell Infiltration, In Triple-Negative Breast Cancer Mouse Model, Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R. Veerabhadraiah, Laura Bond, Matthew W. Turner, Cheryl L. Jorcyk, Greg Hampikian
9s1r Nullomer Peptide Induces Mitochondrial Pathology, Metabolic Suppression, And Enhanced Immune Cell Infiltration, In Triple-Negative Breast Cancer Mouse Model, Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R. Veerabhadraiah, Laura Bond, Matthew W. Turner, Cheryl L. Jorcyk, Greg Hampikian
Biology Faculty Publications and Presentations
Nullomers are the shortest strings of absent amino acid (aa) sequences in a species or group of species. Primes are those nullomers that have not been detected in the genome of any species. 9S1R is a 5-aa peptide prime sequence attached to 5-arginine aa, used to treat triple negative breast cancer (TNBC) in an in vivo mouse model. This unique peptide, administered with a trehalose carrier (9S1R-NulloPT), offers enhanced solubility and exhibits distinct anti-cancer effects against TNBC. In our study, we investigated the effect of 9S1R-NulloPT on tumor growth, metabolism, metastatic burden, tumor immune-microenvironment (TME), and transcriptome of aggressive mouse …
Safeguarding Forensic Dna Reference Samples With Nullomer Barcodes, Jayita Goswami, Michael C. Davis, Tim Andersen, Abdelkrim Alileche, Greg Hampikian
Safeguarding Forensic Dna Reference Samples With Nullomer Barcodes, Jayita Goswami, Michael C. Davis, Tim Andersen, Abdelkrim Alileche, Greg Hampikian
Biology Faculty Publications and Presentations
Unintended transfer of biological material containing DNA is a concern to all laboratories conducting PCR analysis. While forensic laboratories have protocols in place to reduce the possibility of contaminating casework samples, there is no way to detect when a reference sample is mislabeled as evidence, or contaminates a forensic sample. Thus there is public concern regarding the safeguarding of DNA submitted to crime labs. We demonstrate a method of introducing an internal amplification control to reference samples, in the form of a nullomer barcode which is based upon sequences absent or rare from publically accessible DNA databases. The detection of …
Recidivism Among Child Sexual Abusers: Initial Results Of A 13 Year Longitudinal Random Sample, Steven Patrick, Robert Marsh
Recidivism Among Child Sexual Abusers: Initial Results Of A 13 Year Longitudinal Random Sample, Steven Patrick, Robert Marsh
Sociology Faculty Publications and Presentations
In the initial analysis of data from a random sample of all those charged with child sexual abuse in Idaho over a 13 year period, only one predictive variable was found that related to recidivism of those convicted. Variables such as ethnicity, relationship, gender and age differences did not show a significant or even large association with recidivism. The only variable that seemed to show both a significant and almost moderate association to recidivism was the Risk Assessment in the Sex Offender Evaluation re-offense. Comparisons were made to prior research as well as a discussion of implications of the sex …