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Menstrual Cycle And The Temporal Discrimination Threshold, Eavan M. Mc Govern, Emer O'Connor, Ines Beiser, Laura Williams, John Butler, Brendan Quinlivan, Shruti Narasimham, Rebecca Beck, Richard B. Reilly, Sean O'Riordan, Michael Hutchinson
Menstrual Cycle And The Temporal Discrimination Threshold, Eavan M. Mc Govern, Emer O'Connor, Ines Beiser, Laura Williams, John Butler, Brendan Quinlivan, Shruti Narasimham, Rebecca Beck, Richard B. Reilly, Sean O'Riordan, Michael Hutchinson
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The temporal discrimination threshold (TDT) is a proposed pre-clinical biomarker (endophenotype) for adult onset isolated focal dystonia (AOIFD). Age- and sex-related effects on temporal discrimination demonstrate that women, before the age of 40 years, have faster temporal discrimination than men but their TDTs worsen with age at almost three times the rate of men. Thus after 40 years the TDT in women is progressively worse than in men. AOIFD is an increasingly female-predominant disorder after the age of 40; it is not clear whether this age-related sexually-dimorphic difference observed for both the TDT and sex ratio at disease onset in …