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Galectin-3: A Cardiomyocyte Antiapoptotic Mediator At 24-Hour Post Myocardial Infarction, Suhail Al-Salam, Satwat Hashmi, Govindan S. Jagadeesh, Saeed Tariq
Galectin-3: A Cardiomyocyte Antiapoptotic Mediator At 24-Hour Post Myocardial Infarction, Suhail Al-Salam, Satwat Hashmi, Govindan S. Jagadeesh, Saeed Tariq
Department of Biological & Biomedical Sciences
Background/Aims: Galectin 3 (GAL-3) is a beta galactoside binding lectin that has different roles in normal and pathophysiological conditions. GAL-3 has been associated with heart failure and was linked to increased risk of death in a number of studies. GAL-3 was found to be up regulated in animal models of heart failure as well as myocardial infarction (MI). The objective of his study is to test if high GAL-3 after myocardial infarction has a protective role on the heart through its anti-apoptotic and anti-necrotic functions.
Methods: Male C57B6/J mice and GAL-3 knockout (KO) mice were used for permanent ligation of …