Digital Commons Network^™

The Effects Of Combined Aquatic Exercise On Physical Performance And Metabolic Indices In Overweight Healthy Older Adults, Shiva Ebrahimpour Nosrani, Bakhtyar Tartibian, Rasul Eslami, Carlos Farinha, João Serrano, José Pedro Ferreira, Ana Maria Texeira

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1499-1513, 2023. Addressing overweight and obesity to promote healthy aging is essential. Exercise is an outstanding approach to manage metabolic and physical dysfunction. Aquatic exercise has been recommended for older individuals due to reduced weight pressure on joints. The aim of this study was to determine the effects of twenty-eight weeks of combined aquatic exercise (aerobic and resistance) in overweight healthy older individuals. Thirty-two subjects of both genders with mean age of 72.06 ± 5.8 years were randomly assigned into two groups: an aquatic exercise group (EG; n = 19) and a control group …

Combination Of Thymoquinone And Intermittent Fasting As A Treatment For Breast Cancer Implanted In Mice, Shatha Khaled Haif, Lina T. Al Kury, Wamidh H. Talib

All Works

Breast cancer stands out as a particularly challenging form of cancer to treat among various types. Traditional treatment methods have been longstanding approaches, yet their efficacy has diminished over time owing to heightened toxicity, adverse effects, and the emergence of multi-drug resistance. Nevertheless, a viable solution has emerged through the adoption of a complementary treatment strategy utilizing natural substances and the incorporation of intermittent fasting to enhance therapeutic outcomes. This study aimed to assess the anticancer activity of thymoquinone (TQ), intermittent fasting, and their combination using in vivo and in vitro methods. The anti-proliferative activity of TQ and fasting (glucose/serum …

The Effect Of Sleep Extension On Metabolic And Androgen Parameters Of Healthy Women With Habitual Short Sleep Duration: Pilot Study, Isra’A Haj-Husein, Nour Hamdan, Hadeel Ghazzawi

Palestinian Medical and Pharmaceutical Journal

Aims: Sleep curtailment, a common behavior in modern societies, is associated with significant alterations in metabolic and endocrine profiles. This pilot study aimed to investigate the potential benefits of sleep extension, under real-life conditions, on insulin sensitivity, androgens, and leptin, in women with habitual short sleep duration. Methods: In a single-arm study design, healthy pre-menopausal women with ≤ 6 hours of daily sleep (n=10) were instructed to increase their sleep duration by one hour daily for one month. Fasting blood samples were obtained on days 2-3 of the menstrual cycle, at baseline, and after the intervention. Samples were analyzed for …

Targeting Of Notch, Il-1, And Leptin Has Therapeutic Potential In Xenograft Colorectal Cancer, Rumeysa Özyurt, Ni̇lüfer Erkasap, Mete Özkurt, Serdar Mustafa Erkasap, Konstanti̇nos Di̇mas, Ayşe Çakir Gündoğdu, Engi̇n Ulukaya

Turkish Journal of Biology

Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a role in the proliferation, migration, and expression of proangiogenic molecules. In this study, we aimed to investigate the effect of inhibition of Notch, IL-1, and leptin on CRC. Materials and methods: To generate colorectal cancer tumor xenografts, 1 × 107 cells from exponentially growing cultures of HCT15 cells were injected subcutaneously, at the axillary region of the left and right rear flanks of forty NOD.CB17-Prkdcscid/J (NOD/SCID) female mice. The mice were then …

Evaluation Of Leptin And Adiponectin Levels In Obese Patients With Acne Vulgaris, Magda M. Haggag, Manal A. Safan, Nafisa Z. I Abd Algalil

Menoufia Medical Journal

Objective This study aimed to evaluate adipokines such as leptin and adiponectin in obese patients with acne vulgaris. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit characterized by increased sebum production in response to androgens. The adipokines secreted from the sebaceous glands are considered novel factors affecting acne inflammation. Patients and methods This study was carried out at the Dermatology and Medical Biochemistry and Molecular Biology Departments of Faculty of Medicine, Menoufia University. Patients were grouped as follows: group I (patient group) included 60 obese patients with acne vulgaris, and group II (control group) included 30 …

Correlation Between Serum Leptin With Severity Of Knee Osteoarthritis, Khaled Muhammad Abdel Moez, Ahmed Shebl Ezz, Ahmed Abdel Moez Ali, Hmad Muhamad Abdel Ghany Shaalan

Al-Azhar International Medical Journal

Background: Knee osteoarthritis (OA), is a joint degeneration in the knee. due to progressive articular cartilage loss. Knee OA patients’ quality of life may be impacted by pain, physical restrictions, subpar treatment results, and more medication.

Objective: correlation of serum leptin level with severity of knee osteoarthritis.

Patients and Methods: This study involved 100 adult participants. (40-60 years old) presented to Egyptian railway medical center at outpatient clinics to correlate serum level of leptin with severity of knee osteoarthritis.

Results: Our study also showed that cut off leptin level between OA patient and normal population is 13.6 mg/dl and it …

The Association Of Peptide Hormones With Glycemia, Dyslipidemia, And Obesity In Lebanese Individuals, Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian

All Works

Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of these peptide-hormones with obesity-markers, insulin-resistance, and dyslipidemia (total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), triglyceride (TG)). Sixteen-obese (OB) adults and 21 normal-weight (NW) age-and gender-matched counterparts were recruited. OB-participants showed significantly higher levels of leptin, insulin, Homeostatic-Model Assessment of Insulin Resistance (HOMA-IR), and TG. NW participants had significantly higher levels of ghrelin. GLP-1 was positively correlated with insulin, …

Leptin And Metabolic Syndrome In Alopecia Areata, Eman M Abd El Gayed, Heba A. S. Bazid, Mostafa A. Hammam, Yasmine Gamal

Menoufia Medical Journal

Objectives The aim of the study was to assess the role of leptin gene polymorphism in alopecia areata with metabolic syndrome (MS). Background Alopecia areata is considered an organ-specific autoimmune disease of hair follicles. Leptin, an adipocyte-derived hormone, represents a link between metabolism, nutritional status, and immune response. T helper1-promoting effects of leptin have been linked to develop experimentally induced autoimmune disease. Patients and methods This cross-sectional study was carried out on 50 alopecia areata with MS patients. Body mass index, Severity of Alopecia Tool score, blood pressure, serum fasting glucose, triglyceride, and leptin polymerase chain reaction were done for …

Exercise − A Unique Endogenous Regulator Of Irisin, Bdnf, Leptin And Cortisol Against Depression, Gilmara Gomes De Assis, Pawel Cieszczyk

Baltic Journal of Health and Physical Activity

Depression is the most prevalent stress-related disorder affecting the population world-wide with potential for an eminent increase after the 2020 pandemic. The mechanisms through which metabolism is involved in depression and stress disorders have been extensively investigated. However, their assessment using exogenous measures is a current limitation. Exercise, as is well reported in animal studies, exerts a critical regulatory influence on the main factors known to participate in these mechanisms. This overview describes the role of cortisol, leptin, irisin and BDNF in the exercise physiology and the known mechanism through which these factors act in anti-depressant mechanisms. Furthermore, the exercise …

The Association Between Peptide Hormones With Obesity And Insulin Resistance Markers In Lean And Obese Individuals In The United Arab Emirates, Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema

All Works

Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age-and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, …

Palbociclib Suppresses The Cancer Stem Cell Properties And Cell Proliferation Through Increased Levels Of Mir-506 Or Mir-150 In Panc-1 And Miapaca-2 Cells, Özge Rencüzoğullari, Eli̇f Damla Arisan

Turkish Journal of Biology

The prognostic characteristics of pancreatic cancer (PC) are determined by the contributing factors from the tumor microenvironment. Leptin is a critical oncogenic factor released by adipocytes as an adipokine into the tumor microenvironment, where it promotes tumor development by activating cancer stem cell (CSC) molecular regulators Notch, Hedgehog, and Wnt/ß-catenin signaling. One of the downstream targets of these pathways is CDK4/6 and cyclin D which is controlled by P16 INK4A that is highly mutated in PC. Therefore, the purpose of this study was to determine the effect of a CDK4/6 inhibitor, palbociclib, on Leptin-induced PC cells and to target the …

The Effects Of Exercise On Hunger And Satiety Hormone Concentrations Over A 36-Hour Fast: A Randomized Crossover Study, Jacob L. Coleman, Landon Deru, Hunter Chamberlain, Bruce W. Bailey

International Journal of Exercise Science: Conference Proceedings

Background: Feelings of hunger and satiation are known to be influenced physiologically through hormone secretion. Ghrelin (GH) is known as the primary “hunger” hormone, and GLP-1, PP, PYY, and C-Peptide (CP) are hormones known to signal feelings of satiety. The aim of this study was to assess hunger and satiety hormone production during a prolonged fast, and to evaluate how an initial bout of exercise influences this secretion. Subjective feelings of mood and hunger were also assessed throughout.

Methods: In this crossover study, 20 adult subjects (11 Male, 9 Female) completed two 36-hour fasts, with one protocol requiring the subject …

Linking The Brain And Bone Through Fat, Elisabeta Malinici, Anca Sirbu, Miruna Popa, Simona Fica

Journal of Mind and Medical Sciences

Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem cell and this common origin has been proposed as the core of the fat-bone relationship. The central nervous system might be the third player in this association, capable of integrating signals. Numerous adipose tissue secreted factors that influence energy homeostasis and bone have been described: leptin, adiponectin, lipocalin 2, and inflammatory cytokines (e.g. IL-1, IL-6 and …

The Role Of Sleep Curtailment On Leptin Levels In Obesity And Diabetes Mellitus, Maryam Mosavat, Mitra Mirsanjari, Diana Arabiat, Aisling Smyth, Lisa Whitehead

Research outputs 2014 to 2021

Emerging evidence has identified sleep as a significant, but modifiable, risk factor for metabolic syndrome, diabetes, and obesity. Leptin, an adipocyte-derived peptide and a regulator of food intake and energy expenditure, has been shown to be associated with a short sleep duration in the pathophysiology of obesity and consequently type 2 diabetes. This review focuses on the current evidence indicating the effects of a short sleep duration on the regulation of leptin concentration in association with obesity and diabetes mellitus. In summary, the evidence suggests that sleep deprivation, by affecting leptin regulation, may lead to obesity and consequently development of …

The Relationship Of Leptin And Thyroid Hormones With Milk Yield And Some Fertilityparameters In Simmental Dairy Cows During Transition Period, Özkan Duru, Alparslan Kadi̇r Devri̇m, Hasan Ceyhun Macun, Si̇bel Yasa Duru, Ali̇ Şenol

Turkish Journal of Veterinary & Animal Sciences

In this study, transition period cows were used to test the hypothesis that serum levels of leptin and thyroid hormones would correlate the production efficiency such as milk yield, body condition score, and fertility in dairy cows raised under the same controlled conditions. The study comprised 37 Simmental cows, which were 3 years old and between 257-265 days of gestation. Serum levels of leptin, T3, T4, FT3, and FT4 hormones were measured in blood samples obtained from the animals, which were in the period of 3 weeks before and 3 weeks after delivery. Prepartum serum leptin levels were significantly (p < 0.05) lower in cows having increased milk production compared to the first lactation peak value. Also, postpartum serum FT3 levels were significantly (p < 0.05) lower in cows having milk yield of ≥ 30 kg. Leptin levels were found to be inversely related with milk production and fertility. FT3 levels exhibited a negative correlation with milk production and similarly T3 levels showed an inverse correlation with body condition score. The present study proposed that routine monitoring of leptin and thyroid hormones would be useful for the reproductive management of cows with breeding problems.

The Relation Of Fat Tissue Hormones And Some Galactopoietic Hormones With Milk Yield In Holstein And Simmental Cows, Zennure Demi̇r, Devri̇m Saripinar Aksu

Turkish Journal of Veterinary & Animal Sciences

The present study was conducted to investigate the physiological changes in leptin, adiponectin, and ghrelin hormones, which are effective in the regulation of energy metabolism, and the galactopoietic hormones including growth hormone (GH), insulin, insulin-like growth factor-I (IGF-I), cortisol, thyroid stimulating hormone (TSH) and thyroxine (T4 ) levels, which are also effective in the regulation of metabolic activities and their correlation with milk yield levels in Holstein and Simmental cows with low, medium, and high milk yield. Holstein (n = 30) and Simmental cows (n = 30) with low, medium, and high milk yield were used. Cows were divided into …

Effects Of Consuming Sugar-Sweetened Beverages For 2 Weeks On 24-H Circulating Leptin Profiles, Ad Libitum Food Intake And Body Weight In Young Adults, Desiree M. Sigala, Adrianne M. Widaman, Bettina Hieronimus, Marinelle V. Nunez, Vivien Lee, Yanet Benyam, Andrew A. Bremer, Valentina Medici, Peter J. Havel, Kimber L. Stanhope, Nancy L. Keim

Faculty Research, Scholarly, and Creative Activity

Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18–35 kg/m2; 18–40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = 23–28/group). Body weight, ad libitum food intake and 24-h leptin area under the curve (AUC) were assessed at Week 0 and at the end of Week …

No Changes In Appetite-Related Hormones Following Swimming And Cycling Exercise Interventions In Adults With Obesity, Brandon G. Fico, Mohammed Alkatan, Hirofumi Tanaka

International Journal of Exercise Science

International Journal of Exercise Science 13(2): 1819-1825, 2020. Swimming is a favorable and ideal modality of exercise for individuals with obesity and arthritis as it encompasses a minimal weight-bearing stress and a reduced heat load. However, the available evidence indicates that regular swimming may not be effective in reducing body weight and body fatness. A current hypothesis is that exercise in cold water stimulates appetite. We determined the effect of swimming training on appetite-related hormones. Thirty-nine adults with obesity and osteoarthritis were randomly assigned to 12 weeks of supervised swimming or cycling training. In the initial few weeks, participants exercised …

Exercise For Weight Loss: Further Evaluating Energy Compensation With Exercise, Kyle D. Flack, Harry M. Hays, Jack Moreland, Douglas E. Long

Dietetics and Human Nutrition Faculty Publications

PURPOSE: This study assessed how individuals compensate for energy expended during a 12-wk aerobic exercise intervention, elucidating potential mechanisms and the role exercise dose plays in the compensatory response.

PARTICIPANTS AND DESIGN: Three-arm, randomized controlled trial among sedentary adults age 18 to 40 yr, body mass index of 25 to 35. Groups included six exercise sessions per week, two sessions per week, and sedentary control.

METHODS: Rate of exercise energy expenditure was calculated from a graded exercise test averaged across five heart rate zones. Energy compensation was calculated as the difference between expected weight loss (based on exercise energy expenditure) …

Causal Relationship Between Cord Blood Leptin Level And Different Patterns Of Birth Weight, Ahmed A. Khattab, Dalia M. El-Lahony, Osama T. Abd El-Fattah, Wafaa M. Abo El-Fotoh

Menoufia Medical Journal

Objective To estimate the cord blood leptin level in different patterns of birth weight. Background Birth weight is a strong predictor of both neonatal mortality and morbidity. Umbilical cord blood leptin has been consistently shown to be positively associated with birth weight. It has been widely accepted as a marker of neonatal adiposity. Patients and methods A case–control study was conducted on 60 neonates who were divided into 20 small for gestational age (SGA), 20 appropriate for gestational age (AGA), and 20 large for gestational age (LGA). All neonates were recruited from the gynecology and obstetrics department at Menoufia University …

Pre-Surgery Leptin Level And Weight Loss In Female Bariatric Surgery Patients, Miriam Katz

Master's Theses

Background: Improving weight loss after bariatric surgery remains a clinical concern. An unstudied factor is the role of leptin, the appetite control hormone, as a pre-surgical predictor of weight loss. High serum levels, often seen in obesity, are an indicator of leptin resistance as the brain no longer responds to satiety signaling.

Methods: Leptin levels were ascertained in female bariatric patients (n=28) prior to surgery at a large tertiary care hospital. We calculated Pearson Correlation Coefficients (r) and unstandardized β coefficients using multivariate linear regression. Primary outcome: Percent Excess Weight Loss (%EWL) evaluated at 6- and 12-months post-surgery. …

Leptin’S Role In The Obesity Epidemic, Alyssa C. Washeleski

Honors College Theses

Weight loss methods have been around for decades, but yet, individuals still can’t lose weight or keep it off. Researchers have pondered if there is more to being incapable of losing body fat than individuals having a lack of willpower. While the environment plays a critical role in weight regulation, genetics may be just as important.

Research has discovered a hormone called leptin that controls energy expenditure and satiety. Leptin plays a part in many physiological roles, including appetite control, sexual function, immunity, insulin sensitivity, and the metabolism of lipid and bone. Studies done with mice and humans have concluded …

Anorexia Nervosa And Reproduction: Connecting Brain To Gonads, Mihaela Poterasu, David L. Rowland, Corina Ciobanu, Simona Fica

Journal of Mind and Medical Sciences

Anorexia nervosa (AN) is a psychiatric disorder that predominantly affects young women and is characterized by low caloric intake and a major dissatisfaction with one’s body image. It is often overlooked and, while patients and family seek medical help, emaciation and nutritional misbalances may become extreme and potentially life threatening. Among the many somatic complications, an accumulation of early endocrine adaptations occurs, leading to functional amenorrhea and impaired reproduction as a result of dysfunction of the hypothalamic-pituitary-ovarian axis. Even though these conditions are reversible, long-term consequences may affect the fertility of women with AN and can lead to maternal and …

Study Of Serum Leptin Level In Children With Cyanotic And Acyanotic Congenital Heart Disease, Ahmed A. Khatab, Fahima M. Hassan, Mona S. Habib, Rania S. El-Zayat, Rania S.H. Ali

Menoufia Medical Journal

Objective The aim of this study was to measure serum leptin levels in children with cyanotic and acyanotic congenital heart disease and to examine its possible role in growth in these children. Background Leptin has been shown to be an integral component of energy homeostasis and regulation of body weight. Leptin regulates adipose tissue mass and correlates with the fat mass. Research on the physiological function of leptin has primarily focused on its role in the pathogenesis of obesity. Children with congenital heart disease are at increased risk for poor growth. Several factors may play a role in poor growth, …

No Changes In Appetite Stimulating Hormones Following Swimming And Cycling Exercise Interventions, Brandon G. Fico, Mohammed Alkatan, Yuzi Zhang, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Swimming is a favorable and ideal modality of exercise for individuals with obesity and arthritis as it encompasses a minimal weight-bearing stress and a reduced heat load. However, the available evidence indicates that regular swimming may not be effective in reducing body weight and body fatness. A current hypothesis is that exercise in cold water somehow stimulates appetite. PURPOSE: We determined the effect of swimming exercise training on fasting concentrations of ghrelin, insulin, leptin, and peptide YY in obese individuals with osteoarthritis. Cycling training was included as a non-weight bearing land-based comparison group. METHODS: Thirty-nine obese participants with …

The Effects Of Feeding Obese Rats With Bee Bread On Leptin And Ghrelin Expression, Züleyha Doğanyi̇ği̇t, Bi̇rkan Yakan, Meltem Soylu, Emi̇n Kaymak, Si̇bel Si̇li̇ci̇

Turkish Journal of Zoology

Obesity is an important public health problem and a risk factor for many chronic diseases, and its prevalence is increasing rapidly. In recent years there has been interest in the impact of nutrients on obesity and this has been addressed as a research topic. Bee bread is a bee product that has recently attracted attention with its macro- and micronutrients and the enzymes and biocomponents it contains. Although there are many studies on the biological properties and effects of bee bread, its effect on obesity with leptin and ghrelin has not been investigated. In this study, 40 Sprague-Dawley adult female …

The Wickedness Of Obesity, Justin C. Epps

English Department: Research for Change - Wicked Problems in Our World

“The Wickedness of Obesity” is written by myself, Justin Epps. This study evaluates the problems and causes of obesity. It has taken the lives of all different types of people. Being overweight can also affect what a person can do on a daily basis, as their weight can prevent them from participating in activities. Lab results show typical percentages of obesity among men and women along with other factors. This analysis shows that obesity is a major concern throughout the population within different groups. I conclude that obesity is a large issue in the world today.

Leptin Effects On Bone Metabolism, Elizabeth Bark

Williams Honors College, Honors Research Projects

Scales from adult zebrafish, Danio rerio, are an established model for studying osteoblast and osteoclast activity. In this study, scales in a cell culture were used to determine if the hormone leptin has an effect on activity of these bone remodeling scales. Alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities of zebrafish scales were measured and compared with and without leptin treatment. There was no statistically significant difference between leptin treatments in terms of ALP and TRAP activity. Differences between TRAP values between days 1 and 2 did look promising although they were not statistically significant. This study …

Effect Of Supplementing Additives In Leptin-Enriched Maturation Medium During In Vitro Maturation And Vitrification Of Goat Oocytes, Reema Talukdar, Ranjan Kumar Biswas, Govindasamy Kadirvel, Bharat Chandra Deka, Sudip Sinha, Lukumoni Buragohain, Birina Bora

Turkish Journal of Veterinary & Animal Sciences

The present study aimed to evaluate the effect of supplementing epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), fetal bovine serum (FBS), and bovine serum albumin (BSA) in different combinations in a maturation medium (MM) comprising TCM-199 + 5 µg/mL 17-ß estradiol + 5 µg/mL ovine-luteinizing hormone (oLH) + 5 µg/mL pure follicle-stimulating hormone (pFSH) + 100 µM/mL cysteamine containing the best concentration of leptin among 10/20/25/30 ng/mL on in vitro maturation (IVM) and subsequent vitrification of matured goat oocytes. The IVM of oocytes was carried out in a CO2 incubator for 27 h at 38.5 °C. The percentage of …

Role Of Serum Leptin As A Marker Of Severity Of Pre-Eclampsia, Ahmed N. Eissa, Amr S. El-Bagoury, Tarek M. Sayyed

Menoufia Medical Journal

Objective The objective of this study was to evaluate the role of serum leptin level as a marker of severity of pre-eclampsia (PE). Background PE is a hypertensive disorder in pregnancy that is associated with high blood pressure and proteinuria and develops after 20 weeks of gestation. PE is a major contributor to maternal mortality, complicating 2–8% of pregnancies. Patients and methods This study was conducted at the outpatient clinic and obstetric departments of Shebin El-Kom Teaching Hospital from February 2016 to January 2017. This study included 95 pregnant women, among which 20 were diagnosed as having mild PE (group …