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2014

Behavior

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Measurement Of Tooth Brushing Frequency, Time Of Day And Duration Of Adults And Children In Jakarta, Indonesia, Anton Rahardjo, Diah A. Maharani, Bramma Kiswanjaya, Erik Idrus, Julie Nicholson, Paul J. Cunningham, Fred Schäfer Dec 2014

Measurement Of Tooth Brushing Frequency, Time Of Day And Duration Of Adults And Children In Jakarta, Indonesia, Anton Rahardjo, Diah A. Maharani, Bramma Kiswanjaya, Erik Idrus, Julie Nicholson, Paul J. Cunningham, Fred Schäfer

Journal of Dentistry Indonesia

Epidemiological study of tooth brushing is essential to evaluate dental health of a country. Objective: To obtain data on tooth brushing frequency, time of day and duration from adults and children in Jakarta, Indonesia. Methods: Toothbrushes containing data loggers were distributed to 120 random families in Jakarta to record how many times a day, when and for how long subjects brushed their teeth. The families were each composed of a mother, father and two children aged between 6 and 15 years. Results: The mean brushing frequency of the population was 1.27 times per day. The majority of the tooth brushing …


The Olig Family Member Hlh-17 Controls Animal Behavior By Modulating Neurotransmitter Signaling In Caenorhabditis Elegans, Chaquettea Felton Dec 2014

The Olig Family Member Hlh-17 Controls Animal Behavior By Modulating Neurotransmitter Signaling In Caenorhabditis Elegans, Chaquettea Felton

Biology Dissertations

In vertebrate and invertebrate systems, the role of glia-neuron interactions during development and behavior is becoming apparent. Recent studies have been aimed at characterizing glial-expressed proteins that affect the modulation of activities traditionally thought to be regulated by the neuron itself. The soil nematode Caenorhabditis elegans has recently emerged as an important invertebrate model to study glial roles in nervous system function and development. My dissertation work focuses on the characterization of HLH-17, a C. elegans basic helix-loop-helix transcription factor that is strongly and constitutively expressed in the glial cells that associate with four of the cephalic (CEP) neurons in …


A Gis-Centric Approach For Modeling Vessel Management Behavior System Data To Determine Oyster Vessel Behavior On Public Oyster Grounds In Louisiana, David X. Gallegos Dec 2014

A Gis-Centric Approach For Modeling Vessel Management Behavior System Data To Determine Oyster Vessel Behavior On Public Oyster Grounds In Louisiana, David X. Gallegos

University of New Orleans Theses and Dissertations

The satellite communications system called the Vessel Management System was used to provide geospatial data on oyster fishing over the nearly 1.7 million acres of the public water bottoms in Louisiana. An algorithm to analyze the data was developed in order to model vessel behaviors including docked, gearing, fishing and traveling. Vessel speeds were calculated via the Haversine formula at small and large intervals and compared to derive a measure of linearity. The algorithm was implemented into software using Python and inserted into a PostgreSQL database supporting geospatial information. Queries were developed to obtain reports on vessel activities and daily …


Determining The Critical Window Of Influence Of Pcb Perinatally On Behavioral And Hormonal Development In Sprague-Dawley Rat Pups, Natalie Sommerville, Lee A. Meserve, Howard C. Cromwell Dec 2014

Determining The Critical Window Of Influence Of Pcb Perinatally On Behavioral And Hormonal Development In Sprague-Dawley Rat Pups, Natalie Sommerville, Lee A. Meserve, Howard C. Cromwell

Honors Projects

Polychlorinated biphenyls (PCB) had widespread use in the United States in commercial manufacturing in the United States until the late 1970s. Even though they were banned, measurable amounts can still be found in the environment and food sources. PCB has known effects on altering hormone development and behavior in the species Rattus norvegicus. To determine the most crucial developmental time of exposure to PCB in Sprague-Dawley rat pups, rat pups were exposed to PCB at differing weeks of either gestation period or the first postnatal week. Behavioral tests were performed for the different rat pups, as well as blood …


Achieving Success With Pbis: The Teacher’S Role, Adrienne Boisson, Andre Byrd, Chris Williams Dec 2014

Achieving Success With Pbis: The Teacher’S Role, Adrienne Boisson, Andre Byrd, Chris Williams

Georgia Association for Positive Behavior Support Conference

The goal of this presentation is to help high school teachers feel less overwhelmed with the idea of implementing PBIS in their daily routine:

  • By clearly delineating the PBIS initiative, a definition of what PBIS is and what PBIS isn’t, how PBIS can impact your school culture, and the importance of data sharing
  • By offering a step-by-step guide of what it looks like to implement PBIS in your classroom on a daily/weekly/monthly basis
  • By providing PBIS resources, strategies, and examples of PBIS best practices utilized at NHS


Biology And Control Of The Bed Bug Cimex Lectularius L., Kevin Hinson Dec 2014

Biology And Control Of The Bed Bug Cimex Lectularius L., Kevin Hinson

All Dissertations

After vanishing from the public eye for more than 50 years, bed bugs have resurged to become one of the most widely discussed and heavily researched insect pests in the westernized world. Our inability to prevent and successfully treat infestations has been the driving force behind this wave of research. I addressed gaps in our understanding of bed bugs by examining behavioral and life history characteristics, as well as insecticide application responses. I showed that natural-based products are generally ineffective against bed bugs, particularly when used as a residual treatment. I also found that bed bugs may be killed through …


Investigating Infection Control Behaviors In Nurses, Elizabeth L. Beam Dec 2014

Investigating Infection Control Behaviors In Nurses, Elizabeth L. Beam

Theses & Dissertations

Nurses are trained in the use of personal protective equipment (PPE) and have access to policies and procedures to use in their daily work, but errors in technique during patient care are common. The purpose of this study was to better understand the infection control behaviors that nurses demonstrate in practice. The project described nursing behaviors related to basic airborne and contact precautions using personal protective equipment (PPE) in a simulated care environment. The specific aims were to 1) identify infection control behaviors by nurses which may or may not adhere to clinical standards for isolation practice while performing clinical …


The Critical Target Audience: Communicating Water Conservation Behaviors To Critical Thinking Styles, Laura M. Gorham, Alexa J. Lamm, Joy N. Rumble Dec 2014

The Critical Target Audience: Communicating Water Conservation Behaviors To Critical Thinking Styles, Laura M. Gorham, Alexa J. Lamm, Joy N. Rumble

Journal of Applied Communications

Although water covers approximately 70% of the planet, only a fraction is fresh water, and even less is used as a major source of drinking water. With the continuous increase in the amount of water used in modern standards of living, the quantity of water available is decreasing. The public is beginning to understand water needs to be conserved and they must play a role in water conservation. While previous literature examined how the majority of messages were catered toward the cost-effectiveness of conserving water, this study proposed how using a specific audience attribute could affect behaviors. The purpose of …


An Empirical Analysis Of Consumer Behavior In The Online Auction Marketplace, Calvin Salter Dec 2014

An Empirical Analysis Of Consumer Behavior In The Online Auction Marketplace, Calvin Salter

All Theses

The purpose of this paper is to analyze a unique data set pertaining to eBay auctions, in particular auctions of the first generation iPad. This analysis will give some interpretations about consumer behavior in the consumer electronics market on eBay, especially how the reputation of sellers and the shipping price that sellers charge affects the final selling price of an item. Other economics variables are analyzed to provide a broader picture of pricing determinants. Reputation is an important mechanism to consider in any market. However, reputation in the eBay market is particularly important because buyers do not interact with the …


The Neurobehavioral Consequences Of Gestational And Chronic Atrazine Exposure In Male And Female Sprague Dawley Rats, Jennifer L. Walters Dec 2014

The Neurobehavioral Consequences Of Gestational And Chronic Atrazine Exposure In Male And Female Sprague Dawley Rats, Jennifer L. Walters

Dissertations

The adverse health risks of exposure to the herbicide, atrazine, in humans are not fully understood. Although numerous studies have demonstrated atrazine to be an endocrine disrupter, the neurobehavioral consequences of atrazine exposure have not been thoroughly examined. The aim of this study was to investigate the effects of environmentally-relevant levels

of gestational followed by continued chronic atrazine exposure on motor function, learning and memory, anxiety, and striatal dopamine content in rodents. Pregnant Sprague Dawley rats were treated by gavage with 100 µg/kg atrazine (ATZ low), 10 me/kg atrazine (ATZ high), or vehicle on

gestational day l through postnatal day …


Behavioral Assessment Of Acute Inhibition Of System XC - In Rats, Victoria Lutgen, Jon M. Resch, Krista Qualmann, Nicholas J. Raddatz, Cristina Panhans, Ellen M. Olander, Linghai Kong, Sujean Choi, John R. Mantsch, David A. Baker Dec 2014

Behavioral Assessment Of Acute Inhibition Of System XC - In Rats, Victoria Lutgen, Jon M. Resch, Krista Qualmann, Nicholas J. Raddatz, Cristina Panhans, Ellen M. Olander, Linghai Kong, Sujean Choi, John R. Mantsch, David A. Baker

Biomedical Sciences Faculty Research and Publications

Rationale

Gaps in our understanding of glutamatergic signaling may be key obstacles in accurately modeling complex CNS diseases. System xc - is an example of a poorly understood component of glutamate homeostasis that has the potential to contribute to CNS diseases.

Objectives

This study aims to determine whether system xc - contributes to behaviors used to model features of CNS disease states.

Methods

In situ hybridization was used to map mRNA expression of xCT throughout the brain. Microdialysis in the prefrontal cortex was used to sample extracellular glutamate levels; HPLC was used to measure extracellular glutamate and tissue …


Impact Of Birth Order On Autism Spectrum Disorder Children’S Typically-Developing Siblings, Teresa Orozco Dec 2014

Impact Of Birth Order On Autism Spectrum Disorder Children’S Typically-Developing Siblings, Teresa Orozco

Electronic Theses, Projects, and Dissertations

Having a child with autism not only has devastating consequences for the individual child, but it also profoundly influences the entire family, including siblings. Researchers have explored the impact of having an ASD sibling on the typically-developing brother/sister; these studies have yielded inconsistent results, with some children benefitting from the experience while others encounter negative outcomes. The present study examined the role of birth order on ASD children’s typically-developing siblings’ outcome. It was predicted that typically-developing siblings born prior to their ASD sibling would have fewer behavioral difficulties and would do better academically compared to typically-developing siblings born after their …


A Study Of The Symbolic Clothing Disposition Behaviors Of Generation Y, Patti A. Borrello Dec 2014

A Study Of The Symbolic Clothing Disposition Behaviors Of Generation Y, Patti A. Borrello

Masters Theses

This qualitative study explored symbolic clothing disposition behaviors of Generation Y. The disposition of their wedding gowns was investigated using material possession attachment concepts. The study explored the following research questions: (1) What did Generation Y wedding gown owners do with their wedding gowns after the wedding?, (2) What disposition method was used and why the disposition method was chosen?, and (3) How is attachment to a wedding gowns related to the disposition method selected? Subjects were recruited using a non-probability, chain referral or snowball purposive approach. Within the broad categories of keeping and disposing of, many of the specific …


Broker-Dealers And Investment Advisers: A Behaviorial-Economics Analysis Of Competing Suggestions For Reform, Polina Demina Dec 2014

Broker-Dealers And Investment Advisers: A Behaviorial-Economics Analysis Of Competing Suggestions For Reform, Polina Demina

Michigan Law Review

For the average investor trying to save for retirement or a child’s college fund, the world of investing has become increasingly complex. These retail investors must turn more frequently to financial intermediaries, such as broker-dealers and investment advisers, to get sound investment advice. Such intermediaries perform different duties for their clients, however. The investment adviser owes his client a fiduciary duty of care and therefore must provide financial advice that is in the client’s best interests, while the broker-dealer must merely provide advice that is suitable to the client’s interests—a lower standard than the fiduciary duty of care. And yet …


Faculty Ethics In Law School: Shirking, Capture, And "The Matrix", Jeffrey L. Harrison Nov 2014

Faculty Ethics In Law School: Shirking, Capture, And "The Matrix", Jeffrey L. Harrison

Jeffrey L Harrison

The primary focus of this essay is the ethical dimension of the decisions faculty governance requires law professors to make. This essay is devoted to the proposition that conditions are ideal for most law schools to be governed for the benefit of the faculty at the expense of the welfare of students and others (stakeholders) who expect to be served by the law school. This section also suggests that faculty shirking, if it occurs, stems primarily from a lack of respect for those whom the law school serves. Section II addresses the second step. Having described shirking and capture in …


Low Vision Depression Prevention Trial In Age-Related Macular Degeneration: A Randomized Clinical Trial., Barry W. Rovner, Robin J Casten, Mark T Hegel, Robert W Massof, Benjamin E Leiby, Allen C Ho, William S Tasman Nov 2014

Low Vision Depression Prevention Trial In Age-Related Macular Degeneration: A Randomized Clinical Trial., Barry W. Rovner, Robin J Casten, Mark T Hegel, Robert W Massof, Benjamin E Leiby, Allen C Ho, William S Tasman

Department of Psychiatry and Human Behavior Faculty Papers

PURPOSE: To compare the efficacy of behavior activation (BA) + low vision rehabilitation (LVR) with supportive therapy (ST) + LVR to prevent depressive disorders in patients with age-related macular degeneration (AMD).

DESIGN: Single-masked, attention-controlled, randomized, clinical trial with outcome assessment at 4 months.

PARTICIPANTS: Patients with AMD and subsyndromal depressive symptoms attending retina practices (n = 188).

INTERVENTIONS: Before randomization, all subjects had 2 outpatient LVR visits, and were then randomized to in-home BA+LVR or ST+LVR. Behavior activation is a structured behavioral treatment that aims to increase adaptive behaviors and achieve valued goals. Supportive therapy is a nondirective, psychological treatment …


Platinum Dendritic Nanoparticles With Magnetic Behavior, Wenxian Li, Ziqi Sun, Dongliang Tian, Ivan P. Nevirkovets, S X. Dou Oct 2014

Platinum Dendritic Nanoparticles With Magnetic Behavior, Wenxian Li, Ziqi Sun, Dongliang Tian, Ivan P. Nevirkovets, S X. Dou

Shi Xue Dou

Magnetic nanoparticles have attracted increasing attention for biomedical applications in magnetic resonance imaging, high frequency magnetic field hyperthermia therapies, and magnetic-field-gradient-targeted drug delivery. In this study, three-dimensional (3D) platinum nanostructures with large surface area that features magnetic behavior have been demonstrated. The well-developed 3D nanodendrites consist of plentiful interconnected nano-arms ∼4 nm in size. The magnetic behavior of the 3D dendritic Pt nanoparticles is contributed by the localization of surface electrons due to strongly bonded oxygen/Pluronic F127 and the local magnetic moment induced by oxygen vacancies on the neighboring Pt and O atoms. The magnetization of the nanoparticles exhibits a …


Psychological Fears Among Low-Paid Female Sex Workers In Southwest China And Their Implications For Hiv Prevention, Shan Qiao Ph.D., Xiaoming Li Ph.D., Chen Zhang, Yuejiao Zhou, Zhiyong Shen, Zhenzhu Tang, Bonita Stanton Oct 2014

Psychological Fears Among Low-Paid Female Sex Workers In Southwest China And Their Implications For Hiv Prevention, Shan Qiao Ph.D., Xiaoming Li Ph.D., Chen Zhang, Yuejiao Zhou, Zhiyong Shen, Zhenzhu Tang, Bonita Stanton

Faculty Publications

Commercial sex plays a critical role in rapidly increasing heterosexual transmission of HIV in China. Low-paid female sex workers (FSWs) are especially vulnerable to HIV/AIDS. Because of the illegality and stigma associated with sex work, FSWs may constantly live with fears in their daily life. Based on cross-sectional study of 794 low-paid FSWs in China we described their psychological fears related to commercial sex and examined the associations between fears and HIV-related behaviors. Fear of HIV infection was significantly associated with consistent use of condoms with clients. However, fear of breaching sex worker identity significantly prevented the FSWs from consistently …


Family Of Flp Peptides In Caenorhabditis Elegans And Related Nematodes, Chris Li, Kyuhyung Kim Oct 2014

Family Of Flp Peptides In Caenorhabditis Elegans And Related Nematodes, Chris Li, Kyuhyung Kim

Publications and Research

Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system have been identified.The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large …


Do Predator Cues Influence Turn Alternation Behavior In Terrestrial Isopods Porcellio Laevis Latreille And Armadillidium Vulgare Latreille?, Scott L. Kight Oct 2014

Do Predator Cues Influence Turn Alternation Behavior In Terrestrial Isopods Porcellio Laevis Latreille And Armadillidium Vulgare Latreille?, Scott L. Kight

Department of Biology Faculty Scholarship and Creative Works

Terrestrial isopods (Crustacea: Oniscidea) make more alternating maze turns in response to negative stimuli, a navigational behavior that corrects divergence from a straight line. The present study investigates this behavioral pattern in two species, Porcellio laevis Latreille and Armadillidium vulgare Latreille, in response to short-term vs. long-term exposure to indirect cues from predatory ants. Neither isopod species increased the number of alternating turns in response to short-term indirect exposure to ants, but both species made significantly more alternating turns following continuous indirect exposure to ants for a period of one-week. These results are surprising given differences in behavioral and …


Fit To Focus: Measuring The Effects Of Activity On Behavior Management, Rochelle Daughma Oct 2014

Fit To Focus: Measuring The Effects Of Activity On Behavior Management, Rochelle Daughma

Education Undergraduate Research

No abstract provided.


Annotated Bibliography: Altruism, Empathy, And Prosocial Behavior (1998-2013), Erich Yahner Sep 2014

Annotated Bibliography: Altruism, Empathy, And Prosocial Behavior (1998-2013), Erich Yahner

BIBLIOGRAPHIES

No abstract provided.


Hsisp Annotated Bibliography: Altruism, Empathy, And Prosocial Behavior (1998-2013), Erich Yahner Sep 2014

Hsisp Annotated Bibliography: Altruism, Empathy, And Prosocial Behavior (1998-2013), Erich Yahner

Erich Yahner

No abstract provided.


Oh, Behave! Behavior As An Interaction Between Genes & The Environment, Emily G. Weigel, Michael Denieu, Andrew J. Gall Sep 2014

Oh, Behave! Behavior As An Interaction Between Genes & The Environment, Emily G. Weigel, Michael Denieu, Andrew J. Gall

Faculty Publications

This lesson is designed to teach students that behavior is a trait shaped by both genes and the environment. Students will read a scientific paper, discuss and generate predictions based on the ideas and data therein, and model the relationships between genes, the environment, and behavior. The lesson is targeted to meet the educational goals of undergraduate introductory biology, evolution, and animal behavior courses, but it is also suitable for advanced high school biology students. This lesson meets the criteria for the Next Generation Science Standard HS-LS4, Biological Evolution: Unity and Diversity (NGSS Lead States, 2013).


Opening Schumer’S Box: The Empirical Foundations Of Modern Consumer Finance Disclosure Law, Hosea H. Harvey Sep 2014

Opening Schumer’S Box: The Empirical Foundations Of Modern Consumer Finance Disclosure Law, Hosea H. Harvey

University of Michigan Journal of Law Reform

This Article explores the fundamental failure of Congress’ twenty-five-year quest to utilize disclosure as the primary tool to both regulate credit card issuers and educate consumers. From inception until present, reforms to this disclosure regime, even when premised on judgment and decision-making behavioralism, were nomothetic in orientation and ignored clear differences in population behavior and the heterogeniety of consumers. Current law prohibits credit card issuers from acquiring consumer socio-demographic data and prevents issuers and regulators from using market and policy experimentation to enhance disclosure’s efficacy. To explain why this regime was structured this way and why it must change, this …


Systematics Of The Neotropical Genus Leptodactylus Fitzinger, 1826 (Anura: Leptodactylidae): Phylogeny, The Relevance Of Non-Molecular Evidence, And Species Accounts, Rafael O. De Sá, Taran Grant, Arley Camargo, W. R. Heyer, María Laura Ponssa, Edward Stanley Sep 2014

Systematics Of The Neotropical Genus Leptodactylus Fitzinger, 1826 (Anura: Leptodactylidae): Phylogeny, The Relevance Of Non-Molecular Evidence, And Species Accounts, Rafael O. De Sá, Taran Grant, Arley Camargo, W. R. Heyer, María Laura Ponssa, Edward Stanley

Biology Faculty Publications

A phylogeny of the species-rich clade of the Neotropical frog genus Leptodactylus sensu stricto is presented on the basis of a total evidence analysis of molecular (mitochondrial and nuclear markers) and non-molecular (adult and larval morphological and behavioral characters) sampled from > 80% of the 75 currently recognized species. Our results support the monophyly of Leptodactylus sensu stricto, with Hydrolaetare placed as its sister group. The reciprocal monophyly of Hydrolaetare and Leptodactylus sensu stricto does not require that we consider Hydrolaetare as either a subgenus or synonym of Leptodactylus sensu lato. We recognize Leptodactylus sensu stricto, Hydrolaetare, Adenomera, and Lithodytes …


Using Social Cognitive Theory To Predict Behavior, Gretchen Walker, Amy Posner Aug 2014

Using Social Cognitive Theory To Predict Behavior, Gretchen Walker, Amy Posner

Journal of Undergraduate Research at Minnesota State University, Mankato

The purpose of this study was to test a theoretical model where self-efficacy is hypothesized to influence people’s behavioral intentions directly and indirectly through effects on outcome expectancy. Data on self-efficacy, outcome expectancy, and intention to jog two consecutive miles were collected from 115 college students enrolled in general education classes. As anticipated, path analyses indicated that efficacy had both a direct impact on intention and an indirect impact through its effects on outcome expectancy. The more efficacious people were, the more positive the outcomes they associated with jogging and the surer they were they would jog. The model tested …


Distinguishing Observed Inattentive Behaviors In The College Classroom As They Correlate To Brain Wave Activity Utilizing A Wireless Electroencephalograph, Christopher J. Aura, Matthew R. Stanton Aug 2014

Distinguishing Observed Inattentive Behaviors In The College Classroom As They Correlate To Brain Wave Activity Utilizing A Wireless Electroencephalograph, Christopher J. Aura, Matthew R. Stanton

Journal of Undergraduate Research at Minnesota State University, Mankato

A significant amount of research has been devoted to the behavioral correlates of inattention in children (A.P.A., 2000; Arnold, 2000; Gordon & Barkley, 1998). It is proposed by the authors that college students, in their several years of experience, are much more capable of masking these trademark behaviors. When a child loses interest they will begin to openly look around the room, shift in their seat, or chat with their neighbors (Sandberg, Rutter & Taylor, 1978; Arnold, 2000). College students however, are proposed to candidly fidget, shift in their seat, or even maintain eye contact with their instructor while “daydreaming”. …


Pupil Dilation Dynamics Track Attention To High-Level Information, Olivia E. Kang, Katherine E. Huffer, Thalia P. Wheatley Aug 2014

Pupil Dilation Dynamics Track Attention To High-Level Information, Olivia E. Kang, Katherine E. Huffer, Thalia P. Wheatley

Dartmouth Scholarship

It has long been thought that the eyes index the inner workings of the mind. Consistent with this intuition, empirical research has demonstrated that pupils dilate as a consequence of attentional effort. Recently, Smallwood et al. (2011) demonstrated that pupil dilations not only provide an index of overall attentional effort, but are time-locked to stimulus changes during attention (but not during mind-wandering). This finding suggests that pupil dilations afford a dynamic readout of conscious information processing. However, because stimulus onsets in their study involved shifts in luminance as well as information, they could not determine whether this coupling of stimulus …


Neuroinflammation And Neurologic Deficits In Diabetes Linked To Brain Accumulation Of Amylin, Sarah Srodulski, Savita Sharma, Adam B. Bachstetter, Jennifer M. Brelsfoard, Conrado Pascual, Xinmin Simon Xie, Kathryn E. Saatman, Linda J. Van Eldik, Florin Despa Aug 2014

Neuroinflammation And Neurologic Deficits In Diabetes Linked To Brain Accumulation Of Amylin, Sarah Srodulski, Savita Sharma, Adam B. Bachstetter, Jennifer M. Brelsfoard, Conrado Pascual, Xinmin Simon Xie, Kathryn E. Saatman, Linda J. Van Eldik, Florin Despa

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone synthesized and co-secreted with insulin by pancreatic β-cells. Amylin deposition is promoted by chronic hypersecretion of amylin (hyperamylinemia), which is common in humans with obesity or pre-diabetic insulin resistance. Human amylin oligomerizes quickly when oversecreted, which is toxic, induces inflammation in pancreatic islets and contributes to the development of T2D. Here, we tested the hypothesis that accumulation of oligomerized amylin affects brain function.

METHODS: In contrast to amylin from humans, rodent amylin is neither amyloidogenic nor cytotoxic. …