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Genetic Analysis Of A Novel Ftsk Homolog, Hfka, In Streptomyces Coelicolor Development-Associated Chromosome Segregation, Sumedha Sethi

Electronic Theses and Dissertations

A quintessential phenomenon occurring during prokaryotic development is accurate segregation of the replicated genomes into the daughter cells. Key energy-dependent processes like chromosome condensation and subcellular partitioning of the genomes are driven by conserved proteins like SMC, ParB, FtsK. During its complex developmental cycle, Streptomyces coelicolor segregates its genomes into chains of unicellular spores when its multigenomic syncytial aerial hyphae undergo division.

A novel ftsK-like gene, hfkA (Homolog of FtsK protein A), was examined for function and localization during development-associated chromosome segregation. Individual deletions did not affect segregation, but a ΔhfkA ΔftsK mutant exhibited 8% anucleate …

South Bronx Waterfront, Noah Lewis

Capstones

The waterfronts of New York City have seen dramatic transformation and development over the past several decades. Developers have taken advantage of the coveted real estate space and constructed glass monoliths along Manhattan’s shores on the East and Hudson Rivers.

More recent developments in Long Island City and Williamsburg’s waterfront have seen waterfronts transform, and neighborhoods are unrecognizable from where they used to be. But as development continues in those areas, many developers are being priced out, and the Bronx is the logical next step in the process.

This project includes photos, videos, and animations of the South Bronx Waterfront. …

Keeping Track Of Change: Developmental Insights Into The Ability To Represent Objects In Episodic Terms, Emily Yearling

Master's Theses

No abstract provided.

The Design And Development Of A Device To Assist In Boosting Patients, Taylor A. Rieckhoff

Masters Theses

A common task a nurse is required to perform is called boosting patients. Boosting a patient is defined as lifting or sliding a patient back up in the bed after having slid down (Mannheim, Zieve, & Conaway, 2017). The current method for boosting patients involves a minimum of two personnel and an 11-step process. The 11-step process requires the person to manually lift and pull the patient using an existing half sheet on the bed (Mannheim, Zieve, & Conaway, 2017). Patients who cannot move or support themselves are moved every two to six hours or upon request (Bihn, Rieckhoff, Burkman, …

The Museum Of Experiential Living Art: Strategic Plan, Danielle D. Delia

Museum Studies Projects

How can a museum support the new work of artists? Can a Tri-fold business plan offer a sustainable way to support an artists in residency program? Will the local community welcome a new museum into their town? What will be the benefit to the local economy? This capstone project presenting a strategic plan proposes the development of a new art museum located in Buffalo New York called, the Museum of Experiential Living Art (MoELA). The purpose of MoELA is to support practicing artists through an artist in residency program; by providing dedicated time, space, tools, materials, housing and nourishment while …

The Future Development Of Reits In China, Jia Sun

Dissertations and Theses Collection (Open Access)

Real Estate Investment Trust (REIT) is a type of trust fund or corporation that pools the funds of a large number of investors by issuing a certificate of income and invest the raised funds in real estate projects that are managed by a specialized investment institution. The real estate investment risk is moderate, and the rent is stable, but the capital threshold is high, and it is difficult for small and medium investors to enter the market. The invention of REITs aims to solve this problem, through the collection of funds, so that small and medium investors can enter the …

A Novel Switch-Like Function Of Delta-Catenin In Dendrite Development, Ryan Baumert

Dissertations & Theses (Open Access)

The formation of neuronal networks in the brain is tightly regulated, and dependent on the morphology of dendrites, the branch-like signal-receiving structures extending from neurons. Disruptions in dendrite development, or dendritogenesis, can lead to the atypical neuronal connectivity associated with multiple neurodevelopmental diseases. My research addresses molecular processes that underlie dendritogenesis via analysis of a pair of novel interactions involving the protein delta-catenin.

In neurons, delta-catenin localizes to dendrites and synapses, where it functions in their development and maintenance. Structurally, delta-catenin possesses a central Armadillo domain and a C-terminal PDZ-binding motif. This motif associates with PDZ domain-containing proteins, and is …

Improving Professional Development With The Torrance Incubation Model, Susan M. Czyrny

Creativity and Change Leadership Graduate Student Master's Projects

Abstract

The purpose of this project is to introduce and integrate creativity and creative problem solving concepts and methods that are supported by the application of technology and digital media into the professional learning and career development process. The current training framework consisting primarily of instructor-led lectures supported by PowerPoint presentations is not sufficient to provide students with depth and breadth of information needed to achieve competence. Creativity and innovation are critical skills needed to succeed in a globally competitive and changing marketplace and are now required competencies that need to be demonstrated. Interweaving creativity skills training and facilitation with …

The Role Of Gamma Oscillations And Cortical Inhibition In The Development Of Working Memory In Adolescence, Christopher P. Walker

Dissertations & Theses (Open Access)

Adolescence is a dynamic period of social, cognitive, and biological changes. In particular, working memory, the ability to actively encode and maintain information over a short period of time, develops early in childhood and gradually increases in capacity and stability during adolescence. The precise neurophysiological mechanism by which working memory capacity increases during adolescence is unclear. The objective of this investigation was to evaluate the role of cortical gamma-band (> 30 Hz) oscillations—which are associated with working memory in adults—for the development of working memory capacity in adolescents, and to identify the extent to which the temporal profile of gamma-aminobutyric …

The Role Of Xenopus Laevis Reck In Ecm Remodeling And Tissue Patterning, Jessica Willson

Electronic Thesis and Dissertation Repository

Proper cell-cell and cell-extracellular matrix (ECM) interactions are vital for cell migration and patterning of the vertebrate embryo. Matrix metalloproteinases (MMPs) and their inhibitors, reversion-inducing cysteine-rich proteins with Kazal motifs (RECK) and tissue inhibitors of metalloproteinases (TIMPs), are all differentially expressed during embryogenesis to regulate such ECM remodeling events and cell interactions. While TIMPs are a family of 4 secreted proteins that share overlapping substrate specificities of MMPs, RECK is unique in that it is a membrane-anchored MMP inhibitor that is embryonic lethal in mice. I used Xenopus laevis as a model organism to investigate the role of RECK as …

Patterns Of Morphological Plasticity In Metriaclima Zebra And Danio Rerio Suggest Differently Canalized Phenotypes Due To Form-Function Relationships, Dylan Jockel

Masters Theses

In order to ascertain the degree of compatibility in developmental restructuring and behavioral plasticity between two fish species frequently made subject of laboratory research (Metriaclima zebra & Danio rerio), alternative trophic niche exposure experiments utilizing novel three-prong feeding treatments were conducted to obtain morphometric data, which demonstrated both species do bear some degree of plasticity. The results are somewhat complicated by differences in locality of detectable restructuring, which may be due to disparity in the form-function relationship for each species’ lineage. Each is notable in the manner of respective species’ jaw protrusion, as it is driven by anterior …

How Does The Brain Represent Digits? Investigating The Neural Correlates Of Symbolic Number Representation Using Fmri-Adaptation, Celia Goffin

Electronic Thesis and Dissertation Repository

How does the brain represent numerical symbols (e.g., Arabic digits)? Activity in left parietal regions correlates with symbolic number processing. Research with functional resonance imaging adaptation (fMRI-A) indicates that the intraparietal sulcus (IPS) exhibits a rebound (increase in activation) effect when a repeatedly presented number is followed by a new number. Importantly, this rebound effect is modulated by numerical ratio as well as the difference between presented numbers (distance). This ratio-dependent rebound effect could reflect a link between symbolic numerical representation and an approximate number system (ANS). In this doctoral dissertation, fMRI-A is used to investigate mechanisms underlying symbolic number …

Promoting Self-Reflection Of Foreign Language Teachers Through Professional Development: An Action Research Dissertation, Hanan Khaled

Theses and Dissertations

This explanatory mixed-method action research describes how a social constructivist professional development program impacts self-reflection of foreign language teachers at the Defense Language Institute Foreign Language Center (DLIFLC). The problem is that traditional professional development for foreign language teachers does not improve self-reflection. Despite their individual differences and qualifications, most teachers receive traditional in-service professional development (Darling-Hammond, Hyler, Gardner, & Espinoza, 2017) on a specific topic and have no time to reflect on their existing practices, newly presented concepts, or students' responses to instruction. The effectiveness of such professional development is questionable (Darling-Hammond, Wei, Andree, Richardson, & Orphanos, 2009; Penuel, …

The Impact Of Relationships On Youth Developmental Outcomes In A Sport-Based Setting, Khalil Griffith

Master's Theses

No abstract provided.

A Tale Of Two Symbioses: Development And Maintenance Of Bacterial Partnerships With The Hawaiian Bobtail Squid, Sarah J. Mcanulty

Doctoral Dissertations

Beneficial associations with microorganisms are widespread in the animal kingdom. The Hawaiian bobtail squid (Euprymna scolopes) has two symbiotic organs with bacteria. The light organ symbiosis contains one species of bioluminescent bacteria, Vibrio fischeri, which produces light allowing the squid to camouflage itself against down-welling moonlight. The second organ, the accessory nidamental gland (ANG), is found only in female squid and houses a consortium of bacteria¹. Bacteria from the ANG are deposited into the squid’s egg jelly coat ², where they play a defensive role against biofouling ^{3 1,4}.

This dissertation characterizes the …

Floral Preformation In The Warming Boreal Forest: The Effects Of Temperature On The Development Of Vaccinium Vitis-Idaea, Eileen Schaub

Master's Theses

The boreal forest is experiencing climate change at twice the rate of other regions. Although changes in flowering phenology are a known consequence of warming temperatures, much is unknown about the effects of temperature anomalies on floral development. Boreal angiosperms preform flowers a year or more in advance and are consequently subject to varied environmental conditions across that time. My thesis examines the effects of temperature on floral development in order to understand how boreal taxa will respond to climate change.

Collection of Vaccinium vitis-idaeafrom natural populations in Fairbanks, Alaska was carried out over the growing seasons of 2017 …

Brd4 Is Required For Granule Cell Progenitor Proliferation, Marie E. Maloof

Open Access Dissertations

Bromodomain and extraterminal domain proteins are epigenetic reader proteins that recognize and bind acetylated histones to facilitate gene transcription. Because of their influence on transcription of genes involved in proliferation and differentiation, small molecule bromodomain inhibitors have entered clinical trials for various indications including several types of cancer. However, our understanding of bromodomain protein function is incomplete, as we do not completely understand their role in vertebrate development. We are investigating the role of the BET protein, Brd4, in cerebellar granule cell progenitor proliferation and cell cycle exit. Dysregulation of cerebellar granule cell progenitor proliferation leads to medulloblastoma, the most …

The Effects Of Deepwater Horizon Oil, Dispersants, And Environmental Stressors On The Health Of Two Important Gulf Of Mexico Species, Eastern Oysters And Sheepshead Minnows, Lindsay Jasperse

Doctoral Dissertations

The explosion of the Deepwater Horizon oil platform on April 20, 2010 initiated the release of 640 million liters of oil into the Gulf of Mexico (GOM). In efforts to prevent the oiling of coastlines, response officials applied nearly 7.5 million liters of the oil dispersant Corexit. Despite these efforts, oil reached over 2100 km of coastline along the northern GOM, including estuaries that serve as important habitats and nurseries. These estuaries are dynamic ecosystems, with constant fluctuations in salinity and dissolved oxygen. While it is well-established that oil is toxic to marine species, gaps remain in the understanding of …

Determining Kinetic Parameters Of Thiamine Degradation In Three Nasa Spaceflight Foods In Thermal Processing And Long-Term Storage And Methods For Analyzing Microstructure And Precipitant Development In Real And Model Wines, Timothy R. Goulette

Doctoral Dissertations

The current NASA spaceflight food program encompasses a wide variety of commercial and custom-made edible products. These foods are designed to ensure each crewmember receives the Recommended Dietary Allowance (RDA) of vitamins and minerals to maintain adequate health during the entire spaceflight mission. With the desire for long-duration and exploration-class missions, such as the impending mission to Mars, the retention of important nutrients such as labile vitamins in spaceflight foods is critically important. For this reason, multiple studies were conducted to determine the vitamin degradation behavior of thiamine (vitamin B₁) within three spaceflight foods which demonstrated both significant …

Role Of Transient Receptor Potential Channels In Epithelial Morphogenesis In Chick Embryo, Trinity Q. Waddell

Theses and Dissertations

Transient Receptor Potential channels (TRP) are a superfamily of cationic specific ionchannels that are regulated by various stimuli such as temperature, pH, mechanical stress, ligandsand ion concentration. The role of TRP channels in disease states such as autosomal dominantpolycystic kidney disease, cancer metastasis, and developmental defects lend credence to thebelief that they play an important part in epithelial morphogenesis events. The development ofsomites, neural tube closure and migration of neural crest cells to form things such as the faceand heart is a good developmental model for the aforementioned cellular processes. We haveshown that TRP channels can be found in the …

The Origins And Development Of Visual Categorization, Laura Cabral

Electronic Thesis and Dissertation Repository

Forming categories is a core part of human cognition, allowing us to make quickly make inferences about our environment. This thesis investigated some of the major theoretical interpretations surrounding the neural basis of visual category development. In adults, there are category-selective regions (e.g. in ventral temporal cortex) and networks (which include regions outside traditional visual regions—e.g. the amygdala) that support visual categorization. While there has been extensive behavioural work investigating visual categorization in infants, the neural sequence of development remains poorly understood. Based on behavioral experiments, one view holds that infants are initially using subcortical structures to recognize faces. Indeed, …

Defining Young Adulthood, Elena Higley

DNP Qualifying Manuscripts

Young adulthood is a unique developmental period that occurs between the ages of 18 and 25 years, during which there are key developmental tasks that allow the young adult to participate in self-exploration and identity formation. Currently, among various organizations there are differing definitions and age range inclusions for young adulthood, which cause confusion during program development, healthcare service delivery, and research. Young adulthood should be categorized separately from adolescence and adulthood, because young adults have lower rates of healthcare utilization and worse health outcomes related to preventable causes of morbidity and mortality than the surrounding age groups. Young adults …

Digital Childhood: How Mobile Devices Impact Child Development And Adolescent Behavior, Brenna Pinnock

Global Honors Theses

A new wave of smart and modern technology has integrated into lives and homes of families everywhere, thus the effects of early and continual exposure to this technology remain unknown. This is a global problem as many people around the world have access to this technology and interact with it in different ways. Whether it’s embracing it for future generations like Japan, or helping the newer generations with their overuse, almost addiction like tendencies with these devices like in South Korea. Around the world children are engaging with these devices at a young age and it’s found to have an …

Modification Of Host Behavior And Transmission In The Acanthocephalan Acanthocephalus Dirus: Effects Of Development, Intraspecific Conflict, And Host Sex, Sara R. Teemer

College of Science and Health Theses and Dissertations

Parasites are organisms that live on or in another in order to survive. In some cases, parasites require more than one host to complete their life cycle and rely on a predation event for transmission to the next host. Inside the host, the parasite must access host resources to grow and develop from the non-infective to infective stages. At the infective stage, the parasite is able to survive within the definitive host. Development to this stage has been correlated with changes in antipredatory behaviors, body size and color, and reproduction of intermediate hosts in ways that may increase predation by …

The Influence Of Team Cohesion And Contextual Performance On Project Team Performance Over Time, Melissa Vazquez

College of Science and Health Theses and Dissertations

Theory and empirical research suggest that team cohesion and contextual performance relate to team performance. However, while general support exists for a team cohesion and contextual performance relationship, less is known about the how the relationship evolves over time. This study aimed to examine the extent to which team cohesion and contextual performance reciprocally relate over time. Data were collected from 245 individuals comprising 40 student project teams engaged in the Capsim business simulation over a 10-week quarter. Results supported hypothesis 1; based on a cross-lagged path model, a stronger relationship exists between contextual performance at time point 1 and …

What Professional Development Practices Do Mid-Career Teachers Need?, Amy Christie

College of Education Theses and Dissertations

Finding out what keeps teachers engaged, satisfied and feeling successful during their mid-career years is an area that needs further examination. Moreover, what professional development practices do teachers need to thrive and adapt to modern learning practices after their 4th year in the classroom? All teachers, regardless of where they are in their career, should be valued and deserve professional development. To avoid the feeling of a “dull routine,” one may suggest that providing differentiated professional development offerings may sustain a feeling of meaningful work for mid-career teachers. These teachers may be at risk of becoming stagnant in their careers, …

Investigation Of Even-Skipped, A Developmentally-Regulated Gene Controlling Neural Segmentation In Dragonflies, Kathryn Bangser

Honors Theses

A comprehensive understanding of the genetic mechanisms underlying pattern formation and neurogenesis is necessary in order to trace the evolutionary history of insect embryogenesis.

One of the most important processes of embryogenesis is the organized pattern formation that allows for proper body segmentation and neural development. Proper segmentation, which relies on a series of specific gene expressions, is necessary for the development of an operational nervous system. Even-skipped (eve), one such regulatory gene, has been studied extensively in certain model organisms, and theories regarding the evolution of its functional role could be further elucidated by visualizing its expression …

The Proteomic Response Of Northern Elephant Seal (Mirounga Angustirostris) Pups To Physiological Stress During Development, Melissa P. Voisinet

Master's Theses

Background: Northern elephant seals transition from terrestrial nursing pups to pelagic foraging juveniles in a short period of just 8-12 weeks. During the post-weaning period, pups rely solely on the energy reserves gained during nursing for their caloric demands and water supply. The prolonged absence of food after weaning is the first of many fasts for which the seals have evolved adaptations such as decreased urine production and increased blubber reserves. The stressors experienced from learning to dive for the first time are also stressors that they will experience frequently as an adult and for which they have evolved adaptations. …

Assessing Community Based Education In Upper Egypt Failure And Success, Amira Hussein

Theses and Dissertations

Community based education has been used in different developing countries in the context of the Education for All (EFA) commitments as a mechanism to increase access and enrollment for basic education in remote and rural areas. It has been introduced to Egypt in 1992 through a partnership between MOE, INGOs, such as UNICEF, USAID, CARE, and local communities. This study examines the current prevailing perception about the community education model as being a successful alternative for public primary education in Egypt in marginalized areas and for vulnerable and marginalized groups mainly girls. It argues that in spite of achieving satisfactory …

Development Finance Institutions As Tools For Foreign Aid Distribution: A Comparative Analysis Of The Overseas Private Investment Corporation, Findev Canada And Deutsche Investitions – Und Entwicklungsgesellschaft, Kamal Mann

Major Papers

An understanding of how foreign aid has changed requires a thorough examination of the efforts taken in aid to address the widening finance gap in development, alongside the often-contested issue of aid effectiveness. This is particularly the case when looking at how aid should be paid for. Yet the question of how to best program and deliver foreign aid remains unanswered.

Aid remains one of the largest aspects of international transfers of resources that occur in the world, as such it is important to study it. The rise of Development Finance Institutions, which are publicly owned, private lending institutions helps …