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The Effect Of Thyroid Hormone On The Expression Of A7 Myosin Heavy Chain Mrna In Xenopus Laevis, Bradley Thomas Butkovich
The Effect Of Thyroid Hormone On The Expression Of A7 Myosin Heavy Chain Mrna In Xenopus Laevis, Bradley Thomas Butkovich
Master's Theses
It has long been known that thyroid hormone (TH) is responsible for metamorphosis in tadpoles. It is also known that A7 MHC, an adult muscle isoform, is expressed in adult Xenopus laevis frogs, but not in larvae. Furthermore, the appearance of A7 corresponds with the onset of metamorphosis. The present study investigated the relationship between TH and the expression of A7 MHC mRNA in Xenopus laevis. Isolated tails in culture and 6-n-propyl 2-thiouracil (PTU) treated tails were treated with TH and the presence of A7 mRNA analyzed with in-situ hybridization, and RT-PCR. It was found that TH caused substantial …