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Quantifying The Burden Of Vampire Bat Rabies In Peruvian Livestock, Julio A. Benavides, Elizabeth Rojas Paniagua, Katie Hampson

KIP Articles

Background: Knowledge of infectious disease burden is necessary to appropriately allocate resources for prevention and control. In Latin America, rabies is among the most important zoonoses for human health and agriculture, but the burden of disease attributed to its main reservoir, the common vampire bat (Desmodus rotundus), remains uncertain. Methodology/Principal findings: We used questionnaires to quantify under-reporting of livestock deaths across 40 agricultural communities with differing access to health resources and epidemiological histories of vampire bat rabies (VBR) in the regions of Apurimac, Ayacucho and Cusco in southern Peru. Farmers who believed VBR was absent from their communities were one …

Surveys Of The Street And Private Dog Population: Kalhaar Bungalows, Gujarat India, Tamara Kartal, Amit Chaudhari

Demography and Statistics for Companion Animal Populations Collection

This baseline survey was conducted on the 27th and 28th of November, 2017 to generate a dog population size estimate and collect baseline data on the composition of the dog population. We estimate that there are 48 street dogs in the Kalhaar Bungalows area (all the sectors of Kalhaar Bungalows). This translates to about 6 dogs per 100 residents in the Kalhaar Bungalows area. Sterilization rates were high with 90% of the dogs being sterilized and 84% of the female population. The street dog survey was conducted by walking along all the streets of the Kalhaar Bungalows. We teamed-up with …

Surveys Of The Street And Private Dog Population: Jamnagar, Gujarat India, Tamara Kartal, Amit Chaudhari

Stray and Feral Animal Populations Collection

Humane Society International (HSI) conducted two dog population surveys in all 4 Zones of Jamnagar (human population of 609,613). One was a street dog survey and the other was a survey of the private (pet) dog population.

In Vivo Efficacy Of A Cocktail Of Human Monoclonal Antibodies (Cl184) Against Diverse North American Bat Rabies Virus Variants, Richard Franka, William C. Carson, James A. Ellison, Steven T. Taylor, Todd G. Smith, Natalia A. Kuzmina, Ivan V. Kuzmin, Wilfred Marissen, Charles E. Rupprecht

ETSU Faculty Works

Following rabies virus (RABV) exposure, a combination of thorough wound washing, multiple-dose vaccine administration and the local infiltration of rabies immune globulin (RIG) are essential components of modern post-exposure prophylaxis (PEP). Although modern cell-culture-based rabies vaccines are increasingly used in many countries, RIG is much less available. The prohibitive cost of polyclonal serum RIG products has prompted a search for alternatives and design of anti-RABV monoclonal antibodies (MAbs) that can be manufactured on a large scale with a consistent potency and lower production costs. Robust in vitro neutralization activity has been demonstrated for the CL184 MAb cocktail, a 1:1 protein …

Report On Owned Dog Population Survey In Cebu City, Philippines, Kazami Joanne Amano, Tamara Kartal

Demography and Statistics for Companion Animal Populations Collection

Many Southeast Asian countries like the Philippines have been dealing with rabies for a long time. In the Philippines alone, there are about 200 human deaths reported annually. The vast majority of which are caused by dog bites (Deray, 2015). Domestic dogs have been reported as the source of infection of more than 95% of human rabies cases worldwide (Cleaveland, et al., 2006). It is therefore a good strategy to focus on the source in order to eliminate rabies. The recommendation of the World Health Organization is to reach at least 70% vaccination coverage of the existing domestic dog population …

Report On Owned Dog Population Survey In Lapu-Lapu City, Philippines, Kazami Joanne Amano, Tamara Kartal, Amit Chaudhari

Demography and Statistics for Companion Animal Populations Collection

The Philippines has consistently been one of the top countries with an existing rabies problem. There is an average of 200 human rabies deaths reported annually, the majority of which are caused by dog bites (Deray, 2015). Globally, more than 95% of human rabies cases have been reported to have domestic dogs as their sources of infection (Cleaveland, et al., 2006). Therefore, it is paramount to address the rabies problem by focusing on the source. It has been established that communities achieve at least 70% vaccination coverage of the dog population to eliminate canine rabies (WHO, 2015) and maintain the …

Comparing Sight-Resight Methods For Dog Populations: Analysis Of 2015 And 2016 Rabies Vaccination Campaign Data From Haiti, Julie M. Cleaton

Public Health Theses

INTRODUCTION: Sight-resight studies are performed to estimate population sizes, in this case dog populations in rabies endemic areas.

AIM: This study compares one- and two-day sight-resight methods with two-day as the standard to explore the feasibility and accuracy of the one-day method in different vaccination campaign strategies and dog population characteristics.

METHODS: 2015 household survey data and sight-resight data are analyzed to find the percentage of free roaming and confined dogs in the community and use those to adjust the population estimate formulas. 2016 sight-resight data are analyzed as a two-day campaign and as if it had been a one-day …

Rabid Response: Unpacking The History Of The Rabies Virus To Examine Resource Allocation, Eliza C. Ramsey

International Studies Honors Projects

Rabies is a neurological disease transmitted by the bite of an infected animal and has assured fatal consequences if untreated. Despite the existence of an effective vaccine, the virus kills more than 50,000 people every year, primarily in low-income countries where dog-mediated strains of rabies persist. The long history of the disease has seen many transitions in disease context but also given rise to salient socio-cultural narratives that shape control and elimination campaigns. Effective future address of the disease requires knitting together historical lessons with frameworks of resource allocation.

Survey Of The Owned Dog Population In District Ii Of Quezon City, Philippines, Kazami Joanne Amano

Demography and Statistics for Companion Animal Populations Collection

Humane Society International (HSI) in cooperation with the Quezon City Veterinary Department (QCVD) conducted a dog population survey in District II of Quezon City, Philippines (figure 1). Quezon City accounts for 23.3% of Metro Manila’s total population. It is part of the National Capital Region (NCR) and is located near the center of Metro Manila (figure 2). It has a land area of 161.126 km² (16,112.6 hectares) with a human population of 2,936,116 million (Census, 2015) with an estimated annual growth rate of 2.42%. The population density is 19,151 persons per km².

Israel : Translocation Of Rabies, Sarah Baker

Global Public Health

Israel is now faced with a steady growing public health threat as canine rabies has reemerged in the northern region of Israel. While the steady increase in cases is of notable alarm, moreover the close contact most often shared between dog and human populations is of much more concern from a public health prospective. Rabies is a vaccine-preventable disease. Vaccinating dogs has proven to be the most cost-effective strategy for preventing rabies in people. Additionally, education on bite prevention and rabid animal behaviors for both children and adults is an essential extension of the long term rabies vaccination program that …

Comparison Of A Micro-Neutralization Test With The Rapid Fluorescent Focus Inhibition Test For Measuring Rabies Virus Neutralizing Antibodies, Todd G. Smith, Amy T. Gilbert

USDA Wildlife Services: Staff Publications

The rapid fluorescent focus inhibition test (RFFIT) is routinely used in the United States to measure rabies virus neutralizing antibodies (rVNA). RFFIT has a long history of reproducible and reliable results. The test has been modified over the years to use smaller volumes of reagents and samples, but requires a 50 μL minimum volume of test serum. To conduct pathogenesis studies, small laboratory animals such as mice are regularly tested for rVNA, but the minimum volume for a standard RFFIT may be impossible to obtain, particularly in scenarios of repeated sampling. To address this problem, a micro-neutralization test was developed …

The Impact Of Poverty On Dog Ownership And Access To Canine Rabies Vaccination: Results From A Knowledge, Attitudes And Practices Survey, Uganda 2013, Ryan M. Wallace, Jason Mehal, Yoshinori Nakazawa, Sergio Recuenco, Barnabas Bakamutumaho, Modupe Osinubi, Victor Tugumizemu, Jesse D. Blanton, Amy T. Gilbert, Joseph Wamala

USDA Wildlife Services: Staff Publications

Background: Rabies is a neglected disease despite being responsible for more human deaths than any other zoonosis. A lack of adequate human and dog surveillance, resulting in low prioritization, is often blamed for this paradox. Estimation methods are often employed to describe the rabies burden when surveillance data are not available, however these figures are rarely based on country-specific data.

Methods: In 2013 a knowledge, attitudes, and practices survey was conducted in Uganda to understand dog population, rabies vaccination, and human rabies risk factors and improve in-country and regional rabies burden estimates. Poisson and multi-level logistic regression techniques were conducted …

Rabies Virus Antibodies From Oral Vaccination As A Correlate Of Protection Against Lethal Infection In Wildlife, Susan M. Moore, Amy Gilbert, Ad Vos, Conrad M. Freuling, Christine K. Ellis, Jeannette Kliemt, Thomas Müller

USDA Wildlife Services: Staff Publications

Both cell-mediated and humoral immune effectors are important in combating rabies infection, although the humoral response receives greater attention regarding rabies prevention. The principle of preventive vaccination has been adopted for strategies of oral rabies vaccination (ORV) of wildlife reservoir populations for decades to control circulation of rabies virus in free-ranging hosts. There remains much debate about the levels of rabies antibodies (and the assays to measure them) that confer resistance to rabies virus. In this paper, data from published literature and our own unpublished animal studies on the induction of rabies binding and neutralizing antibodies following oral immunization of …

Ecological Potential For Rabies Virus Transmission Via Scavenging Of Dead Bats By Mesocarnivores, Tad C. Theimer, Annie C. Dyer, Brian W. Keeley, Amy T. Gilbert, David L. Bergman

USDA Wildlife Services: Staff Publications

Multiple species of bats are reservoirs of rabies virus in the Americas and are occasionally the source of spillover infections into mesocarnivore species. Although rabies transmission generally is assumed to occur via bite, laboratory studies have demonstrated the potential for rabies transmission via ingestion of rabid animals. We investigated the ecological potential for this mode of transmission by assessing mesocarnivore scavenging behavior of dead bats in suburban habitats of Flagstaff, Arizona, US. In autumn 2013, summer 2014, and autumn 2015, we placed 104 rabies-negative bat carcasses either near buildings, in wildland areas, or in residential yards and then monitored them …

Towards Canine Rabies Elimination In Cebu, Philippines: Assessment Of Health Economic Data, L. M. Miranda, M. E. Miranda, B. Hatch, R. Deray, S. A. Shwiff, M. C. Roces, C. E. Rupprecht

USDA Wildlife Services: Staff Publications

Rabies is endemic in the Philippines. In 2010, with support from the Bill and Melinda Gates Foundation, a canine rabies elimination project was initiated in the Philippine Archipelago of Visayan. We conducted an analysis of dog vaccination and human PEP costs for dog bite patients in a highly urbanized area and a low-income rural municipality in Cebu Province, Philippines, from 2010 to 2012. Our findings indicated that eliminating rabies in dogs through mass vaccination is more cost-effective than treating rabies exposures in humans. The average costs (in USD) per human life saved through PEP were $1620.28 in Cebu City and …

Den Use And Heterothermy During Winter In Free-Living, Suburban Striped Skunks, Tad C. Theimer, Cory T. Williams, Shylo R. Johnson, Amy T. Gilbert, David L. Bergman, C. Loren Buck

USDA Wildlife Services: Staff Publications

Many mammals use heterothermy to meet challenges of reduced food availability and low temperatures, but little is known about the prevalence of heterothermy in wild mesocarnivores. We monitored body temperature (T_b) in free-living striped skunks (Mephitis mephitis) through winter 2015–2016 in suburban Flagstaff, Arizona, a high-elevation site that experiences temperate winters. Subcutaneous T_b and heterothermy index (HI) were significantly affected by ambient temperature, and varied significantly across 7 skunks in midwinter. Twenty-one of 36 (58%) unique diurnal dens used by skunks were associated with human structures, and although females were found in dens under houses …

Estudio Epidemiológico De Rabia Bovina En Colombia Durante El Periodo 2006 A 2015, Orlando Hernández Cárdenas

Maestría en Ciencias Veterinarias

La rabia es una enfermedad fatal de origen viral y en Colombia ha sido la zoonosis de mayor importancia en el área de la salud pública. En la epidemiología de esta enfermedad los murciélagos hematófagos ocupan el primer lugar como reservorios y transmisores. Se realizó un estudio epidemiológico de los focos de rabia del año 2006 al 2015, donde se realizó la caracterización de los focos de rabia transmitida por murciélagos hematófagos mediante la geo-referenciación y su evolución en el tiempo donde las hembras mostraron ser las más afectadas, la especie bovina destinada al doble propósito fue la que mayor …