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This Is A Question? Prosody, Social Communication, And The N400 Effect, Elizabeth A. Kaplan

Theses - ALL

The present study examined electrophysiological responses, specifically the N400 effect, in typically developing adults (N = 37) to spoken questions and statements that contained prosodically congruous and prosodically incongruous contours. In particular, prosodic incongruities were created by cross-splicing the audio signal so that questions ended with a decreasing pitch and statements ended with an increasing pitch. Further, the study examined the extent to which the size of an individual's N400 effect was related to an applied score of social communication as measured by the Social Responsiveness Scale, Second Edition. Results revealed no main effect of sentence congruency, but a main …

The Neuromodulatory And Hormonal Effects Of Transcutaneous Vagus Nerve Stimulation As Evidenced By Salivary Alpha Amylase, Salivary Cortisol, Pupil Diameter, And The P3 Event-Related Potential, Christopher M. Warren, Klodiana D. Tona, L. Ouwerkerk, Jeroen Van Paridon, Fenna Poletiek, Henk Van Steenbergen, Jos A. Bosch, Sander Nieuwenhuis

Psychology Faculty Publications

Background

Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence supporting this notion is limited.

Objective

In order to test for an impact of tVNS on psychophysiological and hormonal indices of noradrenergic function, we applied tVNS in concert with assessment of salivary alpha amylase (SAA) and cortisol, pupil size, and electroencephalograph (EEG) recordings.

Methods

Across three experiments, we applied real and sham tVNS to 61 healthy participants …

Investigating Neural Sensorimotor Mechanisms Underlying Flight Expertise In Pilots: Preliminary Data From An Eeg Study, Mariateresa Sestito, Assaf Harel, Jeff Nador, John Flach

Psychology Faculty Publications

Over the last decade, the efforts toward unraveling the complex interplay between the brain, body, and environment have set a promising line of research that utilizes neuroscience to study human performance in natural work contexts such as aviation. Thus, a relatively new discipline called neuroergonomics is holding the promise of studying the neural mechanisms underlying human performance in pursuit of both theoretical and practical insights. In this work, we utilized a neuroergonomic approach by combining insights from ecological psychology and embodied cognition to study flight expertise. Specifically, we focused on the Mirror Neuron system as a key correlate for understanding …

Motivation Predicts Self-Control Of Racial Bias After Viewing Alcohol Advertisements, Zachary Wolfgang Petzel

Dissertations

Exerting self-control shifts motivation toward rewarding cues (i.e., approach motivation) and impairs control of racial bias. However, whether approach motivation predicts deficits in control of racial bias is unknown. Exertion of self-control is also related to alcohol use, but whether exerting self-control shifts motivation toward alcohol-related cues is not established. Similar to exerting self-control, viewing alcohol-related cues shifts motivation and promotes racial bias. The current study examined the interaction between exerting self-control and viewing alcohol-related cues on approach motivation and its influence on racial bias. Participants (N = 71) exerted (or did not exert) self-control and then viewed neutral …

The Emerging Role Of Neurodiagnostic Informatics In Integrated Neurological And Mental Health Care, William Bosl

Nursing and Health Professions Faculty Research and Publications

Mental, neurological, and neurodevelopmental (MNN) disorders impose an enormous burden of disease globally. Many MNN disorders follow a developmental trajectory. Thus, defining symptoms of MNN disorders may be conceived as the end product of a long developmental process. Many pharmaceutical therapies are aimed at the end symptoms, essentially attempting to reverse pathological brain function that has developed over a long time. A new paradigm is needed to leverage the developmental trajectory of MNN disorders, based on measuring brain function through the life span. Electroencephalography (EEG) is ideally suited for this task. New developments in several fields, including consumer EEG hardware, …

Working Memory And Falls Risk In Older Adults: An Event-Related Potential Study, Yee (Michelle) S. Wong

Electronic Thesis and Dissertation Repository

BACKGROUND: The aging population is rapidly increasing, where currently in North America, the population of older adults (ages 60+) outnumbers the population of children. Falls are a major concern for older adults and their quality of life. Cognitive impairment has been shown to be declined in older adults at-risk for falls, but working memory has not been thoroughly investigated within this population. PURPOSE: To examine differences in Non-Fallers, Moderate Risk for Falls, and Fallers in a working memory task using electroencephalography (EEG). METHODS: Older adults (n=44, female=27) aged 60 – 80 years (m=68.8, SD=4.7) completed two sessions. The first session …

Identification Of The Seizure Onset Zone By Auto-Regressive Model Residual Modulation Applied To Intracranial Eeg And Its Correlation To Channels With High Preponderances Of Detected Hfos, Allison L. Rogutich

Masters Theses

The objective of this thesis was to examine the ability of the Autoregressive Model Residual Modulation (ARRm) method to identify the Seizure Onset Zone (SOZ) in intracranial electroencephalogram (iEEG) of patients with refractory epilepsy. Patients who have not become seizure free after multiple trials of antiepileptic drugs (AEDs) may seek treatment through epilepsy surgery. Cortical electrodes are implanted directly on the cerebral cortex, then iEEG is collected. A specialized neurologist reviews the iEEG, then in consultation with the neurosurgeon, the SOZ is determined and areas of the brain may be chosen for resection. The success rate of epilepsy surgery varies, …

Entropy As A Method For Identifying Treatment Resistant Autism Spectrum Disorder, Nathan Wright

Doctoral Dissertations

Background: Individuals diagnosed with Autism Spectrum Disorder (ASD) experience lifelong challenges which can impact peer relationships, adaptive functioning, and independent living. Verbal intelligence has proven to be the strongest indicator of outcomes and responsiveness to behavioral intervention, but this property only stabilizes in children between 6 and 8 years of age. Behavioral treatment is the primary intervention for individuals diagnosed with ASD, but it is most effective when delivered as an early intervention strategy for toddlers and very young children. A biomarker which could distinguish treatment resistant subgroups of ASD from would allow for the development and implementation of alternative …

Neurobehavioral Signatures In Children-Victim Of Bullying, Isabel Solis

Psychology ETDs

Experiencing bullying victimization can lead to detrimental damage to a child’s life potential, reduced long-term contributions to society, and in severe cases, to suicide or desperate acts of defensive aggression, such as school shootings. The current study aimed to examine risk factors that may increase the vulnerability of a child to become a target of bullying victimization and the related consequences of victimization, using rigorous neuropsychological and EEG measures. The end-goal is to translate these findings into a program of preventive intervention increasing the child’s resilience and improving social culture among youth in the academic environment. We propose a two-component …

The Role Of Visual And Verbal Processes In False Memory Susceptibility On The Misinformation Effect, John E. Kiat

Department of Psychology: Dissertations, Theses, and Student Research

The goal of this dissertation is to investigate links between susceptibility to misinformation on the misinformation effect paradigm and individual differences in visual and verbal source monitoring ability. Results from four studies are reported. The first three studies assess links between individual differences in perceptual misinformation endorsement levels and visualization (Word-As-Picture) as well as verbalization (Picture-As-Word) errors on the memory test of a source monitoring task in which a set of objects were initially presented either as pictures or words during study. In Study 1, this picture-word source monitoring task and a misinformation effect paradigm, with a True/False test format, …

At-Home Neurofeedback Treatment, Sanah Imran, Frank Cannizzaro

Electrical and Computer Engineering Senior Theses

In the past two decades, the prevalence of mental health illnesses and cognitive disorders has dramatically increased both in the United States and worldwide. While the problem is an expensive one, costing billions annually in lost productivity, the greatest cost is to the patient suffering from mental health problems. Those who have the means to seek professional help may be prescribed medications that often have negative side effects and merely mitigate symptoms of these disorders without treating the underlying cause. Fortunately, there is a new and revolutionary therapy available called neurofeedback. It uses electroencephalogram (EEG) signals to self- regulate brain …

Electrophysiological Study Of Action-Affordance Priming Between Object Names., Isabel M. Feven-Parsons, Jeremy Goslin

School of Psychology

If our central representation of an object is defined through embodied experience, we might expect access to action affordances to be privileged over more abstract concepts. We used event-related potentials to examine the relative time course of access to affordances. Written object names were primed with the name of an object sharing the same affordance as the target (e.g. precision-grip: "grape" primed by "tweezers") or the same taxonomic category (e.g. fruit: "grape" primed by "apple"). N200 latencies, related to go/nogo semantic category decisions on target words, revealed no difference in facilitation provided by affordance and semantic priming. However, separate analyses …

Cortical Statistical Correlation Tomography Of Eeg Resting State Networks, Chuang Li, Han Yuan, Guofa Shou, Yoon-Hee Cha, Sridhar Sunderam, Walter Besio, Lei Ding

Biomedical Engineering Faculty Publications

Resting state networks (RSNs) have been found in human brains during awake resting states. RSNs are composed of spatially distributed regions in which spontaneous activity fluctuations are temporally and dynamically correlated. A new computational framework for reconstructing RSNs with human EEG data has been developed in the present study. The proposed framework utilizes independent component analysis (ICA) on short-time Fourier transformed inverse source maps imaged from EEG data and statistical correlation analysis to generate cortical tomography of electrophysiological RSNs. The proposed framework was evaluated on three sets of resting-state EEG data obtained in the comparison of two conditions: (1) healthy …

Attentional Sub-Processes Involved With Emotional Eating, Gregory Denke

University of New Orleans Theses and Dissertations

Emotional eating behavior is characterized by eating a large amount of calorie dense sweet and/or high fat foods in an attempt to control, cope with, or avoid negative emotions. Numerous factors are likely to contribute to emotional eating behavior, including attentional factors, such as rumination and avoidance coping. Rumination based emotional eating (attention focused on negative stimuli while mindlessly eating) is often utilized to improve mood while dwelling on problems. However, for those inclined to escape/avoid troublesome thoughts, another type of emotional-eating pattern may be used. By focusing attention on food, emotional eating is believed to distract individuals from negative …

Electrophysiological Biomarkers Of Chemotherapy-Related Cognitive Impairment In Hematological Malignancy Patients, David E. Anderson

Theses & Dissertations

Multiple cancer populations frequently report cognitive impairment following treatment with chemotherapy agents (“chemo-brain”). Impaired neuropsychological performance is commonly reported in cognitive domains of attention and executive function. Understanding neural mechanisms underlying cognitive impairments is essential to developing prevention and rehabilitation strategies. Brain imaging studies frequently show chemotherapy-related impairments within the attentional control network, which is comprised of a constellation of cortical regions that govern reportedly impaired cognitive functions. In the current dissertation research, I developed a novel electrophysiology battery aimed at recording near-instantaneous neural activity within the attentional control network during cognitive task performance. Cancer patients diagnosed with hematological malignancy …

Time Course Of Brain Network Reconfiguration Supporting Inhibitory Control, Tzvetan Popov, Britta U. Westner, Rebecca L. Silton, Sarah M. Sass, Jeffrey M. Speilberg, Brigitte Rockstroh, Wendy Heller, Gregory A. Miller

Psychology: Faculty Publications and Other Works

Hemodynamic research has recently clarified key nodes and links in brain networks implementing inhibitory control. Although fMRI methods are optimized for identifying the structure of brain networks, the relatively slow temporal course of fMRI limits the ability to characterize network operation. The latter is crucial for developing a mechanistic understanding of how brain networks shift dynamically to support inhibitory control. To address this critical gap, we applied spectrally resolved Granger causality (GC) and random forest machine learning tools to human EEG data in two large samples of adults (test sample n = 96, replication sample n = 237, total N …

Treating Adhd With Suggestion: Neurofeedback And Placebo Therapeutics, Robert T. Thibault, Samuel Vassière, Jay A. Olson, Amir Raz

Psychology Faculty Articles and Research

Objective: We propose that clinicians can use suggestion to help treat conditions such as ADHD. Methods: We use EEG neurofeedback as a case study, alongside evidence from a recent pilot experiment utilizing a sham MRI scanner to highlight the therapeutic potential of suggestion-based treatments. Results: The medical literature demonstrates that many practitioners already prescribe treatments that hardly outperform placebo comparators. Moreover, the sham MRI experiment showed that, even with full disclosure of the procedure, suggestion alone can reduce the symptomatology of ADHD. Conclusion: Non-deceptive suggestion-based treatments, especially those drawing on accessories from neuroscience, may offer a safe complement and potential …

Comprehending Events On The Fly: Inhibition And Selection During Sentence Processing, Yanina Prystauka

Master's Theses

In our everyday conversations we talk about how things or people change. Instantiations of objects in their different states need to be maintained during language comprehension for future selection of the relevant state, as in The chef will chop the onion. And then/but first, she will weigh the onion. Previous fMRI studies (Solomon et al, 2015) demonstrated that selecting between multiple competing representations of the same object token, such as the intact and the chopped onion, elicits increased activation in the brain area associated with conflict resolution -- left pVLPFC. When there is no cue to the earlier introduced …

Sensorimotor Modulations By Cognitive Processes During Accurate Speech Discrimination: An Eeg Investigation Of Dorsal Stream Processing, David E. Jenson

Theses and Dissertations (ETD)

Internal models mediate the transmission of information between anterior and posterior regions of the dorsal stream in support of speech perception, though it remains unclear how this mechanism responds to cognitive processes in service of task demands. The purpose of the current study was to identify the influences of attention and working memory on sensorimotor activity across the dorsal stream during speech discrimination, with set size and signal clarity employed to modulate stimulus predictability and the time course of increased task demands, respectively. Independent Component Analysis of 64–channel EEG data identified bilateral sensorimotor mu and auditory alpha components from a …

Cross-Participant Eeg-Based Assessment Of Cognitive Workload Using Multi-Path Convolutional Recurrent Neural Networks, Ryan G. Hefron, Brett J. Borghetti, Christine M. Schubert Kabban, James Christensen, Justin Estep

Faculty Publications

Applying deep learning methods to electroencephalograph (EEG) data for cognitive state assessment has yielded improvements over previous modeling methods. However, research focused on cross-participant cognitive workload modeling using these techniques is underrepresented. We study the problem of cross-participant state estimation in a non-stimulus-locked task environment, where a trained model is used to make workload estimates on a new participant who is not represented in the training set. Using experimental data from the Multi-Attribute Task Battery (MATB) environment, a variety of deep neural network models are evaluated in the trade-space of computational efficiency, model accuracy, variance and temporal specificity yielding three …

In Pursuit Of A Good Night’S Rest. Steps Towards Improving Electroencephalogram (Eeg) Accessibility And Affordability, Niyant Vora

John Wesley Powell Student Research Conference

The Electroencephalogram (EEG), which is used to effectively record brain waves, has long been a key pillar of sleep research. However, sleep research has an important problem–the natural environment in which people sleep (their bedrooms), is not where sleep research is conducted. Several companies have released EEG headsets to try and address this problem, however, there are still many obstacles to home use. Such headsets are too expensive to be used by everyone and are still not effective enough to be utilized by physicians performing sleep studies. The goal of our research is to find affordable and innovative ways to …

Brain Connectivity Analysis Of Normal Hearing And Hearing Impaired Participants Based On The Cortical Surface Eeg Data, Md Sultan Mahmud

Electronic Theses and Dissertations

Hearing is an important sensory function of human communication and alerts people of dangerous conditions by detecting the emergency auditory alarm, sirens. We localized the source of EEG data (Hearing EEG data) into the cortical surface by solving the inverse problem and extracted the time series data from the 68 regions of Deskin-Killiany (DK) atlas. By using Granger Causality and Phase Transfer Entropy, we analyzed the brain connectivity of people experiencing normal hearing (NH) and hearing loss (HL). These results showed that NH and HL listeners’ connectivity levels are not the same. Moreover, we investigated which connectivities of the human …

Effect Of Sensory Attenuation On Cortical Movement-Related Oscillations, Joseph J. Lee, Brian Schmit

Biomedical Engineering Faculty Research and Publications

This study examined the impact of induced sensory deficits on cortical, movement-related oscillations measured using electroencephalography (EEG). We hypothesized that EEG patterns in healthy subjects with induced sensory reduction would be comparable to EEG found after chronic loss of sensory feedback. EEG signals from 64 scalp locations were measured from 10 healthy subjects. Participants dorsiflexed their ankle after prolonged vibration of the tibialis anterior (TA). Beta band time frequency decompositions were calculated using wavelets and compared across conditions. Changes in patterns of movement-related brain activity were observed following attenuation of sensory feedback. A significant decrease in beta power of event-related …

Mao-A Phenotype Effects Response Sensitivity And The Parietal Old/New Effect During Recognition Memory, Robert S. Ross, Andrew Smolen, Tim Curran, Erika Nyhus

Neuroscience Faculty Publications

A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping …

Neural Underpinnings Of Walking Under Cognitive And Sensory Load: A Mobile Brain/Body Imaging Approach, Brenda R. Malcolm

Dissertations, Theses, and Capstone Projects

Dual-task walking studies, in which individuals engage in an attentionally-demanding task while walking, have provided indirect evidence via behavioral and biomechanical measures, of the recruitment of higher-level cortical resources during gait. Additionally, recent EEG and imaging (PET, fNIRS) studies have revealed direct neurophysiological evidence of cortical contributions to steady-state walking. However, there remains a lack of knowledge regarding the underlying neural mechanisms involved in the allocation of cortical resources while walking under increased load. This dissertation presents three experiments designed to provide a greater understanding of the cortical dynamics implicated in processing load (top-down or bottom-up) during locomotion. Furthermore, we …

Attentional Modulation Of Envelope-Following Responses At Lower (93–109 Hz) But Not Higher (217–233 Hz) Modulation Rates, Emma Holmes, David W. Purcell, Robert P. Carlyon, Hedwig E. Gockel, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Directing attention to sounds of different frequencies allows listeners to perceive a sound of interest, like a talker, in a mixture. Whether cortically generated frequency-specific attention affects responses as low as the auditory brainstem is currently unclear. Participants attended to either a high- or low-frequency tone stream, which was presented simultaneously and tagged with different amplitude modulation (AM) rates. In a replication design, we showed that envelope-following responses (EFRs) were modulated by attention only when the stimulus AM rate was slow enough for the auditory cortex to track—and not for stimuli with faster AM rates, which are thought to reflect …

The Variability Of Neural Responses To Naturalistic Videos Change With Age And Sex, Agustin Petroni, Samantha Cohen, Lei Ai, Nicolas Langer, Simon Henin, Tamara Vanderwal, Michael P. Milham, Lucas C. Parra

Publications and Research

Neural development is generally marked by an increase in the efficiency and diversity of neural processes. In a large sample (n=114) of human children and adults with ages ranging from 5 to 44 yr, we investigated the neural responses to naturalistic video stimuli. Videos from both real-life classroom settings and Hollywood feature films were used to probe different aspects of attention and engagement. For all stimuli, older ages were marked by more variable neural responses. Variability was assessed by the intersubject correlation of evoked electroencephalographic responses. Young males also had less-variable responses than young females. These results were replicated in …

Maturation In Auditory Event-Related Potentials Explains Variation In Language Ability In Children, Elaine Y.L. Kwok, Marc F. Joanisse, Lisa M.D. Archibald, Margot E. Stothers, Heather M. Brown, Janis Oram Cardy

Communication Sciences and Disorders Publications

© 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Processing of auditory information in the cortex continues to develop into later childhood and adolescence. Recent research has indicated that intraclass correlation (ICC) is the best method for capturing maturation in auditory event-related potentials (AEPs) of school-age children. However, the sensitivity of the ICC approach in discerning AEP changes in children has not been consistently demonstrated and positive results have not been replicated. We attempted this replication and further explored whether AEP maturation estimated using the ICC approach predicts cognitive and linguistic abilities in addition to chronological …

Assessing Listening With Engaging, Real-World Auditory Signals, Brainscan , Western University, Björn Herrmann, Ingrid Johnsrude 6612111

Project Summaries

Our project will develop and evaluate a novel way (using functional imaging, fMRI, and electrophysiology, EEG) to assess this cognitive impact of hearing loss with engaging, real‐world auditory stimuli. We will try to assess listening effort in more realistic listening situations among healthy listeners, comparing detected effort in degraded and clear acoustic conditions.

Using EEG, we will then develop measures that are sensitive to the cognitive demands imposed by degraded speech, using these features to assess hearing function with engaging narratives in natural listening conditions.

Maturation In Auditory Event-Related Potentials Explains Variation In Language Ability In Children., Elaine Yuen Ling Kwok, Marc F Joanisse, Lisa Archibald, Margot E. Stothers, Heather M Brown, Janis Oram Cardy

Health and Rehabilitation Sciences Publications

Processing of auditory information in the cortex continues to develop into later childhood and adolescence. Recent research has indicated that intraclass correlation (ICC) is the best method for capturing maturation in auditory event-related potentials (AEPs) of school-age children. However, the sensitivity of the ICC approach in discerning AEP changes in children has not been consistently demonstrated and positive results have not been replicated. We attempted this replication and further explored whether AEP maturation estimated using the ICC approach predicts cognitive and linguistic abilities in addition to chronological age. We measured AEPs in response to simple tones in groups of 7-, …