Digital Commons Network^™

Exploring The Willingness Toward Hiv Immediate Test And Treat Among Msm In Nairobi And Its Environs: A Cross-Sectional Study., Kingori Ndungu, Peter Gichanga, Marleen Temmerman

Centre of Excellence in Women and Child Health

Background: In the test and treat initiative, high-risk populations are screened for human immunodeficiency virus (HIV) infection and start early treatment if diagnosed positive. This study explores factors associated with willingness to initiate testing and immediate treatment among men who have sex with men (MSM) in Nairobi and its environs. The study was informed by a conceptual framework combining the AIDS Risk Reduction Model (ARRM) and the Modified Social Ecological Model.

Methods: This cross-sectional exploratory study targeted MSM (aged 18–60 years) reporting active engagement in anal or oral sex with men in Nairobi and its surrounding areas. Purposive sampling was …

Desc(Art) Or The 21st Century Cartesian Meditator, Andreea Mihali

Comparative Philosophy

In this paper I argue that the continued relevance of Descartes' philosophy for present-day concerns can be demonstrated by bringing to bear on his Meditations state-of-the-art developments in Informal logic and Argumentation theory, specifically Leo Groarke’s approach to multimodal arguments. I show that the meditative exercises that Descartes viewed as preconditions of establishing the metaphysical tenets of his system can be recast in present-day form using technological tools and media that we are familiar with. We will see that, due to the different historical and cultural contexts, the 21st century Cartesian meditating process can be: 1) technology-enhanced (a customizable, multimodal …

Independent Effects Of Hiv And Antiretroviral Therapy On The Oral Microbiome Identified By Multivariate Analyses, Clifford J. Beall, Elizabeth A. Lilly, Carolina Granada, Kelly Treas, Kenneth R. Dubois, Shahr B. Hashmi, Jose A. Vazquez, Michael E. Hagensee, Ann L. Griffen, Eugene J. Leys, Paul L. Fidel

School of Dentistry Faculty Publications

The oral microbiome is an important predictor of health and disease. We recently reported significant yet modest effects of HIV under highly active antiretroviral therapy (ART) on the oral microbiome (bacterial and fungal) in a large cohort of HIV-positive (HIV+) and matched HIV-negative (HIV-) individuals. As it was unclear whether ART added to or masked further effects of HIV on the oral microbiome, the present study aimed to analyze the effects of HIV and ART independently, which also included HIV- subjects on preexposure prophylaxis (PrEP) therapy. Cross-sectional analyses of the effect of HIV devoid of ART (HIV+ ART- versus matched …

In Vitro Gametogenesis: A Research Timeline And Implications For The Future Of Assisted Reproductive Technology, Nicole Buckley

Senior Honors Theses

The novel reproductive technology, In Vitro Gametogenesis (IVG), includes the process of obtaining mature viable germ cells from pluripotent stem cells. To do so, embryonic stem cells and induced pluripotent stem cells are specified to primordial germ cells and differentiated to form gametes that undergo further maturation, which subsequently may undergo in vitro fertilization to form an embryo. With this capability, IVG holds the power to provide a novel treatment option for human infertility. As of now, research has been conducted on mice successfully, and with limited success in humans. Future research will likely focus on discovering the species-specific differences …

Hiv-Seropositive Patients’ Experiences With Social Workers: A South African Hiv+ Social Worker’S Reflective Log, Delarise Maud Mulqueeny

The Qualitative Report

Social workers play a pivotal role in HIV-seropositive patients’ treatment and care within South African public antiretroviral treatment (ART) programs. This article is a reflective log of an HIV-seropositive social worker’s observations and reflections on her positionality during a study on HIV-seropositive patients’ experiences of the public ART program in eThekwini, KwaZulu-Natal, South Africa. The primary investigator (PI) utilized various tools and techniques including reflexive bracketing, participatory action research and a reflexive diary to navigate a sensitive study. This was while being cognizant of the fluidity of her insider/outsider positionality. The disclosure of the PI’s HIV-seropositive status culminated in all …

A Retrospective Cross Sectional Study Assessing Factors Associated With Retention And Non-Viral Suppression Among Hiv Positive Fsws Receiving Antiretroviral Therapy From Primary Health Care Facilities In Kampala, Uganda, Lydia Atuhaire, Constance Shumba, Lovemore Mapahla, Peter S. Nyasulu

School of Nursing & Midwifery, East Africa

Background: Patient retention in care and sustained viral load suppression are a cornerstone to improved health and quality of life, among people living with HIV. However, challenges of retention on ART remain among female sex workers (FSWs). We report lost to follow up (LTFU), viral load suppression, and the associated factors among FSWs that access HIV treatment at primary health care facilities in Kampala.

Methods: We retrospectively abstracted and analysed patient management data of HIV positive FSWs who enrolled in care between January 2018 to December 2020. LTFU was defined as failure of a FSW to return for …

Offspring Conceived Through Art Have Normal Thyroid Function In Adolescence And As Young Adults, L. A. Wijs, D. A. Doherty, J. A. Keelan, V. Panicker, P. Burton, J. L. Yovich, R. J. Hart

Research outputs 2022 to 2026

STUDY QUESTION: Are there differences in thyroid function between adolescents and young adults conceived with and without ART? SUMMARY ANSWER: This study demonstrated no evidence of clinically relevant differences in thyroid function between adolescents and young adults conceived with and without ART. WHAT IS KNOWN ALREADY: Studies to date have reported an increase in subclinical hypothyroidism in offspring conceived after ART. It has been suggested that the increase in maternal estrogen (E2) after fresh embryo transfers could affect thyroid function of the offspring. Suboptimal thyroid function at a young age can cause irreversible damage to the central nervous system, which …

Proportion Of Depression Symptoms And Its Relationship With Arv Therapy: A Study At The Vct Clinic, Dr. Kariadi General Hospital, Muchlis Achsan Udji Sofro, Tommy Raharja, Titis Haidati, Linda Kartika Sari, Innawati Jusup

Jurnal Penyakit Dalam Indonesia

Introduction. Indonesia has the second largest HIV burden in Asia. The prevalence of depression in HIV/AIDS is 2-10 times higher than the general population, influenced by biological, environmental, psychological, and demographic factors. Data on the proportion of depression symptoms in HIV/AIDS patients and their relationship to biological factors are still limited, which needed for better treatment of HIV/AIDS. This study aimed to determine the prevalence of depression and its relationship to the biologic factors of ARV therapy (ART) in HIV/AIDS patients.Methods. Cross-sectional study was conducted among 142 HIV/AIDS patients undergoing ARV treatment at RSUP. Dr. Kariadi in January – March …

Frozen Embryos, Male Consent, And Masculinities, Dara E. Purvis

Indiana Law Journal

Picture two men facing the possibility of unwanted fatherhood. One man agreed to go through in vitro fertilization (IVF) with his partner, but years later has changed his mind. Despite the fact that the embryos created through IVF are his partner’s last chance to be a genetic parent, a court allows him to block her use of the embryos.

By contrast, another couple’s sexual relationship broke the law. The woman was a legal adult, and her partner was a child under the age of eighteen. Their encounter was thus statutory rape. Her crime led to pregnancy, and after she gave …

A Method For Predicting Dose Changes For Hn Treatment Using Surface Imaging, Sarah E. Holler

Theses and Dissertations

Head and neck cancer is commonly treated with a six- to seven-week course of radiotherapy, during which a patient’s anatomy may change substantially, due to target reduction or weight loss. Anatomical changes lead to reduction in treatment quality due to decreased setup reproducibility and altered dose deposition compared to the original plan. Few clinics have developed a standard method for triggering resimulation and replan due to anatomic changes. This work investigates a new method for determining when to resimulate and replan HNC patients by utilizing their topographic anatomical changes to predict differences in planned versus delivered dose distributions. The first …

Comparison Of The Cardiometabolic Profiles Of Adolescents Conceived Through Art With Those Of A Non-Art Cohort, L. A. Wijs, D. A. Doherty, J. A. Keelan, P. Burton, J. L. Yovich, L. Beilin, T. A. Mori, R. C. Huang, L. A. Adams, John K. Olynyk, O. T. Ayonrinde, B. Penova-Veselinovic, R. J. Hart

Research outputs 2022 to 2026

STUDY QUESTION: Is the cardiometabolic health of adolescents conceived through ART worse than that of their counterparts conceived without ART? SUMMARY ANSWER: The majority of cardiometabolic and vascular health parameters of adolescents conceived through ART are similar or more favourable, than those of their counterparts of similar age and conceived without ART. WHAT IS KNOWN ALREADY: It has been proposed that the cardiometabolic health of offspring conceived with ART may be unfavourable compared to that of their counterparts conceived without ART. The literature pertaining to cardiometabolic health of offspring conceived after ART is contradictory, but generally suggests unfavourable cardiometabolic health …

I Just Took A Dna Test—Turns Out, I'M 100% Breaching My Donor Anonymity Contract: Direct-To-Consumer Dna Testing And Parental Medical-Decision-Making, Morgan C. York

Indiana Journal of Global Legal Studies

Part I of this note provides a brief history of assisted reproductive technology and its increased use throughout the world, illustrating the growing number of donor-conceived children and the related importance of knowing genetic information. Part I also surveys regulations concerning donor anonymity in the United States and the United Kingdom to illustrate different jurisdictions' approaches to the regulation of donor anonymity. This note uses the United Kingdom as a model of countries that have prohibited sperm donor anonymity. Part II of this note discusses direct-to-consumer DNA testing, specifically 23andMe's products. This note selects 23andMe as the direct-to-consumer company for …

Class Of 2020 Reunites For Commencement Celebration, Jill Rodrigues

Featured News Story

RWU celebrates the Class of 2020’s accomplishments and first year as alumni during a weekend of commencement celebrations.

Rwu Graduates Urged To Create Equity, Welcome Challenges And Dream Big, Jill Rodrigues

Featured News Story

Local Indigenous leaders William Guy and Lorén Spears call on Class of 2021 and Class of 2020 to “be the change” and never “give up your dream”.

Student Commencement Speaker Wants To Celebrate Resilience Of Class Of '21, Anna Cohen

Featured News Story

'We have grown and learned how to communicate and band together as a community. I wanted to really celebrate what we’ve gone through, and motivate us to face what is coming next,' says Shannon DeFranza '21, human rights advocate and National Vice President Elect of the American Institute of Architecture Students.

Disparities In Access To Assisted Reproductive Technology Among Hispanic Women In The United States, Madison Gallagher

Honors Thesis

Infertility is a health problem that affects approximately 7 million women in the United States (Ethics Committee of the American Society for Reproductive Medicine, 2015). Due to the high costs of reproductive medicine and infertility treatment, these services tend to be expensive and have limited accessibility without full insurance coverage. Emerging literature outlines the disparities in access to proper treatment for reproductive complications. These existing studies highlight that many minority populations in the United States experience increased challenges regarding access to reproductive medicine and infertility treatment. Among these minority groups are Hispanic women, who are more likely to require reproductive …

Child Support And Joint Physical Custody, Raymond C. O'Brien

Catholic University Law Review

Child custody has evolved to the point where, at a minimum, states provide a mediated process by which parents may formulate parenting plans with court-appointed assistance. At a maximum state legislatures and courts increasingly consider joint physical custody awards. While joint physical custody safeguards the fundamental rights of parents, it nonetheless prompts practical concerns in awarding child support. Today, child support begins with state statutory guidelines, but the guidelines often fail to adequately address the economic consequences of two complete residences, one supported by a parent with fewer economic resources, and the fact that oftentimes the child drifts from one …

Celebrating Student Research And Academic Projects At Sash, Anna Cohen

Featured News Story

Students presented their research and academic projects to faculty, staff, and their peers at the annual Student Academic Showcase and Honors (SASH,) a full-day celebration of student achievement.

Multi-Level Considerations For Optimal Implementation Of Long-Acting Injectable Antiretroviral Therapy To Treat People Living With Hiv: Perspectives Of Health Care Providers Participating In Phase 3 Trials, Andrea Mantsios, Miranda Murray, Tahilin S. Karver, Wendy Davis, Noya Galai, Princy Kumar, Susan Swindells, U. Fritz Bredeek, Rafael Rubio García, Antonio Antela, Santiago Cenoz Gomis, Miguel Pascual Bernáldez, Maggie Czarnogorski, Krischan Hudson, Nicki Walters, Deanna Kerrigan

Journal Articles: Infectious Diseases

BACKGROUND: Long-acting injectable antiretroviral therapy (LA ART) has been shown to be non-inferior to daily oral ART, with high patient satisfaction and preference to oral standard of care in research to date, and has recently been approved for use in the United States and Europe. This study examined the perspectives of health care providers participating in LA ART clinical trials on potential barriers and solutions to LA ART roll-out into real world settings.

METHODS: This analysis draws on two data sources: (1) open-ended questions embedded in a structured online survey of 329 health care providers participating in the ATLAS-2 M …

Hiv-1 Latency And Viral Reservoirs: Existing Reversal Approaches And Potential Technologies, Targets, And Pathways Involved In Hiv Latency Studies, Sushant Khanal, Madison Schank, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV cure. While antiretroviral therapy (ART) halts HIV replication by targeting multiple steps in the HIV life cycle, including viral entry, integration, replication, and production, it cannot get rid of the occult provirus incorporated into the host-cell genome. These latent proviruses are replication-competent and can rebound in cases of ART interruption or cessation. In general, a very small population of cells harbor provirus, …

Direction Of The Play 'Art', Kathryn Young

All Graduate Projects

The following documentation includes the conceptualization, research, implementation, and reflection of the entire production process of ‘ART’ in May 2021. The documentation includes character and visual production research, historical context and significance, as well as the evaluation of the play as a vehicle for production in the community of Etna, California.

The Impact Of Hiv-And Art-Induced Mitochondrial Dysfunction In Cellular Senescence And Aging, Madison Schank, Juan Zhao, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure and is associated with viral persistence, residual inflammation, and metabolic disturbances. Indeed, due to the presence of viral reservoirs, lifelong ART therapy is required to control viremia and prevent disease progression into acquired immune deficiency syndrome (AIDS). Successful ART treatment allows people living with HIV (PLHIV) to achieve a similar life expectancy to uninfected individuals. However, recent studies have illustrated the …

Modulation Of P3 And The Late Positive Potential Erp Components By Standard Stimulus Restorativeness And Naturalness, Salif P. Mahamane

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Tests of attention restoration theory (ART) consistently support that exposure to restorative environments can replenish finite cognitive resources, needed to focus attention, from a depleted state. These environments are usually natural, but the dimensions of naturalness and restorativeness are not one and the same, and yet have not been empirically delineated. The restorative effect has been documented in children and adults. However, neuroscientists have barely begun to test for neural correlates of ART. In this dissertation, I employ electroencephalography (EEG) to record electrophysiological brain activity during an active visual oddball task to capture and analyze p3 elicitation and late positive …

Hiv/Hcv/Sti Cases, Marshal Miller, Md, Aahivs

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives:

• Discuss approach to Syphilis testing and management in persons infected with HIV and HIV negative patients
• Review strategies to improve ART adherence
• Review ART options and considerations for initiating and modifying ART and clinically relevant Rx-Rx interactions
• Assess patients for HCV treatment and review simplified treatment strategies for patients with chronic HCV infection

Imaging Of Our Ancestors Written By Italo Calvino Through Illustrations And An Animation, Wenpei Li

Theses - ALL

The aim of this thesis is to combine my artwork with literature. The first part of the thesis is an examination of Italo Calvino’s role in 20th-century literature, Our Ancestor. The second section of the thesis explains my evolution as a creative artist. I made an animation called Drifting of A Leaf.

From 1952 to 1957, Italo Calvino published three novels: The Cloven Viscount (1952), The Baron in the Trees (1957), and The Nonexistent Knight (1959). I want to show how an illustrator thinking about this book. It is a series of 8 pieces of illustrations. In this illustration part, …

Assisted Reproductive Technologies In Male Ambystoma Tigrinum With Application To Threatened Newt Species, Amanda Gillis

Theses and Dissertations

The world is currently facing an amphibian extinction crisis and wild salamanders and newts (Order: Caudata) are the most disadvantaged with 52% of species threatened. Captive breeding programs are been established to act as assurance colonies, but they are overwhelmingly failing due to the lack of environmental cues to stimulate reproduction and other factors. Therefore, assisted reproductive technologies (ART) are being developed to overcome these barriers. This project expands upon the limited existing information on caudate ART through studies in the model species, Ambystoma tigrinum, for application to threatened species. Specific objectives included the characterization of motility longevity in artificially …

Men's Reproductive Rights: A Legal History, Mary Ziegler

Pepperdine Law Review

This Article offers the first legal history of men’s procreative rights, filling a gap in scholarship on assisted reproduction, constitutional law, and social movements. A rich literature addresses women’s procreative rights in contexts from abortion to infertility. By comparison, we know relatively little about the history of the debate about reproductive rights for men. This void is particularly troubling at a time when the law of reproductive rights is increasingly up for grabs, especially in the context of assisted reproduction technologies (ART). Men’s rights advocates—and the abortion-rights supporters responding to them—championed a jurisprudential approach to parenting that casts a long …

Predictors Of Tb-Mortality Among Hospitalized Hiv-Infected Children In Kenya, Henry Sohre Kitiabi Mr., Lisa Marie Cranmer Dr.

Public Health Theses

Abstract

Background: Tuberculosis (TB) is a bacterial disease caused by Mycobacterium tuberculosis, resulting in an estimated one million new cases and over 200,000 deaths annually among children. TB is the leading cause of death in HIV-infected children globally (Swaminathan & Rekha, 2010), but few studies have evaluated cofactors of pediatric TB mortality the era ART. We evaluated predictors of TB mortality in a cohort of HIV-infected hospitalized Kenyan children initiating antiretroviral therapy (ART).

Methods: HIV-infected children age(PUSH) trial. Children were ART-naïve and started ART within 2 weeks of enrollment. All children underwent intensified TB case finding at enrollment and were …

Ivf Errors - Is This Only The Tip Of The Iceberg?, Jody L. Madeira, Steven R. Lindheim Md, Mark P. Trolice

Articles by Maurer Faculty

ART errors are fortunately a rare occurrence. but humans are fallible and mistakes are inevitable. As social media sensationalizes these events, we, as infertility specialists, must be vigilant in reviewing existing risk management systems and consider other options to minimize/eliminate these events. ART programs should work to emphasize honesty and transparency to improve quality of care.

The Path To Pregnancy: Fertility Services And Assisted Reproductive Technologies, Olivia H. Gilbert

Scripps Senior Theses

The emergence of reproductive assistance like fertility treatments and assisted reproductive technologies (ART) in recent decades have provided new paths to pregnancy for many individuals. However, certain demographics in the US like low-income women and women of color are often excluded from utilizing these services on the basis of race, geography, and socioeconomic status. This in turn leads to significant disparities in access to and usage rates of such services. This research points out the perceived shortcomings in the current academic discussion surrounding fertility service disparities with the ultimate goal of expanding access to fertility assistance services for those who …